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The map label for this gene is lysC [H]

Identifier: 187736447

GI number: 187736447

Start: 2384480

End: 2385697

Strand: Direct

Name: lysC [H]

Synonym: Amuc_1965

Alternate gene names: 187736447

Gene position: 2384480-2385697 (Clockwise)

Preceding gene: 187736446

Following gene: 187736450

Centisome position: 89.5

GC content: 58.78

Gene sequence:

>1218_bases
ATGGCTCTTATCGTTCAAAAATTCGGGGGCAGCTCCGTCGGCACCATTGACCGCATCCGCAATGTAGCGCGCCGCATCCA
TGAAACCGCCAGGGAAGGCAACCAGGTGGTCGCCGTCGTTTCCGCCATGAGCGGCGTGACGGACAAGCTGATCGGGCTTG
CCAGGGAATTGTCTGAAACGCCTTGCGAACGTGAACTTGACGTGCTGATGGCCACCGGCGAACAGCAGTCCATCGCCCTG
CTCTGCATGGCCCTGCATGAACTGGGTGAAAAAGCCATGTCCTTTACGGGGGCGCAGGCCGGAATCACCACCTTCGGCAG
CCACACGCGGGGGCGCATCCACAGCATTGACCCGACGCTGATGAACAAGTACCTGCAGGAAGGCAACATCCTTATCTGCG
CCGGCTTTCAGGGGGTTACGGAAGAAGGAATGGTCCAGACGCTGGGCCGCGGAGGTTCCGACCTCTCCGCCATCGCCATC
GCGGCCGCTCTGAAAGCGGACGTGTGCCAGATTTTTACAGATGTGGACGGCGTCTATACCTGTGACCCCCGCGTGGTCAA
AGACGCCAAGAAGATACAAACCCTTTCATATGACGAGATGCTGGAAATGGCTTCCAACGGGTCCAAGGTGATGCAGTCGC
GTTCCGTGGAATTCGCCAAAAAATTCGGTGTCGTCTTTGAAGTTCGCAACTCCATGAACAACAACCCCGGTACAATCGTG
CAAGAAGAAACTCCCTCCATGGAAGCCGTCGTCATCCGCGGCATTTCCATTGACCGCAACCAGGCCCGCGTCACCATTAC
CGGCATTCCGGACCAAATCGGCTACACGGCCCAGATACTGGGCGCCCTGGCAGAAGCGGAAATCAACCTGGATATGATTC
TGGCCAATACTGCCCACGACGGCTATGTCCGCCAGTCCTTTACGATGCCCTCCAACGAACTGGGCCGCGCCCAAGCCGCC
CTTAAACCGGTCATGGCCGCCCTCGGCTCCACCGTCAAGGTGGAAACGGAAGCGGGGCTGGCCAAGCTTTCCCTGGTCGG
CATCGGCATGCGTTCCCACTCAGGCGTGGGAGCCACCGCTTTCAAGGCCCTGGCGGACGCCAACATCAAGACCGGCATGA
TTTCCACCTCGGAAATCAAGATTGCCGTGATGGTGGACGAATCCGATATTGAGGAAGCGGCCCGGGTCGTACATAAGGCG
TTCAACCTGGGAGCCTGA

Upstream 100 bases:

>100_bases
TGGAGGAAATAACCCGCATTTCCTGCGTGGCGGCGGAGCCCCGTGTCCTGCGCATAGAACATCTTCTTCCTCAATCCTAA
CCTACATATCATCCTGTTAC

Downstream 100 bases:

>100_bases
TTTTCTCAATATTTATCAACTCTCTTTTCCACGCCGGTTCACGTCCCCGTGAACCGGCTTTTTCATGCGGCAAAAAAAGC
AGCCCCTTCCCGGAAAAGGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MALIVQKFGGSSVGTIDRIRNVARRIHETAREGNQVVAVVSAMSGVTDKLIGLARELSETPCERELDVLMATGEQQSIAL
LCMALHELGEKAMSFTGAQAGITTFGSHTRGRIHSIDPTLMNKYLQEGNILICAGFQGVTEEGMVQTLGRGGSDLSAIAI
AAALKADVCQIFTDVDGVYTCDPRVVKDAKKIQTLSYDEMLEMASNGSKVMQSRSVEFAKKFGVVFEVRNSMNNNPGTIV
QEETPSMEAVVIRGISIDRNQARVTITGIPDQIGYTAQILGALAEAEINLDMILANTAHDGYVRQSFTMPSNELGRAQAA
LKPVMAALGSTVKVETEAGLAKLSLVGIGMRSHSGVGATAFKALADANIKTGMISTSEIKIAVMVDESDIEEAARVVHKA
FNLGA

Sequences:

>Translated_405_residues
MALIVQKFGGSSVGTIDRIRNVARRIHETAREGNQVVAVVSAMSGVTDKLIGLARELSETPCERELDVLMATGEQQSIAL
LCMALHELGEKAMSFTGAQAGITTFGSHTRGRIHSIDPTLMNKYLQEGNILICAGFQGVTEEGMVQTLGRGGSDLSAIAI
AAALKADVCQIFTDVDGVYTCDPRVVKDAKKIQTLSYDEMLEMASNGSKVMQSRSVEFAKKFGVVFEVRNSMNNNPGTIV
QEETPSMEAVVIRGISIDRNQARVTITGIPDQIGYTAQILGALAEAEINLDMILANTAHDGYVRQSFTMPSNELGRAQAA
LKPVMAALGSTVKVETEAGLAKLSLVGIGMRSHSGVGATAFKALADANIKTGMISTSEIKIAVMVDESDIEEAARVVHKA
FNLGA
>Mature_404_residues
ALIVQKFGGSSVGTIDRIRNVARRIHETAREGNQVVAVVSAMSGVTDKLIGLARELSETPCERELDVLMATGEQQSIALL
CMALHELGEKAMSFTGAQAGITTFGSHTRGRIHSIDPTLMNKYLQEGNILICAGFQGVTEEGMVQTLGRGGSDLSAIAIA
AALKADVCQIFTDVDGVYTCDPRVVKDAKKIQTLSYDEMLEMASNGSKVMQSRSVEFAKKFGVVFEVRNSMNNNPGTIVQ
EETPSMEAVVIRGISIDRNQARVTITGIPDQIGYTAQILGALAEAEINLDMILANTAHDGYVRQSFTMPSNELGRAQAAL
KPVMAALGSTVKVETEAGLAKLSLVGIGMRSHSGVGATAFKALADANIKTGMISTSEIKIAVMVDESDIEEAARVVHKAF
NLGA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=469, Percent_Identity=28.3582089552239, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790455, Length=458, Percent_Identity=26.8558951965066, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790376, Length=122, Percent_Identity=33.6065573770492, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320893, Length=417, Percent_Identity=24.220623501199, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43067; Mature: 42936

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKFGGSSVGTIDRIRNVARRIHETAREGNQVVAVVSAMSGVTDKLIGLARELSET
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHHHHHCC
PCERELDVLMATGEQQSIALLCMALHELGEKAMSFTGAQAGITTFGSHTRGRIHSIDPTL
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEECCCHHH
MNKYLQEGNILICAGFQGVTEEGMVQTLGRGGSDLSAIAIAAALKADVCQIFTDVDGVYT
HHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
CDPRVVKDAKKIQTLSYDEMLEMASNGSKVMQSRSVEFAKKFGVVFEVRNSMNNNPGTIV
CCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCEEE
QEETPSMEAVVIRGISIDRNQARVTITGIPDQIGYTAQILGALAEAEINLDMILANTAHD
ECCCCCEEEEEEEEEEECCCCCEEEEECCCCHHCHHHHHHHHHHHCCCCEEEEEEECCCC
GYVRQSFTMPSNELGRAQAALKPVMAALGSTVKVETEAGLAKLSLVGIGMRSHSGVGATA
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCCCCHHH
FKALADANIKTGMISTSEIKIAVMVDESDIEEAARVVHKAFNLGA
HHHHHCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVQKFGGSSVGTIDRIRNVARRIHETAREGNQVVAVVSAMSGVTDKLIGLARELSET
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHHHHHCC
PCERELDVLMATGEQQSIALLCMALHELGEKAMSFTGAQAGITTFGSHTRGRIHSIDPTL
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEECCCHHH
MNKYLQEGNILICAGFQGVTEEGMVQTLGRGGSDLSAIAIAAALKADVCQIFTDVDGVYT
HHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
CDPRVVKDAKKIQTLSYDEMLEMASNGSKVMQSRSVEFAKKFGVVFEVRNSMNNNPGTIV
CCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCEEE
QEETPSMEAVVIRGISIDRNQARVTITGIPDQIGYTAQILGALAEAEINLDMILANTAHD
ECCCCCEEEEEEEEEEECCCCCEEEEECCCCHHCHHHHHHHHHHHCCCCEEEEEEECCCC
GYVRQSFTMPSNELGRAQAALKPVMAALGSTVKVETEAGLAKLSLVGIGMRSHSGVGATA
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCCCCHHH
FKALADANIKTGMISTSEIKIAVMVDESDIEEAARVVHKAFNLGA
HHHHHCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]