Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 183222240

GI number: 183222240

Start: 2981989

End: 2983200

Strand: Reverse

Name: icd [H]

Synonym: LEPBI_I2891

Alternate gene names: 183222240

Gene position: 2983200-2981989 (Counterclockwise)

Preceding gene: 183222241

Following gene: 183222239

Centisome position: 82.87

GC content: 38.53

Gene sequence:

>1212_bases
ATGGGAAAAATTAAAGTAAAAACACCGTTAGTTGAGTTAGACGGCGATGAAATGACAAGAATCATCTGGAAAGAAATCAA
AGATCGATTCATTCACCCTTACTTAGATATTACTTTAGAGTATTATGACTTAGGTGTTGAGTATCGAGATAAAACTGATG
ACCAAGTGACTGTTGATTCTGCTAACGCGATTAAAAAACATGGCGTAGGTGTTAAATGTGCAACCATCACTCCAAATGCT
GACCGTGTAAAAGAATACAATTTAAAACAAGAATGGAAATCTCCTAACGGAACAATCCGAGCGATCTTAGATGGAACTGT
ATTTCGTAAACCGATCATCATAAAAAACATTCCAGCTGCGGTGAATTCTTGGAAAAAACCAATTGCGATTGGTCGTCATG
CTTATGGTGATATTTATCGTGATGTTGAAATTTCTGTAGATGGTCCAGGTAAAGTTGAACTTGTTTATACGGATGCTTCT
GGAAACGAAAAACAAAGACTTCTTGTGAATGAATTCAAAGGTTCAGGTGTTGCTCTTGCTATGCACAACTTAGATGAATC
AATTAAGTCTTTTGCAAAAGCATGTTTTAACTATGCTTTGTCTGAAAAGATCAGCATTTGGTTTGCAACAAAAGATACAA
TTTCTAAAAAATACCACGCACGTTTCCGTGATATCTTTGATACCATGGCAAAAGAACAAGACGCAGCGATGAAAGCGGCA
GGTATCACTTATAGTTACTACCTCATTGATGATGCTGTTGCACAAATCATGAAAAACGAAGGTGGTCAACTTTGGGCTCT
CATGAACTATGATGGTGATGTGATGAGTGATATGGTTGCATCAGGGTTTGGTTCACTTGGACTCATGACTTCTGTGCTAG
TGTCTCCAGATGGAAAGTATGAATACGAAGCGGCTCACGGAACTGTGACTCGCCACTACCGAAAGTACCAAAAAGGGGAA
ACCACTTCGACAAATTCTGTCGCATCCATTTTTGCTTGGACGGGTGCATTGGCAAAACGTGGTGAACTTGATGGAACTCC
TGATGTAGTGAATTTTGCTCACAAATTGGAAGAAGCCATTATCGAAACCATCGAAGGAGGAGAAATGACAAAAGATCTAC
TTTCTCTTTCTACTGCTGCCAAAAAAACAGAATTGGATACATTCCAATTTATGGAAGCAGTACAAAAACGTTTGGATGCA
AAACTCAAATAA

Upstream 100 bases:

>100_bases
TTCGACAGAGTTTTGTCATCATCTTTGGAATACATACATGGCAAATCCAAATTAAGTATTATAAATTAGAATCAAAATGG
AAAGAGTTTAGGAGAAATCA

Downstream 100 bases:

>100_bases
TTTTTGCACATCACCCTGTCTCTTGGCAGGGTGATTTTTCTTTCTTTATTTTCTTGCCTTCTTTTCTTTTCCTAATCCAA
TAAACATTCCATGACGAACG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MGKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDITLEYYDLGVEYRDKTDDQVTVDSANAIKKHGVGVKCATITPNA
DRVKEYNLKQEWKSPNGTIRAILDGTVFRKPIIIKNIPAAVNSWKKPIAIGRHAYGDIYRDVEISVDGPGKVELVYTDAS
GNEKQRLLVNEFKGSGVALAMHNLDESIKSFAKACFNYALSEKISIWFATKDTISKKYHARFRDIFDTMAKEQDAAMKAA
GITYSYYLIDDAVAQIMKNEGGQLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKYEYEAAHGTVTRHYRKYQKGE
TTSTNSVASIFAWTGALAKRGELDGTPDVVNFAHKLEEAIIETIEGGEMTKDLLSLSTAAKKTELDTFQFMEAVQKRLDA
KLK

Sequences:

>Translated_403_residues
MGKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDITLEYYDLGVEYRDKTDDQVTVDSANAIKKHGVGVKCATITPNA
DRVKEYNLKQEWKSPNGTIRAILDGTVFRKPIIIKNIPAAVNSWKKPIAIGRHAYGDIYRDVEISVDGPGKVELVYTDAS
GNEKQRLLVNEFKGSGVALAMHNLDESIKSFAKACFNYALSEKISIWFATKDTISKKYHARFRDIFDTMAKEQDAAMKAA
GITYSYYLIDDAVAQIMKNEGGQLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKYEYEAAHGTVTRHYRKYQKGE
TTSTNSVASIFAWTGALAKRGELDGTPDVVNFAHKLEEAIIETIEGGEMTKDLLSLSTAAKKTELDTFQFMEAVQKRLDA
KLK
>Mature_402_residues
GKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDITLEYYDLGVEYRDKTDDQVTVDSANAIKKHGVGVKCATITPNAD
RVKEYNLKQEWKSPNGTIRAILDGTVFRKPIIIKNIPAAVNSWKKPIAIGRHAYGDIYRDVEISVDGPGKVELVYTDASG
NEKQRLLVNEFKGSGVALAMHNLDESIKSFAKACFNYALSEKISIWFATKDTISKKYHARFRDIFDTMAKEQDAAMKAAG
ITYSYYLIDDAVAQIMKNEGGQLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKYEYEAAHGTVTRHYRKYQKGET
TSTNSVASIFAWTGALAKRGELDGTPDVVNFAHKLEEAIIETIEGGEMTKDLLSLSTAAKKTELDTFQFMEAVQKRLDAK
LK

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=400, Percent_Identity=57.75, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=53.3169533169533, Blast_Score=437, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17540874, Length=399, Percent_Identity=55.3884711779449, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17550822, Length=403, Percent_Identity=54.3424317617866, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320137, Length=409, Percent_Identity=57.9462102689486, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6324319, Length=403, Percent_Identity=56.575682382134, Blast_Score=455, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6323203, Length=403, Percent_Identity=55.5831265508685, Blast_Score=445, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21356561, Length=401, Percent_Identity=55.1122194513716, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI221330987, Length=401, Percent_Identity=55.1122194513716, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI221330985, Length=401, Percent_Identity=55.1122194513716, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI28574947, Length=401, Percent_Identity=55.1122194513716, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24660849, Length=401, Percent_Identity=55.1122194513716, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI221330983, Length=401, Percent_Identity=55.1122194513716, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24660856, Length=401, Percent_Identity=55.1122194513716, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24660868, Length=401, Percent_Identity=55.1122194513716, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24660860, Length=401, Percent_Identity=55.1122194513716, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 44994; Mature: 44863

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDITLEYYDLGVEYRDKTDDQVTVDS
CCCEEEECCEEEECCHHHHHHHHHHHHHHHCCCHHEEEEEEEECCEEECCCCCCEEEECC
ANAIKKHGVGVKCATITPNADRVKEYNLKQEWKSPNGTIRAILDGTVFRKPIIIKNIPAA
CHHHHHCCCCEEEEEECCCHHHHHHCCCHHHHCCCCCEEEEEECCHHHCCCEEEECCCHH
VNSWKKPIAIGRHAYGDIYRDVEISVDGPGKVELVYTDASGNEKQRLLVNEFKGSGVALA
HHCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEE
MHNLDESIKSFAKACFNYALSEKISIWFATKDTISKKYHARFRDIFDTMAKEQDAAMKAA
EHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GITYSYYLIDDAVAQIMKNEGGQLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKY
CCEEEEEEHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCE
EYEAAHGTVTRHYRKYQKGETTSTNSVASIFAWTGALAKRGELDGTPDVVNFAHKLEEAI
EEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IETIEGGEMTKDLLSLSTAAKKTELDTFQFMEAVQKRLDAKLK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDITLEYYDLGVEYRDKTDDQVTVDS
CCEEEECCEEEECCHHHHHHHHHHHHHHHCCCHHEEEEEEEECCEEECCCCCCEEEECC
ANAIKKHGVGVKCATITPNADRVKEYNLKQEWKSPNGTIRAILDGTVFRKPIIIKNIPAA
CHHHHHCCCCEEEEEECCCHHHHHHCCCHHHHCCCCCEEEEEECCHHHCCCEEEECCCHH
VNSWKKPIAIGRHAYGDIYRDVEISVDGPGKVELVYTDASGNEKQRLLVNEFKGSGVALA
HHCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEE
MHNLDESIKSFAKACFNYALSEKISIWFATKDTISKKYHARFRDIFDTMAKEQDAAMKAA
EHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GITYSYYLIDDAVAQIMKNEGGQLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKY
CCEEEEEEHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCE
EYEAAHGTVTRHYRKYQKGETTSTNSVASIFAWTGALAKRGELDGTPDVVNFAHKLEEAI
EEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IETIEGGEMTKDLLSLSTAAKKTELDTFQFMEAVQKRLDAKLK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]