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The map label for this gene is prlC [H]

Identifier: 187736519

GI number: 187736519

Start: 2477612

End: 2479792

Strand: Direct

Name: prlC [H]

Synonym: Amuc_2040

Alternate gene names: 187736519

Gene position: 2477612-2479792 (Clockwise)

Preceding gene: 187736513

Following gene: 187736520

Centisome position: 93.0

GC content: 59.06

Gene sequence:

>2181_bases
ATGGCCGCCATGAGTTTACTCAGGCAGTCTCTTCATCTCTTTTTCCTCTTCCTCTCCGTGGCCCTTCCCTCCCCGGCGGC
CACTTCCGCCCACCCTTTCCTGGACAGGGAGCGTCCCATCCGCTGGAGCCGGCTGACCCAGGACAAGCTGGAACCGGATA
TTCAGGAAGCCATGCGCCTCACCCGGACAGCCATAGAGGAAATCAGCCGCCTCCGTCCGGAAGAAATGACGTATGAAAAT
ACGTTCGGCGCGCTGGAGAAAAGCAATGACCTCCTTACGGAAGGCATGTGCAAGGCTTATGTCCTGAAAAGCCTGTGCGA
CAGCGGGGAACTTCGCAAGGCCATGGATTCGGTCGCTCCCCGCGTGTCCGCCTTCCTTTCCTCCGTCACGAAAGACCAGG
CCCTGTGGAAAGTCCTGAAAACCGCGGAGGAACGCCTGCGGCAAACTCACCTGAACCCCGAACAGGAACGGTACATGGAG
CTAAGCATGCAGAGCTTCCGGGATAACGGCGCTGATCTGCCGCCGGACAAGCGCGCACGGCTTGAGTCCATTGACAGGGA
ACTGACGCTCGCCTCCCAGCGTTTCAACAATTTGTATATGGATGCCAGGAAATCCTGGACCTGGACGGTGCGGAACGCCG
CCCTTCTGGAAGGGATAGACGGAAGCGCCCTGCAGCAGGCGCGTGAAGAATTTCTGAAGCGCCAGCCCGGCCAGTCCGGT
CCGGGCTGGACGTTCACGCTTGATTCCGCGGCTTCCGCCCGGGTCATGGAAAAAGCCCGGAGGGAAGAATGCCGGAAAGA
TTTATGGGAACACCGCCAGTCTCTGGCTACGGGAACATGCGACACGGAACCCGTCATCAGGGAAATCCTCTCCCTGCGCC
GTGAAAAGGCGCATTTGTGCGGATATAAGGAATACCCGGATTACGCCCTGCGCGAGAGCATGGCGGAAAACGGGGAAAAC
GCCATAAAGTTCGTCAATGAGCTGCTGGACAAGATCAAGGCCCCCTTTTTCCGTGAAATGGAAACGCTCCGCAGCCTGAA
GGCCCGCCTTACGGGGCAGGAAAACGCCCGCCTGAATCCCTGGGACGTGGCATATTACGCCAATCTCCGGGCAGAAGAAC
ATTTCCGGCTGGACCAGGAGGAGCTGCGCCGCCACTTTCCCCTTCCCCGCGTGCTGGACGGCCTGTTTTCCCTGGCGGAG
CGGCTGTACGGCATCCGCGTGAAGGAAGTTCCGGCGCGGCAGTCCCTCTCCGGCATCCCGGCAGGCGAATCCGCCGGAAC
CGTGGAAGTATGGCATCCGGACGTACGCTTTTTCACGATTGACGACGGCAACGGCAACCAACTGGGTTCCTTTTACCTGG
ATCTTTTCTCCCGTAGCAATAAACGGGCCGGAGCGTGGATGAACACCCTGGATACGGGCAGCCCGTCCACGCCGGAGACC
CCGGGCAAGCCGCGCCTGGGCATGGTCTGCCTCAATATCCATCCCCCCGCGGCAGGAGACACGGTGATACTGTCCCACCG
GGAAGTCAGGACTTTATTCCATGAGTTCGGCCACTTGCTGCACCTGATGTTTACCAGGGTTTCCATTCCTTCCCTGGCGG
GGACCAGCGTGCCGCGGGATTTTGTGGAAGTCCCCTCCCAATTCATGGAAAACTGGTGCTGGCGGCCGGACGTGCTGAAA
AGCTTTGCGCGCCATGAACGAACGGGACTCCCCATTCCGGAGGAAATGCTGAACTCTCTGGACGCCTCCCGCGGCAATAC
GCCTGCCCTCGCGCTGGCCGGGCAGCTCCTGTACGCAAAGATGGACCTGGCCGTGCATTCGGAACCGGAACGCTTCTCCG
CCGGCTCTCTTGATGATGTGGATTCCGCCGTAGCGGGAGATATGGATTATTTCAAAGATTTCAAAAGAGCCGGCAAGCTG
CGCACGGCGCGTCACTTGTTTTCCTCTCCTGCGGGCTATGCCTCCTTTTATTTCTCCTACCAATGGGCGGAAGTTTTGGA
CAAAGATATTTTTGAAGCCTTTGAACGGGCCGGAGGCCAGGACAGGGAAACGGCAGGAAAATTCCGGAAAACCATTCTGG
AAAAAGGCTATGCTGTCCCGCCCATGCGGCAGTTCATGGATTTCATGGGAAGAAAGCCGCGCATGGACGCCATGCTCCGC
AAGAGGCGGCTGGCATCCTGA

Upstream 100 bases:

>100_bases
TACATGCAAACGGGAAGCCGTTCAAGACCGGGCCCCGGCTTTTCCCCTGATGCAGACACGAAAAGCGCAAGGCTTGAAGG
AGAAACCTGCTTCCGGTAGG

Downstream 100 bases:

>100_bases
AATAAAGGAGCCCCAAACCGCAGCAGCCTCTTCCGCGCGGCACAGAGGCAAGTCACATATTATACATTTGTTTAATTAAA
TTATCCCTTCATTATGCAAA

Product: Oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MAAMSLLRQSLHLFFLFLSVALPSPAATSAHPFLDRERPIRWSRLTQDKLEPDIQEAMRLTRTAIEEISRLRPEEMTYEN
TFGALEKSNDLLTEGMCKAYVLKSLCDSGELRKAMDSVAPRVSAFLSSVTKDQALWKVLKTAEERLRQTHLNPEQERYME
LSMQSFRDNGADLPPDKRARLESIDRELTLASQRFNNLYMDARKSWTWTVRNAALLEGIDGSALQQAREEFLKRQPGQSG
PGWTFTLDSAASARVMEKARREECRKDLWEHRQSLATGTCDTEPVIREILSLRREKAHLCGYKEYPDYALRESMAENGEN
AIKFVNELLDKIKAPFFREMETLRSLKARLTGQENARLNPWDVAYYANLRAEEHFRLDQEELRRHFPLPRVLDGLFSLAE
RLYGIRVKEVPARQSLSGIPAGESAGTVEVWHPDVRFFTIDDGNGNQLGSFYLDLFSRSNKRAGAWMNTLDTGSPSTPET
PGKPRLGMVCLNIHPPAAGDTVILSHREVRTLFHEFGHLLHLMFTRVSIPSLAGTSVPRDFVEVPSQFMENWCWRPDVLK
SFARHERTGLPIPEEMLNSLDASRGNTPALALAGQLLYAKMDLAVHSEPERFSAGSLDDVDSAVAGDMDYFKDFKRAGKL
RTARHLFSSPAGYASFYFSYQWAEVLDKDIFEAFERAGGQDRETAGKFRKTILEKGYAVPPMRQFMDFMGRKPRMDAMLR
KRRLAS

Sequences:

>Translated_726_residues
MAAMSLLRQSLHLFFLFLSVALPSPAATSAHPFLDRERPIRWSRLTQDKLEPDIQEAMRLTRTAIEEISRLRPEEMTYEN
TFGALEKSNDLLTEGMCKAYVLKSLCDSGELRKAMDSVAPRVSAFLSSVTKDQALWKVLKTAEERLRQTHLNPEQERYME
LSMQSFRDNGADLPPDKRARLESIDRELTLASQRFNNLYMDARKSWTWTVRNAALLEGIDGSALQQAREEFLKRQPGQSG
PGWTFTLDSAASARVMEKARREECRKDLWEHRQSLATGTCDTEPVIREILSLRREKAHLCGYKEYPDYALRESMAENGEN
AIKFVNELLDKIKAPFFREMETLRSLKARLTGQENARLNPWDVAYYANLRAEEHFRLDQEELRRHFPLPRVLDGLFSLAE
RLYGIRVKEVPARQSLSGIPAGESAGTVEVWHPDVRFFTIDDGNGNQLGSFYLDLFSRSNKRAGAWMNTLDTGSPSTPET
PGKPRLGMVCLNIHPPAAGDTVILSHREVRTLFHEFGHLLHLMFTRVSIPSLAGTSVPRDFVEVPSQFMENWCWRPDVLK
SFARHERTGLPIPEEMLNSLDASRGNTPALALAGQLLYAKMDLAVHSEPERFSAGSLDDVDSAVAGDMDYFKDFKRAGKL
RTARHLFSSPAGYASFYFSYQWAEVLDKDIFEAFERAGGQDRETAGKFRKTILEKGYAVPPMRQFMDFMGRKPRMDAMLR
KRRLAS
>Mature_725_residues
AAMSLLRQSLHLFFLFLSVALPSPAATSAHPFLDRERPIRWSRLTQDKLEPDIQEAMRLTRTAIEEISRLRPEEMTYENT
FGALEKSNDLLTEGMCKAYVLKSLCDSGELRKAMDSVAPRVSAFLSSVTKDQALWKVLKTAEERLRQTHLNPEQERYMEL
SMQSFRDNGADLPPDKRARLESIDRELTLASQRFNNLYMDARKSWTWTVRNAALLEGIDGSALQQAREEFLKRQPGQSGP
GWTFTLDSAASARVMEKARREECRKDLWEHRQSLATGTCDTEPVIREILSLRREKAHLCGYKEYPDYALRESMAENGENA
IKFVNELLDKIKAPFFREMETLRSLKARLTGQENARLNPWDVAYYANLRAEEHFRLDQEELRRHFPLPRVLDGLFSLAER
LYGIRVKEVPARQSLSGIPAGESAGTVEVWHPDVRFFTIDDGNGNQLGSFYLDLFSRSNKRAGAWMNTLDTGSPSTPETP
GKPRLGMVCLNIHPPAAGDTVILSHREVRTLFHEFGHLLHLMFTRVSIPSLAGTSVPRDFVEVPSQFMENWCWRPDVLKS
FARHERTGLPIPEEMLNSLDASRGNTPALALAGQLLYAKMDLAVHSEPERFSAGSLDDVDSAVAGDMDYFKDFKRAGKLR
TARHLFSSPAGYASFYFSYQWAEVLDKDIFEAFERAGGQDRETAGKFRKTILEKGYAVPPMRQFMDFMGRKPRMDAMLRK
RRLAS

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=716, Percent_Identity=26.536312849162, Blast_Score=236, Evalue=7e-62,
Organism=Homo sapiens, GI14149738, Length=708, Percent_Identity=26.4124293785311, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI156105687, Length=610, Percent_Identity=26.5573770491803, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1789913, Length=690, Percent_Identity=32.463768115942, Blast_Score=341, Evalue=8e-95,
Organism=Escherichia coli, GI1787819, Length=722, Percent_Identity=28.2548476454294, Blast_Score=257, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI32565901, Length=541, Percent_Identity=23.2902033271719, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71999758, Length=673, Percent_Identity=21.9910846953938, Blast_Score=99, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319793, Length=583, Percent_Identity=27.1012006861063, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322715, Length=675, Percent_Identity=24.1481481481481, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20129717, Length=419, Percent_Identity=28.8782816229117, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21356111, Length=619, Percent_Identity=25.8481421647819, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 82784; Mature: 82653

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMSLLRQSLHLFFLFLSVALPSPAATSAHPFLDRERPIRWSRLTQDKLEPDIQEAMRL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
TRTAIEEISRLRPEEMTYENTFGALEKSNDLLTEGMCKAYVLKSLCDSGELRKAMDSVAP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RVSAFLSSVTKDQALWKVLKTAEERLRQTHLNPEQERYMELSMQSFRDNGADLPPDKRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
LESIDRELTLASQRFNNLYMDARKSWTWTVRNAALLEGIDGSALQQAREEFLKRQPGQSG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PGWTFTLDSAASARVMEKARREECRKDLWEHRQSLATGTCDTEPVIREILSLRREKAHLC
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
GYKEYPDYALRESMAENGENAIKFVNELLDKIKAPFFREMETLRSLKARLTGQENARLNP
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
WDVAYYANLRAEEHFRLDQEELRRHFPLPRVLDGLFSLAERLYGIRVKEVPARQSLSGIP
CCCHHEECCCCHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHCCCCC
AGESAGTVEVWHPDVRFFTIDDGNGNQLGSFYLDLFSRSNKRAGAWMNTLDTGSPSTPET
CCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCC
PGKPRLGMVCLNIHPPAAGDTVILSHREVRTLFHEFGHLLHLMFTRVSIPSLAGTSVPRD
CCCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FVEVPSQFMENWCWRPDVLKSFARHERTGLPIPEEMLNSLDASRGNTPALALAGQLLYAK
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MDLAVHSEPERFSAGSLDDVDSAVAGDMDYFKDFKRAGKLRTARHLFSSPAGYASFYFSY
HHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QWAEVLDKDIFEAFERAGGQDRETAGKFRKTILEKGYAVPPMRQFMDFMGRKPRMDAMLR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHH
KRRLAS
HHHCCC
>Mature Secondary Structure 
AAMSLLRQSLHLFFLFLSVALPSPAATSAHPFLDRERPIRWSRLTQDKLEPDIQEAMRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
TRTAIEEISRLRPEEMTYENTFGALEKSNDLLTEGMCKAYVLKSLCDSGELRKAMDSVAP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RVSAFLSSVTKDQALWKVLKTAEERLRQTHLNPEQERYMELSMQSFRDNGADLPPDKRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
LESIDRELTLASQRFNNLYMDARKSWTWTVRNAALLEGIDGSALQQAREEFLKRQPGQSG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PGWTFTLDSAASARVMEKARREECRKDLWEHRQSLATGTCDTEPVIREILSLRREKAHLC
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
GYKEYPDYALRESMAENGENAIKFVNELLDKIKAPFFREMETLRSLKARLTGQENARLNP
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
WDVAYYANLRAEEHFRLDQEELRRHFPLPRVLDGLFSLAERLYGIRVKEVPARQSLSGIP
CCCHHEECCCCHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHCCCCC
AGESAGTVEVWHPDVRFFTIDDGNGNQLGSFYLDLFSRSNKRAGAWMNTLDTGSPSTPET
CCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCC
PGKPRLGMVCLNIHPPAAGDTVILSHREVRTLFHEFGHLLHLMFTRVSIPSLAGTSVPRD
CCCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FVEVPSQFMENWCWRPDVLKSFARHERTGLPIPEEMLNSLDASRGNTPALALAGQLLYAK
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MDLAVHSEPERFSAGSLDDVDSAVAGDMDYFKDFKRAGKLRTARHLFSSPAGYASFYFSY
HHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QWAEVLDKDIFEAFERAGGQDRETAGKFRKTILEKGYAVPPMRQFMDFMGRKPRMDAMLR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHH
KRRLAS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]