Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 187736363

GI number: 187736363

Start: 2285299

End: 2286546

Strand: Reverse

Name: icd [H]

Synonym: Amuc_1880

Alternate gene names: 187736363

Gene position: 2286546-2285299 (Counterclockwise)

Preceding gene: 187736364

Following gene: 187736361

Centisome position: 85.83

GC content: 57.29

Gene sequence:

>1248_bases
ATGGCCAATTTAACATTCACCCCTCCCGCGGACGGTGCAGCCGTCACCATGCAGAACGGCAGGCTTTGCGTTCCGGACAG
GCCCGTCATTCCCTTCATCATCGGTGATGGAACCGGTCCTGAGATATGGGCGGCGGCCTCCCGTGTCATTGACGCAGCCG
TAGCCAAGGCTTATCAGGGCAGGCGTTCCATCGCATGGTATGAAGTTTTTGCCGGGCAGAAATCTTTTGACAATCTGGGC
ACCTGGCTTCCGAATGAAACGGTGGAAGCTTTCCGCACGTACCTCATCGGCATCAAAGGCCCCCTCACCACTCCGGTGGG
CGGAGGCATCCGCAGCCTGAACGTCACGCTGCGGCAGGATCTGGATCTGTTTGTCTGCCTGCGTCCCGTGCGCTATTTCA
ACGGCATTGAAACTCCCGTCAAAGCTCCGGAAAAAGTGGACATGGTCGTTTTCCGCGAAAACACGGAAGACATCTACGCC
GGAATCGAATTCAAGGAAGGCACGGAGGATGCCAAGCTGTTTTTTGATACCATGAGCCGCATTTTCCCGGACCGCATGAA
AAAGGTTCGTTTCCCGGAAAGCTCCGGCTTCGGCATCAAGCCCGTTTCCCGTGAAGGCACGGAGCGCCTGGTGCGCGCCG
CCATTGACTATGCCGTGAAAAACGGAAGGAAAAGCGTCACGCTGGTGCATAAGGGCAACATCATGAAATTCACGGAAGGC
GGCTTCCGTGACTGGGGATACGATGTCGCACGGCGGGAATACGGCGCCCTCCCCATAGGGGACGGCCCCTGGCTGAAACT
TCCCAACGGTATCGTTATCAAGGACTGCATTGCAGACGCCTTCCTTCAGGAAATTCTGCTCCATCCGGAAAACTTCGACG
TGGTAGCCACGCTGAATCTGAACGGGGATTACATCTCCGACGCCCTGGCGGCGCAAGTCGGCGGCATCGGAATCGCCCCC
GGAGGCAACATCAACTACCTGACGGGGCATTCCATTTTTGAAGCTACGCACGGCACCGGGCCGAAACTGGCCGGACTGAA
CAAGGCCAACCCCAGCTCCGTCATCCTGTCTGCGGAGATGATGTTGCGCTACATGGGCTGGACGGAAGCCGCCGATCTGC
TGATTCAGGCCATTGACCGGGTGATTTCCGAAAAAACGGTTACGTTCGACCTTGCGGAAATGATTCCCGGTTCCACGGAA
CTTACCTGCTCCGCTTACGGCGACAAACTGGTGGAAACCCTGAGCTGA

Upstream 100 bases:

>100_bases
GGAAAACATTTTCAAGGCCGGTTGCTCCACGAAGCGCAGTTCCCCATTCCGCTCTTTTATCTTGCCAAACCGGGTTGCGT
CCTATAAAGGAACGCACGTC

Downstream 100 bases:

>100_bases
TCCCTGTTTTTCCCGCTTTTTCCATCCGGACTGCCCTCCCGCCACACGATGCGGAGGGCAGTTTTTTGTCTCCATGCCGG
AATTTATCCGATCAGGTACC

Product: isocitrate/isopropylmalate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MANLTFTPPADGAAVTMQNGRLCVPDRPVIPFIIGDGTGPEIWAAASRVIDAAVAKAYQGRRSIAWYEVFAGQKSFDNLG
TWLPNETVEAFRTYLIGIKGPLTTPVGGGIRSLNVTLRQDLDLFVCLRPVRYFNGIETPVKAPEKVDMVVFRENTEDIYA
GIEFKEGTEDAKLFFDTMSRIFPDRMKKVRFPESSGFGIKPVSREGTERLVRAAIDYAVKNGRKSVTLVHKGNIMKFTEG
GFRDWGYDVARREYGALPIGDGPWLKLPNGIVIKDCIADAFLQEILLHPENFDVVATLNLNGDYISDALAAQVGGIGIAP
GGNINYLTGHSIFEATHGTGPKLAGLNKANPSSVILSAEMMLRYMGWTEAADLLIQAIDRVISEKTVTFDLAEMIPGSTE
LTCSAYGDKLVETLS

Sequences:

>Translated_415_residues
MANLTFTPPADGAAVTMQNGRLCVPDRPVIPFIIGDGTGPEIWAAASRVIDAAVAKAYQGRRSIAWYEVFAGQKSFDNLG
TWLPNETVEAFRTYLIGIKGPLTTPVGGGIRSLNVTLRQDLDLFVCLRPVRYFNGIETPVKAPEKVDMVVFRENTEDIYA
GIEFKEGTEDAKLFFDTMSRIFPDRMKKVRFPESSGFGIKPVSREGTERLVRAAIDYAVKNGRKSVTLVHKGNIMKFTEG
GFRDWGYDVARREYGALPIGDGPWLKLPNGIVIKDCIADAFLQEILLHPENFDVVATLNLNGDYISDALAAQVGGIGIAP
GGNINYLTGHSIFEATHGTGPKLAGLNKANPSSVILSAEMMLRYMGWTEAADLLIQAIDRVISEKTVTFDLAEMIPGSTE
LTCSAYGDKLVETLS
>Mature_414_residues
ANLTFTPPADGAAVTMQNGRLCVPDRPVIPFIIGDGTGPEIWAAASRVIDAAVAKAYQGRRSIAWYEVFAGQKSFDNLGT
WLPNETVEAFRTYLIGIKGPLTTPVGGGIRSLNVTLRQDLDLFVCLRPVRYFNGIETPVKAPEKVDMVVFRENTEDIYAG
IEFKEGTEDAKLFFDTMSRIFPDRMKKVRFPESSGFGIKPVSREGTERLVRAAIDYAVKNGRKSVTLVHKGNIMKFTEGG
FRDWGYDVARREYGALPIGDGPWLKLPNGIVIKDCIADAFLQEILLHPENFDVVATLNLNGDYISDALAAQVGGIGIAPG
GNINYLTGHSIFEATHGTGPKLAGLNKANPSSVILSAEMMLRYMGWTEAADLLIQAIDRVISEKTVTFDLAEMIPGSTEL
TCSAYGDKLVETLS

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=364, Percent_Identity=32.967032967033, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.2727272727273, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.2727272727273, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=25.9562841530055, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4758582, Length=355, Percent_Identity=26.1971830985915, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=33.1491712707182, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=59.5641646489104, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1788101, Length=376, Percent_Identity=29.2553191489362, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87081683, Length=397, Percent_Identity=29.2191435768262, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI25144293, Length=363, Percent_Identity=29.4765840220386, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550882, Length=368, Percent_Identity=27.445652173913, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=367, Percent_Identity=28.6103542234332, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324709, Length=370, Percent_Identity=33.2432432432432, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322097, Length=370, Percent_Identity=29.4594594594595, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324291, Length=392, Percent_Identity=29.3367346938776, Blast_Score=135, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24643270, Length=389, Percent_Identity=33.6760925449871, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24643268, Length=363, Percent_Identity=34.7107438016529, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24661184, Length=388, Percent_Identity=31.9587628865979, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161078635, Length=272, Percent_Identity=31.6176470588235, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078637, Length=272, Percent_Identity=31.6176470588235, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078633, Length=272, Percent_Identity=31.6176470588235, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24650122, Length=272, Percent_Identity=31.6176470588235, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078639, Length=272, Percent_Identity=31.6176470588235, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130355, Length=360, Percent_Identity=25.2777777777778, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281362242, Length=372, Percent_Identity=28.2258064516129, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24648872, Length=372, Percent_Identity=28.2258064516129, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45308; Mature: 45177

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLTFTPPADGAAVTMQNGRLCVPDRPVIPFIIGDGTGPEIWAAASRVIDAAVAKAYQG
CCCCCCCCCCCCCEEEECCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RRSIAWYEVFAGQKSFDNLGTWLPNETVEAFRTYLIGIKGPLTTPVGGGIRSLNVTLRQD
CCCEEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEEEECCC
LDLFVCLRPVRYFNGIETPVKAPEKVDMVVFRENTEDIYAGIEFKEGTEDAKLFFDTMSR
CCEEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
IFPDRMKKVRFPESSGFGIKPVSREGTERLVRAAIDYAVKNGRKSVTLVHKGNIMKFTEG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCC
GFRDWGYDVARREYGALPIGDGPWLKLPNGIVIKDCIADAFLQEILLHPENFDVVATLNL
CCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
NGDYISDALAAQVGGIGIAPGGNINYLTGHSIFEATHGTGPKLAGLNKANPSSVILSAEM
CCCHHHHHHHHHHCCEEECCCCCEEEEECCHHEEECCCCCCCCCCCCCCCCCCEEEEHHH
MLRYMGWTEAADLLIQAIDRVISEKTVTFDLAEMIPGSTELTCSAYGDKLVETLS
HHHHHCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
ANLTFTPPADGAAVTMQNGRLCVPDRPVIPFIIGDGTGPEIWAAASRVIDAAVAKAYQG
CCCCCCCCCCCCEEEECCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RRSIAWYEVFAGQKSFDNLGTWLPNETVEAFRTYLIGIKGPLTTPVGGGIRSLNVTLRQD
CCCEEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEEEECCC
LDLFVCLRPVRYFNGIETPVKAPEKVDMVVFRENTEDIYAGIEFKEGTEDAKLFFDTMSR
CCEEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
IFPDRMKKVRFPESSGFGIKPVSREGTERLVRAAIDYAVKNGRKSVTLVHKGNIMKFTEG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCC
GFRDWGYDVARREYGALPIGDGPWLKLPNGIVIKDCIADAFLQEILLHPENFDVVATLNL
CCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
NGDYISDALAAQVGGIGIAPGGNINYLTGHSIFEATHGTGPKLAGLNKANPSSVILSAEM
CCCHHHHHHHHHHCCEEECCCCCEEEEECCHHEEECCCCCCCCCCCCCCCCCCEEEEHHH
MLRYMGWTEAADLLIQAIDRVISEKTVTFDLAEMIPGSTELTCSAYGDKLVETLS
HHHHHCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]