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The map label for this gene is hom [H]

Identifier: 187736446

GI number: 187736446

Start: 2383131

End: 2384459

Strand: Direct

Name: hom [H]

Synonym: Amuc_1964

Alternate gene names: 187736446

Gene position: 2383131-2384459 (Clockwise)

Preceding gene: 187736445

Following gene: 187736447

Centisome position: 89.45

GC content: 57.19

Gene sequence:

>1329_bases
ATGACGGAAAAACCTATACAACTTGGGCTTGCCGGGCTGGGAACGGTCGGTTCCGGCGTTTATGAAACGCTGTGCCGCAA
TCACGCCCTTCTGGAAGCCCGGAGCAAGATTCCTTTCAGGCTCAAGCGCATCGCCGTGCGCAACCTGGAAAAGCCCAGGG
AAACCGTCGTTCCCCGGGAACTGCTGACGGACGATTGGCAGGATTTGGTAAACGACCCGGAGATAGACATCATTATTGAG
CTGATTGGCGGAACGCGCCAGGCTTACGATCTGGTGACGCTGGCCCTCCGTGCCGGCAAGCCCGTCGTTACGGGGAACAA
GGCTCTTCTGGCCGAATATGGAGCGGAGATTTTCAAGCTTTCCGCGGAAATGGGCACCCCCATTTATTTCGAAGCGTCCG
CCGGCGGCGGCATCCCCATTATCCAGAGCTTGCAGAATTCCCTGATTTGCAACCACATCAATTCCATTGTGGGCATTATC
AACGGAACGTCCAACTATATTCTCTCCGCCATGGGGGAACACGGGGCCGATTACGCGGACGCCCTGGCCCAGGCCCAGAA
GCTGGGCTTCGCGGAAGAAGACCCCTCCCTGGACGTCAACGGCTGGGACGCCGCCCATAAGGCGCTCATCCTGGCGATGC
TGGCCTACGGAACAACCATTTCCCCGGATAAAATTTACGTCAGAGGCATTGAGAATATCACCAGCCGGGATTTCGAATTT
GCCAAAAAACTGGGCTATACCATCAAGCTCCTTGTCGTCATCCGCTACCATGAGGGGCAGGAAGACGCTCTGGAACTGCG
TGTCCAGCCCTGTTTTGTCCATGACTGGCATATCCTGGCTTCCGTGAACGGCGTGTTCAACGCTATTTCCGTCAACGGGG
ACATTGTGGGGGAAACGCTGTTTTACGGCCGGGGAGCGGGCAAGAACCCCACAGCTTCCGCCGTCATCAGCGACATCATC
ACCGCCATGCGCGAAAGCCGCTATCCGGAATACCATACGGGCTTCAATCCCTATGCCAAGGCCTGCGGGATCATGCATAT
CAATGATACGGTCACTCCGTATTACGTCCGCTTCCAGGTAGCGGACCAGCCGGGAGTCATTGCGGAAATAGCCCGCATTC
TGGCCACCTTCGGCATCGGCATTTCCGCCACCTCTTCCGCTCCCAGCCATATTGATGAAGGCGGAGCCCCCTGGAACGAC
CTCGTTTTCATCCTCCATTCCTGCCCGTGGGGCCAGCTCCAGAAGGCTCTGGAGGAAATAACCCGCATTTCCTGCGTGGC
GGCGGAGCCCCGTGTCCTGCGCATAGAACATCTTCTTCCTCAATCCTAA

Upstream 100 bases:

>100_bases
CCGGAAAGAAGGGTATTCCATGAGCATCGCACACACGGCATTCCGGGGCGGTAAAAGCTCTTGCGTTACAGGGATTTTTT
TGCATAATCCCCCGGCAGGA

Downstream 100 bases:

>100_bases
CCTACATATCATCCTGTTACATGGCTCTTATCGTTCAAAAATTCGGGGGCAGCTCCGTCGGCACCATTGACCGCATCCGC
AATGTAGCGCGCCGCATCCA

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTEKPIQLGLAGLGTVGSGVYETLCRNHALLEARSKIPFRLKRIAVRNLEKPRETVVPRELLTDDWQDLVNDPEIDIIIE
LIGGTRQAYDLVTLALRAGKPVVTGNKALLAEYGAEIFKLSAEMGTPIYFEASAGGGIPIIQSLQNSLICNHINSIVGII
NGTSNYILSAMGEHGADYADALAQAQKLGFAEEDPSLDVNGWDAAHKALILAMLAYGTTISPDKIYVRGIENITSRDFEF
AKKLGYTIKLLVVIRYHEGQEDALELRVQPCFVHDWHILASVNGVFNAISVNGDIVGETLFYGRGAGKNPTASAVISDII
TAMRESRYPEYHTGFNPYAKACGIMHINDTVTPYYVRFQVADQPGVIAEIARILATFGIGISATSSAPSHIDEGGAPWND
LVFILHSCPWGQLQKALEEITRISCVAAEPRVLRIEHLLPQS

Sequences:

>Translated_442_residues
MTEKPIQLGLAGLGTVGSGVYETLCRNHALLEARSKIPFRLKRIAVRNLEKPRETVVPRELLTDDWQDLVNDPEIDIIIE
LIGGTRQAYDLVTLALRAGKPVVTGNKALLAEYGAEIFKLSAEMGTPIYFEASAGGGIPIIQSLQNSLICNHINSIVGII
NGTSNYILSAMGEHGADYADALAQAQKLGFAEEDPSLDVNGWDAAHKALILAMLAYGTTISPDKIYVRGIENITSRDFEF
AKKLGYTIKLLVVIRYHEGQEDALELRVQPCFVHDWHILASVNGVFNAISVNGDIVGETLFYGRGAGKNPTASAVISDII
TAMRESRYPEYHTGFNPYAKACGIMHINDTVTPYYVRFQVADQPGVIAEIARILATFGIGISATSSAPSHIDEGGAPWND
LVFILHSCPWGQLQKALEEITRISCVAAEPRVLRIEHLLPQS
>Mature_441_residues
TEKPIQLGLAGLGTVGSGVYETLCRNHALLEARSKIPFRLKRIAVRNLEKPRETVVPRELLTDDWQDLVNDPEIDIIIEL
IGGTRQAYDLVTLALRAGKPVVTGNKALLAEYGAEIFKLSAEMGTPIYFEASAGGGIPIIQSLQNSLICNHINSIVGIIN
GTSNYILSAMGEHGADYADALAQAQKLGFAEEDPSLDVNGWDAAHKALILAMLAYGTTISPDKIYVRGIENITSRDFEFA
KKLGYTIKLLVVIRYHEGQEDALELRVQPCFVHDWHILASVNGVFNAISVNGDIVGETLFYGRGAGKNPTASAVISDIIT
AMRESRYPEYHTGFNPYAKACGIMHINDTVTPYYVRFQVADQPGVIAEIARILATFGIGISATSSAPSHIDEGGAPWNDL
VFILHSCPWGQLQKALEEITRISCVAAEPRVLRIEHLLPQS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=350, Percent_Identity=24.8571428571429, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=25.7028112449799, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48194; Mature: 48063

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKPIQLGLAGLGTVGSGVYETLCRNHALLEARSKIPFRLKRIAVRNLEKPRETVVPRE
CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHH
LLTDDWQDLVNDPEIDIIIELIGGTRQAYDLVTLALRAGKPVVTGNKALLAEYGAEIFKL
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHCHHHEEE
SAEMGTPIYFEASAGGGIPIIQSLQNSLICNHINSIVGIINGTSNYILSAMGEHGADYAD
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCHHHH
ALAQAQKLGFAEEDPSLDVNGWDAAHKALILAMLAYGTTISPDKIYVRGIENITSRDFEF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHH
AKKLGYTIKLLVVIRYHEGQEDALELRVQPCFVHDWHILASVNGVFNAISVNGDIVGETL
HHHCCCEEEEEEEEEECCCCCCEEEEEECEEEEECHHHEEEHHHHHEEEECCCCEEECHH
FYGRGAGKNPTASAVISDIITAMRESRYPEYHTGFNPYAKACGIMHINDTVTPYYVRFQV
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEECCCCCEEEEEEEE
ADQPGVIAEIARILATFGIGISATSSAPSHIDEGGAPWNDLVFILHSCPWGQLQKALEEI
CCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHEEHECCCCHHHHHHHHHHH
TRISCVAAEPRVLRIEHLLPQS
HHHHHCCCCCCEEEEHHCCCCC
>Mature Secondary Structure 
TEKPIQLGLAGLGTVGSGVYETLCRNHALLEARSKIPFRLKRIAVRNLEKPRETVVPRE
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHH
LLTDDWQDLVNDPEIDIIIELIGGTRQAYDLVTLALRAGKPVVTGNKALLAEYGAEIFKL
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHCHHHEEE
SAEMGTPIYFEASAGGGIPIIQSLQNSLICNHINSIVGIINGTSNYILSAMGEHGADYAD
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCHHHH
ALAQAQKLGFAEEDPSLDVNGWDAAHKALILAMLAYGTTISPDKIYVRGIENITSRDFEF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHH
AKKLGYTIKLLVVIRYHEGQEDALELRVQPCFVHDWHILASVNGVFNAISVNGDIVGETL
HHHCCCEEEEEEEEEECCCCCCEEEEEECEEEEECHHHEEEHHHHHEEEECCCCEEECHH
FYGRGAGKNPTASAVISDIITAMRESRYPEYHTGFNPYAKACGIMHINDTVTPYYVRFQV
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEECCCCCEEEEEEEE
ADQPGVIAEIARILATFGIGISATSSAPSHIDEGGAPWNDLVFILHSCPWGQLQKALEEI
CCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHEEHECCCCHHHHHHHHHHH
TRISCVAAEPRVLRIEHLLPQS
HHHHHCCCCCCEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]