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The map label for this gene is folP-A [H]

Identifier: 187735879

GI number: 187735879

Start: 1653674

End: 1654513

Strand: Direct

Name: folP-A [H]

Synonym: Amuc_1386

Alternate gene names: 187735879

Gene position: 1653674-1654513 (Clockwise)

Preceding gene: 187735877

Following gene: 187735880

Centisome position: 62.07

GC content: 63.57

Gene sequence:

>840_bases
ATGAACTGGCTTGTAAGGAGAGACGTATTGGAGGTGGCGCGCGGAGGCGTGCTGATGGGAATTGTGAACGTTACTCCGGA
TTCCTTTTCCGACGGAGGGCGTTTTTATGCGACGGAACGCGCTGTCTCCCATGCAAAAGAGCTTGAACGGCAGGGCGCCC
TTATTCTGGACATTGGGGGGGAGTCCACCAGGCCGGGGGCCGCGGAGGTTTCCGCGGAGGAGGAATTGGACAGGGTGCTG
CCCGTGGTGCGGGAACTCCGTTCATGCACGGATGCCGTGATTTCCGTGGACACGCGCCATGCCGCCGTAGCGGCGGCTGT
GCTGGAAGCGGGTGCGGACGTCATTAATGATATTTCCGGATTGCGGGAGGCGGGGATGGCGGAATTGTGCGCTGCGGCGC
GCTGCGGCGTGGTGGCGATGCACATGCAGGGACGGCCTGAAACCATGCAGGACGCTCCTTCTTATGGGGATGTGGTGCGG
GAAGTGCGCGGCTATTTTGAGGAACGTTATGATTTTCTGCTGGGGCGGGGGCTGGAACCGGAGCAGATCTGCTGGGATCC
CGGCATCGGCTTTGGCAAAACGGCGGAACACAATCTGGCCCTGCTGTCCAACATGGACAAGCTTCAGGTGGCAGGCCGCC
CGGTGCTGCTGGGCCTTTCCCGCAAGCGCATGCTGGGCGCCGTCCTGGGGGATGCGGAGCAGGGACGCGCGCCGCTGAGC
ACCGCCGTGATGACGGTGTGGGGGCATTTGCACGGCGCGCAGATTCACCGTGTCCATGACGTGGCGGAATGCGCCCGCGC
CCTCCGGCTGATCCGGGCCGCTGAACCGTTTGTCCGCTGA

Upstream 100 bases:

>100_bases
CAGGGGGATGAAGAGAAGCAGGGGCGTTGTTTTCATGGTGAAAAAAGAGTTTCTGACTTATTAAAGTGATGTATAGTGGC
TTTGACAAGAACGTAATTAG

Downstream 100 bases:

>100_bases
TTGAGCCATGGAATCCGCTTCTTCCCGTCCGGTATTGACGTCCCTGGCGTCCATTGCATTTTCCCTGGCGGTGGTGTTCC
TTTTTCTGGCGGTACGGGGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNWLVRRDVLEVARGGVLMGIVNVTPDSFSDGGRFYATERAVSHAKELERQGALILDIGGESTRPGAAEVSAEEELDRVL
PVVRELRSCTDAVISVDTRHAAVAAAVLEAGADVINDISGLREAGMAELCAAARCGVVAMHMQGRPETMQDAPSYGDVVR
EVRGYFEERYDFLLGRGLEPEQICWDPGIGFGKTAEHNLALLSNMDKLQVAGRPVLLGLSRKRMLGAVLGDAEQGRAPLS
TAVMTVWGHLHGAQIHRVHDVAECARALRLIRAAEPFVR

Sequences:

>Translated_279_residues
MNWLVRRDVLEVARGGVLMGIVNVTPDSFSDGGRFYATERAVSHAKELERQGALILDIGGESTRPGAAEVSAEEELDRVL
PVVRELRSCTDAVISVDTRHAAVAAAVLEAGADVINDISGLREAGMAELCAAARCGVVAMHMQGRPETMQDAPSYGDVVR
EVRGYFEERYDFLLGRGLEPEQICWDPGIGFGKTAEHNLALLSNMDKLQVAGRPVLLGLSRKRMLGAVLGDAEQGRAPLS
TAVMTVWGHLHGAQIHRVHDVAECARALRLIRAAEPFVR
>Mature_279_residues
MNWLVRRDVLEVARGGVLMGIVNVTPDSFSDGGRFYATERAVSHAKELERQGALILDIGGESTRPGAAEVSAEEELDRVL
PVVRELRSCTDAVISVDTRHAAVAAAVLEAGADVINDISGLREAGMAELCAAARCGVVAMHMQGRPETMQDAPSYGDVVR
EVRGYFEERYDFLLGRGLEPEQICWDPGIGFGKTAEHNLALLSNMDKLQVAGRPVLLGLSRKRMLGAVLGDAEQGRAPLS
TAVMTVWGHLHGAQIHRVHDVAECARALRLIRAAEPFVR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=46.5116279069767, Blast_Score=213, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=314, Percent_Identity=30.5732484076433, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30172; Mature: 30172

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLVRRDVLEVARGGVLMGIVNVTPDSFSDGGRFYATERAVSHAKELERQGALILDIGG
CCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAAEVSAEEELDRVLPVVRELRSCTDAVISVDTRHAAVAAAVLEAGADVINDISG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LREAGMAELCAAARCGVVAMHMQGRPETMQDAPSYGDVVREVRGYFEERYDFLLGRGLEP
HHHHHHHHHHHHHHCCEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
EQICWDPGIGFGKTAEHNLALLSNMDKLQVAGRPVLLGLSRKRMLGAVLGDAEQGRAPLS
HHHCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCEEECCHHHHHHHHHHCCHHCCCCHHH
TAVMTVWGHLHGAQIHRVHDVAECARALRLIRAAEPFVR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWLVRRDVLEVARGGVLMGIVNVTPDSFSDGGRFYATERAVSHAKELERQGALILDIGG
CCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAAEVSAEEELDRVLPVVRELRSCTDAVISVDTRHAAVAAAVLEAGADVINDISG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LREAGMAELCAAARCGVVAMHMQGRPETMQDAPSYGDVVREVRGYFEERYDFLLGRGLEP
HHHHHHHHHHHHHHCCEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
EQICWDPGIGFGKTAEHNLALLSNMDKLQVAGRPVLLGLSRKRMLGAVLGDAEQGRAPLS
HHHCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCEEECCHHHHHHHHHHCCHHCCCCHHH
TAVMTVWGHLHGAQIHRVHDVAECARALRLIRAAEPFVR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]