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The map label for this gene is glcD [H]

Identifier: 187735957

GI number: 187735957

Start: 1757920

End: 1759296

Strand: Reverse

Name: glcD [H]

Synonym: Amuc_1466

Alternate gene names: 187735957

Gene position: 1759296-1757920 (Counterclockwise)

Preceding gene: 187735958

Following gene: 187735956

Centisome position: 66.04

GC content: 61.29

Gene sequence:

>1377_bases
ATGTCTTTGAAAGAAGACATTTCCCGCATTCTGGGGCCTGAAAAAGTTTCCGGAGCCCCGGATGTGCTGGCGACGCACGC
CGGGGACAAATGGTACGCCTCCGTGCTGCCGGAGGCAGTCGTTTTCCCGGAAAGTACGGAAGACGTCTCCCTGTTGCTGC
GCTATGCATCCTCCATGAACATCCCCGTCACGGCCCGCGGCGGCGGGGTGGGATACGTAGGAGGGTGTGTTCCCGTGCGC
GGAGGCATCAGCCTTTCCCTGGAACGGATGAACCGTATCCTGGAGATATCCCCGGAAGACGGCGTTGCCGTGGTGGAACC
CGGAGTTATCACAGCGGATCTCCAGCGGGAAGCCCGTGCTCTGGGATGGTTCTACCCGCCGGACCCGGCCTCCAGAAAGG
AATGCAGCATCGGAGGAAACATCGCCACGAACGCAGGCGGCCCCAGATGCCTGAAATATGGAGTCACCAGAGCTTACGTG
CTGGGGCTGACCGTGGTGCTTGCCAGCGGAGAGGTAGTGGAATGCGGCGGACGCACCCATAAAAACAAGACGGGGTTCGA
TATCGGGGACCTTTTTATCGGTTCGGAAGGAATGCTGGGCATCATCACCCGGGCCGTTTTGAGGCTCATCCCCCACCCGG
AAGCATTCGGCGCGCTCAGCGCCGGCTTCCCGCAATTCCCGCTGGCCGCTGCCGCCGTGCAGCGCATCCTGAACAGCGGG
CATCTTCCCTCCGCCCTGGAAATAACGGACAGTTTCACTCTCCGCGCCGCCCGGAACTATCTGGGGGACAGCGCCCTGCC
TTCCGGCTGCCGCGGCCACCTGATTGTGGAAGTGGACGGCAGGCGGCCCGCCGTGCGTGAGGAACTGGATTCGCTATGCA
CCCTGCTGGAAGAATGCGGCGCGACCGGAATTCTGCGCGCAGACACGGAAGCGGAGGCGGAAGCCATCTGGCAACTCCGC
CGGGAATTTTCCTACAGCCTGAAAGCAACCGGAATGACCAAGCTCAACGAAGACATCGTCATCCCCAGATCGCGCCTGGT
GGCCCTGGTGGAATTCTGCGAGGCCCTGAACCGGGAAACAGGGCTGGACATCGCGTGTTTCGGCCATTCCGGGGACGGCA
ACATCCATACCAACATCATGGTGGACGATTATGCGAATCCAGAGAAGAAAGCCCTGGCGGACGCCTGTGTGGACAGGCTG
TTCCACTGGGTGCTGGCACACGGAGGCGCCATTACCGGGGAACACGGCATCGGCCTGGCGAAGGCCAAATGGTTCCGGAA
AGCCGTGGGGGAAGGCGCCTACCACCTGCACGAACTGGTCAAATCCGCCCTGGACCCAAAAAATTTGCTGAATCCTGGAA
AAATGGGGCTTCCGTAA

Upstream 100 bases:

>100_bases
TACTCCGGACCAGATTTTCCTGACTACGGCGGACGACCTTTCCGGCAATCCGGATTTCCACCGCCCGGACTGCTTCTGCA
CCCCCATTCTCAAATAATCC

Downstream 100 bases:

>100_bases
CGTAAAATAAACTTCCATGACGCCTCCGGACGGGGCATCATGAATGCCGTACTTCATGAATAGCCCGCACAAGTCCATCC
TAGCTGCCCTTTACGATTGC

Product: FAD linked oxidase domain protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSLKEDISRILGPEKVSGAPDVLATHAGDKWYASVLPEAVVFPESTEDVSLLLRYASSMNIPVTARGGGVGYVGGCVPVR
GGISLSLERMNRILEISPEDGVAVVEPGVITADLQREARALGWFYPPDPASRKECSIGGNIATNAGGPRCLKYGVTRAYV
LGLTVVLASGEVVECGGRTHKNKTGFDIGDLFIGSEGMLGIITRAVLRLIPHPEAFGALSAGFPQFPLAAAAVQRILNSG
HLPSALEITDSFTLRAARNYLGDSALPSGCRGHLIVEVDGRRPAVREELDSLCTLLEECGATGILRADTEAEAEAIWQLR
REFSYSLKATGMTKLNEDIVIPRSRLVALVEFCEALNRETGLDIACFGHSGDGNIHTNIMVDDYANPEKKALADACVDRL
FHWVLAHGGAITGEHGIGLAKAKWFRKAVGEGAYHLHELVKSALDPKNLLNPGKMGLP

Sequences:

>Translated_458_residues
MSLKEDISRILGPEKVSGAPDVLATHAGDKWYASVLPEAVVFPESTEDVSLLLRYASSMNIPVTARGGGVGYVGGCVPVR
GGISLSLERMNRILEISPEDGVAVVEPGVITADLQREARALGWFYPPDPASRKECSIGGNIATNAGGPRCLKYGVTRAYV
LGLTVVLASGEVVECGGRTHKNKTGFDIGDLFIGSEGMLGIITRAVLRLIPHPEAFGALSAGFPQFPLAAAAVQRILNSG
HLPSALEITDSFTLRAARNYLGDSALPSGCRGHLIVEVDGRRPAVREELDSLCTLLEECGATGILRADTEAEAEAIWQLR
REFSYSLKATGMTKLNEDIVIPRSRLVALVEFCEALNRETGLDIACFGHSGDGNIHTNIMVDDYANPEKKALADACVDRL
FHWVLAHGGAITGEHGIGLAKAKWFRKAVGEGAYHLHELVKSALDPKNLLNPGKMGLP
>Mature_457_residues
SLKEDISRILGPEKVSGAPDVLATHAGDKWYASVLPEAVVFPESTEDVSLLLRYASSMNIPVTARGGGVGYVGGCVPVRG
GISLSLERMNRILEISPEDGVAVVEPGVITADLQREARALGWFYPPDPASRKECSIGGNIATNAGGPRCLKYGVTRAYVL
GLTVVLASGEVVECGGRTHKNKTGFDIGDLFIGSEGMLGIITRAVLRLIPHPEAFGALSAGFPQFPLAAAAVQRILNSGH
LPSALEITDSFTLRAARNYLGDSALPSGCRGHLIVEVDGRRPAVREELDSLCTLLEECGATGILRADTEAEAEAIWQLRR
EFSYSLKATGMTKLNEDIVIPRSRLVALVEFCEALNRETGLDIACFGHSGDGNIHTNIMVDDYANPEKKALADACVDRLF
HWVLAHGGAITGEHGIGLAKAKWFRKAVGEGAYHLHELVKSALDPKNLLNPGKMGLP

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=458, Percent_Identity=33.8427947598253, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI37595754, Length=481, Percent_Identity=32.2245322245322, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI119964728, Length=426, Percent_Identity=31.924882629108, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4501993, Length=220, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=34.8448687350835, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1787977, Length=509, Percent_Identity=28.4872298624754, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI48994907, Length=487, Percent_Identity=22.3819301848049, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994914, Length=135, Percent_Identity=28.1481481481481, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992373, Length=459, Percent_Identity=30.9368191721133, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17534361, Length=434, Percent_Identity=31.3364055299539, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71992381, Length=459, Percent_Identity=30.2832244008715, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71992392, Length=383, Percent_Identity=30.8093994778068, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17556096, Length=235, Percent_Identity=25.531914893617, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320023, Length=432, Percent_Identity=31.0185185185185, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320764, Length=458, Percent_Identity=27.9475982532751, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320027, Length=472, Percent_Identity=27.1186440677966, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI18921117, Length=427, Percent_Identity=29.7423887587822, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24639277, Length=427, Percent_Identity=29.7423887587822, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24639275, Length=427, Percent_Identity=29.7423887587822, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24653753, Length=467, Percent_Identity=23.5546038543897, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 48882; Mature: 48750

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKEDISRILGPEKVSGAPDVLATHAGDKWYASVLPEAVVFPESTEDVSLLLRYASSMN
CCCHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHCCHHEECCCCCHHHHHHHHHHHCCC
IPVTARGGGVGYVGGCVPVRGGISLSLERMNRILEISPEDGVAVVEPGVITADLQREARA
CEEEECCCCEEEECCCEEECCCCEEEHHHHCHHEEECCCCCEEEECCCEEEHHHHHHHHH
LGWFYPPDPASRKECSIGGNIATNAGGPRCLKYGVTRAYVLGLTVVLASGEVVECGGRTH
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
KNKTGFDIGDLFIGSEGMLGIITRAVLRLIPHPEAFGALSAGFPQFPLAAAAVQRILNSG
CCCCCCCHHHEEECCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCC
HLPSALEITDSFTLRAARNYLGDSALPSGCRGHLIVEVDGRRPAVREELDSLCTLLEECG
CCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
ATGILRADTEAEAEAIWQLRREFSYSLKATGMTKLNEDIVIPRSRLVALVEFCEALNRET
CCCEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCCCEECCHHHHHHHHHHHHHHCCCC
GLDIACFGHSGDGNIHTNIMVDDYANPEKKALADACVDRLFHWVLAHGGAITGEHGIGLA
CCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHH
KAKWFRKAVGEGAYHLHELVKSALDPKNLLNPGKMGLP
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SLKEDISRILGPEKVSGAPDVLATHAGDKWYASVLPEAVVFPESTEDVSLLLRYASSMN
CCHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHCCHHEECCCCCHHHHHHHHHHHCCC
IPVTARGGGVGYVGGCVPVRGGISLSLERMNRILEISPEDGVAVVEPGVITADLQREARA
CEEEECCCCEEEECCCEEECCCCEEEHHHHCHHEEECCCCCEEEECCCEEEHHHHHHHHH
LGWFYPPDPASRKECSIGGNIATNAGGPRCLKYGVTRAYVLGLTVVLASGEVVECGGRTH
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
KNKTGFDIGDLFIGSEGMLGIITRAVLRLIPHPEAFGALSAGFPQFPLAAAAVQRILNSG
CCCCCCCHHHEEECCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCC
HLPSALEITDSFTLRAARNYLGDSALPSGCRGHLIVEVDGRRPAVREELDSLCTLLEECG
CCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
ATGILRADTEAEAEAIWQLRREFSYSLKATGMTKLNEDIVIPRSRLVALVEFCEALNRET
CCCEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCCCEECCHHHHHHHHHHHHHHCCCC
GLDIACFGHSGDGNIHTNIMVDDYANPEKKALADACVDRLFHWVLAHGGAITGEHGIGLA
CCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHH
KAKWFRKAVGEGAYHLHELVKSALDPKNLLNPGKMGLP
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]