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The map label for this gene is ispH [H]

Identifier: 187736135

GI number: 187736135

Start: 1989053

End: 1990252

Strand: Direct

Name: ispH [H]

Synonym: Amuc_1646

Alternate gene names: 187736135

Gene position: 1989053-1990252 (Clockwise)

Preceding gene: 187736131

Following gene: 187736137

Centisome position: 74.66

GC content: 53.67

Gene sequence:

>1200_bases
ATGAATCAGGACTCAACCCGCAAAGCCAGAGTGAATGTGAGACGGGCCGAAGTAATGGAGCAGGTGGAAAAGGAAATCCA
GCAGCATTACCAGAGTGAATTGATTTCCCACATCCGTTCTGCGGGCAATGTGTACAATCTGGGCCATACGGAATTTTTTC
TCGCCCGGGAGTTCGGGTTCTGCAACGGCGTGCGCCGTGCTATTGATATAGCATATGCGGCACGCAGAGTGTTTCCTGAC
CGGCGGATTTTTCTGATTGGGGACATTATTCACAATCCGGAAGTGAACCGGCAGCTGGAGGAAATGGGCATTCGAAAACT
TCCCTGGAAGCAGTTGGATTCCTCCTATGACCGGGTTGCTCCGGACGATGTGGTGATTATTCCCGCGTTCGGTGTTCCCA
CTCCTTTCATGGATGCGCTGGAGGAGAAGGGCGTGCAGATTGTGGATACGACATGCGGGGACGTGATGAAGGTCTGGAAA
AGAGTGAAGAATTACGCCGCCATGGGGATTACCTCCATTATCCACGGTAAGGCTACCCATGAGGAAACCAGCGCTACGGC
TTCCCGGGCTCTTGGGGAACGGGGAAGGGGGAAATACCTGGTGGTTTACGATTTGGAGGATGCCCGTATCCTGTGCGACT
ACATCATGGGCCGCGGAGACCGCGAGGCATTCCTGAAACGGTTTGAAGGATGCTGTTCCCCGGGATTCGATCCCGACCGG
GATCTGGAGGAGGTTGGCATCGCCAACCAGACCACCATGTTGAAAACGGAGACGCAGACGCTCCAGAAGATGGTGAAGGA
TGCCATTGTTCAGAGGGATGGGGACGATGATAATTTTTATGTGTTTGACACCATTTGCGGTGCTACCCAGGATCGCCAGG
ATGCCCTGTATGAACTGCTTAAAAATCCTCTGGACGTCATGTTTGTGGTGGGTGGCTACAACAGTTCCAACACAACGCAT
CTGGTGGATATTGCCAGGGAGCATGTGCCCACGTACTTCATTGAGTCCGCAGAATGCATCAAGTCCATCCAGTATGTGGA
TGCTTTTGATACGAAGACGCGGGAAGTGCGCCGCATGACTACGGAACCGGTAGTGCAGAATCTGGGCAAATCCCTGAAGG
TGGGAATTACGGCGGGCGCCTCATGTCCGGCCAACCTGATTGAGGCCACCATCCTCCGCATTGCGGATCTGCGCAAGTAG

Upstream 100 bases:

>100_bases
GGCCAGGGCCAGGAGCATGGGTCTGTGCATACCGTGAAAAGCTCCGGTTGGCAAGCTGTGATTGTCTTGACGAAAGAAGG
AAAGTGTGGAAGCTGGGAGC

Downstream 100 bases:

>100_bases
CAAAACGCCTCCGGTTTGGCGAATGAGAAAAAAGAAGAGTTCTCTTTCAACGGCGGCACGACCGTTTTTTCCGTAACACG
GCGCAGTAGCCTGGGCTGCG

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNQDSTRKARVNVRRAEVMEQVEKEIQQHYQSELISHIRSAGNVYNLGHTEFFLAREFGFCNGVRRAIDIAYAARRVFPD
RRIFLIGDIIHNPEVNRQLEEMGIRKLPWKQLDSSYDRVAPDDVVIIPAFGVPTPFMDALEEKGVQIVDTTCGDVMKVWK
RVKNYAAMGITSIIHGKATHEETSATASRALGERGRGKYLVVYDLEDARILCDYIMGRGDREAFLKRFEGCCSPGFDPDR
DLEEVGIANQTTMLKTETQTLQKMVKDAIVQRDGDDDNFYVFDTICGATQDRQDALYELLKNPLDVMFVVGGYNSSNTTH
LVDIAREHVPTYFIESAECIKSIQYVDAFDTKTREVRRMTTEPVVQNLGKSLKVGITAGASCPANLIEATILRIADLRK

Sequences:

>Translated_399_residues
MNQDSTRKARVNVRRAEVMEQVEKEIQQHYQSELISHIRSAGNVYNLGHTEFFLAREFGFCNGVRRAIDIAYAARRVFPD
RRIFLIGDIIHNPEVNRQLEEMGIRKLPWKQLDSSYDRVAPDDVVIIPAFGVPTPFMDALEEKGVQIVDTTCGDVMKVWK
RVKNYAAMGITSIIHGKATHEETSATASRALGERGRGKYLVVYDLEDARILCDYIMGRGDREAFLKRFEGCCSPGFDPDR
DLEEVGIANQTTMLKTETQTLQKMVKDAIVQRDGDDDNFYVFDTICGATQDRQDALYELLKNPLDVMFVVGGYNSSNTTH
LVDIAREHVPTYFIESAECIKSIQYVDAFDTKTREVRRMTTEPVVQNLGKSLKVGITAGASCPANLIEATILRIADLRK
>Mature_399_residues
MNQDSTRKARVNVRRAEVMEQVEKEIQQHYQSELISHIRSAGNVYNLGHTEFFLAREFGFCNGVRRAIDIAYAARRVFPD
RRIFLIGDIIHNPEVNRQLEEMGIRKLPWKQLDSSYDRVAPDDVVIIPAFGVPTPFMDALEEKGVQIVDTTCGDVMKVWK
RVKNYAAMGITSIIHGKATHEETSATASRALGERGRGKYLVVYDLEDARILCDYIMGRGDREAFLKRFEGCCSPGFDPDR
DLEEVGIANQTTMLKTETQTLQKMVKDAIVQRDGDDDNFYVFDTICGATQDRQDALYELLKNPLDVMFVVGGYNSSNTTH
LVDIAREHVPTYFIESAECIKSIQYVDAFDTKTREVRRMTTEPVVQNLGKSLKVGITAGASCPANLIEATILRIADLRK

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 45104; Mature: 45104

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQDSTRKARVNVRRAEVMEQVEKEIQQHYQSELISHIRSAGNVYNLGHTEFFLAREFGF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHH
CNGVRRAIDIAYAARRVFPDRRIFLIGDIIHNPEVNRQLEEMGIRKLPWKQLDSSYDRVA
HHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCHHHHHHHHCCCCCCCHHHHCCCCCCCC
PDDVVIIPAFGVPTPFMDALEEKGVQIVDTTCGDVMKVWKRVKNYAAMGITSIIHGKATH
CCCEEEEECCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EETSATASRALGERGRGKYLVVYDLEDARILCDYIMGRGDREAFLKRFEGCCSPGFDPDR
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
DLEEVGIANQTTMLKTETQTLQKMVKDAIVQRDGDDDNFYVFDTICGATQDRQDALYELL
CHHHHCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCHHHHHHHHH
KNPLDVMFVVGGYNSSNTTHLVDIAREHVPTYFIESAECIKSIQYVDAFDTKTREVRRMT
CCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TEPVVQNLGKSLKVGITAGASCPANLIEATILRIADLRK
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQDSTRKARVNVRRAEVMEQVEKEIQQHYQSELISHIRSAGNVYNLGHTEFFLAREFGF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHH
CNGVRRAIDIAYAARRVFPDRRIFLIGDIIHNPEVNRQLEEMGIRKLPWKQLDSSYDRVA
HHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCHHHHHHHHCCCCCCCHHHHCCCCCCCC
PDDVVIIPAFGVPTPFMDALEEKGVQIVDTTCGDVMKVWKRVKNYAAMGITSIIHGKATH
CCCEEEEECCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EETSATASRALGERGRGKYLVVYDLEDARILCDYIMGRGDREAFLKRFEGCCSPGFDPDR
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
DLEEVGIANQTTMLKTETQTLQKMVKDAIVQRDGDDDNFYVFDTICGATQDRQDALYELL
CHHHHCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCHHHHHHHHH
KNPLDVMFVVGGYNSSNTTHLVDIAREHVPTYFIESAECIKSIQYVDAFDTKTREVRRMT
CCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TEPVVQNLGKSLKVGITAGASCPANLIEATILRIADLRK
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA