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The map label for this gene is ahpC1 [H]

Identifier: 183222356

GI number: 183222356

Start: 3123133

End: 3123696

Strand: Reverse

Name: ahpC1 [H]

Synonym: LEPBI_I3009

Alternate gene names: 183222356

Gene position: 3123696-3123133 (Counterclockwise)

Preceding gene: 183222357

Following gene: 183222355

Centisome position: 86.78

GC content: 42.02

Gene sequence:

>564_bases
ATGTCCAATATCAACACACAAATCCCTGACTTCACAACAGAAGCTTTCCATAACGGTGCTTTTAAAAAAATCAGCAAAAA
GGACGTACTCGGAAAGTGGTCTGTTTTCGTATTTTATCCAGCAGACTTTACCTTTGTTTGCCCCACTGAACTTGGTGATG
TAGCAGATCATTACGAAGAACTTCAAAAGATGGGAGTGGAAGTGTATTCTGTATCTACAGACACTCACTTCGTTCACAAA
GCATGGCACGAAGCAAGTGATACCATCAAAAAAATCAAATTCCCAATGCTTGGTGATGCATCAGGAAAAATCACAAGAGG
ATTTGGAGTCATGATCGAAGATGATGGCCAAGCACTACGAGGAACTTTTGTCGTAAACCCAGAAGGTGTGATCAAAACTG
CTGAAATCCATGACCTTGGAATCGGAAGATCTGCTGAAGAGTTAGTGAGAAAAGTCCAAGCGGCTCAGTACGTTGCCAAT
AACGACGGAGAAGTATGCCCTGCGAAGTGGAAACCAGGTAACACAACGTTAAAACCTGGTCTTGACTTGGTAGGAAAAAT
CTAA

Upstream 100 bases:

>100_bases
TGTAGTCATAGCTTTTATAAATCATATCATTTATAACATTTATTTTACAAATGACGCGATATGGGTTATATTCTTCTTAA
CAAGAAAAGGAGGATATTCA

Downstream 100 bases:

>100_bases
ACAAAATTAGGCGGGCCTAGCCCGCCTAAAACTAGGAGGAAGTTATGTTAGATGAATCAACCAAACAACAAGTAAAACAA
TACTTTGAAAGGATTAAAAA

Product: alkyl hydroperoxide reductase subunit C

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSNINTQIPDFTTEAFHNGAFKKISKKDVLGKWSVFVFYPADFTFVCPTELGDVADHYEELQKMGVEVYSVSTDTHFVHK
AWHEASDTIKKIKFPMLGDASGKITRGFGVMIEDDGQALRGTFVVNPEGVIKTAEIHDLGIGRSAEELVRKVQAAQYVAN
NDGEVCPAKWKPGNTTLKPGLDLVGKI

Sequences:

>Translated_187_residues
MSNINTQIPDFTTEAFHNGAFKKISKKDVLGKWSVFVFYPADFTFVCPTELGDVADHYEELQKMGVEVYSVSTDTHFVHK
AWHEASDTIKKIKFPMLGDASGKITRGFGVMIEDDGQALRGTFVVNPEGVIKTAEIHDLGIGRSAEELVRKVQAAQYVAN
NDGEVCPAKWKPGNTTLKPGLDLVGKI
>Mature_186_residues
SNINTQIPDFTTEAFHNGAFKKISKKDVLGKWSVFVFYPADFTFVCPTELGDVADHYEELQKMGVEVYSVSTDTHFVHKA
WHEASDTIKKIKFPMLGDASGKITRGFGVMIEDDGQALRGTFVVNPEGVIKTAEIHDLGIGRSAEELVRKVQAAQYVANN
DGEVCPAKWKPGNTTLKPGLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=184, Percent_Identity=41.304347826087, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI32483377, Length=178, Percent_Identity=44.3820224719101, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI5802974, Length=179, Percent_Identity=43.5754189944134, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI5453549, Length=189, Percent_Identity=40.2116402116402, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=40.6417112299465, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=40.6417112299465, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=40.6417112299465, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=45.7831325301205, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI4758638, Length=173, Percent_Identity=27.7456647398844, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=65.7754010695187, Blast_Score=264, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI193204376, Length=181, Percent_Identity=41.9889502762431, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32565831, Length=181, Percent_Identity=41.9889502762431, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=40.1129943502825, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=35.6756756756757, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320661, Length=182, Percent_Identity=35.7142857142857, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319407, Length=188, Percent_Identity=28.1914893617021, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=42.8571428571429, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24656348, Length=179, Percent_Identity=42.4581005586592, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17864676, Length=179, Percent_Identity=42.4581005586592, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17738015, Length=179, Percent_Identity=37.9888268156425, Blast_Score=149, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=40.5555555555556, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=40.5555555555556, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=29.1891891891892, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17975518, Length=158, Percent_Identity=25.3164556962025, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24652436, Length=158, Percent_Identity=25.3164556962025, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652434, Length=158, Percent_Identity=25.3164556962025, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20605; Mature: 20473

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNINTQIPDFTTEAFHNGAFKKISKKDVLGKWSVFVFYPADFTFVCPTELGDVADHYEE
CCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHH
LQKMGVEVYSVSTDTHFVHKAWHEASDTIKKIKFPMLGDASGKITRGFGVMIEDDGQALR
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECEEEEEECCCCEEE
GTFVVNPEGVIKTAEIHDLGIGRSAEELVRKVQAAQYVANNDGEVCPAKWKPGNTTLKPG
EEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LDLVGKI
CHHHCCC
>Mature Secondary Structure 
SNINTQIPDFTTEAFHNGAFKKISKKDVLGKWSVFVFYPADFTFVCPTELGDVADHYEE
CCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHH
LQKMGVEVYSVSTDTHFVHKAWHEASDTIKKIKFPMLGDASGKITRGFGVMIEDDGQALR
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECEEEEEECCCCEEE
GTFVVNPEGVIKTAEIHDLGIGRSAEELVRKVQAAQYVANNDGEVCPAKWKPGNTTLKPG
EEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LDLVGKI
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]