Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is lipA [H]
Identifier: 187735587
GI number: 187735587
Start: 1303611
End: 1304549
Strand: Reverse
Name: lipA [H]
Synonym: Amuc_1092
Alternate gene names: 187735587
Gene position: 1304549-1303611 (Counterclockwise)
Preceding gene: 187735588
Following gene: 187735586
Centisome position: 48.97
GC content: 60.17
Gene sequence:
>939_bases ATGGAACGCCGGAACGACAATGAGACTGCGGAAGGAACGGAACGCAAACCGTCGTGGATCAAGGTTCGTCTGCCCAACGG CCGGGAATTCTGGGACGTCAAGCAGCTTGTGGAAGGCAAAAACCTCTTCACCGTCTGTGAAGAAGCACACTGCCCCAACC GTTATGAATGTTGGAACCAGGGTACGGCCACGTTCATGATTGCCGGAGAACGGTGCACGCGCGCCTGCGGATTCTGCGCC ACCCGCACGGCCAAGCCCGGCCCGCTGGATCCTGAAGAACCGCAGCACGTGGCGGAAGCCGTCGTGCACATGAAGCTGCG CCACGCCGTGATTACCATGGTCACCCGGGATGATTTGCCGGACGGCGCCGCCGCGCATTTCGCCCAGGTAATTAGGGCCG TCAGAAAAGCCAGCCCTTCCACGATCATTGAAGTGCTTGCCTCGGACTTGAATGAGAAGCCCTCCTCCATCCAGACGCTC ATGGCGGCCCGTCCGCATATTTTCGGACACAATCTGGAGACGGTGGAACGCCTCACGCCCATTGTCCGCTTCCGCGCCCA GTACCGGCGGTCCCTGCGCGTTCTCCGGATGGCTCTGGAGTGCGTGGACGGCAAAGTGTCTACAAAGAGCGGCATCATGC TGGGCCTGGGGGAAACGGAAGAAGAGCTTTTCCGCTCCATGGACGATTTGCTGGAGCACGGCGTCACGGTCCTGACGTTG GGGCAATACCTGCGCCCCTCCCGCAACCATCTTCCGGTGGTCAAATACGTCCATCCGGATGATTTCGCCCGGTATGAGGA AGTTGCGCGCTCCAAAGGCTTCAGGCACGTGGCATCCGGGCCGTTGGTCCGCAGCTCCTACCATGCCGCCAATTTCACCC CGGAAGCGGATGTTCTGGAAGCCATTAACGAAGACCTGAGAAAGGCCGGCGAACTTTAG
Upstream 100 bases:
>100_bases CGCGTCTTTCTTCCCCTCCGGATGAAAACGGGGAATGAAGTCCGGAATAAAACACTTTGCATTTGCCAAAGCAGCAGAGT CACGGCAAGCTAGCGGGACT
Downstream 100 bases:
>100_bases AATAAATCTTGATTTTTTATCCTTCCCCTTTTACCATCCGGGCAATTCCACGTCATTGAGAATCTCATGAGCAAAACATG TTCCTTCATCAAGGCAGGAG
Product: lipoyl synthase
Products: NA
Alternate protein names: Lip-syn; LS; Lipoate synthase; Lipoic acid synthase; Sulfur insertion protein lipA [H]
Number of amino acids: Translated: 312; Mature: 312
Protein sequence:
>312_residues MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL
Sequences:
>Translated_312_residues MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL >Mature_312_residues MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL
Specific function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives [H]
COG id: COG0320
COG function: function code H; Lipoate synthase
Gene ontology:
Cell location: Cytoplasm (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the radical SAM superfamily. Lipoyl synthase family [H]
Homologues:
Organism=Homo sapiens, GI37577166, Length=299, Percent_Identity=41.8060200668896, Blast_Score=240, Evalue=1e-63, Organism=Homo sapiens, GI37577164, Length=246, Percent_Identity=41.869918699187, Blast_Score=199, Evalue=2e-51, Organism=Escherichia coli, GI1786846, Length=281, Percent_Identity=48.3985765124555, Blast_Score=257, Evalue=7e-70, Organism=Caenorhabditis elegans, GI32564533, Length=256, Percent_Identity=45.703125, Blast_Score=232, Evalue=2e-61, Organism=Saccharomyces cerevisiae, GI6324770, Length=290, Percent_Identity=43.1034482758621, Blast_Score=243, Evalue=4e-65, Organism=Drosophila melanogaster, GI221513272, Length=285, Percent_Identity=44.5614035087719, Blast_Score=249, Evalue=2e-66,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013785 - InterPro: IPR006638 - InterPro: IPR003698 - InterPro: IPR007197 [H]
Pfam domain/function: PF04055 Radical_SAM [H]
EC number: =2.8.1.8 [H]
Molecular weight: Translated: 35140; Mature: 35140
Theoretical pI: Translated: 7.34; Mature: 7.34
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.2 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 2.2 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 4.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQ CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCC GTATFMIAGERCTRACGFCATRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLP CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC DGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTLMAARPHIFGHNLETVERLTP CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH IVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEH GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLE HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCCEECCCCCCCCCCHHHHHH AINEDLRKAGEL HHHHHHHHHCCC >Mature Secondary Structure MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQ CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCC GTATFMIAGERCTRACGFCATRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLP CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC DGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTLMAARPHIFGHNLETVERLTP CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH IVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEH GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLE HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCCEECCCCCCCCCCHHHHHH AINEDLRKAGEL HHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA