Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is arcB

Identifier: 187736241

GI number: 187736241

Start: 2135706

End: 2136623

Strand: Reverse

Name: arcB

Synonym: Amuc_1754

Alternate gene names: 187736241

Gene position: 2136623-2135706 (Counterclockwise)

Preceding gene: 187736242

Following gene: 187736240

Centisome position: 80.2

GC content: 60.02

Gene sequence:

>918_bases
ATGAACAACCTCCTTTCCATCGAACAGCTTACCGGAGACGAAATCCGGGACCTGCTCGCCCTGGGCCACCGGCTTAAGGC
GGAACGCGGCCATCACGAACGCCTTCCCCTGAAGGGGCAGACCTGGGCGCTCATCTTTTCCAAATCCTCCACCCGCACCC
GCGTTTCCTTTGAAGTGGGCATCAGTGAACTGGGGGGCCGTCCCATGTTCCTTTCCGTCCATGACATCCAGCTCGGGCGT
GGAGAGCCCATCAAGGATACGGCCCGCGTGCTGGGACGTATGATCCACGGCGCCGCCATCCGGACTTACGGACAGCAGGA
GGTGGAGGAATTCGCCAGCTTTTCCGGCATTCCCACCATCAATGCCCTGACGGACGAGGAGCACCCCTGCCAGATCCTGG
CGGACCTGCTTACCATTGAGGAAATCTACGGCCCCGGTTCCTGGAAGGATATGAAAATCGCCTTCGTGGGGGACGGGGAC
AACAACATGTCCCGCTCTTGGATGTGGGCGGCCAAGAGGCTGGGCTTTACGCTCGCCATCGGAGCCCCTACCAATTACCT
TCCCCTGGAAGACTTCCGCAGGCATCTGGACTGCGAGAACGTCATCTTCACCACGGACCCCGTGGAAGCCGTCAAGGGAG
CTTCCGTCATCAACACGGATGTCTGGCTTTCCATGGGCCAGGAATCGGAAGGACTGTCCAAGGAAAAACACTTCTACCCC
TACCAGGTGAACAGGGAGCTGCTGGAACATGCCGCCTCCGGCCACTCCGTTTTCCACTGCCTGCCCGCCTACCGCGGCAA
GGAAATCACGGAAGACGTGCTGGAACATTTTGCTCCCGTTATCTTCCGGGAAGCGGAAAACAGGGTGCATGCCCAGAAAG
CCGTGCTCGCCACGCTTGCAGACGCCCGCCGGGGATAA

Upstream 100 bases:

>100_bases
GCATCTCCATCCCTCCCTGGAAAGCCGCATTATTCCCTTTTCTTTTAAGAAAACAGGGAGTATGGTGCGGCTTTCCCGTT
TTTATTCCCTTTCAAAAACC

Downstream 100 bases:

>100_bases
CCCGCCCGGCCCATCCTACCCAATCTCCGAGCCATGAACTACGAAGAACGCCTGCAAGACCTGCTGGATGAACTGGATTT
GTTCCAGGACTGGACGGAAC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNNLLSIEQLTGDEIRDLLALGHRLKAERGHHERLPLKGQTWALIFSKSSTRTRVSFEVGISELGGRPMFLSVHDIQLGR
GEPIKDTARVLGRMIHGAAIRTYGQQEVEEFASFSGIPTINALTDEEHPCQILADLLTIEEIYGPGSWKDMKIAFVGDGD
NNMSRSWMWAAKRLGFTLAIGAPTNYLPLEDFRRHLDCENVIFTTDPVEAVKGASVINTDVWLSMGQESEGLSKEKHFYP
YQVNRELLEHAASGHSVFHCLPAYRGKEITEDVLEHFAPVIFREAENRVHAQKAVLATLADARRG

Sequences:

>Translated_305_residues
MNNLLSIEQLTGDEIRDLLALGHRLKAERGHHERLPLKGQTWALIFSKSSTRTRVSFEVGISELGGRPMFLSVHDIQLGR
GEPIKDTARVLGRMIHGAAIRTYGQQEVEEFASFSGIPTINALTDEEHPCQILADLLTIEEIYGPGSWKDMKIAFVGDGD
NNMSRSWMWAAKRLGFTLAIGAPTNYLPLEDFRRHLDCENVIFTTDPVEAVKGASVINTDVWLSMGQESEGLSKEKHFYP
YQVNRELLEHAASGHSVFHCLPAYRGKEITEDVLEHFAPVIFREAENRVHAQKAVLATLADARRG
>Mature_305_residues
MNNLLSIEQLTGDEIRDLLALGHRLKAERGHHERLPLKGQTWALIFSKSSTRTRVSFEVGISELGGRPMFLSVHDIQLGR
GEPIKDTARVLGRMIHGAAIRTYGQQEVEEFASFSGIPTINALTDEEHPCQILADLLTIEEIYGPGSWKDMKIAFVGDGD
NNMSRSWMWAAKRLGFTLAIGAPTNYLPLEDFRRHLDCENVIFTTDPVEAVKGASVINTDVWLSMGQESEGLSKEKHFYP
YQVNRELLEHAASGHSVFHCLPAYRGKEITEDVLEHFAPVIFREAENRVHAQKAVLATLADARRG

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=305, Percent_Identity=39.344262295082, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=38.6503067484663, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1786469, Length=329, Percent_Identity=37.3860182370821, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI2367364, Length=312, Percent_Identity=28.8461538461538, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=336, Percent_Identity=26.4880952380952, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=323, Percent_Identity=31.2693498452012, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=27.4193548387097, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24642586, Length=164, Percent_Identity=31.0975609756098, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_AKKM8 (B2UML6)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878353.1
- GeneID:   6275012
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1754
- HOGENOM:   HBG579429
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34145; Mature: 34145

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 101-101 BINDING 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLLSIEQLTGDEIRDLLALGHRLKAERGHHERLPLKGQTWALIFSKSSTRTRVSFEVG
CCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEC
ISELGGRPMFLSVHDIQLGRGEPIKDTARVLGRMIHGAAIRTYGQQEVEEFASFSGIPTI
HHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCE
NALTDEEHPCQILADLLTIEEIYGPGSWKDMKIAFVGDGDNNMSRSWMWAAKRLGFTLAI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEE
GAPTNYLPLEDFRRHLDCENVIFTTDPVEAVKGASVINTDVWLSMGQESEGLSKEKHFYP
CCCCCCCCHHHHHHHCCCCCEEEECCHHHHHCCCCEEEHHHHEECCCCCCCCCCCCCCCC
YQVNRELLEHAASGHSVFHCLPAYRGKEITEDVLEHFAPVIFREAENRVHAQKAVLATLA
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DARRG
HHCCC
>Mature Secondary Structure
MNNLLSIEQLTGDEIRDLLALGHRLKAERGHHERLPLKGQTWALIFSKSSTRTRVSFEVG
CCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEC
ISELGGRPMFLSVHDIQLGRGEPIKDTARVLGRMIHGAAIRTYGQQEVEEFASFSGIPTI
HHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCE
NALTDEEHPCQILADLLTIEEIYGPGSWKDMKIAFVGDGDNNMSRSWMWAAKRLGFTLAI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEE
GAPTNYLPLEDFRRHLDCENVIFTTDPVEAVKGASVINTDVWLSMGQESEGLSKEKHFYP
CCCCCCCCHHHHHHHCCCCCEEEECCHHHHHCCCCEEEHHHHEECCCCCCCCCCCCCCCC
YQVNRELLEHAASGHSVFHCLPAYRGKEITEDVLEHFAPVIFREAENRVHAQKAVLATLA
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DARRG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA