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The map label for this gene is yeaE [H]

Identifier: 187736262

GI number: 187736262

Start: 2160807

End: 2161637

Strand: Direct

Name: yeaE [H]

Synonym: Amuc_1775

Alternate gene names: 187736262

Gene position: 2160807-2161637 (Clockwise)

Preceding gene: 187736261

Following gene: 187736273

Centisome position: 81.11

GC content: 55.84

Gene sequence:

>831_bases
ATGATGGAACATTCAGTAATTTTTCCGGACCATCGGAAGGTTTGCGCCCTGGGGCAGGGAACCTGGAAAATGGGAAAGTC
AGCGTTGAGGGAAGCCGATGAAATAGATGCTTTGCGCGCCGGCATTGAGCTGGGCATGAGCGTAGTGGATACGGCGGAGA
TGTATGGCAACGAGGAAATGGTGGGAGCGGCAATCCGCGGTTTGCGCGACCGTGTTTTCCTGGTTACCAAGGTGTTGCCC
GGCAACGCCAGCAGGACAGGAACCAAAGCGGCCTGCGAACGGAGCCTGAACAGGCTGAAGACGGATTACGTGGATTTGTT
TCTGCTTCACTGGGGAGGTCCCCATCCCATTGAAGATACGGTTGCTTCAATGATTGAGCTGCAGCAGGAGGGAAAAATAA
AAGCATGGGGCGTCAGCAATATGGACGTTCCGGAAATGGAGCGGTTTTACGCCGTCCCGGGAGGAGTTTCCTGCGCCGCC
AACCAGATTCTTTATAATCTGGCCCATCGAGGTGTGGAGTACGATTTGCTGCCATGGTGCCGGGAACGCCACCTTCCCGT
GATGGCCTATTCGCCTGCGGATGAAGGGCGGCTTTCCCGTAATCCGGTGCTGATGGAGATTGCGCAGAAGCATGAGGCCA
CCCCGGTGCAGATTGCCCTGGCCTGGATTTTGCGCTGCCCTGGAATGATTGCGATCCCCAAAGCCGGTTCCGTCACGCAT
GTGCAGGAAAATTACCGGAGTTTGTCCATCAGGCTGACTGCGGAAGATGTGGATTTGCTGGATGGGGCTTTTCCGCCCCC
GGTCAGAAAGGTGCATCTGGATTCCTGGTAA

Upstream 100 bases:

>100_bases
GTTCAGGAAAAACGTCCTGATTTTTGAGCTTTTTTTTATCCTCTGCTGTCAAAGGTTTGTACGGCATGGAATGATGCGAT
CAGGTAGAAAGAAGATATTA

Downstream 100 bases:

>100_bases
ACCGTGATGCCGTCCGGCAGTTGGGGAGAAGCGGGACGCGCGGATTTTCCTGCCGCATCAGAATTGTTTCAAGCCTTTCA
TCTGTCCGGGATGAAAGGGC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MMEHSVIFPDHRKVCALGQGTWKMGKSALREADEIDALRAGIELGMSVVDTAEMYGNEEMVGAAIRGLRDRVFLVTKVLP
GNASRTGTKAACERSLNRLKTDYVDLFLLHWGGPHPIEDTVASMIELQQEGKIKAWGVSNMDVPEMERFYAVPGGVSCAA
NQILYNLAHRGVEYDLLPWCRERHLPVMAYSPADEGRLSRNPVLMEIAQKHEATPVQIALAWILRCPGMIAIPKAGSVTH
VQENYRSLSIRLTAEDVDLLDGAFPPPVRKVHLDSW

Sequences:

>Translated_276_residues
MMEHSVIFPDHRKVCALGQGTWKMGKSALREADEIDALRAGIELGMSVVDTAEMYGNEEMVGAAIRGLRDRVFLVTKVLP
GNASRTGTKAACERSLNRLKTDYVDLFLLHWGGPHPIEDTVASMIELQQEGKIKAWGVSNMDVPEMERFYAVPGGVSCAA
NQILYNLAHRGVEYDLLPWCRERHLPVMAYSPADEGRLSRNPVLMEIAQKHEATPVQIALAWILRCPGMIAIPKAGSVTH
VQENYRSLSIRLTAEDVDLLDGAFPPPVRKVHLDSW
>Mature_276_residues
MMEHSVIFPDHRKVCALGQGTWKMGKSALREADEIDALRAGIELGMSVVDTAEMYGNEEMVGAAIRGLRDRVFLVTKVLP
GNASRTGTKAACERSLNRLKTDYVDLFLLHWGGPHPIEDTVASMIELQQEGKIKAWGVSNMDVPEMERFYAVPGGVSCAA
NQILYNLAHRGVEYDLLPWCRERHLPVMAYSPADEGRLSRNPVLMEIAQKHEATPVQIALAWILRCPGMIAIPKAGSVTH
VQENYRSLSIRLTAEDVDLLDGAFPPPVRKVHLDSW

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=269, Percent_Identity=28.996282527881, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI223468663, Length=283, Percent_Identity=27.5618374558304, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI24497585, Length=287, Percent_Identity=29.9651567944251, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI45446745, Length=289, Percent_Identity=26.9896193771626, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4503285, Length=289, Percent_Identity=26.9896193771626, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI310109920, Length=289, Percent_Identity=26.9896193771626, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5453543, Length=289, Percent_Identity=26.643598615917, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI291291012, Length=260, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4502049, Length=297, Percent_Identity=28.956228956229, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI24497577, Length=300, Percent_Identity=23.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5174391, Length=300, Percent_Identity=23.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788081, Length=282, Percent_Identity=48.936170212766, Blast_Score=286, Evalue=8e-79,
Organism=Escherichia coli, GI1786400, Length=251, Percent_Identity=31.0756972111554, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082198, Length=250, Percent_Identity=31.6, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788070, Length=305, Percent_Identity=28.8524590163934, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081735, Length=275, Percent_Identity=28.7272727272727, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787674, Length=255, Percent_Identity=27.843137254902, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI48994888, Length=284, Percent_Identity=24.2957746478873, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552492, Length=265, Percent_Identity=28.6792452830189, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17561298, Length=265, Percent_Identity=28.3018867924528, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71998625, Length=252, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17564128, Length=290, Percent_Identity=26.2068965517241, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538386, Length=278, Percent_Identity=27.6978417266187, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=281, Percent_Identity=24.9110320284698, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537077, Length=286, Percent_Identity=26.2237762237762, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17566692, Length=294, Percent_Identity=25.8503401360544, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=25.3333333333333, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=254, Percent_Identity=25.5905511811024, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562292, Length=263, Percent_Identity=25.8555133079848, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537079, Length=284, Percent_Identity=22.1830985915493, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=285, Percent_Identity=27.3684210526316, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320576, Length=272, Percent_Identity=28.6764705882353, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320079, Length=233, Percent_Identity=27.0386266094421, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319958, Length=299, Percent_Identity=24.7491638795987, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=28.0936454849498, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24657054, Length=276, Percent_Identity=27.8985507246377, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553081, Length=281, Percent_Identity=27.7580071174377, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24662789, Length=305, Percent_Identity=24.5901639344262, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=27.2413793103448, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129731, Length=279, Percent_Identity=27.2401433691756, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281366140, Length=254, Percent_Identity=27.5590551181102, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30655; Mature: 30655

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEHSVIFPDHRKVCALGQGTWKMGKSALREADEIDALRAGIELGMSVVDTAEMYGNEEM
CCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHH
VGAAIRGLRDRVFLVTKVLPGNASRTGTKAACERSLNRLKTDYVDLFLLHWGGPHPIEDT
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
VASMIELQQEGKIKAWGVSNMDVPEMERFYAVPGGVSCAANQILYNLAHRGVEYDLLPWC
HHHHHHHHHCCCEEEECCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCHHH
RERHLPVMAYSPADEGRLSRNPVLMEIAQKHEATPVQIALAWILRCPGMIAIPKAGSVTH
HHCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHH
VQENYRSLSIRLTAEDVDLLDGAFPPPVRKVHLDSW
HHHCCEEEEEEEEECCHHHHCCCCCCCCEEEECCCC
>Mature Secondary Structure
MMEHSVIFPDHRKVCALGQGTWKMGKSALREADEIDALRAGIELGMSVVDTAEMYGNEEM
CCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHH
VGAAIRGLRDRVFLVTKVLPGNASRTGTKAACERSLNRLKTDYVDLFLLHWGGPHPIEDT
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
VASMIELQQEGKIKAWGVSNMDVPEMERFYAVPGGVSCAANQILYNLAHRGVEYDLLPWC
HHHHHHHHHCCCEEEECCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCHHH
RERHLPVMAYSPADEGRLSRNPVLMEIAQKHEATPVQIALAWILRCPGMIAIPKAGSVTH
HHCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHH
VQENYRSLSIRLTAEDVDLLDGAFPPPVRKVHLDSW
HHHCCEEEEEEEEECCHHHHCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]