BacMap

Definition	Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession	NC_010655
Length	2,664,102

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The map label for this gene is ppiB [H]

Identifier: 187735521

GI number: 187735521

Start: 1218179

End: 1218682

Strand: Direct

Name: ppiB [H]

Synonym: Amuc_1026

Alternate gene names: 187735521

Gene position: 1218179-1218682 (Clockwise)

Preceding gene: 187735510

Following gene: 187735522

Centisome position: 45.73

GC content: 56.75

Gene sequence:

>504_bases
ATGGCAACTGACAAAAATATCACCATCCATACTTCCAAGGGCGACATCAAGCTGACGGTGTTTGCTTCCAAGACGCCCGT
GACGGCGGCTTCCTTTCTGAATCTGGCGTCCAGGGGATTTTATGACGGGCTCAAATTTCACCGTGTGATCCCGGATTTCA
TGATTCAGGGCGGCGATCCCACCGGCACGGGCATGGGGGGGCCCGGCTACAGGTTTGAAGACGAGTGCCGCCCGGACCTC
AGGCATGACGGCCCCGGCGTGCTTTCCATGGCAAACGCGGGCCCCGGCACCAACGGTTCCCAATTCTTCATCACCCATGT
GCCCACCGACTGGCTGAATGGCAAACACACCGTCTTCGGCAAGGTGACGGAAGGTCAGAGCGTGGTGGATTCCATTAAGC
AGGGAGATACCATCTCCGGCATTACGATTGAAGATAATGCGGACGATCTGTTTACGGAACAGGCCGACCGCATTGCCGCG
TGGAACAAGGCACTTGGTAAGTAA

Upstream 100 bases:

>100_bases
GAAAGAGGCGGAAGAGTGGCTGGAGGGAAATGACGGAGGGGCCCGGGGACTGCACGCAATAAGCCTTTACCATGCCTTTC
CGCGCGTTTAACATATACCT

Downstream 100 bases:

>100_bases
CCTCATTCCGGCATTCACTCGGCGGAGCGCGGCGCGGGGACGCCCGTTCCGCTGTTTTCCTCTCTCTGCTTTTTCAGTAC
ATGGTTCTGTCTGTTCAAAA

Product: Peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MATDKNITIHTSKGDIKLTVFASKTPVTAASFLNLASRGFYDGLKFHRVIPDFMIQGGDPTGTGMGGPGYRFEDECRPDL
RHDGPGVLSMANAGPGTNGSQFFITHVPTDWLNGKHTVFGKVTEGQSVVDSIKQGDTISGITIEDNADDLFTEQADRIAA
WNKALGK

Sequences:

>Translated_167_residues
MATDKNITIHTSKGDIKLTVFASKTPVTAASFLNLASRGFYDGLKFHRVIPDFMIQGGDPTGTGMGGPGYRFEDECRPDL
RHDGPGVLSMANAGPGTNGSQFFITHVPTDWLNGKHTVFGKVTEGQSVVDSIKQGDTISGITIEDNADDLFTEQADRIAA
WNKALGK
>Mature_166_residues
ATDKNITIHTSKGDIKLTVFASKTPVTAASFLNLASRGFYDGLKFHRVIPDFMIQGGDPTGTGMGGPGYRFEDECRPDLR
HDGPGVLSMANAGPGTNGSQFFITHVPTDWLNGKHTVFGKVTEGQSVVDSIKQGDTISGITIEDNADDLFTEQADRIAAW
NKALGK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=137, Percent_Identity=54.7445255474453, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI24308049, Length=127, Percent_Identity=59.0551181102362, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI19557636, Length=131, Percent_Identity=51.1450381679389, Blast_Score=133, Evalue=6e-32,
Organism=Homo sapiens, GI10863927, Length=144, Percent_Identity=51.3888888888889, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI5031987, Length=144, Percent_Identity=52.7777777777778, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI64276486, Length=147, Percent_Identity=42.1768707482993, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI310129267, Length=144, Percent_Identity=48.6111111111111, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI310120620, Length=144, Percent_Identity=48.6111111111111, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI4758950, Length=133, Percent_Identity=54.1353383458647, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI45439316, Length=136, Percent_Identity=50, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI303305009, Length=127, Percent_Identity=51.1811023622047, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI5174637, Length=127, Percent_Identity=51.1811023622047, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI256017253, Length=144, Percent_Identity=47.9166666666667, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI221139811, Length=144, Percent_Identity=47.9166666666667, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI256017251, Length=144, Percent_Identity=47.9166666666667, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=50, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI178057341, Length=144, Percent_Identity=47.9166666666667, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI310127646, Length=145, Percent_Identity=46.8965517241379, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI310114371, Length=145, Percent_Identity=46.8965517241379, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI310119221, Length=145, Percent_Identity=46.8965517241379, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4505991, Length=127, Percent_Identity=53.5433070866142, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI169163387, Length=169, Percent_Identity=43.1952662721894, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI169164185, Length=169, Percent_Identity=43.1952662721894, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI169163623, Length=169, Percent_Identity=43.1952662721894, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI22547212, Length=134, Percent_Identity=47.7611940298507, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI7657473, Length=134, Percent_Identity=47.7611940298507, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI22547215, Length=134, Percent_Identity=47.7611940298507, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI209417936, Length=144, Percent_Identity=47.2222222222222, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI30102944, Length=144, Percent_Identity=47.2222222222222, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI219842199, Length=144, Percent_Identity=47.2222222222222, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI5454154, Length=137, Percent_Identity=48.1751824817518, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI310132444, Length=153, Percent_Identity=45.0980392156863, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI310113152, Length=153, Percent_Identity=45.0980392156863, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI169214050, Length=145, Percent_Identity=46.8965517241379, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI239751853, Length=145, Percent_Identity=46.8965517241379, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI113428306, Length=145, Percent_Identity=46.8965517241379, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI310127745, Length=143, Percent_Identity=47.5524475524476, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310119290, Length=143, Percent_Identity=47.5524475524476, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310114540, Length=143, Percent_Identity=47.5524475524476, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI4826932, Length=130, Percent_Identity=48.4615384615385, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=37.410071942446, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI150418007, Length=144, Percent_Identity=43.75, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI42560244, Length=101, Percent_Identity=51.4851485148515, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI6631100, Length=139, Percent_Identity=43.8848920863309, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI14277126, Length=136, Percent_Identity=39.7058823529412, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI27735045, Length=145, Percent_Identity=33.1034482758621, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=37.6811594202899, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI1789763, Length=141, Percent_Identity=36.8794326241135, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=138, Percent_Identity=56.5217391304348, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17539496, Length=134, Percent_Identity=52.2388059701493, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17532641, Length=140, Percent_Identity=45, Blast_Score=126, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=45.0381679389313, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=45.0381679389313, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=55.9055118110236, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559074, Length=148, Percent_Identity=46.6216216216216, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17565860, Length=154, Percent_Identity=47.4025974025974, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506307, Length=134, Percent_Identity=52.9850746268657, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17539498, Length=134, Percent_Identity=51.4925373134328, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17552782, Length=143, Percent_Identity=48.2517482517483, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17566266, Length=141, Percent_Identity=47.5177304964539, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71997782, Length=164, Percent_Identity=38.4146341463415, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17532643, Length=132, Percent_Identity=47.7272727272727, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17552784, Length=152, Percent_Identity=41.4473684210526, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=35.9712230215827, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551282, Length=101, Percent_Identity=54.4554455445545, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551284, Length=101, Percent_Identity=54.4554455445545, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115533296, Length=137, Percent_Identity=32.1167883211679, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=150, Percent_Identity=48.6666666666667, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320359, Length=136, Percent_Identity=50.7352941176471, Blast_Score=114, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320510, Length=135, Percent_Identity=50.3703703703704, Blast_Score=108, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321848, Length=131, Percent_Identity=48.8549618320611, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323246, Length=137, Percent_Identity=45.2554744525547, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322492, Length=159, Percent_Identity=34.5911949685535, Blast_Score=71, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17986117, Length=134, Percent_Identity=54.4776119402985, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI19922376, Length=152, Percent_Identity=42.1052631578947, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI19922912, Length=131, Percent_Identity=54.9618320610687, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI20130249, Length=131, Percent_Identity=51.9083969465649, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45549139, Length=136, Percent_Identity=50, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652460, Length=131, Percent_Identity=39.6946564885496, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664125, Length=144, Percent_Identity=47.2222222222222, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357783, Length=144, Percent_Identity=47.2222222222222, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17647301, Length=134, Percent_Identity=47.0149253731343, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357249, Length=139, Percent_Identity=39.568345323741, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136360, Length=174, Percent_Identity=39.0804597701149, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24586038, Length=135, Percent_Identity=43.7037037037037, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650807, Length=135, Percent_Identity=43.7037037037037, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355677, Length=135, Percent_Identity=37.037037037037, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24661775, Length=117, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355237, Length=117, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24661771, Length=117, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17917; Mature: 17786

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDKNITIHTSKGDIKLTVFASKTPVTAASFLNLASRGFYDGLKFHRVIPDFMIQGGDP
CCCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHCHHHEEECCCC
TGTGMGGPGYRFEDECRPDLRHDGPGVLSMANAGPGTNGSQFFITHVPTDWLNGKHTVFG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHCCCCEEEEE
KVTEGQSVVDSIKQGDTISGITIEDNADDLFTEQADRIAAWNKALGK
EECCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATDKNITIHTSKGDIKLTVFASKTPVTAASFLNLASRGFYDGLKFHRVIPDFMIQGGDP
CCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHCHHHEEECCCC
TGTGMGGPGYRFEDECRPDLRHDGPGVLSMANAGPGTNGSQFFITHVPTDWLNGKHTVFG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHCCCCEEEEE
KVTEGQSVVDSIKQGDTISGITIEDNADDLFTEQADRIAAWNKALGK
EECCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]