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The map label for this gene is lysA [H]

Identifier: 187735226

GI number: 187735226

Start: 849108

End: 850397

Strand: Direct

Name: lysA [H]

Synonym: Amuc_0720

Alternate gene names: 187735226

Gene position: 849108-850397 (Clockwise)

Preceding gene: 187735225

Following gene: 187735227

Centisome position: 31.87

GC content: 54.88

Gene sequence:

>1290_bases
ATGCATTCATTCGCTTACAAAAACGGCACGCTCTACTGTGAAAACGTCAACCTTCAGGAACTGGCGGACAAGGAAAGCAC
ACCCCTGTACGTTTATAGCAAACAAACCATTTTAAACCACTTTCACCGCCTCAGGGAAGCTCTGGCACCGCTTAACGCGG
AAGTGGCCTACGCCGTCAAAGCCTGCTCCAACATCGCCATCCTGAACCTCATGGCCCGCAACGGGGCGGGATTCGACATC
GTCTCCGGCGGAGAACTCTTCCGTGTCCTCAAAGCCGGGGGAGATCCGTCCAAATGCACTTATGCCGGCGTAGGAAAAAC
CGAGCAGGAAATCCGTTATGCCCTGGCCCAGGGCATTTATTGCTTCAATGTGGAATCCGAAGCGGAACTGCGGGCCATTA
ACGCCATTGCCGCCTCCATGGGAGTCAAGGCTCCGGTGGCCGTGCGCGTCAATCCCAACGTAGAGGCGGGAACGCACAAA
TACATTACTACCGGCAAGGCTGAAAATAAATTCGGCGTGGACTTCGAACGCATTGAATCTCTTTATGAGATGGCGGCCCG
CGAACTTCCGAACCTTCATCTGAAAGGGTTGCAAATGCATATCGGCTCCCAGCTTACCCAGGCGAAACCCTTCCTAGAAG
CCGTCAGGAAAGTCGCCCCCCTGGCTGCTTCCCTGAAAGAAAAACACGGCATTGAATTTTTCTCCATCGGAGGAGGAATT
GGCATCGTTTACCAGGGCACGCTGGATTCCGGCGTTCAGGAATGGTGGAATGAGGACTGCGCCCAGCTCACGCTGAGCAC
TTACGCCCAGGCCGTCGTCCCCACCCTGCAACCTCTGGGATTACACATCATTGTGGAACCGGGCCGTCTTATCGTAGGAA
ATGCGGGAGCACTCATCACGCGTTGCCTGTATGAAAAAAACGGGAAAGCCAAAACCTTTAAAATTGTGGATGCAGGGATG
AACGACCTCATCCGCCCCGCCCTCTACCAGGGCTATCATGAAATTATCCCGGTCAGAGAACACCCCTCCGGATCCTGCGT
CACAGCGGATGTTGTGGGTCCCATTTGTGAATCCGGAGACTTCCTCGCCCAAAACAGGGACATGCCGGACGTGCGCCAGG
GAGAACTCCTGGCCGTACTGTCCGCCGGAGCCTATGGTTTTTCCATGTCTTCCAACTACAATTCACGGCCTATGGCGGAA
GAAGTCCTGGTGGACGGGGACCAATGGAACGTCATTCGCAGCCGCCAAAGCTGGGAAGACCTCATCCGGGGAGAATCCAT
TCCGGAATAA

Upstream 100 bases:

>100_bases
CTGGATCGCCCAGCTCATTGACAACCCTCCCACTCCCAGATTCCCTCTCCCCCCTCTCCATTCCGGGAAAACCAACGAAA
GCACAACCAAGGAATAATCC

Downstream 100 bases:

>100_bases
CACCCCCATCCCTCCCATCTTTAGAATGCCCTTCCAGCGGTAAAACGAAGGAGGGGCATTTCCTTTCAACCGTACTGAAT
GGAAAGCAAGGCGGAATTTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MHSFAYKNGTLYCENVNLQELADKESTPLYVYSKQTILNHFHRLREALAPLNAEVAYAVKACSNIAILNLMARNGAGFDI
VSGGELFRVLKAGGDPSKCTYAGVGKTEQEIRYALAQGIYCFNVESEAELRAINAIAASMGVKAPVAVRVNPNVEAGTHK
YITTGKAENKFGVDFERIESLYEMAARELPNLHLKGLQMHIGSQLTQAKPFLEAVRKVAPLAASLKEKHGIEFFSIGGGI
GIVYQGTLDSGVQEWWNEDCAQLTLSTYAQAVVPTLQPLGLHIIVEPGRLIVGNAGALITRCLYEKNGKAKTFKIVDAGM
NDLIRPALYQGYHEIIPVREHPSGSCVTADVVGPICESGDFLAQNRDMPDVRQGELLAVLSAGAYGFSMSSNYNSRPMAE
EVLVDGDQWNVIRSRQSWEDLIRGESIPE

Sequences:

>Translated_429_residues
MHSFAYKNGTLYCENVNLQELADKESTPLYVYSKQTILNHFHRLREALAPLNAEVAYAVKACSNIAILNLMARNGAGFDI
VSGGELFRVLKAGGDPSKCTYAGVGKTEQEIRYALAQGIYCFNVESEAELRAINAIAASMGVKAPVAVRVNPNVEAGTHK
YITTGKAENKFGVDFERIESLYEMAARELPNLHLKGLQMHIGSQLTQAKPFLEAVRKVAPLAASLKEKHGIEFFSIGGGI
GIVYQGTLDSGVQEWWNEDCAQLTLSTYAQAVVPTLQPLGLHIIVEPGRLIVGNAGALITRCLYEKNGKAKTFKIVDAGM
NDLIRPALYQGYHEIIPVREHPSGSCVTADVVGPICESGDFLAQNRDMPDVRQGELLAVLSAGAYGFSMSSNYNSRPMAE
EVLVDGDQWNVIRSRQSWEDLIRGESIPE
>Mature_429_residues
MHSFAYKNGTLYCENVNLQELADKESTPLYVYSKQTILNHFHRLREALAPLNAEVAYAVKACSNIAILNLMARNGAGFDI
VSGGELFRVLKAGGDPSKCTYAGVGKTEQEIRYALAQGIYCFNVESEAELRAINAIAASMGVKAPVAVRVNPNVEAGTHK
YITTGKAENKFGVDFERIESLYEMAARELPNLHLKGLQMHIGSQLTQAKPFLEAVRKVAPLAASLKEKHGIEFFSIGGGI
GIVYQGTLDSGVQEWWNEDCAQLTLSTYAQAVVPTLQPLGLHIIVEPGRLIVGNAGALITRCLYEKNGKAKTFKIVDAGM
NDLIRPALYQGYHEIIPVREHPSGSCVTADVVGPICESGDFLAQNRDMPDVRQGELLAVLSAGAYGFSMSSNYNSRPMAE
EVLVDGDQWNVIRSRQSWEDLIRGESIPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=421, Percent_Identity=25.41567695962, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789203, Length=440, Percent_Identity=34.5454545454545, Blast_Score=177, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17562780, Length=423, Percent_Identity=21.2765957446809, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=24.5382585751979, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46854; Mature: 46854

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFAYKNGTLYCENVNLQELADKESTPLYVYSKQTILNHFHRLREALAPLNAEVAYAVK
CCCCEECCCEEEEECCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHH
ACSNIAILNLMARNGAGFDIVSGGELFRVLKAGGDPSKCTYAGVGKTEQEIRYALAQGIY
HHCCEEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCEE
CFNVESEAELRAINAIAASMGVKAPVAVRVNPNVEAGTHKYITTGKAENKFGVDFERIES
EEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
LYEMAARELPNLHLKGLQMHIGSQLTQAKPFLEAVRKVAPLAASLKEKHGIEFFSIGGGI
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
GIVYQGTLDSGVQEWWNEDCAQLTLSTYAQAVVPTLQPLGLHIIVEPGRLIVGNAGALIT
EEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEECCHHHHH
RCLYEKNGKAKTFKIVDAGMNDLIRPALYQGYHEIIPVREHPSGSCVTADVVGPICESGD
HHHHHCCCCEEEEEEEECCHHHHHHHHHHCCHHHEEECCCCCCCCEEEHHHHHHHHCCCC
FLAQNRDMPDVRQGELLAVLSAGAYGFSMSSNYNSRPMAEEVLVDGDQWNVIRSRQSWED
CHHCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCCHHHHEECCCCHHEHHCHHHHHH
LIRGESIPE
HHCCCCCCC
>Mature Secondary Structure
MHSFAYKNGTLYCENVNLQELADKESTPLYVYSKQTILNHFHRLREALAPLNAEVAYAVK
CCCCEECCCEEEEECCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHH
ACSNIAILNLMARNGAGFDIVSGGELFRVLKAGGDPSKCTYAGVGKTEQEIRYALAQGIY
HHCCEEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCEE
CFNVESEAELRAINAIAASMGVKAPVAVRVNPNVEAGTHKYITTGKAENKFGVDFERIES
EEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
LYEMAARELPNLHLKGLQMHIGSQLTQAKPFLEAVRKVAPLAASLKEKHGIEFFSIGGGI
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
GIVYQGTLDSGVQEWWNEDCAQLTLSTYAQAVVPTLQPLGLHIIVEPGRLIVGNAGALIT
EEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEECCHHHHH
RCLYEKNGKAKTFKIVDAGMNDLIRPALYQGYHEIIPVREHPSGSCVTADVVGPICESGD
HHHHHCCCCEEEEEEEECCHHHHHHHHHHCCHHHEEECCCCCCCCEEEHHHHHHHHCCCC
FLAQNRDMPDVRQGELLAVLSAGAYGFSMSSNYNSRPMAEEVLVDGDQWNVIRSRQSWED
CHHCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCCHHHHEECCCCHHEHHCHHHHHH
LIRGESIPE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]