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The map label for this gene is acrE [H]

Identifier: 187736520

GI number: 187736520

Start: 2480015

End: 2481274

Strand: Direct

Name: acrE [H]

Synonym: Amuc_2041

Alternate gene names: 187736520

Gene position: 2480015-2481274 (Clockwise)

Preceding gene: 187736519

Following gene: 187736521

Centisome position: 93.09

GC content: 58.33

Gene sequence:

>1260_bases
ATGTATAATAAGCCTTTGACGTTTGCCGCAACAACCCTGCTCCTTTGCTCCCCGGTGATGATATTAACTTCCTGCGAAGG
GGAAAAGGATTCCGCAGCCCAGGCGCCGGCGCTCGTTCCCGAAGTGCAGGTGACCAAACTGGTCACGAAGGATGTTCCCA
TCAGGCAGGAATGGGTGGGCACCCTGCGCGGCACGGAAGATGCCGAAATCCGCTCCCAGGTGACGGGATACCTTCTTTCC
AAGGATTACCGGGACGGCGCTTATGTCAAGAAGGGCCAGGTGCTTTTCCAGATTGATCCCCGCCCGTTCCAGGCAACGCT
GGACCAGGCCCAGGGGAGACTGGAACAATATGAAGCCACGCTGAAAAAATACAAGCTGGACGTGGAACGCTATACCCCGC
TGGTGAAAACCGGCTCCGTCAGCCGCAAGCAGCTGGACGACGCCCTGCAGCAGGTCCAGGAAACGGAAGCCGCCATCGCC
ACGGCAAAGGCCCAGGTGGATGAAGCAAAAATCAATCTTAAATTCACCACCATTACAGCCCCCATTTCCGGCCTGGCCGG
CCTGGCAACCCCTTCCATCGGCAACCTGCTGACGCCCTCCAGCCCCACGCCGCTGACCACCATTTCCTCCATTGACCCCA
TTCGGGTGGATTTCTCCGTAAGCGAACGGGACTTCCTGAACTCCATGGACAATAATCTGACCAGGCAGAAGCACCTCAAA
TTTGACGTGATTCTTGCCAACGGCACGGAATATCCCATGCAGGGCGAACCCGTGGCCATTGACAGGAATGTGGATGCCCA
GACCGGTACCATCAACATCGTCGGGCATATTCCCAATCCGAACCTGACGCTGCGGCCCGGCATGTTCGTCCGCGTCCGCG
CCACGGTGAAAACGCTGGAAAACGCCGCGCTGGTGCCTCCGCGCGCCATTCTGTCCGCCCAGAGCGCCAAATTCATCATT
TACCTGGATGACAAGAACATTCCCCACATGCAGGTCGTCAACCTCGGCCCCGTTGTTGACGGCATGCAGGTAATCAACAT
CATTCCCATGCCGCACTCCACCTTCACGAAGGACAGCCCCATCGTGGTGGAGGGAATCATGCAGGCGGCCAAGGTGCAGG
GACAAGCCCCCGTCAAGCCGCTTCCCTACAAGCCCGTAGTTTCCCAGCCCGTCATGCCCTCCATAGGGGCCCAGTCCTTT
GAAAAGGCCAGGACGCCAGAAGGCATGAAGGATGGAGAAGCCCAGCCGTCCGCCAAGTAA

Upstream 100 bases:

>100_bases
TCAGAACACATCTTTGCGTTGACTTTGCAAGAAAAAGAAGAGAAAATTCTTCCGCTTTGCCGCATCTTCCGGCACCAGCC
GCAACCAACCGCATTCATTT

Downstream 100 bases:

>100_bases
CCTCCCTTATCCGGAGACCCACCATCTTCCCTTTTCCCGCGCATTTTCATGATTTAACGCCATGTCCAGCTTCTTCATCA
AACACCCGACCATTGCCATC

Product: efflux transporter, RND family, MFP subunit

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MYNKPLTFAATTLLLCSPVMILTSCEGEKDSAAQAPALVPEVQVTKLVTKDVPIRQEWVGTLRGTEDAEIRSQVTGYLLS
KDYRDGAYVKKGQVLFQIDPRPFQATLDQAQGRLEQYEATLKKYKLDVERYTPLVKTGSVSRKQLDDALQQVQETEAAIA
TAKAQVDEAKINLKFTTITAPISGLAGLATPSIGNLLTPSSPTPLTTISSIDPIRVDFSVSERDFLNSMDNNLTRQKHLK
FDVILANGTEYPMQGEPVAIDRNVDAQTGTINIVGHIPNPNLTLRPGMFVRVRATVKTLENAALVPPRAILSAQSAKFII
YLDDKNIPHMQVVNLGPVVDGMQVINIIPMPHSTFTKDSPIVVEGIMQAAKVQGQAPVKPLPYKPVVSQPVMPSIGAQSF
EKARTPEGMKDGEAQPSAK

Sequences:

>Translated_419_residues
MYNKPLTFAATTLLLCSPVMILTSCEGEKDSAAQAPALVPEVQVTKLVTKDVPIRQEWVGTLRGTEDAEIRSQVTGYLLS
KDYRDGAYVKKGQVLFQIDPRPFQATLDQAQGRLEQYEATLKKYKLDVERYTPLVKTGSVSRKQLDDALQQVQETEAAIA
TAKAQVDEAKINLKFTTITAPISGLAGLATPSIGNLLTPSSPTPLTTISSIDPIRVDFSVSERDFLNSMDNNLTRQKHLK
FDVILANGTEYPMQGEPVAIDRNVDAQTGTINIVGHIPNPNLTLRPGMFVRVRATVKTLENAALVPPRAILSAQSAKFII
YLDDKNIPHMQVVNLGPVVDGMQVINIIPMPHSTFTKDSPIVVEGIMQAAKVQGQAPVKPLPYKPVVSQPVMPSIGAQSF
EKARTPEGMKDGEAQPSAK
>Mature_419_residues
MYNKPLTFAATTLLLCSPVMILTSCEGEKDSAAQAPALVPEVQVTKLVTKDVPIRQEWVGTLRGTEDAEIRSQVTGYLLS
KDYRDGAYVKKGQVLFQIDPRPFQATLDQAQGRLEQYEATLKKYKLDVERYTPLVKTGSVSRKQLDDALQQVQETEAAIA
TAKAQVDEAKINLKFTTITAPISGLAGLATPSIGNLLTPSSPTPLTTISSIDPIRVDFSVSERDFLNSMDNNLTRQKHLK
FDVILANGTEYPMQGEPVAIDRNVDAQTGTINIVGHIPNPNLTLRPGMFVRVRATVKTLENAALVPPRAILSAQSAKFII
YLDDKNIPHMQVVNLGPVVDGMQVINIIPMPHSTFTKDSPIVVEGIMQAAKVQGQAPVKPLPYKPVVSQPVMPSIGAQSF
EKARTPEGMKDGEAQPSAK

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=339, Percent_Identity=33.0383480825959, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789665, Length=312, Percent_Identity=35.8974358974359, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786668, Length=331, Percent_Identity=34.7432024169184, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082036, Length=304, Percent_Identity=31.25, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87081796, Length=274, Percent_Identity=28.1021897810219, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45637; Mature: 45637

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNKPLTFAATTLLLCSPVMILTSCEGEKDSAAQAPALVPEVQVTKLVTKDVPIRQEWVG
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
TLRGTEDAEIRSQVTGYLLSKDYRDGAYVKKGQVLFQIDPRPFQATLDQAQGRLEQYEAT
HHCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHH
LKKYKLDVERYTPLVKTGSVSRKQLDDALQQVQETEAAIATAKAQVDEAKINLKFTTITA
HHHHHCCHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEC
PISGLAGLATPSIGNLLTPSSPTPLTTISSIDPIRVDFSVSERDFLNSMDNNLTRQKHLK
CHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHHCCCHHHHCCE
FDVILANGTEYPMQGEPVAIDRNVDAQTGTINIVGHIPNPNLTLRPGMFVRVRATVKTLE
EEEEEECCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCEEECCCCEEEEEHHHHHHH
NAALVPPRAILSAQSAKFIIYLDDKNIPHMQVVNLGPVVDGMQVINIIPMPHSTFTKDSP
CCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCC
IVVEGIMQAAKVQGQAPVKPLPYKPVVSQPVMPSIGAQSFEKARTPEGMKDGEAQPSAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYNKPLTFAATTLLLCSPVMILTSCEGEKDSAAQAPALVPEVQVTKLVTKDVPIRQEWVG
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
TLRGTEDAEIRSQVTGYLLSKDYRDGAYVKKGQVLFQIDPRPFQATLDQAQGRLEQYEAT
HHCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHH
LKKYKLDVERYTPLVKTGSVSRKQLDDALQQVQETEAAIATAKAQVDEAKINLKFTTITA
HHHHHCCHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEC
PISGLAGLATPSIGNLLTPSSPTPLTTISSIDPIRVDFSVSERDFLNSMDNNLTRQKHLK
CHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHHCCCHHHHCCE
FDVILANGTEYPMQGEPVAIDRNVDAQTGTINIVGHIPNPNLTLRPGMFVRVRATVKTLE
EEEEEECCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCEEECCCCEEEEEHHHHHHH
NAALVPPRAILSAQSAKFIIYLDDKNIPHMQVVNLGPVVDGMQVINIIPMPHSTFTKDSP
CCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCC
IVVEGIMQAAKVQGQAPVKPLPYKPVVSQPVMPSIGAQSFEKARTPEGMKDGEAQPSAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]