Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is folD
Identifier: 187736130
GI number: 187736130
Start: 1984050
End: 1984925
Strand: Direct
Name: folD
Synonym: Amuc_1641
Alternate gene names: 187736130
Gene position: 1984050-1984925 (Clockwise)
Preceding gene: 187736129
Following gene: 187736131
Centisome position: 74.47
GC content: 57.42
Gene sequence:
>876_bases ATGCAAATCATCGATGGAAAACAAGTAGCTTCCCAGGTGCTGGAAGAGGTTGAAAGGGATATTGCCCGGCTCAGGGAACA GGGAATAACGCCCGGCTTGGCCGTGGTTCTGGTAGGGGAAGATCCCGCTTCCCAGGTATATGTAAATTCCAAGGTGAAAA AGTGTGCGGAGCTGGGGATGAATTCCCGTAAAATAGTTCTCCCTTCCGACGCCTCCCAGGAAGAACTGCTCCGGATTGTC CGTGAATTGAACGTGGATCCTTCCGTCCACGGCATACTGGTGCAAAGCCCGCCTCCCCCCCATATCGACGAGGCGGCCGT GGTCCTGGAAATAGACCCTGCCAAGGATGTGGACGGCTTCCATCCGGAGAATGTCGCCAAGCTGGTGCTGGAAGATGAGA CCGGTTTTGTACCCTGTACCCCTCTGGGCTGTATGAGGCTGTTAAAGGCCGCCGGCATTGAAACGGCGGGAGCGAATGCC GTGGTCATTGGCCGCAGCATGATTGTGGGCAAACCGATGGCGCATCTTTTGATGTCCAAACAGGCAAACGCTACCGTAAC CGTGGCTCATTCCCGTACGAAAAACCTGCCGGAACTTTGCCGTTCCGCTGATATCATCGTGGCAGCCATAGGCCGGCCCG CTTTTGTGACGGCTGATTTTGTGAAAGACGGCGCCGTAGTGGTGGATGTGGGCATCAACCGCGTGGAAGATGCCTCCGCC AAGCGCGGCTACCGGATTGTGGGAGACGTAGCCTATGACGAGGTGGCTCCCAAGTGCCGGGCCATTACTCCCGTGCCCGG CGGCGTGGGGCCGATGACTATCGCCATGTTGATGGCTAATACGGTCAAAGCGTGCCGCCAGCAGACGGGAGCCTGA
Upstream 100 bases:
>100_bases CGGACGCGACGGATGAACAGGTGGCGGATTATGCCCGTCTTCTGGCCGGGCTGCTTGGCGAGGGGCTTCCGGACTTCCCG CCTCTTAACCAATCATTATT
Downstream 100 bases:
>100_bases CGAAAATGCCGTGACGTCCGTTTTTCTTGTCAAATGAAGGAAAGTAGGGCAGTATTCAGTTACCATTATGTCAAGTAAAT TACTCGAAGGCAAAGTTGGT
Product: Methenyltetrahydrofolate cyclohydrolase
Products: NA
Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase
Number of amino acids: Translated: 291; Mature: 291
Protein sequence:
>291_residues MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGMNSRKIVLPSDASQEELLRIV RELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGFHPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANA VVIGRSMIVGKPMAHLLMSKQANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASA KRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA
Sequences:
>Translated_291_residues MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGMNSRKIVLPSDASQEELLRIV RELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGFHPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANA VVIGRSMIVGKPMAHLLMSKQANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASA KRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA >Mature_291_residues MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGMNSRKIVLPSDASQEELLRIV RELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGFHPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANA VVIGRSMIVGKPMAHLLMSKQANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASA KRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA
Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COG id: COG0190
COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family
Homologues:
Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=43.6426116838488, Blast_Score=242, Evalue=3e-64, Organism=Homo sapiens, GI222418558, Length=294, Percent_Identity=43.8775510204082, Blast_Score=228, Evalue=4e-60, Organism=Homo sapiens, GI94721354, Length=294, Percent_Identity=44.8979591836735, Blast_Score=223, Evalue=1e-58, Organism=Homo sapiens, GI36796743, Length=224, Percent_Identity=25, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1786741, Length=285, Percent_Identity=49.1228070175439, Blast_Score=258, Evalue=3e-70, Organism=Caenorhabditis elegans, GI17568735, Length=295, Percent_Identity=41.0169491525424, Blast_Score=202, Evalue=1e-52, Organism=Saccharomyces cerevisiae, GI6319558, Length=291, Percent_Identity=45.0171821305842, Blast_Score=257, Evalue=1e-69, Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=43.9597315436242, Blast_Score=238, Evalue=1e-63, Organism=Saccharomyces cerevisiae, GI6322933, Length=319, Percent_Identity=25.705329153605, Blast_Score=64, Evalue=4e-11, Organism=Drosophila melanogaster, GI17136816, Length=296, Percent_Identity=48.9864864864865, Blast_Score=259, Evalue=1e-69, Organism=Drosophila melanogaster, GI17136818, Length=296, Percent_Identity=48.9864864864865, Blast_Score=259, Evalue=1e-69, Organism=Drosophila melanogaster, GI24645718, Length=288, Percent_Identity=47.5694444444444, Blast_Score=251, Evalue=4e-67, Organism=Drosophila melanogaster, GI17137370, Length=288, Percent_Identity=47.5694444444444, Blast_Score=251, Evalue=4e-67, Organism=Drosophila melanogaster, GI62472483, Length=289, Percent_Identity=47.4048442906574, Blast_Score=251, Evalue=4e-67, Organism=Drosophila melanogaster, GI45551871, Length=289, Percent_Identity=47.4048442906574, Blast_Score=251, Evalue=4e-67,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): FOLD_AKKM8 (B2UM17)
Other databases:
- EMBL: CP001071 - RefSeq: YP_001878242.1 - ProteinModelPortal: B2UM17 - SMR: B2UM17 - GeneID: 6274645 - GenomeReviews: CP001071_GR - KEGG: amu:Amuc_1641 - HOGENOM: HBG328751 - OMA: CLERISP - GO: GO:0005488 - HAMAP: MF_01576 - InterPro: IPR016040 - InterPro: IPR000672 - InterPro: IPR020630 - InterPro: IPR020867 - InterPro: IPR020631 - Gene3D: G3DSA:3.40.50.720 - PRINTS: PR00085
Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C
EC number: =1.5.1.5; =3.5.4.9
Molecular weight: Translated: 30847; Mature: 30847
Theoretical pI: Translated: 6.04; Mature: 6.04
Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 5.2 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 5.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGM CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHCCC NSRKIVLPSDASQEELLRIVRELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGF CCCEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCC HPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANAVVIGRSMIVGKPMAHLLMSK CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHHCCHHHHHHHHC QANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASA CCCCEEEEECCCCCCHHHHHCCCCEEEEECCCCCEEEHHHHCCCCEEEEECCCCCCCHHH KRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA CCCCEEEEECHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGM CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHCCC NSRKIVLPSDASQEELLRIVRELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGF CCCEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCC HPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANAVVIGRSMIVGKPMAHLLMSK CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHHCCHHHHHHHHC QANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASA CCCCEEEEECCCCCCHHHHHCCCCEEEEECCCCCEEEHHHHCCCCEEEEECCCCCCCHHH KRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA CCCCEEEEECHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA