Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is ziaA [H]
Identifier: 187735590
GI number: 187735590
Start: 1306359
End: 1308284
Strand: Direct
Name: ziaA [H]
Synonym: Amuc_1095
Alternate gene names: 187735590
Gene position: 1306359-1308284 (Clockwise)
Preceding gene: 187735589
Following gene: 187735598
Centisome position: 49.04
GC content: 61.11
Gene sequence:
>1926_bases ATGAGCACGGAACATTCCCACGAACATTTTCCGGAAGGTGCTTCCTGTTGTTCCGGAAGCTGCGGTTCTGGAAGCTGTTG CTGCTCCGGAGACGCCATCGGGCCTGTTCCCGCCGTGCTGGGCATTGCCCTGTTCATCAGTGCGCTGGCGGCGGGCGGCG ATTCCCTGGCCGGTATGGCCGCCTACGTGGGCTCCTACCTGCTGATAGGCTGGGATGTACTGAAGGCCGCCTTTCTGGGG ATGATGCGCGGCCGCGCCATCAATGAAAATTTTCTGATGAGTATTGCTTCCCTGGGGGCGATGTTCCTGGGGGATTATTC CGAGGCGGTGGGGGTGATGCTGTTCTACCGCGTGGGAGAGTACCTTCAGGAACGTGCGGTGGGCAGCTCCCGCCGGTCCG TAAGCGAACTGATGAGTCTGAGGCCTGAGGCCGTCCATGTGAAAAAAGCCGGAGCCGTAGATGACGTTCCTCCTTCCGAG GTTCTGCCCGGCTCCCTGATTGAAGTGCGCCCCGGCGAACGCGTTCCGTTGGACGGTGTGGTAACGGGAGGCTGCTCCGT GCTGGATACCTCCGCCATGACCGGGGAATCCCTGCCGGTGGAAGCCGGATCCGGAAGCTCCGTGCTGGCGGGGTACATCA ACGGGCAGGGTGTGCTGGAAGTGTGTACGGAGCGGGACTGGCGGCATTCCGCCCTGGCGCGGGTCCAGGAACTGGTGGAA GCCGCATCAGGCCGCAAATCCCCTCTGGAGGGGAGGCTGTCCTCATTTTCCCGCATTTATACGCCGCTGGTGATTTCCAT AGCCGCTCTGGTATTTTTGCTTTATCCCCTTGTGACGGGCGGAAGCTGGGCGGACGGTCTGTTCCGCGCCCTGGTCCTGC TGGTGATTTCCTGCCCCTGCGCGCTGGTGCTGTCCATCCCGCTGGGCTTTTTTGCCGGAATAGGGAGAGCGGCGCGGCAG GGGATTTTGCTGAAAGGGAGCAACTATCTGGATGCCCTGCGGAAGGTGAAGACGGTGGTGTTTGACAAAACCGGAACCTT GACGGAAGGCGTTTTTTCCGTGGATGAAGTGCTTCCCCGTGACGGCGTTTCCCCGGAGGAACTGCTGTACTGGGCGGCCC ATGCGGAACTCTCCGCCTCCCATCCGCTGGGGCGTTCCATTGTGAAGGCATATGAAGGGACTCTGTTTCCGGACCGCGTG GCGGAACTGGTGGAGGTGACGGGCGGCGGCGTTTCAGCCCGCGTGGAAGGGAGACCGGTTCTGGTGGGGAAAAAGTCTTT TCTTCAAGAGGCCGGCGTAAGGACGGAGGAGGGAGAAGACCGTGGCGTGACCGTTTATGCGGCGTTGGACGGCATACTTC TGGGATGCCTCCGCCTGTCTGACCGCGTCAAGCCGGGAGCGGAGCGTGCGGTGCGGAAATTGAGGGAACTGGGCGTTTCC AACCTGGTCATGCTGACGGGGGATTCTTCTTCCGCCGGAACGGAAGTGGGGCTTAAGCTGGGGATGGACGGGGTATTCTG CGGGCTGATGCCTGCCGGCAAGCTGGAGCATGTGCGCCGGCTGAAACCTGAAACGGGGCTGCTTGCCTTTGTGGGGGACG GTATGAATGACGCCCCTTCCCTCGCTGCTGCCGACATCGGAATTGCCATGGGCGGCGTAGGGTCCGATACGGCTCTTCAG GCGGCTGACGTAGTGGTGATGAAGGGAGATCCTTTGGCTGTTCCGCTGGGGATGATGCTTTCCCAAGCCACAGAGCGCAT CATTGTGCAGAACATCGTTCTTATTTTGGGCGTCAAAATTCTGGTCATGGTGCTGGGTATTCTGGGGCTGGCTGGGATGT GGGCCGCCGTGATGGCGGATGTGGGCGTCTGCCTGCTTGCGGTGGGCAACTCCATGCGTATTTTCCGGGTGAAGCTGGAC ATGTGA
Upstream 100 bases:
>100_bases GAACGGTTTAAGAACCAGAAATCAACGCAGACTTTTTGTTAGTTTGGGCTAATATAGGGCTTGCCATGCCGGAGAGGCAG GCGTACAAGCGGAACAGGTC
Downstream 100 bases:
>100_bases CGAAAGGGAACTCTCTTCCTCCCCCTGTTTATGGGAGGATGCCCCCATCCCGATATCCGGATGCTGCCGCGGAATCTTGG AACAGCGGAAGATATCCTGA
Product: heavy metal translocating P-type ATPase
Products: NA
Alternate protein names: Zn(2+)-translocating P-type ATPase [H]
Number of amino acids: Translated: 641; Mature: 640
Protein sequence:
>641_residues MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLG MMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSE VLPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQ GILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRV AELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQ AADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLD M
Sequences:
>Translated_641_residues MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLG MMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSE VLPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQ GILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRV AELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQ AADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLD M >Mature_640_residues STEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLGM MRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEV LPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVEA ASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQG ILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVA ELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVSN LVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQA ADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM
Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]
COG id: COG2217
COG function: function code P; Cation transport ATPase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HMA domain [H]
Homologues:
Organism=Homo sapiens, GI55743071, Length=562, Percent_Identity=30.4270462633452, Blast_Score=232, Evalue=8e-61, Organism=Homo sapiens, GI115529486, Length=580, Percent_Identity=30, Blast_Score=228, Evalue=2e-59, Organism=Homo sapiens, GI55743073, Length=493, Percent_Identity=32.0486815415822, Blast_Score=211, Evalue=2e-54, Organism=Homo sapiens, GI237681111, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12, Organism=Homo sapiens, GI237681109, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12, Organism=Homo sapiens, GI21361181, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12, Organism=Homo sapiens, GI22748667, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=6e-12, Organism=Homo sapiens, GI4502271, Length=247, Percent_Identity=24.6963562753036, Blast_Score=70, Evalue=8e-12, Organism=Homo sapiens, GI48762689, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=5e-11, Organism=Homo sapiens, GI48762685, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=5e-11, Organism=Homo sapiens, GI48762691, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=6e-11, Organism=Homo sapiens, GI48762687, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=6e-11, Organism=Escherichia coli, GI1789879, Length=586, Percent_Identity=37.7133105802048, Blast_Score=312, Evalue=5e-86, Organism=Escherichia coli, GI1786691, Length=503, Percent_Identity=33.3996023856859, Blast_Score=234, Evalue=1e-62, Organism=Escherichia coli, GI1786914, Length=573, Percent_Identity=27.7486910994764, Blast_Score=135, Evalue=8e-33, Organism=Caenorhabditis elegans, GI17556548, Length=590, Percent_Identity=27.9661016949153, Blast_Score=180, Evalue=2e-45, Organism=Caenorhabditis elegans, GI71997262, Length=569, Percent_Identity=22.6713532513181, Blast_Score=74, Evalue=3e-13, Organism=Caenorhabditis elegans, GI32566766, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6320475, Length=494, Percent_Identity=29.1497975708502, Blast_Score=221, Evalue=2e-58, Organism=Saccharomyces cerevisiae, GI6319772, Length=517, Percent_Identity=27.2727272727273, Blast_Score=157, Evalue=4e-39, Organism=Saccharomyces cerevisiae, GI6321430, Length=615, Percent_Identity=26.1788617886179, Blast_Score=109, Evalue=2e-24, Organism=Saccharomyces cerevisiae, GI6325221, Length=632, Percent_Identity=26.5822784810127, Blast_Score=108, Evalue=3e-24, Organism=Saccharomyces cerevisiae, GI6321271, Length=150, Percent_Identity=28, Blast_Score=71, Evalue=5e-13, Organism=Drosophila melanogaster, GI221329854, Length=310, Percent_Identity=31.6129032258064, Blast_Score=122, Evalue=8e-28, Organism=Drosophila melanogaster, GI24668696, Length=295, Percent_Identity=23.3898305084746, Blast_Score=66, Evalue=9e-11, Organism=Drosophila melanogaster, GI281366617, Length=295, Percent_Identity=23.3898305084746, Blast_Score=66, Evalue=9e-11, Organism=Drosophila melanogaster, GI24668708, Length=295, Percent_Identity=23.3898305084746, Blast_Score=65, Evalue=1e-10,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008250 - InterPro: IPR001366 - InterPro: IPR006404 - InterPro: IPR006416 - InterPro: IPR001757 - InterPro: IPR018303 - InterPro: IPR005834 - InterPro: IPR023214 - InterPro: IPR017969 - InterPro: IPR006121 [H]
Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]
EC number: =3.6.3.5 [H]
Molecular weight: Translated: 66870; Mature: 66739
Theoretical pI: Translated: 5.28; Mature: 5.28
Prosite motif: PS00154 ATPASE_E1_E2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.0 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 5.5 %Cys+Met (Translated Protein) 2.0 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 5.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMA CCCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH AYVGSYLLIGWDVLKAAFLGMMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGE HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH YLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEVLPGSLIEVRPGERVPLDGV HHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCCCEEEECCCCCCCCCCE VTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHH AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPC HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH ALVLSIPLGFFAGIGRAARQGILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPR HHHHHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC DGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVAELVEVTGGGVSARVEGRPV CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCEE LVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS EECCHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPS CEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCC LAAADIGIAMGGVGSDTALQAADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKI HHHHHHHHEECCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC >Mature Secondary Structure STEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMA CCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH AYVGSYLLIGWDVLKAAFLGMMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGE HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH YLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEVLPGSLIEVRPGERVPLDGV HHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCCCEEEECCCCCCCCCCE VTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHH AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPC HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH ALVLSIPLGFFAGIGRAARQGILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPR HHHHHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC DGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVAELVEVTGGGVSARVEGRPV CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCEE LVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS EECCHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPS CEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCC LAAADIGIAMGGVGSDTALQAADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKI HHHHHHHHEECCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 8590279; 8905231; 9724772 [H]