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The map label for this gene is rsmA [H]

Identifier: 187735621

GI number: 187735621

Start: 1349585

End: 1350964

Strand: Direct

Name: rsmA [H]

Synonym: Amuc_1126

Alternate gene names: 187735621

Gene position: 1349585-1350964 (Clockwise)

Preceding gene: 187735615

Following gene: 187735622

Centisome position: 50.66

GC content: 57.25

Gene sequence:

>1380_bases
ATGAAACCGTCCGAGATCAGGAATGTTCTGGAAGACCATGAAGTGCGCCCCAGCAAGTCCCTGGGGCAGAATTTCCTGAC
GGATGAAAATGTGGCCCGCTGGATTGTGGAGCAGCTCGAAATCCGGCCGCAGGATTGCGTGGTGGAGGTAGGGCCTGGAA
CCGGCTCCCTGACGGAACATGCCGCACCCCTTTGCCGCAAACTGGTTCTGGTGGAATTTGATTCCCGTCTGGCGGAGTAC
CAGAAAGAGCGCTGGGCCGGTGATCCCCATGTGGAGGTTCACCATGCAGACGGCGCTTCCTGGGATCCGCGGGGGCTGTT
TGCGGAGGCCCCTGTCAAATTCCTTGGCAATCTTCCCTATTCCGCGGGGGGAGCCATCCTCCAGAATTTCCTGTCCAGGC
CCAGTGCTGTGGAACGTGCCGTGGTGATGCTTCAGAAGGAGTTTATCGACCGCATTCTGGCGACGCCGGATGATGATGCC
TTCGGGCTGTTGTCCCTGCGCATCCAGAAAAACTGGATTCCCCGTGCCCTCAAAACCATTCCGCCGGAAGCGTTTCATCC
CCGTCCGCGTATTGATTCCACCGTGATGCTGCTCACTCCCCGTCCTGCCCGCGAGTTGCCTCCATATGACGACCGCCTGA
TGGATGAACTGATGCGCAAGGCTTTTTCCCAGCGGCGCAAACAATTGAAAAAACAGCTCCCCGCTTCTCCTCCGTGGGAG
GGCGTGGCTGCTTCCCTGGGGCTTTCCCCTTCCGCCAGGGCTGAGGAATTGAATTTGTCCCAGTGGGTGGAATTGGCGCG
CGTTTATGATACCAATCCTCTCAAGGATGTGGCGCAGAGCGGAGATGAATTGTTTGACATCGTGGACGAACTCAATCAGG
TGACGGGGCAGGGCACGCGCCGGGAAATACATGAAGGCAGCCTTCGTCATCGCGCCGTACATATGTTCCTGGTCAATAAG
CATGGAGCTGTGCTTCTCCAGAAAAGGTCCCTGTGGAAAGACAGGCAGCCGGGCAAATGGGATTCCTCCGCAGCCGGGCA
TCTGGATGCCGGGGAAAGTTATGAGGAAGCTGCGGTGCGGGAGCTGAAGGAAGAACTGGGGGTGTCCGGCTGCGGGCTGC
AGAAAATCGCGGATTTTGACGCCGGAGAAAATAACGGCTGGGAATTCATCTCCCTCTATGAAGGGCGGTATTCCGGGAAA
GTTCGTTTTCCGGCGGCGGAGGTGGACAGCGTGCAGTGGTTTACGCCGGAGCAAATCCAGGCGTGGGTGGAACGCCGTCC
GCAGGATTTCTCGCCTGCGTTCATTCCCTGCTGGAATGCATGGCTGGCCGCGAATAGAAAAAATCATTCTAACTCAAATA
CATATCATGATAAACCCTGA

Upstream 100 bases:

>100_bases
TTCTTTGCCTGCGGCGGTTGGAGCTTCTCCGTTTTCATGCCGGAAACTGCCCCGCTTTTTACTGGCTCCTGACAGGCATT
TTTGCGAACATCACTTCATT

Downstream 100 bases:

>100_bases
TCAATTATCTCCGGAACAGATCCAGTCCATCCGAACCTGGGCGGAAGAAGGACTGGATTTAAACGCCATCCAGAAAAGGC
TGCATGAGGACTTGAACATC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKPSEIRNVLEDHEVRPSKSLGQNFLTDENVARWIVEQLEIRPQDCVVEVGPGTGSLTEHAAPLCRKLVLVEFDSRLAEY
QKERWAGDPHVEVHHADGASWDPRGLFAEAPVKFLGNLPYSAGGAILQNFLSRPSAVERAVVMLQKEFIDRILATPDDDA
FGLLSLRIQKNWIPRALKTIPPEAFHPRPRIDSTVMLLTPRPARELPPYDDRLMDELMRKAFSQRRKQLKKQLPASPPWE
GVAASLGLSPSARAEELNLSQWVELARVYDTNPLKDVAQSGDELFDIVDELNQVTGQGTRREIHEGSLRHRAVHMFLVNK
HGAVLLQKRSLWKDRQPGKWDSSAAGHLDAGESYEEAAVRELKEELGVSGCGLQKIADFDAGENNGWEFISLYEGRYSGK
VRFPAAEVDSVQWFTPEQIQAWVERRPQDFSPAFIPCWNAWLAANRKNHSNSNTYHDKP

Sequences:

>Translated_459_residues
MKPSEIRNVLEDHEVRPSKSLGQNFLTDENVARWIVEQLEIRPQDCVVEVGPGTGSLTEHAAPLCRKLVLVEFDSRLAEY
QKERWAGDPHVEVHHADGASWDPRGLFAEAPVKFLGNLPYSAGGAILQNFLSRPSAVERAVVMLQKEFIDRILATPDDDA
FGLLSLRIQKNWIPRALKTIPPEAFHPRPRIDSTVMLLTPRPARELPPYDDRLMDELMRKAFSQRRKQLKKQLPASPPWE
GVAASLGLSPSARAEELNLSQWVELARVYDTNPLKDVAQSGDELFDIVDELNQVTGQGTRREIHEGSLRHRAVHMFLVNK
HGAVLLQKRSLWKDRQPGKWDSSAAGHLDAGESYEEAAVRELKEELGVSGCGLQKIADFDAGENNGWEFISLYEGRYSGK
VRFPAAEVDSVQWFTPEQIQAWVERRPQDFSPAFIPCWNAWLAANRKNHSNSNTYHDKP
>Mature_459_residues
MKPSEIRNVLEDHEVRPSKSLGQNFLTDENVARWIVEQLEIRPQDCVVEVGPGTGSLTEHAAPLCRKLVLVEFDSRLAEY
QKERWAGDPHVEVHHADGASWDPRGLFAEAPVKFLGNLPYSAGGAILQNFLSRPSAVERAVVMLQKEFIDRILATPDDDA
FGLLSLRIQKNWIPRALKTIPPEAFHPRPRIDSTVMLLTPRPARELPPYDDRLMDELMRKAFSQRRKQLKKQLPASPPWE
GVAASLGLSPSARAEELNLSQWVELARVYDTNPLKDVAQSGDELFDIVDELNQVTGQGTRREIHEGSLRHRAVHMFLVNK
HGAVLLQKRSLWKDRQPGKWDSSAAGHLDAGESYEEAAVRELKEELGVSGCGLQKIADFDAGENNGWEFISLYEGRYSGK
VRFPAAEVDSVQWFTPEQIQAWVERRPQDFSPAFIPCWNAWLAANRKNHSNSNTYHDKP

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=219, Percent_Identity=28.7671232876712, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156415992, Length=293, Percent_Identity=26.6211604095563, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786236, Length=264, Percent_Identity=32.1969696969697, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788637, Length=171, Percent_Identity=32.7485380116959, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25146882, Length=212, Percent_Identity=31.1320754716981, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25141369, Length=322, Percent_Identity=23.6024844720497, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324989, Length=216, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358017, Length=261, Percent_Identity=28.735632183908, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357273, Length=292, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 51880; Mature: 51880

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00893 NUDIX ; PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSEIRNVLEDHEVRPSKSLGQNFLTDENVARWIVEQLEIRPQDCVVEVGPGTGSLTEH
CCHHHHHHHHHHCCCCCCHHHCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
AAPLCRKLVLVEFDSRLAEYQKERWAGDPHVEVHHADGASWDPRGLFAEAPVKFLGNLPY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHCHHHHHCCCCC
SAGGAILQNFLSRPSAVERAVVMLQKEFIDRILATPDDDAFGLLSLRIQKNWIPRALKTI
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHC
PPEAFHPRPRIDSTVMLLTPRPARELPPYDDRLMDELMRKAFSQRRKQLKKQLPASPPWE
CCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVAASLGLSPSARAEELNLSQWVELARVYDTNPLKDVAQSGDELFDIVDELNQVTGQGTR
HHHHHCCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHH
REIHEGSLRHRAVHMFLVNKHGAVLLQKRSLWKDRQPGKWDSSAAGHLDAGESYEEAAVR
HHHHHHHHHHHEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ELKEELGVSGCGLQKIADFDAGENNGWEFISLYEGRYSGKVRFPAAEVDSVQWFTPEQIQ
HHHHHHCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHH
AWVERRPQDFSPAFIPCWNAWLAANRKNHSNSNTYHDKP
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPSEIRNVLEDHEVRPSKSLGQNFLTDENVARWIVEQLEIRPQDCVVEVGPGTGSLTEH
CCHHHHHHHHHHCCCCCCHHHCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
AAPLCRKLVLVEFDSRLAEYQKERWAGDPHVEVHHADGASWDPRGLFAEAPVKFLGNLPY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHCHHHHHCCCCC
SAGGAILQNFLSRPSAVERAVVMLQKEFIDRILATPDDDAFGLLSLRIQKNWIPRALKTI
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHC
PPEAFHPRPRIDSTVMLLTPRPARELPPYDDRLMDELMRKAFSQRRKQLKKQLPASPPWE
CCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVAASLGLSPSARAEELNLSQWVELARVYDTNPLKDVAQSGDELFDIVDELNQVTGQGTR
HHHHHCCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHH
REIHEGSLRHRAVHMFLVNKHGAVLLQKRSLWKDRQPGKWDSSAAGHLDAGESYEEAAVR
HHHHHHHHHHHEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ELKEELGVSGCGLQKIADFDAGENNGWEFISLYEGRYSGKVRFPAAEVDSVQWFTPEQIQ
HHHHHHCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHH
AWVERRPQDFSPAFIPCWNAWLAANRKNHSNSNTYHDKP
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA