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The map label for this gene is degP [H]

Identifier: 187735312

GI number: 187735312

Start: 952283

End: 953746

Strand: Reverse

Name: degP [H]

Synonym: Amuc_0810

Alternate gene names: 187735312

Gene position: 953746-952283 (Counterclockwise)

Preceding gene: 187735315

Following gene: 187735311

Centisome position: 35.8

GC content: 52.53

Gene sequence:

>1464_bases
ATGATGACGGTTATGATGACCGTGGTCTCCGTTGCCTATTGGAGATGGAACAGTCGTGTTACGGAGAAGAATGTTTCCTT
CCGGTCGGAAGTGTTTACCCTGGCCCAGCAGCCCGAATTGAAGGAGGAGGATATTCCTGTTTTGCACCAGCTCAATGAGG
AATATTCACGCGTTGCCCGGCTGGTGGAACGGGTATTGGTCAGCATAGACACTACAGGCGTGACAAGCGTTCCTCAGCCT
TCCGAGGATGGTGATTTCATGGTTGAAAAGAGGCTGACGGTTCATGGTTTGGGTTCCGGCGTCATTGTTACTGAAGAAGG
GCATATTATTACCGCCTACCATGTCATTCAGAACAAGCATGCGCTGCGCGTTACGCTGAGCAATGGGAAAAGCGTTTCCG
TACGCCTGGTAGGGGTGGATCCGGAATTGGATATCGCCGTGCTGCAGGTAGAAAACCCGATGACGTTTACCCCCCTTCCG
TTCGGCAACAGTGATGAAATTGCGCCCGGCATGATTGTTCTGGCATGCGGCAATCCCTATGGGCTGGGCACGACTGTTTC
CCGCGGCATTATCAGTGCCCGTGAACGCAAGCTGGTGGATTCCGGCATTAACTTGATCCAGACGGATGCCAGTATCTTCC
CGGGGAATTCGGGAGGCCCCCTCATCAACATCCGCGGGGAAATCATCGGCATCAATAAATCGGTGCTTCCCAATGCGGAG
AAAAATTACGCCGGCATTGGGTTTGCCATTCCCTCCAATCTGGTGATGCACAGCTTTGAGCAGATTTGCAAACATGGCCG
CCCCATGAAAGGGTATCTGGGATTGGACATTGTGCGCAATACTCCCCCGCTTCGCAGCTTCCTGGATTATCATGAGGCGG
GAGGCGCAGTAATCAACATCGTGAAGCATGGTTCCCCGGCGGAGCAGGCAGGCCTTCAAACAGGTGACGTAATACTGAGT
TTCAACGAAGTCCCCATCCAGACGGATGAGGAAGTGAAGGAACGCATTGAAAATCTTTCCATCGGCGACAAGTTCCGGCT
GAAAGTCTGGCGCAAAGGGCAAAAAATGAACGTCACCCTGAAGGTGGGAGATAGTATTTTAAAAAATGTTCCTTCTCCTT
GGGAAGACTTCATGGAAGGAGTGGGAATGCATTTGCGTGAACTGACTGCGGAAGAACAATCCATAGGTGCTCGGGGGTTG
CTGGTCATTCAAGTGAATCCGAAGAAATCCGTGGGGCAGATATTGCAGGCCGGCGACATGGTCTTTGCCGTAAACCACCA
GAGTGTCAGCACCAAGGAAGCCTTGGTCAAAGCTCTTAGGGAAGGGCCGGCATTGCTGACCGTTTCCCGCGATGGGCAGC
AATTCAATGTGAAAGTGGATGCGCGCCCCGTTTCTGAAAAAACATTGCTTCCCCGCATTCCGGAGGCGACAAAAGGCAAC
GCCATCATACCGCACGAGCTTTGA

Upstream 100 bases:

>100_bases
CAGGCATCTCCTTGTGATCAAGCCGCAAACCGTTTGATCGTTATTACGGCAGGGCATTTCCATGAGATCGACCATATGGA
CACGGGCTTTACTTGTCATC

Downstream 100 bases:

>100_bases
TCCGGCCTGAGCGGTTCCTGCCGGAACCCCCGTTAGGAAAAACGTTTTCCGGCATCGCCGTCCGCAGGCTTGACTGGCAG
TTAAAAGTGCTTACAATGCA

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MMTVMMTVVSVAYWRWNSRVTEKNVSFRSEVFTLAQQPELKEEDIPVLHQLNEEYSRVARLVERVLVSIDTTGVTSVPQP
SEDGDFMVEKRLTVHGLGSGVIVTEEGHIITAYHVIQNKHALRVTLSNGKSVSVRLVGVDPELDIAVLQVENPMTFTPLP
FGNSDEIAPGMIVLACGNPYGLGTTVSRGIISARERKLVDSGINLIQTDASIFPGNSGGPLINIRGEIIGINKSVLPNAE
KNYAGIGFAIPSNLVMHSFEQICKHGRPMKGYLGLDIVRNTPPLRSFLDYHEAGGAVINIVKHGSPAEQAGLQTGDVILS
FNEVPIQTDEEVKERIENLSIGDKFRLKVWRKGQKMNVTLKVGDSILKNVPSPWEDFMEGVGMHLRELTAEEQSIGARGL
LVIQVNPKKSVGQILQAGDMVFAVNHQSVSTKEALVKALREGPALLTVSRDGQQFNVKVDARPVSEKTLLPRIPEATKGN
AIIPHEL

Sequences:

>Translated_487_residues
MMTVMMTVVSVAYWRWNSRVTEKNVSFRSEVFTLAQQPELKEEDIPVLHQLNEEYSRVARLVERVLVSIDTTGVTSVPQP
SEDGDFMVEKRLTVHGLGSGVIVTEEGHIITAYHVIQNKHALRVTLSNGKSVSVRLVGVDPELDIAVLQVENPMTFTPLP
FGNSDEIAPGMIVLACGNPYGLGTTVSRGIISARERKLVDSGINLIQTDASIFPGNSGGPLINIRGEIIGINKSVLPNAE
KNYAGIGFAIPSNLVMHSFEQICKHGRPMKGYLGLDIVRNTPPLRSFLDYHEAGGAVINIVKHGSPAEQAGLQTGDVILS
FNEVPIQTDEEVKERIENLSIGDKFRLKVWRKGQKMNVTLKVGDSILKNVPSPWEDFMEGVGMHLRELTAEEQSIGARGL
LVIQVNPKKSVGQILQAGDMVFAVNHQSVSTKEALVKALREGPALLTVSRDGQQFNVKVDARPVSEKTLLPRIPEATKGN
AIIPHEL
>Mature_487_residues
MMTVMMTVVSVAYWRWNSRVTEKNVSFRSEVFTLAQQPELKEEDIPVLHQLNEEYSRVARLVERVLVSIDTTGVTSVPQP
SEDGDFMVEKRLTVHGLGSGVIVTEEGHIITAYHVIQNKHALRVTLSNGKSVSVRLVGVDPELDIAVLQVENPMTFTPLP
FGNSDEIAPGMIVLACGNPYGLGTTVSRGIISARERKLVDSGINLIQTDASIFPGNSGGPLINIRGEIIGINKSVLPNAE
KNYAGIGFAIPSNLVMHSFEQICKHGRPMKGYLGLDIVRNTPPLRSFLDYHEAGGAVINIVKHGSPAEQAGLQTGDVILS
FNEVPIQTDEEVKERIENLSIGDKFRLKVWRKGQKMNVTLKVGDSILKNVPSPWEDFMEGVGMHLRELTAEEQSIGARGL
LVIQVNPKKSVGQILQAGDMVFAVNHQSVSTKEALVKALREGPALLTVSRDGQQFNVKVDARPVSEKTLLPRIPEATKGN
AIIPHEL

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=328, Percent_Identity=31.7073170731707, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4506141, Length=262, Percent_Identity=35.8778625954198, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI7019477, Length=260, Percent_Identity=35.3846153846154, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI22129776, Length=260, Percent_Identity=35.3846153846154, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1786356, Length=358, Percent_Identity=35.4748603351955, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789629, Length=412, Percent_Identity=32.2815533980583, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=35.0877192982456, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=32.8671328671329, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53287; Mature: 53287

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTVMMTVVSVAYWRWNSRVTEKNVSFRSEVFTLAQQPELKEEDIPVLHQLNEEYSRVAR
CHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LVERVLVSIDTTGVTSVPQPSEDGDFMVEKRLTVHGLGSGVIVTEEGHIITAYHVIQNKH
HHHHHHHEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEECCCCEEEEEEEECCCC
ALRVTLSNGKSVSVRLVGVDPELDIAVLQVENPMTFTPLPFGNSDEIAPGMIVLACGNPY
EEEEEECCCCEEEEEEEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEEECCCCC
GLGTTVSRGIISARERKLVDSGINLIQTDASIFPGNSGGPLINIRGEIIGINKSVLPNAE
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCCCCCEEEECCEEEECCCCCCCCCC
KNYAGIGFAIPSNLVMHSFEQICKHGRPMKGYLGLDIVRNTPPLRSFLDYHEAGGAVINI
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEEE
VKHGSPAEQAGLQTGDVILSFNEVPIQTDEEVKERIENLSIGDKFRLKVWRKGQKMNVTL
EECCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCEEEEEE
KVGDSILKNVPSPWEDFMEGVGMHLRELTAEEQSIGARGLLVIQVNPKKSVGQILQAGDM
EECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCE
VFAVNHQSVSTKEALVKALREGPALLTVSRDGQQFNVKVDARPVSEKTLLPRIPEATKGN
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
AIIPHEL
EECCCCC
>Mature Secondary Structure
MMTVMMTVVSVAYWRWNSRVTEKNVSFRSEVFTLAQQPELKEEDIPVLHQLNEEYSRVAR
CHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LVERVLVSIDTTGVTSVPQPSEDGDFMVEKRLTVHGLGSGVIVTEEGHIITAYHVIQNKH
HHHHHHHEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEECCCCEEEEEEEECCCC
ALRVTLSNGKSVSVRLVGVDPELDIAVLQVENPMTFTPLPFGNSDEIAPGMIVLACGNPY
EEEEEECCCCEEEEEEEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEEECCCCC
GLGTTVSRGIISARERKLVDSGINLIQTDASIFPGNSGGPLINIRGEIIGINKSVLPNAE
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCCCCCEEEECCEEEECCCCCCCCCC
KNYAGIGFAIPSNLVMHSFEQICKHGRPMKGYLGLDIVRNTPPLRSFLDYHEAGGAVINI
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEEE
VKHGSPAEQAGLQTGDVILSFNEVPIQTDEEVKERIENLSIGDKFRLKVWRKGQKMNVTL
EECCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCEEEEEE
KVGDSILKNVPSPWEDFMEGVGMHLRELTAEEQSIGARGLLVIQVNPKKSVGQILQAGDM
EECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCE
VFAVNHQSVSTKEALVKALREGPALLTVSRDGQQFNVKVDARPVSEKTLLPRIPEATKGN
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
AIIPHEL
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]