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The map label for this gene is msrA1 [H]

Identifier: 183222274

GI number: 183222274

Start: 3023111

End: 3023623

Strand: Reverse

Name: msrA1 [H]

Synonym: LEPBI_I2925

Alternate gene names: 183222274

Gene position: 3023623-3023111 (Counterclockwise)

Preceding gene: 183222275

Following gene: 183222269

Centisome position: 84.0

GC content: 39.57

Gene sequence:

>513_bases
ATGACGGAAAAAGCAATTTTAGGTGGAGGGTGTTTTTGGTGTACGGAAGCAGTGTACTTACGTATTCCAGGAGTTTTATC
CGTTGTTTCTGGGTATGCTGGAGGATCATCACCAAACCCAAGTTATAAAGAGATTTGTACAGGCACCACAGGGCATGCGG
AAGTGATCCAAATTGAATACAATCCTGAAATCATTTCGTATGCAAAAATCCTTGAGATCTTTTGGGTTTCCCATGATCCA
ACGACTCTCAACAAACAAGGAAATGATGTGGGAACACAATACCGTTCTGTGATTTTTTATTTGAACGAAAAGCAAAAAGA
ATTAGCAGTTGAATCCAAACGTAAACACGCGTTTCTGTTTCCAGATCCTATTGTCACAGAAATTTCTCCTGCTCCCACCT
TTTACCCTGCAGAAGACTACCACCAAAATTATTTTACCTTAAACCCACAAAATCCGTACTGCCATTATGTGATCTTTCCC
AAACTGAAAAAACTGGGATTGAAGTTGAATTAG

Upstream 100 bases:

>100_bases
ATCCATCCTTTGACATCACAAAGGCAAAATTTATCAAAAACTTTATCACAGAATTAGGATGTTTTGTACCTGAGGAGATT
TCTTTTCGTCTAAAGAATGT

Downstream 100 bases:

>100_bases
ATCGAACCAATCAGTTGAGACAAAATTAGTATCGACTTGAATTAGGCTAAATTAGATTAGATTGTACCAGACTAGACTAG
AAAATTCCCAATAGCAGATT

Product: peptide methionine sulfoxide reductase MsrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTEKAILGGGCFWCTEAVYLRIPGVLSVVSGYAGGSSPNPSYKEICTGTTGHAEVIQIEYNPEIISYAKILEIFWVSHDP
TTLNKQGNDVGTQYRSVIFYLNEKQKELAVESKRKHAFLFPDPIVTEISPAPTFYPAEDYHQNYFTLNPQNPYCHYVIFP
KLKKLGLKLN

Sequences:

>Translated_170_residues
MTEKAILGGGCFWCTEAVYLRIPGVLSVVSGYAGGSSPNPSYKEICTGTTGHAEVIQIEYNPEIISYAKILEIFWVSHDP
TTLNKQGNDVGTQYRSVIFYLNEKQKELAVESKRKHAFLFPDPIVTEISPAPTFYPAEDYHQNYFTLNPQNPYCHYVIFP
KLKKLGLKLN
>Mature_169_residues
TEKAILGGGCFWCTEAVYLRIPGVLSVVSGYAGGSSPNPSYKEICTGTTGHAEVIQIEYNPEIISYAKILEIFWVSHDPT
TLNKQGNDVGTQYRSVIFYLNEKQKELAVESKRKHAFLFPDPIVTEISPAPTFYPAEDYHQNYFTLNPQNPYCHYVIFPK
LKKLGLKLN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=47.1337579617834, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=47.1337579617834, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=48.6238532110092, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=48.0263157894737, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=39.4557823129252, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=41.9753086419753, Blast_Score=110, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24664627, Length=159, Percent_Identity=37.7358490566038, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45553131, Length=154, Percent_Identity=37.6623376623377, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=37.0588235294118, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19170; Mature: 19039

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKAILGGGCFWCTEAVYLRIPGVLSVVSGYAGGSSPNPSYKEICTGTTGHAEVIQIEY
CCCCEEECCCHHHHHCEEEEECCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEEEEEE
NPEIISYAKILEIFWVSHDPTTLNKQGNDVGTQYRSVIFYLNEKQKELAVESKRKHAFLF
CCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHHEEEEEEEECCCHHHHHHHCCCCEEEEC
PDPIVTEISPAPTFYPAEDYHQNYFTLNPQNPYCHYVIFPKLKKLGLKLN
CCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCEEEEEECCCHHCCCCCCC
>Mature Secondary Structure 
TEKAILGGGCFWCTEAVYLRIPGVLSVVSGYAGGSSPNPSYKEICTGTTGHAEVIQIEY
CCCEEECCCHHHHHCEEEEECCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEEEEEE
NPEIISYAKILEIFWVSHDPTTLNKQGNDVGTQYRSVIFYLNEKQKELAVESKRKHAFLF
CCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHHEEEEEEEECCCHHHHHHHCCCCEEEEC
PDPIVTEISPAPTFYPAEDYHQNYFTLNPQNPYCHYVIFPKLKKLGLKLN
CCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCEEEEEECCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA