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The map label for this gene is corA [H]

Identifier: 186475998

GI number: 186475998

Start: 1391740

End: 1392717

Strand: Reverse

Name: corA [H]

Synonym: Bphy_1239

Alternate gene names: 186475998

Gene position: 1392717-1391740 (Counterclockwise)

Preceding gene: 186475999

Following gene: 186475996

Centisome position: 40.03

GC content: 61.25

Gene sequence:

>978_bases
ATGCTGATCAATTGCGCCGCGTACCAGGATGGCCGCAAACTGGCCGACATCGAGATCGACGACATCAGCGTGTATGTCGC
CAAACGGGAGTGCTTCGTCTGGGTCGCGTTGAAAGATCCCGGTCCCGGTGAGCTCGAAGTGATGAAGCACGAGTTCGGCC
TGCACGAACTGGCCGTCGAAGACGTTCGCCACGGCCATCAACGCCCGAAGATAGAGGAGTACGGCGACTCGCTGTTTGCC
GTGATGCATACCATCGAGACCGACGACGACGGCGAGTTCGTGATCGGCGAGGTCGATGTGTTCGTCGGCGCGAACTACGC
GCTGTCGGTGCGGCGCGGCACGCGCCACGGGTTCCAGGAAGTGCGCGCGCGCTGCGAGCGCGAGCCGCAATTGTTGAAGG
AGGGCGCGGCGTTCGTGCTGTATGCGCTGGCCGATAACGTCGTCGATCGCTACTTTCCGATTCTCGAGGCGATGGGCGCC
GAAATCGAGCAGATCGAAGACCGCATTTTCGACAAGCACGATCTGGCCGCTTCGCGCGCCATTATCGAAGACCTGTACTC
GATGAAGCGCCGGCTCGTGATGCTACAGCATCATATCGAGCCGCTGCTCGAAGGCATCAGCCGGCTGACGGGCGGACGCA
TTCCCGCCATCTGCGTCGGCATGCAGGCGTACTTCCGCGACGTCTACGATCACCTCGACCGTATCGTGCGCACCATCGAA
GGCCGGCGCGAAATCATCGTCACGGCGATCCAGGTCAACCTCGGCATGATCTCGCTCGCCGAGAACGAAGTGACCAAGCG
GCTCGGTTCGTTCGCCGCGCTGTTTGCGGTGCCGACGATGATCGCCGGCATCTACGGGATGAACTTCCAGGAGATCCCCG
AGCTGCATTTCAAATACGGGTATCCCATCTGCCTGCTGGTGATGCTGCTGATCGACATCGCGCTGTACCGGGGGTTCAAG
AAGGCGAACTGGCTGTAG

Upstream 100 bases:

>100_bases
TGCGCGGCTTTGCATGACGGTCCCGCAGGAGACGTCGGACCGCCCATTCAACTGACGATCTGTAAGCCGCAAAGCCGATT
CGAATCCAAGGTATTCAAAC

Downstream 100 bases:

>100_bases
CGCGTGCTCGCACCGCGTGGACGTCTCCTCCGTGCGAGCGCAGACGCGTCAACGCCGGGTCAGCGCGAGCCGCACACCAA
GACCGATGAAGCCTGCACCC

Product: magnesium and cobalt transport protein CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLINCAAYQDGRKLADIEIDDISVYVAKRECFVWVALKDPGPGELEVMKHEFGLHELAVEDVRHGHQRPKIEEYGDSLFA
VMHTIETDDDGEFVIGEVDVFVGANYALSVRRGTRHGFQEVRARCEREPQLLKEGAAFVLYALADNVVDRYFPILEAMGA
EIEQIEDRIFDKHDLAASRAIIEDLYSMKRRLVMLQHHIEPLLEGISRLTGGRIPAICVGMQAYFRDVYDHLDRIVRTIE
GRREIIVTAIQVNLGMISLAENEVTKRLGSFAALFAVPTMIAGIYGMNFQEIPELHFKYGYPICLLVMLLIDIALYRGFK
KANWL

Sequences:

>Translated_325_residues
MLINCAAYQDGRKLADIEIDDISVYVAKRECFVWVALKDPGPGELEVMKHEFGLHELAVEDVRHGHQRPKIEEYGDSLFA
VMHTIETDDDGEFVIGEVDVFVGANYALSVRRGTRHGFQEVRARCEREPQLLKEGAAFVLYALADNVVDRYFPILEAMGA
EIEQIEDRIFDKHDLAASRAIIEDLYSMKRRLVMLQHHIEPLLEGISRLTGGRIPAICVGMQAYFRDVYDHLDRIVRTIE
GRREIIVTAIQVNLGMISLAENEVTKRLGSFAALFAVPTMIAGIYGMNFQEIPELHFKYGYPICLLVMLLIDIALYRGFK
KANWL
>Mature_325_residues
MLINCAAYQDGRKLADIEIDDISVYVAKRECFVWVALKDPGPGELEVMKHEFGLHELAVEDVRHGHQRPKIEEYGDSLFA
VMHTIETDDDGEFVIGEVDVFVGANYALSVRRGTRHGFQEVRARCEREPQLLKEGAAFVLYALADNVVDRYFPILEAMGA
EIEQIEDRIFDKHDLAASRAIIEDLYSMKRRLVMLQHHIEPLLEGISRLTGGRIPAICVGMQAYFRDVYDHLDRIVRTIE
GRREIIVTAIQVNLGMISLAENEVTKRLGSFAALFAVPTMIAGIYGMNFQEIPELHFKYGYPICLLVMLLIDIALYRGFK
KANWL

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=345, Percent_Identity=25.2173913043478, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324442, Length=164, Percent_Identity=25, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321058, Length=350, Percent_Identity=21.4285714285714, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 36974; Mature: 36974

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINCAAYQDGRKLADIEIDDISVYVAKRECFVWVALKDPGPGELEVMKHEFGLHELAVE
CEEEEEECCCCCEEECEEECCEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHCHHHHHHH
DVRHGHQRPKIEEYGDSLFAVMHTIETDDDGEFVIGEVDVFVGANYALSVRRGTRHGFQE
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCHHH
VRARCEREPQLLKEGAAFVLYALADNVVDRYFPILEAMGAEIEQIEDRIFDKHDLAASRA
HHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
IIEDLYSMKRRLVMLQHHIEPLLEGISRLTGGRIPAICVGMQAYFRDVYDHLDRIVRTIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GRREIIVTAIQVNLGMISLAENEVTKRLGSFAALFAVPTMIAGIYGMNFQEIPELHFKYG
CCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCCC
YPICLLVMLLIDIALYRGFKKANWL
CHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MLINCAAYQDGRKLADIEIDDISVYVAKRECFVWVALKDPGPGELEVMKHEFGLHELAVE
CEEEEEECCCCCEEECEEECCEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHCHHHHHHH
DVRHGHQRPKIEEYGDSLFAVMHTIETDDDGEFVIGEVDVFVGANYALSVRRGTRHGFQE
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCHHH
VRARCEREPQLLKEGAAFVLYALADNVVDRYFPILEAMGAEIEQIEDRIFDKHDLAASRA
HHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
IIEDLYSMKRRLVMLQHHIEPLLEGISRLTGGRIPAICVGMQAYFRDVYDHLDRIVRTIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GRREIIVTAIQVNLGMISLAENEVTKRLGSFAALFAVPTMIAGIYGMNFQEIPELHFKYG
CCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCCC
YPICLLVMLLIDIALYRGFKKANWL
CHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]