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The map label for this gene is nhaC [H]

Identifier: 187735741

GI number: 187735741

Start: 1496790

End: 1498115

Strand: Reverse

Name: nhaC [H]

Synonym: Amuc_1247

Alternate gene names: 187735741

Gene position: 1498115-1496790 (Counterclockwise)

Preceding gene: 187735742

Following gene: 187735740

Centisome position: 56.23

GC content: 58.75

Gene sequence:

>1326_bases
ATGACCAGCCCCCCGGACAACCAGGATACGCCCCCCGCCAAAGCCAGCCTGTGGGCGCTGAGCCCCCTGCTGGTTTTCTT
CCTGCTTTACCTGGTCATCTCCATAGCCGTACAGGATTTTTACGCCGTGCCGGTCACGGTAGCCTTTATGGCGGCAGCTG
TCTGGGCCGTTTTCATCACCCGCGGAAAAAGCATGGCGGAACGGGTGGATCTGTTTTCCTCCGGAGTAGCCAACCGGAAC
ATCCTGATGATGGTCTGGATTTTCGTGCTGGCAGGAGCCTTCGCCCAGTCTGCTAGGGATATGGGAGCCATTGACGCCAC
CGTGCAGCTTACGCTGCGGCTTCTTCCGGACAATCTGCTGCTTGCCAGCGTGTTCATCGCCTCCTGTTTCATCTCCCTCT
CCGTAGGAACATCCGTAGGCACCATTGTCGCTCTGGCTCCCGTAGCCACAGGGCTGGCACAAGCCACGCAGGTCAGTGCC
GGCATGATGACGGCCATTGTGGTGGGGGGAGCATTCTTCGGAGACAATCTTTCCTTCATTTCAGACACCACGATCGCCGC
CACCCGTACGCAGGGCTGCGCCATGCGGGACAAATTCCGGGCCAACATAAAGGTGGCGCTCCCCGCCGCCCTGCTGGCCC
TGGCCTGCTACATCCTGCTCGGATGGAACGTGCAGTCCCCCTCCACAGCGGATATCTCCATTGAATGGATGAAGGTATTC
CCCTATCTGCTCGTACTGGTGACGGCCCTGGCCGGAATCCATGTCATGGCCGTTCTGACCATGGGGCTCCTTGCAACGGG
ACTGATTGGCATCGGCATGGGGTATTTCTCCTTCATGGCCTGGTTCCAAGCCATGGGCAGCGGCATGACCGGCATGGGAG
AACTGATCATCGTCACTCTGCTGGCCGGCGGCGTGCTGTCCATCATCCGTTTCAACGGAGGCATCGCGTATATTATCGGA
AAAATTACGGCCCATATCCACAGCAGGCGCGGCGCGGAATTCAGCATTGCCGGGCTGGTTTCCCTGGCCAACCTCTGCAC
GGCCAACAATACGATCGCCATCATCACGGCAGGCCCCATCGCCAAGGAAATAAGCGACAAATTCCATATCCCACCCAAAC
GCAGCGCCAGCATTCTGGACACCTTTTCCTGCCTGGTTCAGGGAGTCATCCCCTACGGCGCTCAAATGCTCATGGCCACC
GGAATCTCCCAGGTTTCTCCCCTGCTGGTCATGAAATACCTGTATTATCCCCTGATTCTGGGCATCTGCTCCACCCTTGC
CATTGCGCTGGCACCGGGAGGGACGGAAAGACGGAGGAAACGCTGA

Upstream 100 bases:

>100_bases
GGGTGGAGCTGGAAGAGGGAGTGGAACGCATTTACCGGTGGTATCTGAGCCGGATGGAAGCCGACGGCAACTGACTTTTC
GGCCAGCTCCCCTCACTCCA

Downstream 100 bases:

>100_bases
AAAGCCCATACGGAGAAAGGACGGCAAGGCCGCCTTTTTTGTTACCGACATGTTATCCCTGTTATCTTCATGTTACTCAA
CATATGGGATTCTTGTGCTA

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTSPPDNQDTPPAKASLWALSPLLVFFLLYLVISIAVQDFYAVPVTVAFMAAAVWAVFITRGKSMAERVDLFSSGVANRN
ILMMVWIFVLAGAFAQSARDMGAIDATVQLTLRLLPDNLLLASVFIASCFISLSVGTSVGTIVALAPVATGLAQATQVSA
GMMTAIVVGGAFFGDNLSFISDTTIAATRTQGCAMRDKFRANIKVALPAALLALACYILLGWNVQSPSTADISIEWMKVF
PYLLVLVTALAGIHVMAVLTMGLLATGLIGIGMGYFSFMAWFQAMGSGMTGMGELIIVTLLAGGVLSIIRFNGGIAYIIG
KITAHIHSRRGAEFSIAGLVSLANLCTANNTIAIITAGPIAKEISDKFHIPPKRSASILDTFSCLVQGVIPYGAQMLMAT
GISQVSPLLVMKYLYYPLILGICSTLAIALAPGGTERRRKR

Sequences:

>Translated_441_residues
MTSPPDNQDTPPAKASLWALSPLLVFFLLYLVISIAVQDFYAVPVTVAFMAAAVWAVFITRGKSMAERVDLFSSGVANRN
ILMMVWIFVLAGAFAQSARDMGAIDATVQLTLRLLPDNLLLASVFIASCFISLSVGTSVGTIVALAPVATGLAQATQVSA
GMMTAIVVGGAFFGDNLSFISDTTIAATRTQGCAMRDKFRANIKVALPAALLALACYILLGWNVQSPSTADISIEWMKVF
PYLLVLVTALAGIHVMAVLTMGLLATGLIGIGMGYFSFMAWFQAMGSGMTGMGELIIVTLLAGGVLSIIRFNGGIAYIIG
KITAHIHSRRGAEFSIAGLVSLANLCTANNTIAIITAGPIAKEISDKFHIPPKRSASILDTFSCLVQGVIPYGAQMLMAT
GISQVSPLLVMKYLYYPLILGICSTLAIALAPGGTERRRKR
>Mature_440_residues
TSPPDNQDTPPAKASLWALSPLLVFFLLYLVISIAVQDFYAVPVTVAFMAAAVWAVFITRGKSMAERVDLFSSGVANRNI
LMMVWIFVLAGAFAQSARDMGAIDATVQLTLRLLPDNLLLASVFIASCFISLSVGTSVGTIVALAPVATGLAQATQVSAG
MMTAIVVGGAFFGDNLSFISDTTIAATRTQGCAMRDKFRANIKVALPAALLALACYILLGWNVQSPSTADISIEWMKVFP
YLLVLVTALAGIHVMAVLTMGLLATGLIGIGMGYFSFMAWFQAMGSGMTGMGELIIVTLLAGGVLSIIRFNGGIAYIIGK
ITAHIHSRRGAEFSIAGLVSLANLCTANNTIAIITAGPIAKEISDKFHIPPKRSASILDTFSCLVQGVIPYGAQMLMATG
ISQVSPLLVMKYLYYPLILGICSTLAIALAPGGTERRRKR

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 46605; Mature: 46474

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPPDNQDTPPAKASLWALSPLLVFFLLYLVISIAVQDFYAVPVTVAFMAAAVWAVFIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGKSMAERVDLFSSGVANRNILMMVWIFVLAGAFAQSARDMGAIDATVQLTLRLLPDNLL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
LASVFIASCFISLSVGTSVGTIVALAPVATGLAQATQVSAGMMTAIVVGGAFFGDNLSFI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHH
SDTTIAATRTQGCAMRDKFRANIKVALPAALLALACYILLGWNVQSPSTADISIEWMKVF
CCCCEEEECCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHH
PYLLVLVTALAGIHVMAVLTMGLLATGLIGIGMGYFSFMAWFQAMGSGMTGMGELIIVTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LAGGVLSIIRFNGGIAYIIGKITAHIHSRRGAEFSIAGLVSLANLCTANNTIAIITAGPI
HHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCH
AKEISDKFHIPPKRSASILDTFSCLVQGVIPYGAQMLMATGISQVSPLLVMKYLYYPLIL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
GICSTLAIALAPGGTERRRKR
HHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
TSPPDNQDTPPAKASLWALSPLLVFFLLYLVISIAVQDFYAVPVTVAFMAAAVWAVFIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGKSMAERVDLFSSGVANRNILMMVWIFVLAGAFAQSARDMGAIDATVQLTLRLLPDNLL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
LASVFIASCFISLSVGTSVGTIVALAPVATGLAQATQVSAGMMTAIVVGGAFFGDNLSFI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHH
SDTTIAATRTQGCAMRDKFRANIKVALPAALLALACYILLGWNVQSPSTADISIEWMKVF
CCCCEEEECCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHH
PYLLVLVTALAGIHVMAVLTMGLLATGLIGIGMGYFSFMAWFQAMGSGMTGMGELIIVTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LAGGVLSIIRFNGGIAYIIGKITAHIHSRRGAEFSIAGLVSLANLCTANNTIAIITAGPI
HHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCH
AKEISDKFHIPPKRSASILDTFSCLVQGVIPYGAQMLMATGISQVSPLLVMKYLYYPLIL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
GICSTLAIALAPGGTERRRKR
HHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]