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The map label for this gene is betC [H]

Identifier: 187735528

GI number: 187735528

Start: 1226293

End: 1228038

Strand: Reverse

Name: betC [H]

Synonym: Amuc_1033

Alternate gene names: 187735528

Gene position: 1228038-1226293 (Counterclockwise)

Preceding gene: 187735529

Following gene: 187735527

Centisome position: 46.1

GC content: 55.96

Gene sequence:

>1746_bases
ATGAACCGTCATGCCGCCACCGCCCTGATGCTTGCGGCCTGTTCCCTGTCCGCTTCCGCGGACCAGCCTCAAAAGCAGAC
GCCGGACCAGCGCCCCAACATCGTGGTCATTGTCACCGACGACCATTCCTACCAGACCCTGGGCACCTGTGAAAAGGATT
CTCCCATGCCTTATCCGAACTTCCGCAAACTGGCGGACGAAGGCATGGTCTTTGACCGGAGCTACTGCGCCAACTCCCTG
TGCGGACCTTCGCGGGCCTGTATTTACACTGGCCGCCATTCCCACATGAACGGGTACCTCTTCAACGAACATGCGGCTCC
CTTTGACGGTTCCCAGCCCACTTTCCCGAAAATGCTCCAAAAGGCCGGTTACCAGACGGCTATTGTCGGCAAGTGGCACC
TGGAAGCCATTCCGCCGGGCGCCAAGGGAGATACGTCCAAATATGAATCCGACCCCACCGGATTCGATTACTGGGAAATT
TTCCCCGGCCAGGGCAACTATTTCAATCCGGATTTCATCACTCCCGGCAAGGACGGCAAACGCGTGGTGAAAACGGAGCC
CGGCTATGCCACGGAACTGGTTACGCAAAAAAGCCTCAAATGGCTGGACCAGAGGGACAAGAACAAACCCTTCATGCTCG
TCGTGGGCCACAAGGCACCCCACCGTTGCTGGTGCCCCTCCATTCAGAATCTGGGCCGCGCCAAACAGTATGCGGACGCC
ATTGACCCGCCCGCCAATCTGGAAGACGATTTTGCAGACCGCCCGGAATTCCTGAAAATGACGGAACAAACCCTGCTCAA
CCATTTCAACGTATGGTCTGACGAACACCTGATCAAGGAGGTGGTCCCCGAAGACATCCAGAAAATGCTTTCCTGCCCGG
AATCCAAGACCCTGCATACTCAGTATGACTGGGAAATGCCGGAATGGGTGCGCATGGACCCGCAGCAGAAGGAAGCCTGG
TACAACTACCACAAGGCCCGTACCGTACAGCTTGTCAAAGATATTAAAAACGGGAAAATCAAAACGCAGCGCGACATTTT
GCTGCGCCGCTGGCGCCATTATATGGAAGACTATCTGGGCACCGTTCTTTCCGTGGACGAAAGCATCGGCCAGATCATGG
ACTATCTGAAACAAAACGGTCTGGACAGGAATACGCTGGTGCTCTACTGCGGAGACCAGGGATTCTACATGGGCGAACAC
GGCCTGTACGACAAACGCTGGATTTTCGAAGAATCCTTCCGCATGCCCCTCATCATGAGATGGCCGGGCCACATCAGGCC
GGGCGTGCGCTCCTCCGCCATGGTGCAGGAACTGGATTATGCTCCCACTTTCTGCGACGTGGCCGGGGTAAATACCAAGG
AAAATATGAATACCTTCCAGGGCCGCAGCCTCACTCCCCTGTTCAAGACCGGAGAACATCAGGATTTCAAAAACCGTTCT
CTTTACTACGCCTTTTACGAAAATCCGGGTGAACACAACGCTCCGCGCCATGATGGCCTGCGCACGGACCGCTACACGCT
GTCCTATATCTGGACCAGCGACGAATGGATGCTCTTTGACAACCAGAAGGACCCGGCCCAAATGCACAACGTCATCAACA
AACCGGAATATGCGGAAACCGTGAAAGAACTCAAAGCCCTGTACGGCAAGCTCCGCAAAGACTACCAGGTACCGGAAGGC
TTCCCCGGGGCCACCGGCAAACTGGCCGTCAAGCCGCAGTGGGACTGCGCTCCCTCCAGAGATTGA

Upstream 100 bases:

>100_bases
CGGGGATGTGGTCTTTTCCGGACCGGCAGGAATGCCCTTGCGGACAAATTCTGCCGCATCCCCCTCCAACCATTCGCCTG
TTTAATTCATGATTTCAACA

Downstream 100 bases:

>100_bases
CGCCGCCATTCACCGTTCCTCCCGAAACACGGTTGTCCGGAACACGCCATTGACGACGGAGGAACAGGGTTTAAATCCTC
ACACAAACAACCATTACCAT

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MNRHAATALMLAACSLSASADQPQKQTPDQRPNIVVIVTDDHSYQTLGTCEKDSPMPYPNFRKLADEGMVFDRSYCANSL
CGPSRACIYTGRHSHMNGYLFNEHAAPFDGSQPTFPKMLQKAGYQTAIVGKWHLEAIPPGAKGDTSKYESDPTGFDYWEI
FPGQGNYFNPDFITPGKDGKRVVKTEPGYATELVTQKSLKWLDQRDKNKPFMLVVGHKAPHRCWCPSIQNLGRAKQYADA
IDPPANLEDDFADRPEFLKMTEQTLLNHFNVWSDEHLIKEVVPEDIQKMLSCPESKTLHTQYDWEMPEWVRMDPQQKEAW
YNYHKARTVQLVKDIKNGKIKTQRDILLRRWRHYMEDYLGTVLSVDESIGQIMDYLKQNGLDRNTLVLYCGDQGFYMGEH
GLYDKRWIFEESFRMPLIMRWPGHIRPGVRSSAMVQELDYAPTFCDVAGVNTKENMNTFQGRSLTPLFKTGEHQDFKNRS
LYYAFYENPGEHNAPRHDGLRTDRYTLSYIWTSDEWMLFDNQKDPAQMHNVINKPEYAETVKELKALYGKLRKDYQVPEG
FPGATGKLAVKPQWDCAPSRD

Sequences:

>Translated_581_residues
MNRHAATALMLAACSLSASADQPQKQTPDQRPNIVVIVTDDHSYQTLGTCEKDSPMPYPNFRKLADEGMVFDRSYCANSL
CGPSRACIYTGRHSHMNGYLFNEHAAPFDGSQPTFPKMLQKAGYQTAIVGKWHLEAIPPGAKGDTSKYESDPTGFDYWEI
FPGQGNYFNPDFITPGKDGKRVVKTEPGYATELVTQKSLKWLDQRDKNKPFMLVVGHKAPHRCWCPSIQNLGRAKQYADA
IDPPANLEDDFADRPEFLKMTEQTLLNHFNVWSDEHLIKEVVPEDIQKMLSCPESKTLHTQYDWEMPEWVRMDPQQKEAW
YNYHKARTVQLVKDIKNGKIKTQRDILLRRWRHYMEDYLGTVLSVDESIGQIMDYLKQNGLDRNTLVLYCGDQGFYMGEH
GLYDKRWIFEESFRMPLIMRWPGHIRPGVRSSAMVQELDYAPTFCDVAGVNTKENMNTFQGRSLTPLFKTGEHQDFKNRS
LYYAFYENPGEHNAPRHDGLRTDRYTLSYIWTSDEWMLFDNQKDPAQMHNVINKPEYAETVKELKALYGKLRKDYQVPEG
FPGATGKLAVKPQWDCAPSRD
>Mature_581_residues
MNRHAATALMLAACSLSASADQPQKQTPDQRPNIVVIVTDDHSYQTLGTCEKDSPMPYPNFRKLADEGMVFDRSYCANSL
CGPSRACIYTGRHSHMNGYLFNEHAAPFDGSQPTFPKMLQKAGYQTAIVGKWHLEAIPPGAKGDTSKYESDPTGFDYWEI
FPGQGNYFNPDFITPGKDGKRVVKTEPGYATELVTQKSLKWLDQRDKNKPFMLVVGHKAPHRCWCPSIQNLGRAKQYADA
IDPPANLEDDFADRPEFLKMTEQTLLNHFNVWSDEHLIKEVVPEDIQKMLSCPESKTLHTQYDWEMPEWVRMDPQQKEAW
YNYHKARTVQLVKDIKNGKIKTQRDILLRRWRHYMEDYLGTVLSVDESIGQIMDYLKQNGLDRNTLVLYCGDQGFYMGEH
GLYDKRWIFEESFRMPLIMRWPGHIRPGVRSSAMVQELDYAPTFCDVAGVNTKENMNTFQGRSLTPLFKTGEHQDFKNRS
LYYAFYENPGEHNAPRHDGLRTDRYTLSYIWTSDEWMLFDNQKDPAQMHNVINKPEYAETVKELKALYGKLRKDYQVPEG
FPGATGKLAVKPQWDCAPSRD

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=263, Percent_Identity=30.7984790874525, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4504061, Length=210, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI45430057, Length=143, Percent_Identity=37.0629370629371, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI71852586, Length=141, Percent_Identity=34.7517730496454, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71852584, Length=141, Percent_Identity=34.7517730496454, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI58743319, Length=119, Percent_Identity=36.9747899159664, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI53831991, Length=161, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI157266309, Length=136, Percent_Identity=31.6176470588235, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI31742482, Length=164, Percent_Identity=30.4878048780488, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI39930577, Length=265, Percent_Identity=27.1698113207547, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI109389362, Length=213, Percent_Identity=26.7605633802817, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI59797060, Length=206, Percent_Identity=30.0970873786408, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87081924, Length=258, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790112, Length=247, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790233, Length=291, Percent_Identity=25.085910652921, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533416, Length=223, Percent_Identity=31.390134529148, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17568795, Length=203, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17559078, Length=116, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533418, Length=197, Percent_Identity=31.4720812182741, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666109, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24666175, Length=203, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363223, Length=220, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24647401, Length=115, Percent_Identity=36.5217391304348, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281366397, Length=235, Percent_Identity=24.2553191489362, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281366395, Length=235, Percent_Identity=24.2553191489362, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666163, Length=235, Percent_Identity=24.2553191489362, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 66999; Mature: 66999

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRHAATALMLAACSLSASADQPQKQTPDQRPNIVVIVTDDHSYQTLGTCEKDSPMPYPN
CCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
FRKLADEGMVFDRSYCANSLCGPSRACIYTGRHSHMNGYLFNEHAAPFDGSQPTFPKMLQ
HHHHHHCCCEEEHHHHHHCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHH
KAGYQTAIVGKWHLEAIPPGAKGDTSKYESDPTGFDYWEIFPGQGNYFNPDFITPGKDGK
HCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
RVVKTEPGYATELVTQKSLKWLDQRDKNKPFMLVVGHKAPHRCWCPSIQNLGRAKQYADA
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IDPPANLEDDFADRPEFLKMTEQTLLNHFNVWSDEHLIKEVVPEDIQKMLSCPESKTLHT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
QYDWEMPEWVRMDPQQKEAWYNYHKARTVQLVKDIKNGKIKTQRDILLRRWRHYMEDYLG
EECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TVLSVDESIGQIMDYLKQNGLDRNTLVLYCGDQGFYMGEHGLYDKRWIFEESFRMPLIMR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
WPGHIRPGVRSSAMVQELDYAPTFCDVAGVNTKENMNTFQGRSLTPLFKTGEHQDFKNRS
CCCCCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHCCCCCCCCCCCHHHHCCCCCCCCCCC
LYYAFYENPGEHNAPRHDGLRTDRYTLSYIWTSDEWMLFDNQKDPAQMHNVINKPEYAET
EEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHCCCHHHHH
VKELKALYGKLRKDYQVPEGFPGATGKLAVKPQWDCAPSRD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MNRHAATALMLAACSLSASADQPQKQTPDQRPNIVVIVTDDHSYQTLGTCEKDSPMPYPN
CCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
FRKLADEGMVFDRSYCANSLCGPSRACIYTGRHSHMNGYLFNEHAAPFDGSQPTFPKMLQ
HHHHHHCCCEEEHHHHHHCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHH
KAGYQTAIVGKWHLEAIPPGAKGDTSKYESDPTGFDYWEIFPGQGNYFNPDFITPGKDGK
HCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
RVVKTEPGYATELVTQKSLKWLDQRDKNKPFMLVVGHKAPHRCWCPSIQNLGRAKQYADA
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IDPPANLEDDFADRPEFLKMTEQTLLNHFNVWSDEHLIKEVVPEDIQKMLSCPESKTLHT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
QYDWEMPEWVRMDPQQKEAWYNYHKARTVQLVKDIKNGKIKTQRDILLRRWRHYMEDYLG
EECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TVLSVDESIGQIMDYLKQNGLDRNTLVLYCGDQGFYMGEHGLYDKRWIFEESFRMPLIMR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
WPGHIRPGVRSSAMVQELDYAPTFCDVAGVNTKENMNTFQGRSLTPLFKTGEHQDFKNRS
CCCCCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHCCCCCCCCCCCHHHHCCCCCCCCCCC
LYYAFYENPGEHNAPRHDGLRTDRYTLSYIWTSDEWMLFDNQKDPAQMHNVINKPEYAET
EEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHCCCHHHHH
VKELKALYGKLRKDYQVPEGFPGATGKLAVKPQWDCAPSRD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]