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The map label for this gene is dnaX1 [H]

Identifier: 183222800

GI number: 183222800

Start: 3579644

End: 3581137

Strand: Direct

Name: dnaX1 [H]

Synonym: LEPBI_I3461

Alternate gene names: 183222800

Gene position: 3579644-3581137 (Clockwise)

Preceding gene: 183222799

Following gene: 183222801

Centisome position: 99.44

GC content: 36.68

Gene sequence:

>1494_bases
TTGAATACGGACCAAATGAGCGAAAACCACCAAGTACTCTTTCGAAAATACCGACCACAATTCTTTCGCGATGTAATTTA
CCAAGACCTCGCAGTCGGATCCTTACAAAACGCATTTAAATCAAAAAAAATAGGGCATGCCTATATCTTCATTGGACCAC
GTGGTGTGGGAAAAACAACTATCGCAAGAATTTTAGCCAAACGACTCAACTGTGAAAGGCCTGATGGAGTAGAACCTTGC
AACGAATGTACTTCTTGTTTGGAAATCACAAAAGGAAATTCTAATGATGTCTTTGAAATTGATGCCGCTTCCAACAGTGG
TGTGGATAACATTCGAGAACTAAGAGAAAATGTGAAATTCAATGCAATGGGTGGTAAGTACCGCGTTTATATTTTAGATG
AAGTGCATATGTTAAGTGGAGCTGCTTTTAATGCGCTTTTAAAAACATTGGAAGAACCTCCAGCCCATGTAGTTTTTATT
TTAGCAACCACCGAGTATCACAAAATTCCAGAGACCATCTTATCCCGATGCCAAGACTTCCATTTTCGCAAAGTTCCCGT
GACAGTTTTACAAAACTACATAGAAACTCTTTGCACAAAGGAAGGCCTAAAATACGATTCCGAAGGTTTATTTTGGATCG
CAAAAAAAGGTGATGGTTCTGTACGAGATACCTTATCGTTCATGGAACAAGCTGTCATTTTTACAGATGGAAACTTAACT
GGCGTTAAACTTCGTAAAATGATTGGGTATCATGGGATCGATACCTTTACTGATTTTCTAAACCAATTGATTGATACCTC
TCAAAGTGCCCAAATTTTTGAAACTTTAGAAAATTTATTCCAAGCGGGTATCGATTTAAGTAAGTTCATTTGGGATTTTA
TTGAATTTTTAAACTCTTTATTGTTAATCAAAGACAATCTCGCTGACCGTGAATCCATCAATATTCCCCATGAAGACTTA
CAGAAACTCAAACAAAACTACCGGGAACTTGATCGGGAGATATTGGTTTTACTCGCAGAAAGAATTTTTTCCATTCACGA
AAAATTAAATCTGATGAAACTACGTAGTTCTTACGAGATGAAAGTGTATTTGGAAATCCAATTTCGAAAACTGATTTTGG
ATCGCGAAAAACCTAGTGTATCTGGATTACTCGCTAAAATTTCAGAACTTACTAAACTTGTGCAAGGTGATCTGAGTAAC
ATTCCAGAGTCAGTAGAGCCGGTTAAAAAAATATCTACTCCTCCACCAACTCAATCCGCCACACAAAAAAAAGAACCAAC
TACCACAGCACAGAAGGAAAACGATCAAATCGATTCCAATCACACTAAACAAAATGAAAATATGGATTCAAATCCATTAC
CATCCAAATCAGAATCACAATCCATAAACAAACCAATATCCACACCTCCGTCATCTCCAGAAGATATGGAAAAACTATTA
AAGGAAAAATTTTCCGGTATGGAAGTGGATCCTAACCAATTTAAAAATTTATAA

Upstream 100 bases:

>100_bases
CACTCTAAAATACTCCTTCCTTTCAAAATAATTTCATTGCCTCTAAGTTAGGAAATTTCATACTCAAAGGGAAACTGAAA
GATTCGAAGCATTCAGTAAG

Downstream 100 bases:

>100_bases
GTCCAAAGGTAAGTATGGGAATTTTTGATCAAATGAAACAAATGCGGGAAGCTTTTTCGCAACTGGGTAACATCAAAGAA
AAACAGGAAGAATTACAAAA

Product: DNA polymerase III subunit gamma

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MNTDQMSENHQVLFRKYRPQFFRDVIYQDLAVGSLQNAFKSKKIGHAYIFIGPRGVGKTTIARILAKRLNCERPDGVEPC
NECTSCLEITKGNSNDVFEIDAASNSGVDNIRELRENVKFNAMGGKYRVYILDEVHMLSGAAFNALLKTLEEPPAHVVFI
LATTEYHKIPETILSRCQDFHFRKVPVTVLQNYIETLCTKEGLKYDSEGLFWIAKKGDGSVRDTLSFMEQAVIFTDGNLT
GVKLRKMIGYHGIDTFTDFLNQLIDTSQSAQIFETLENLFQAGIDLSKFIWDFIEFLNSLLLIKDNLADRESINIPHEDL
QKLKQNYRELDREILVLLAERIFSIHEKLNLMKLRSSYEMKVYLEIQFRKLILDREKPSVSGLLAKISELTKLVQGDLSN
IPESVEPVKKISTPPPTQSATQKKEPTTTAQKENDQIDSNHTKQNENMDSNPLPSKSESQSINKPISTPPSSPEDMEKLL
KEKFSGMEVDPNQFKNL

Sequences:

>Translated_497_residues
MNTDQMSENHQVLFRKYRPQFFRDVIYQDLAVGSLQNAFKSKKIGHAYIFIGPRGVGKTTIARILAKRLNCERPDGVEPC
NECTSCLEITKGNSNDVFEIDAASNSGVDNIRELRENVKFNAMGGKYRVYILDEVHMLSGAAFNALLKTLEEPPAHVVFI
LATTEYHKIPETILSRCQDFHFRKVPVTVLQNYIETLCTKEGLKYDSEGLFWIAKKGDGSVRDTLSFMEQAVIFTDGNLT
GVKLRKMIGYHGIDTFTDFLNQLIDTSQSAQIFETLENLFQAGIDLSKFIWDFIEFLNSLLLIKDNLADRESINIPHEDL
QKLKQNYRELDREILVLLAERIFSIHEKLNLMKLRSSYEMKVYLEIQFRKLILDREKPSVSGLLAKISELTKLVQGDLSN
IPESVEPVKKISTPPPTQSATQKKEPTTTAQKENDQIDSNHTKQNENMDSNPLPSKSESQSINKPISTPPSSPEDMEKLL
KEKFSGMEVDPNQFKNL
>Mature_497_residues
MNTDQMSENHQVLFRKYRPQFFRDVIYQDLAVGSLQNAFKSKKIGHAYIFIGPRGVGKTTIARILAKRLNCERPDGVEPC
NECTSCLEITKGNSNDVFEIDAASNSGVDNIRELRENVKFNAMGGKYRVYILDEVHMLSGAAFNALLKTLEEPPAHVVFI
LATTEYHKIPETILSRCQDFHFRKVPVTVLQNYIETLCTKEGLKYDSEGLFWIAKKGDGSVRDTLSFMEQAVIFTDGNLT
GVKLRKMIGYHGIDTFTDFLNQLIDTSQSAQIFETLENLFQAGIDLSKFIWDFIEFLNSLLLIKDNLADRESINIPHEDL
QKLKQNYRELDREILVLLAERIFSIHEKLNLMKLRSSYEMKVYLEIQFRKLILDREKPSVSGLLAKISELTKLVQGDLSN
IPESVEPVKKISTPPPTQSATQKKEPTTTAQKENDQIDSNHTKQNENMDSNPLPSKSESQSINKPISTPPSSPEDMEKLL
KEKFSGMEVDPNQFKNL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=305, Percent_Identity=23.9344262295082, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI31881687, Length=305, Percent_Identity=23.9344262295082, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786676, Length=326, Percent_Identity=37.4233128834356, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1787341, Length=170, Percent_Identity=31.7647058823529, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554730, Length=231, Percent_Identity=23.8095238095238, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=230, Percent_Identity=24.3478260869565, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=220, Percent_Identity=25.4545454545455, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17647857, Length=227, Percent_Identity=28.6343612334802, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 56581; Mature: 56581

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDQMSENHQVLFRKYRPQFFRDVIYQDLAVGSLQNAFKSKKIGHAYIFIGPRGVGKTT
CCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
IARILAKRLNCERPDGVEPCNECTSCLEITKGNSNDVFEIDAASNSGVDNIRELRENVKF
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEE
NAMGGKYRVYILDEVHMLSGAAFNALLKTLEEPPAHVVFILATTEYHKIPETILSRCQDF
EECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHC
HFRKVPVTVLQNYIETLCTKEGLKYDSEGLFWIAKKGDGSVRDTLSFMEQAVIFTDGNLT
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCCCC
GVKLRKMIGYHGIDTFTDFLNQLIDTSQSAQIFETLENLFQAGIDLSKFIWDFIEFLNSL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLIKDNLADRESINIPHEDLQKLKQNYRELDREILVLLAERIFSIHEKLNLMKLRSSYEM
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KVYLEIQFRKLILDREKPSVSGLLAKISELTKLVQGDLSNIPESVEPVKKISTPPPTQSA
EEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
TQKKEPTTTAQKENDQIDSNHTKQNENMDSNPLPSKSESQSINKPISTPPSSPEDMEKLL
CCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHH
KEKFSGMEVDPNQFKNL
HHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MNTDQMSENHQVLFRKYRPQFFRDVIYQDLAVGSLQNAFKSKKIGHAYIFIGPRGVGKTT
CCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
IARILAKRLNCERPDGVEPCNECTSCLEITKGNSNDVFEIDAASNSGVDNIRELRENVKF
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEE
NAMGGKYRVYILDEVHMLSGAAFNALLKTLEEPPAHVVFILATTEYHKIPETILSRCQDF
EECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHC
HFRKVPVTVLQNYIETLCTKEGLKYDSEGLFWIAKKGDGSVRDTLSFMEQAVIFTDGNLT
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCCCC
GVKLRKMIGYHGIDTFTDFLNQLIDTSQSAQIFETLENLFQAGIDLSKFIWDFIEFLNSL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLIKDNLADRESINIPHEDLQKLKQNYRELDREILVLLAERIFSIHEKLNLMKLRSSYEM
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KVYLEIQFRKLILDREKPSVSGLLAKISELTKLVQGDLSNIPESVEPVKKISTPPPTQSA
EEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
TQKKEPTTTAQKENDQIDSNHTKQNENMDSNPLPSKSESQSINKPISTPPSSPEDMEKLL
CCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHH
KEKFSGMEVDPNQFKNL
HHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]