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The map label for this gene is yhdG [H]

Identifier: 183222328

GI number: 183222328

Start: 3084491

End: 3085795

Strand: Reverse

Name: yhdG [H]

Synonym: LEPBI_I2980

Alternate gene names: 183222328

Gene position: 3085795-3084491 (Counterclockwise)

Preceding gene: 183222336

Following gene: 183222323

Centisome position: 85.72

GC content: 39.08

Gene sequence:

>1305_bases
ATGAACGATAGCCCAAAATTGCACAAAGCCCTCCATTCTGTTCACCTTTGGGGGATGGCTGTTGGGCTTGTGATCTCTGG
TGATTATTTCGGATGGAATTTCGGTTGGGCAAAAGCAAACTTTTGGGAATTTGGTTTTGCCATCATATGGATCGCATTAT
TTTATGTGATGTTTGCTTTGTGTTTTACTGAACTTGCTGCCAGCATTCCGCAAGCAGGTGGACCTTCTGCCTATGCAAAA
CGTGCTTTGGGTGATACGTTTGGTTTTTATACAGGTTATCTTGTGTTAGTCGAGTTTCTCCTTGCTCCACCTGCCATCGC
TTCAGCACTTGGTGGATACATTCATTTTTTATTTCCCATCATTCCTTCGTTTTATGCAGGAATTGGAATGTTTGTTTTAT
TATTACTCATCAATTTAACAGGGATCAAACAAACCGCTCGCTTTGAATTGTTTGTTACCTTCGTTGCTGTGATGGGCCTT
TTGTTTTATTTGGGATTAGTTTTCCCTCATCTTTCTATGGAAAGAATTCCGAGTTTTCCAACATTTCCATCCATCTCTTT
TTCTTCAATTTTCATTTCGATACCATTTGCGATCTGGTTCTTTTTAGCTGTGGAAGGAGTCGCTTTGGCGGCTGAAGAAG
TTAAAAATCCAGCAAAAGATATTCCCAAAGGTTACATCGCAGGTATTTTCACCTTACTTTGTTTAGCTGGAATGATCTAT
GTATTTACTGCTTCTGTGGTGCAAACAAATGAAATTGCAACAATTGAGTATCCTTTGTCTTTTGTATTAAATTCATTGTA
TGGAGTTGAATCCATTTGGCCCATTCTTTTCACTTTCATCGGATTGTTTGGGCTTGTTGCTTCCCTTTTTGGTATCATCT
TAGGAAACTCACGTTTGTTGTATGCGATGAGTAAAGAAGGATACCTTCCCAATTATTTGTCAAAGTTAACCAAAGGTCCT
CTTGTCCCTCAAAATGCAGTTTTATCTGGCGGAATCTTGGGGATTCTATGTATGCTGTTTTTAGATACAGCAGAACTCAT
CACCATCTCTGCATTAGGTGCATGTGGCATGTATCTATTGAGTTTGGTTTCTTATATCATTTTACGAAAGAAAGAACCTC
ATTTGGATCGTCCTTACAAGGCTCCCCTGTATCCAATTTTGCCAGTTGTTGCAATCTTATTTGGTCTATTTGCGTTTGGA
TCTGTCTTTTATGCGGAGCCAATTTTAACAATCGTGGTGTTTGTCGTAGGAATATTACTAGGTGGTGGATATAATATGAG
CCAAACCAGAAGGAATCGTATTTGA

Upstream 100 bases:

>100_bases
TCATTTAGCAAGATCATTTCTAAAAAAAATTGGAAGACATAAAGTATAGGAATGGGATTTGAATGTTGGAATCCTATGAT
TCAAAAAAAAAGGCACAATA

Downstream 100 bases:

>100_bases
TTTAGCTCGTCCCAATCTCGAGTTTTGAACGTTCGAGTGCATCCTTGCAGCGTTCGAAAAACAGTCGTGAGACGGAATCA
TCTGGATTTTTATCTAGAAG

Product: putative amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNDSPKLHKALHSVHLWGMAVGLVISGDYFGWNFGWAKANFWEFGFAIIWIALFYVMFALCFTELAASIPQAGGPSAYAK
RALGDTFGFYTGYLVLVEFLLAPPAIASALGGYIHFLFPIIPSFYAGIGMFVLLLLINLTGIKQTARFELFVTFVAVMGL
LFYLGLVFPHLSMERIPSFPTFPSISFSSIFISIPFAIWFFLAVEGVALAAEEVKNPAKDIPKGYIAGIFTLLCLAGMIY
VFTASVVQTNEIATIEYPLSFVLNSLYGVESIWPILFTFIGLFGLVASLFGIILGNSRLLYAMSKEGYLPNYLSKLTKGP
LVPQNAVLSGGILGILCMLFLDTAELITISALGACGMYLLSLVSYIILRKKEPHLDRPYKAPLYPILPVVAILFGLFAFG
SVFYAEPILTIVVFVVGILLGGGYNMSQTRRNRI

Sequences:

>Translated_434_residues
MNDSPKLHKALHSVHLWGMAVGLVISGDYFGWNFGWAKANFWEFGFAIIWIALFYVMFALCFTELAASIPQAGGPSAYAK
RALGDTFGFYTGYLVLVEFLLAPPAIASALGGYIHFLFPIIPSFYAGIGMFVLLLLINLTGIKQTARFELFVTFVAVMGL
LFYLGLVFPHLSMERIPSFPTFPSISFSSIFISIPFAIWFFLAVEGVALAAEEVKNPAKDIPKGYIAGIFTLLCLAGMIY
VFTASVVQTNEIATIEYPLSFVLNSLYGVESIWPILFTFIGLFGLVASLFGIILGNSRLLYAMSKEGYLPNYLSKLTKGP
LVPQNAVLSGGILGILCMLFLDTAELITISALGACGMYLLSLVSYIILRKKEPHLDRPYKAPLYPILPVVAILFGLFAFG
SVFYAEPILTIVVFVVGILLGGGYNMSQTRRNRI
>Mature_434_residues
MNDSPKLHKALHSVHLWGMAVGLVISGDYFGWNFGWAKANFWEFGFAIIWIALFYVMFALCFTELAASIPQAGGPSAYAK
RALGDTFGFYTGYLVLVEFLLAPPAIASALGGYIHFLFPIIPSFYAGIGMFVLLLLINLTGIKQTARFELFVTFVAVMGL
LFYLGLVFPHLSMERIPSFPTFPSISFSSIFISIPFAIWFFLAVEGVALAAEEVKNPAKDIPKGYIAGIFTLLCLAGMIY
VFTASVVQTNEIATIEYPLSFVLNSLYGVESIWPILFTFIGLFGLVASLFGIILGNSRLLYAMSKEGYLPNYLSKLTKGP
LVPQNAVLSGGILGILCMLFLDTAELITISALGACGMYLLSLVSYIILRKKEPHLDRPYKAPLYPILPVVAILFGLFAFG
SVFYAEPILTIVVFVVGILLGGGYNMSQTRRNRI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=386, Percent_Identity=28.2383419689119, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33286428, Length=432, Percent_Identity=26.8518518518519, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI115648063, Length=416, Percent_Identity=24.0384615384615, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI115648022, Length=416, Percent_Identity=24.0384615384615, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI186910308, Length=393, Percent_Identity=24.4274809160305, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI186910306, Length=393, Percent_Identity=24.4274809160305, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI186910304, Length=393, Percent_Identity=24.4274809160305, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790653, Length=385, Percent_Identity=26.2337662337662, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081708, Length=430, Percent_Identity=22.3255813953488, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786789, Length=349, Percent_Identity=21.7765042979943, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786302, Length=410, Percent_Identity=25.3658536585366, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082250, Length=384, Percent_Identity=22.65625, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790584, Length=277, Percent_Identity=25.9927797833935, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786602, Length=396, Percent_Identity=22.4747474747475, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=401, Percent_Identity=22.6932668329177, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321053, Length=380, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24668806, Length=361, Percent_Identity=24.6537396121884, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356285, Length=361, Percent_Identity=24.6537396121884, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668802, Length=361, Percent_Identity=24.6537396121884, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=24.5810055865922, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=24.5810055865922, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667468, Length=341, Percent_Identity=23.7536656891496, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331183, Length=376, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17647653, Length=376, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664379, Length=376, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24651635, Length=380, Percent_Identity=23.4210526315789, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24651633, Length=380, Percent_Identity=23.4210526315789, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47604; Mature: 47604

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHCCC
>Mature Secondary Structure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CCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]