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The map label for this gene is thiC [H]

Identifier: 187736326

GI number: 187736326

Start: 2236215

End: 2238038

Strand: Direct

Name: thiC [H]

Synonym: Amuc_1840

Alternate gene names: 187736326

Gene position: 2236215-2238038 (Clockwise)

Preceding gene: 187736325

Following gene: 187736327

Centisome position: 83.94

GC content: 59.54

Gene sequence:

>1824_bases
ATGAACGATACCTCCAATTTGTCTTATCCCGGTTCCCGCCGCATTTATGTTCCGGGCCGTCTGTACCCGGATGTTCGGGT
TCCCATGAGGGAAATCATTTTGGGCGATACCTTGTTGCCCGACGGCACCGCCCACCCTAATGACCCGGTGCGCGTGTACG
ATTGCTCCGGCCCCTGGGGGGACGCTGCTTATGAGGGAACTGCGGAGGAGGGGCTTCCCTCCCTGCGTGCCGCCTGGATA
CGGGCCCGCGGGGATGTGAAAGAGGATGTGGGGCACGAGCGCACCCTGCGTGCTGCGGGCAAGACGCCTGTGACACAGCG
TTATTACGCCCAACAGGGCGTCATTACGCCGGAAATGGAATTTGTCGCCATCCGGGAAAATCTGGGCAGGGAACAGGCTT
TCAAGGCGATATACGACCGCTATCCAAATGCCAAGAGCCGCCCGGACGAAGCTGCGGAAGCCCTGGAAACGCTCACCATG
ATGCCGCGTCCGTCCGAATTGGAGGCGCAGGAGGGATTTGGGCCGTCCAGCATGGTGGCCCGCGACCGCCTGGATCACCA
GCATGCCCCGGAACGCCGGAACGGCTGCCGCATGCCTGCCTACTTTACGCCGGAATTCGTCAGGGATGAAATTGCCTCCG
GCCGTGCGCTGATTCCCGCCAACATCAATCATCCGGAATGTGAGCCGATGGCTATCGGCCGCAATTTCCTGGTAAAAATC
AACGCCAACATAGGCAACTCCGCGCTGGGATCCAGCATTGAGGAGGAGGTGGAAAAGCTGCGCTGGGCCATTCACTGGGG
GGCGGATACCGTTATGGACCTGTCCACCGGGAAGAATATCCACGCGACGAGGGAATGGATTTTAAGAAACTCCCCTGTCC
CCATCGGTACTGTTCCCATTTACCAGGCTCTGGAAAAGGTGGGAGGAAAGGTGGCTGACCTGAGTTGGGAGGTTTTTCGC
GATACCCTGCTTGAACAGGCCCGCCAGGGCGTGGACTATGTGACGGTGCACGCCGCCCTTCTGCTCAGGTTCGTGAACCA
TACGGCGCGGCGCATGACGGGCATCGTTTCCCGCGGCGGTTCCATCATGGCGCAGTGGAGCATGATCCACGAACAGGAAA
ATTTCCTTTATTCCCATTGGGATGAAATTTGTTCCATTCTGGCGGCTTACGATATTGCCGTCTCCATCGGGGATGGCCTG
CGGCCCGGTTCCGTGGCGGACGCCAACGACTTCGCCCAGCTGGCGGAGCTGGAAGTGCAGGGGGATTTGACCATGCGCGC
GTGGAAAGCGGGCGTGCAGGTCATGAATGAAGGCCCCGGCCACGTTCCCATGCACCTTATTAGGGAGAACATGAGCAAGC
AGCTGGAATGGTGCATGGAAGCGCCCTTTTACACGCTGGGGCCGCTGGTAACGGACATCGCCCCCGGTTACGACCATATT
ACCGGAGCTATCGGAGGGGCGATTATCGGCCAGCTTGGCTGCGCCATGCTTTGCTATGTAACCAGAAAAGAGCATCTGGG
GCTTCCTGACCGGGAGGATGTGAGGGAAGGCGTGGTTGCCTACAAGCTGGCGGCCCACGCCGCAGACCTGGCGAAGGGGC
ATCCATCCGCGCAATGGAGGGATAATGCTCTGGCCCAGGCCAGGTTTGAATTCCGCTGGGAGGATCAATTCAACCTTTCC
CTGGATCCGCAAAAGGCCCGTTCCTTCCATGACCTGACGCTTCCCCATGCCAACGCCAAAAAAGCCCATTTCTGTTCCAT
GTGCGGTCCGGACTTCTGCGCCATGCGCCTGAGCCAGGATATCCGCCGCCGCTCACAGCAATAG

Upstream 100 bases:

>100_bases
TAATTCCGCCGCAGGGAGTTCGATTGAACGGGCTTGTCCCGTTTTTCGGGGAGGTTTCGTTTCCGCTGTTCCCCTGCCGG
AACAGAACAGCATTCATCCC

Downstream 100 bases:

>100_bases
GCGTCTTTTCTCCGGCATTTCGCGGGGCTTGCGGTTCCGAGGGGGCCAGCCCTTAAAAAAGAATGACAAGCCCCGGTATC
CTGCTATAGTACGGTTAAGA

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MNDTSNLSYPGSRRIYVPGRLYPDVRVPMREIILGDTLLPDGTAHPNDPVRVYDCSGPWGDAAYEGTAEEGLPSLRAAWI
RARGDVKEDVGHERTLRAAGKTPVTQRYYAQQGVITPEMEFVAIRENLGREQAFKAIYDRYPNAKSRPDEAAEALETLTM
MPRPSELEAQEGFGPSSMVARDRLDHQHAPERRNGCRMPAYFTPEFVRDEIASGRALIPANINHPECEPMAIGRNFLVKI
NANIGNSALGSSIEEEVEKLRWAIHWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPIYQALEKVGGKVADLSWEVFR
DTLLEQARQGVDYVTVHAALLLRFVNHTARRMTGIVSRGGSIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGL
RPGSVADANDFAQLAELEVQGDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHI
TGAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWRDNALAQARFEFRWEDQFNLS
LDPQKARSFHDLTLPHANAKKAHFCSMCGPDFCAMRLSQDIRRRSQQ

Sequences:

>Translated_607_residues
MNDTSNLSYPGSRRIYVPGRLYPDVRVPMREIILGDTLLPDGTAHPNDPVRVYDCSGPWGDAAYEGTAEEGLPSLRAAWI
RARGDVKEDVGHERTLRAAGKTPVTQRYYAQQGVITPEMEFVAIRENLGREQAFKAIYDRYPNAKSRPDEAAEALETLTM
MPRPSELEAQEGFGPSSMVARDRLDHQHAPERRNGCRMPAYFTPEFVRDEIASGRALIPANINHPECEPMAIGRNFLVKI
NANIGNSALGSSIEEEVEKLRWAIHWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPIYQALEKVGGKVADLSWEVFR
DTLLEQARQGVDYVTVHAALLLRFVNHTARRMTGIVSRGGSIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGL
RPGSVADANDFAQLAELEVQGDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHI
TGAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWRDNALAQARFEFRWEDQFNLS
LDPQKARSFHDLTLPHANAKKAHFCSMCGPDFCAMRLSQDIRRRSQQ
>Mature_607_residues
MNDTSNLSYPGSRRIYVPGRLYPDVRVPMREIILGDTLLPDGTAHPNDPVRVYDCSGPWGDAAYEGTAEEGLPSLRAAWI
RARGDVKEDVGHERTLRAAGKTPVTQRYYAQQGVITPEMEFVAIRENLGREQAFKAIYDRYPNAKSRPDEAAEALETLTM
MPRPSELEAQEGFGPSSMVARDRLDHQHAPERRNGCRMPAYFTPEFVRDEIASGRALIPANINHPECEPMAIGRNFLVKI
NANIGNSALGSSIEEEVEKLRWAIHWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPIYQALEKVGGKVADLSWEVFR
DTLLEQARQGVDYVTVHAALLLRFVNHTARRMTGIVSRGGSIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGL
RPGSVADANDFAQLAELEVQGDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHI
TGAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWRDNALAQARFEFRWEDQFNLS
LDPQKARSFHDLTLPHANAKKAHFCSMCGPDFCAMRLSQDIRRRSQQ

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=621, Percent_Identity=58.7761674718196, Blast_Score=731, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 67662; Mature: 67662

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTSNLSYPGSRRIYVPGRLYPDVRVPMREIILGDTLLPDGTAHPNDPVRVYDCSGPWG
CCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCC
DAAYEGTAEEGLPSLRAAWIRARGDVKEDVGHERTLRAAGKTPVTQRYYAQQGVITPEME
CCCCCCCHHHCCHHHHHHHHHHCCCCHHHCCCHHHHHHCCCCCCHHHHHHHCCCCCCCHH
FVAIRENLGREQAFKAIYDRYPNAKSRPDEAAEALETLTMMPRPSELEAQEGFGPSSMVA
HHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHH
RDRLDHQHAPERRNGCRMPAYFTPEFVRDEIASGRALIPANINHPECEPMAIGRNFLVKI
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCEEEEEE
NANIGNSALGSSIEEEVEKLRWAIHWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPI
ECCCCCHHHCCHHHHHHHHHHHHHEECCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCHH
YQALEKVGGKVADLSWEVFRDTLLEQARQGVDYVTVHAALLLRFVNHTARRMTGIVSRGG
HHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGLRPGSVADANDFAQLAELEVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHC
GDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
TGAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DNALAQARFEFRWEDQFNLSLDPQKARSFHDLTLPHANAKKAHFCSMCGPDFCAMRLSQD
HHHHHHHHEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
IRRRSQQ
HHHHCCC
>Mature Secondary Structure
MNDTSNLSYPGSRRIYVPGRLYPDVRVPMREIILGDTLLPDGTAHPNDPVRVYDCSGPWG
CCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCC
DAAYEGTAEEGLPSLRAAWIRARGDVKEDVGHERTLRAAGKTPVTQRYYAQQGVITPEME
CCCCCCCHHHCCHHHHHHHHHHCCCCHHHCCCHHHHHHCCCCCCHHHHHHHCCCCCCCHH
FVAIRENLGREQAFKAIYDRYPNAKSRPDEAAEALETLTMMPRPSELEAQEGFGPSSMVA
HHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHH
RDRLDHQHAPERRNGCRMPAYFTPEFVRDEIASGRALIPANINHPECEPMAIGRNFLVKI
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCEEEEEE
NANIGNSALGSSIEEEVEKLRWAIHWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPI
ECCCCCHHHCCHHHHHHHHHHHHHEECCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCHH
YQALEKVGGKVADLSWEVFRDTLLEQARQGVDYVTVHAALLLRFVNHTARRMTGIVSRGG
HHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGLRPGSVADANDFAQLAELEVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHC
GDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
TGAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DNALAQARFEFRWEDQFNLSLDPQKARSFHDLTLPHANAKKAHFCSMCGPDFCAMRLSQD
HHHHHHHHEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
IRRRSQQ
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA