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The map label for this gene is cbl

Identifier: 187733604

GI number: 187733604

Start: 894266

End: 895216

Strand: Direct

Name: cbl

Synonym: SbBS512_E0971

Alternate gene names: 187733604

Gene position: 894266-895216 (Clockwise)

Preceding gene: 187733189

Following gene: 187732866

Centisome position: 19.37

GC content: 48.26

Gene sequence:

>951_bases
GTGAATTTCCAACAACTAAAGATAATCCGCGAGGCTGCACGTCAGGATTACAACCTGACAGAGGTTGCGAATATGCTTTT
TACCTCACAGTCCGGCGTCAGCCGTCATATTCGGGAACTGGAGGATGAACTTGGCATCGAAATATTTGTTCGACGAGGTA
AGCGGCTGCTGGGCATGACTGAACCGGGCAAAGCATTACTGGTCATTGCAGAACGTATTCTGAATGAAGCCAGTAATGTT
CGTCGGCTTGCAGACCTGTTTACCAACGATACGTTTGGCGTTCTCACTATTGCAACGACGCATACTCAGGCACGTTATAG
CTTGCCAGAGGTCATTAAAGCTTTTCGCGAACTTTTCCCGGAGGTTCGGCTCGAGCTAATCCAGGGGACGCCACAGGAAA
TTGCGACGTTGTTGCAAAATGGCGAAGCTGATATTGGTATCGCCAGCGAGCGTTTGAGTAATGACCCGCAGCTCGTCGCC
TTCCCGTGGTTTCGTTGGCACCATAGTTTGCTTGTTCCACTCGATCATCCCTTAACGCAAATTACACCATTGACGCTGGA
ATCAATAGCGAAGTGGCCGTTAATCACTTACCGACAGGGGATTACGGGGCGCTCACGTATTGATGACGCATTTGCCCGCA
AAGGTTTGCTGGCAGATATTGTATTAAGTGCGCAGGATTCTGATGTCATTAAAACCTATGTTGCTCTTGGGCTTGGGATC
GGATTAGTTGCCGAACAATCCAGCGGCGAACAAGAGGAAGAGAATTTAATCCGTCTGGATACGCGGCATCTTTTCGATGC
TAATACTGTCTGGTTGGGACTGAAGCGAGGACAACTTCAGCGTAACTATGTCTGGCGCTTTCTGGAACTTTGTAATGCAG
GACTGTCAGTTGAGGATATCAAGCGGCAGGTGATGGAAAACAGTGAAGAGGAAATTGATTATCAGATATAG

Upstream 100 bases:

>100_bases
CGTTATATCGGGATGGAATAAGATGCGGGTTTTTATTATTTGTTATGCCGGGCATTAGACTTTAACAATAACGGGAAATC
TGAACTGCCCGGAGTTTACC

Downstream 100 bases:

>100_bases
CAAAAAGCCCGCTATAAAAGCGGGCTTTTCAGAAATTTGGCTCCTCTGACTGGGATCGCCGTAGCCATTAACTGGCTGAT
TGGAAAGCTAAAACAAAAAA

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTFGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTFGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTFGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=98.7341772151899, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1787530, Length=313, Percent_Identity=41.2140575079872, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1788481, Length=293, Percent_Identity=27.3037542662116, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI157672245, Length=213, Percent_Identity=28.169014084507, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=28.0851063829787, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=28.1124497991968, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=24.1935483870968, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI145693105, Length=232, Percent_Identity=25, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.2798353909465, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=211, Percent_Identity=30.3317535545024, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082132, Length=137, Percent_Identity=34.3065693430657, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35934; Mature: 35934

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTFGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTFGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]