Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is ilvC

Identifier: 187735672

GI number: 187735672

Start: 1413087

End: 1414067

Strand: Direct

Name: ilvC

Synonym: Amuc_1178

Alternate gene names: 187735672

Gene position: 1413087-1414067 (Clockwise)

Preceding gene: 187735671

Following gene: 187735673

Centisome position: 53.04

GC content: 57.9

Gene sequence:

>981_bases
ATGGATATTATTCATGACAACGCCGCTGATCTCAGCGCATTGAACGGCAAGACCGTTGCCGTGATCGGATATGGCGCCCA
GGGGCGCGCTCAGGCACTTTGCATGCGTGATTCCGGTGTGAACGTGATTATCGGCGTTCGCCCCGGCAAGTCTTTTGACG
CCGCCGCCCAGGATGGATTCCAGGTAATGAGCGTCGCGGAAGCCGCCGAAAAAGCGGACATCATTCACATTCTGCTGCCG
GATGAAAGCCACGGCGCCGTGTATGAAGCTGAAATCAAGCCTCACTTGAAGGCCGGCAAGACGCTTTGCTGCTCCCATGG
CTTCGCGTATGTTTTCAATACCATCGTCCCCCCTGCGGATGTAGATGTAATCATGGTGGCCCCCAAGGGCCCGGGCACGG
AAGTGCGCCGAGTATTTGAAGAAGGGTTCGGCTGCCCCGGCCTGATTGCCGTTCATCAGAACCCCTCCGGCAAGGCCCGT
GACGTGGCTCTTGCCATGGCCAAGGCGGAAGGCCTGACCCGCGGCGGCGTGCTGGAATGCACCATGGCCCAGGAAACGTA
TGAAGACCTGTTCGGTGAACAGAACGTCCTGTGCGGTGGTCTGGTGGACCTGATGAAGTACGGCTTTGAAACCCTGACGG
AAGCCGGCTATCCGCCGGAAATGGCCTACTTTGAGTGCGTGCATGAAGCCAAGCTCATCGTGGACCTGATTTATAACGGC
GGCATCCAGAAGATGAACTCCGTGATTTCCAACACGGCCGAATTCGGCGAATATTACAACGGCCCGCAGATCCTGCCCGC
AGAGGTGAAGGAACGCATGAAGGAATCCCTCAAGCGCATTGAATCCGGCAAGTTCGCCAAGGACTGGCTGGAAGAGGCAG
CCAAGGGCGCTCCCAACCTCAAAGCCAAGCGCGAAGCCCTGGGTCAGCACCCGGTGGAAATCGTGGGCGCCAAGATCCGC
AGTCTGTTTGAAAGGAACTAA

Upstream 100 bases:

>100_bases
CGCCTGCTTAAAATAGGCTTGCAATCATGAGAAGGATGGATATGTTGGCATTCATCCAAACATTGGATGTTTGGATGAAT
TACTTAAAGAAGGAGTAACA

Downstream 100 bases:

>100_bases
GGTTTCTTTTACTTGAAACACATGCCGTTCCGTCGGAATACGGCGGAGCGGCACGTATATTCCCGGGCTTTTCCCGGAAA
TCCGCCATTGATTCAGTTTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDIIHDNAADLSALNGKTVAVIGYGAQGRAQALCMRDSGVNVIIGVRPGKSFDAAAQDGFQVMSVAEAAEKADIIHILLP
DESHGAVYEAEIKPHLKAGKTLCCSHGFAYVFNTIVPPADVDVIMVAPKGPGTEVRRVFEEGFGCPGLIAVHQNPSGKAR
DVALAMAKAEGLTRGGVLECTMAQETYEDLFGEQNVLCGGLVDLMKYGFETLTEAGYPPEMAYFECVHEAKLIVDLIYNG
GIQKMNSVISNTAEFGEYYNGPQILPAEVKERMKESLKRIESGKFAKDWLEEAAKGAPNLKAKREALGQHPVEIVGAKIR
SLFERN

Sequences:

>Translated_326_residues
MDIIHDNAADLSALNGKTVAVIGYGAQGRAQALCMRDSGVNVIIGVRPGKSFDAAAQDGFQVMSVAEAAEKADIIHILLP
DESHGAVYEAEIKPHLKAGKTLCCSHGFAYVFNTIVPPADVDVIMVAPKGPGTEVRRVFEEGFGCPGLIAVHQNPSGKAR
DVALAMAKAEGLTRGGVLECTMAQETYEDLFGEQNVLCGGLVDLMKYGFETLTEAGYPPEMAYFECVHEAKLIVDLIYNG
GIQKMNSVISNTAEFGEYYNGPQILPAEVKERMKESLKRIESGKFAKDWLEEAAKGAPNLKAKREALGQHPVEIVGAKIR
SLFERN
>Mature_326_residues
MDIIHDNAADLSALNGKTVAVIGYGAQGRAQALCMRDSGVNVIIGVRPGKSFDAAAQDGFQVMSVAEAAEKADIIHILLP
DESHGAVYEAEIKPHLKAGKTLCCSHGFAYVFNTIVPPADVDVIMVAPKGPGTEVRRVFEEGFGCPGLIAVHQNPSGKAR
DVALAMAKAEGLTRGGVLECTMAQETYEDLFGEQNVLCGGLVDLMKYGFETLTEAGYPPEMAYFECVHEAKLIVDLIYNG
GIQKMNSVISNTAEFGEYYNGPQILPAEVKERMKESLKRIESGKFAKDWLEEAAKGAPNLKAKREALGQHPVEIVGAKIR
SLFERN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=322, Percent_Identity=36.0248447204969, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=36.3914373088685, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_AKKM8 (B2URB8)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001877784.1
- ProteinModelPortal:   B2URB8
- SMR:   B2URB8
- GeneID:   6273775
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1178
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35145; Mature: 35145

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: ACT_SITE 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIIHDNAADLSALNGKTVAVIGYGAQGRAQALCMRDSGVNVIIGVRPGKSFDAAAQDGF
CCCCCCCCCHHHHCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHCCH
QVMSVAEAAEKADIIHILLPDESHGAVYEAEIKPHLKAGKTLCCSHGFAYVFNTIVPPAD
HHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHCCCEEEHHCCHHHHHHHCCCCCC
VDVIMVAPKGPGTEVRRVFEEGFGCPGLIAVHQNPSGKARDVALAMAKAEGLTRGGVLEC
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEE
TMAQETYEDLFGEQNVLCGGLVDLMKYGFETLTEAGYPPEMAYFECVHEAKLIVDLIYNG
EHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GIQKMNSVISNTAEFGEYYNGPQILPAEVKERMKESLKRIESGKFAKDWLEEAAKGAPNL
CHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
KAKREALGQHPVEIVGAKIRSLFERN
HHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIIHDNAADLSALNGKTVAVIGYGAQGRAQALCMRDSGVNVIIGVRPGKSFDAAAQDGF
CCCCCCCCCHHHHCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHCCH
QVMSVAEAAEKADIIHILLPDESHGAVYEAEIKPHLKAGKTLCCSHGFAYVFNTIVPPAD
HHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHCCCEEEHHCCHHHHHHHCCCCCC
VDVIMVAPKGPGTEVRRVFEEGFGCPGLIAVHQNPSGKARDVALAMAKAEGLTRGGVLEC
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEE
TMAQETYEDLFGEQNVLCGGLVDLMKYGFETLTEAGYPPEMAYFECVHEAKLIVDLIYNG
EHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GIQKMNSVISNTAEFGEYYNGPQILPAEVKERMKESLKRIESGKFAKDWLEEAAKGAPNL
CHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
KAKREALGQHPVEIVGAKIRSLFERN
HHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA