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The map label for this gene is mtnA

Identifier: 183222275

GI number: 183222275

Start: 3023620

End: 3024693

Strand: Reverse

Name: mtnA

Synonym: LEPBI_I2926

Alternate gene names: 183222275

Gene position: 3024693-3023620 (Counterclockwise)

Preceding gene: 183222277

Following gene: 183222274

Centisome position: 84.03

GC content: 41.71

Gene sequence:

>1074_bases
ATGTCCCAACCGGAATTTTTACCCATCCAGTGGAAATCCACTTTTCTCTCCCTTCTTGACCAAAGGGTACTACCCGGGAA
AAAGGAATTTTTGCAAATCCAAACAATGGAAGAAACAATTGTGGCTATCCGTGAAATGGCCGTTAGGGGAGCTCCCGCAA
TTGCCATCACAGGCATCTTTGGTATCACACTGGGTGCCAAAAAAAAATCTGGAAATTCAAATCCAGTGGATGTTGATTCC
CTCATCAAACAAGTGTTTGAGTCAAGACCTACTGCAGTGAACTTAAGTTTTGCATTGAAGGAAGCAAAAAAACGAGTAGA
AGGGGTCTCCCATTGGGATTCCATCGCTAAGGTTTGGGAATCATATGCCCTAGAGATGATGGTTCAAGACTTAAAGGCAA
ATCAAACCTTAGGAAAAAACGGTGCCGATCTTTTTCCAAAAAACCAAAATGAGTTTCATATCATCACCCATTGTAATACA
GGAGCACTTGCCACAGCTGGGCATGGCACAGCACTCGGTGTGATTCGGAGTTTGCGAGACCAAGGTAAAAAAGTGGTGGT
TTATGCTGATGAAACTCGGCCCTTCCTCCAAGGTTCAAGGCTCACTGCCTTTGAGATGATGGAAGAGGGGATTGAATGTT
ATATCATTACGGATGGAATGTCTGGTTGGCTTATGAACCATCGTAAGATTGATGCCGTGCTTGTGGGTTGTGACCGCGTT
GCCACTAATGGAGATACAGCCAATAAAATTGGTACTTACAATCTTGCCATTGTTGCTTATGAACACAAAGTGCCATTTTA
TGTCTGTGCCACAAAAGACAGTTTTGACTTAAAACTAAAAACGGGAGATGAGATTCCCATTGAAATGCGCAAAGAATCAG
AAGTCACCCAATTTGATTTTTTGAAAAACGAAGAAGGAAACTTTTTATTTCCAGAGGGAAAAACCTCTCCAATCGGTGCA
CGGGCTCTCAATCCATCCTTTGACATCACAAAGGCAAAATTTATCAAAAACTTTATCACAGAATTAGGATGTTTTGTACC
TGAGGAGATTTCTTTTCGTCTAAAGAATGTATGA

Upstream 100 bases:

>100_bases
TGTCAGTTGTGCAATGCACTATTCTTTTTTGTGCGATGCACACGGATCCGTCAACCCGTTTTTTCATTTTTTTTCCACAC
CTACCAAAAAAAATGGAGAG

Downstream 100 bases:

>100_bases
CGGAAAAAGCAATTTTAGGTGGAGGGTGTTTTTGGTGTACGGAAGCAGTGTACTTACGTATTCCAGGAGTTTTATCCGTT
GTTTCTGGGTATGCTGGAGG

Product: putative 5-methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSQPEFLPIQWKSTFLSLLDQRVLPGKKEFLQIQTMEETIVAIREMAVRGAPAIAITGIFGITLGAKKKSGNSNPVDVDS
LIKQVFESRPTAVNLSFALKEAKKRVEGVSHWDSIAKVWESYALEMMVQDLKANQTLGKNGADLFPKNQNEFHIITHCNT
GALATAGHGTALGVIRSLRDQGKKVVVYADETRPFLQGSRLTAFEMMEEGIECYIITDGMSGWLMNHRKIDAVLVGCDRV
ATNGDTANKIGTYNLAIVAYEHKVPFYVCATKDSFDLKLKTGDEIPIEMRKESEVTQFDFLKNEEGNFLFPEGKTSPIGA
RALNPSFDITKAKFIKNFITELGCFVPEEISFRLKNV

Sequences:

>Translated_357_residues
MSQPEFLPIQWKSTFLSLLDQRVLPGKKEFLQIQTMEETIVAIREMAVRGAPAIAITGIFGITLGAKKKSGNSNPVDVDS
LIKQVFESRPTAVNLSFALKEAKKRVEGVSHWDSIAKVWESYALEMMVQDLKANQTLGKNGADLFPKNQNEFHIITHCNT
GALATAGHGTALGVIRSLRDQGKKVVVYADETRPFLQGSRLTAFEMMEEGIECYIITDGMSGWLMNHRKIDAVLVGCDRV
ATNGDTANKIGTYNLAIVAYEHKVPFYVCATKDSFDLKLKTGDEIPIEMRKESEVTQFDFLKNEEGNFLFPEGKTSPIGA
RALNPSFDITKAKFIKNFITELGCFVPEEISFRLKNV
>Mature_356_residues
SQPEFLPIQWKSTFLSLLDQRVLPGKKEFLQIQTMEETIVAIREMAVRGAPAIAITGIFGITLGAKKKSGNSNPVDVDSL
IKQVFESRPTAVNLSFALKEAKKRVEGVSHWDSIAKVWESYALEMMVQDLKANQTLGKNGADLFPKNQNEFHIITHCNTG
ALATAGHGTALGVIRSLRDQGKKVVVYADETRPFLQGSRLTAFEMMEEGIECYIITDGMSGWLMNHRKIDAVLVGCDRVA
TNGDTANKIGTYNLAIVAYEHKVPFYVCATKDSFDLKLKTGDEIPIEMRKESEVTQFDFLKNEEGNFLFPEGKTSPIGAR
ALNPSFDITKAKFIKNFITELGCFVPEEISFRLKNV

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=363, Percent_Identity=38.8429752066116, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI23943880, Length=357, Percent_Identity=32.7731092436975, Blast_Score=168, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17557462, Length=350, Percent_Identity=35.1428571428571, Blast_Score=203, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17557123, Length=203, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=394, Percent_Identity=35.2791878172589, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6322878, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357667, Length=361, Percent_Identity=36.5650969529086, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24651647, Length=361, Percent_Identity=36.5650969529086, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_LEPBA (B0SFD6)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963882.1
- ProteinModelPortal:   B0SFD6
- SMR:   B0SFD6
- GeneID:   6389045
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2827
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK574624
- BioCyc:   LBIF355278:LBF_2827-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 39723; Mature: 39592

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: ACT_SITE 238-238 BINDING 89-89 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPEFLPIQWKSTFLSLLDQRVLPGKKEFLQIQTMEETIVAIREMAVRGAPAIAITGIF
CCCCCEEEEHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
GITLGAKKKSGNSNPVDVDSLIKQVFESRPTAVNLSFALKEAKKRVEGVSHWDSIAKVWE
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SYALEMMVQDLKANQTLGKNGADLFPKNQNEFHIITHCNTGALATAGHGTALGVIRSLRD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHH
QGKKVVVYADETRPFLQGSRLTAFEMMEEGIECYIITDGMSGWLMNHRKIDAVLVGCDRV
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHCCCCEEEEEEEECCCE
ATNGDTANKIGTYNLAIVAYEHKVPFYVCATKDSFDLKLKTGDEIPIEMRKESEVTQFDF
ECCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCEEEEEECCCCCCEEECCCCCCHHHHH
LKNEEGNFLFPEGKTSPIGARALNPSFDITKAKFIKNFITELGCFVPEEISFRLKNV
EECCCCCEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEECCC
>Mature Secondary Structure 
SQPEFLPIQWKSTFLSLLDQRVLPGKKEFLQIQTMEETIVAIREMAVRGAPAIAITGIF
CCCCEEEEHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
GITLGAKKKSGNSNPVDVDSLIKQVFESRPTAVNLSFALKEAKKRVEGVSHWDSIAKVWE
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SYALEMMVQDLKANQTLGKNGADLFPKNQNEFHIITHCNTGALATAGHGTALGVIRSLRD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHH
QGKKVVVYADETRPFLQGSRLTAFEMMEEGIECYIITDGMSGWLMNHRKIDAVLVGCDRV
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHCCCCEEEEEEEECCCE
ATNGDTANKIGTYNLAIVAYEHKVPFYVCATKDSFDLKLKTGDEIPIEMRKESEVTQFDF
ECCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCEEEEEECCCCCCEEECCCCCCHHHHH
LKNEEGNFLFPEGKTSPIGARALNPSFDITKAKFIKNFITELGCFVPEEISFRLKNV
EECCCCCEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA