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The map label for this gene is moeB [H]

Identifier: 183222130

GI number: 183222130

Start: 2873408

End: 2874472

Strand: Reverse

Name: moeB [H]

Synonym: LEPBI_I2773

Alternate gene names: 183222130

Gene position: 2874472-2873408 (Counterclockwise)

Preceding gene: 183222136

Following gene: 183222122

Centisome position: 79.85

GC content: 38.03

Gene sequence:

>1065_bases
ATGAAGTCAGAAAAAGAGATTTTTTTCCAAAGACAATGTTTGGTCCCTGAAATTGGTCAGGAAGGGCAAAAAAAATGGAA
TGATGCCTCAGTTCTTATCATTGGATTGGGTGGCTTGGGATGTCCTTCCGCTTTGCAACTTGCACTAGCCGGGGTATCCA
GAATTGGGCTCGTCGATTTCGACGTGGTCGAAGTATCAAATTTACATCGACAAACATTGTTTACTTGGAAGGACATAGGT
CGAAAAAAAACAGAAGTTGTATCGGAAGTTCTAAAGGAACACATACCATGGATTCAAATCGAAACATTTTCTGAATTTTT
AAATTCAAATTCCAATACTCAAATATTTGAAACCTGGGATATTGTGTTGGACTGTACGGATACAATTATCTCCAAATATG
CTATAAACGACTTTTGTTTAGAAAAAAAGATTCCGCTCGTGACTGCTTCTGTATTCAGAACCAGTGCACAGTTTGCCATC
TTTTCAGGCGATGGCAAACCATGTTATCGTTGTTTGTTTCCCAATTTAAGTGAAGGGGATACGTTCAGTTGTAATGAAGG
GGGAGTATTGGGAATTCAAACTTCATTAGCAGGAAATTACCAAGCCTCATTGGTGTTACAATATTTACTGAATCCTCACC
AATTTGAACTGAATACAGTTTATTTTATCGAATGGAATCCCATTTCATTTTACCAATCAAAGGTAGAACAAGATCTTCAG
TGTCCATCTTGTAGCGAACAAAGATATCTTAAAAAAAGTGAAGGGAATTGTTTAGAAATCGATCAAGTTGGATACTTGGA
ACTTAAGTCAAAAACATCTGTCATTTTACTAGACGTCAGGGAAGAAGAAGAGGTGATCCATTCCCCCATCCCAGATGCAG
TTTGGTTTCCTTTATCTGAATTGGAAAAGGGAAAGTCTCCACCAGGAATCTCTGACCAAACGATTGTTTGTGTTTGTGAG
ACAGGAGTGCGCTCACTGAAGGCAACTTCCTATCTCACAAATTTTCAAAACAAATTTTCATTGATTGGTGGTCGAAGGGT
TTTGTCTCGATTCAAAAATGAGTAA

Upstream 100 bases:

>100_bases
AGTTGGAAACCAAAATTGAATTTTTTCTTTATGACTAAAATAAAAATTAATGAATATCCATTTCCAAAGTTGATTTCTCT
AACAAAGTGCGATTAGATTC

Downstream 100 bases:

>100_bases
ACAATTCTTATGAAGGAATCTTTATGATTTTTACCTGAATGCCGCTGAACGCAGCATTTCCAGAAAATTCATCAATGATT
TGATCATCAGTCAGGTCATT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKSEKEIFFQRQCLVPEIGQEGQKKWNDASVLIIGLGGLGCPSALQLALAGVSRIGLVDFDVVEVSNLHRQTLFTWKDIG
RKKTEVVSEVLKEHIPWIQIETFSEFLNSNSNTQIFETWDIVLDCTDTIISKYAINDFCLEKKIPLVTASVFRTSAQFAI
FSGDGKPCYRCLFPNLSEGDTFSCNEGGVLGIQTSLAGNYQASLVLQYLLNPHQFELNTVYFIEWNPISFYQSKVEQDLQ
CPSCSEQRYLKKSEGNCLEIDQVGYLELKSKTSVILLDVREEEEVIHSPIPDAVWFPLSELEKGKSPPGISDQTIVCVCE
TGVRSLKATSYLTNFQNKFSLIGGRRVLSRFKNE

Sequences:

>Translated_354_residues
MKSEKEIFFQRQCLVPEIGQEGQKKWNDASVLIIGLGGLGCPSALQLALAGVSRIGLVDFDVVEVSNLHRQTLFTWKDIG
RKKTEVVSEVLKEHIPWIQIETFSEFLNSNSNTQIFETWDIVLDCTDTIISKYAINDFCLEKKIPLVTASVFRTSAQFAI
FSGDGKPCYRCLFPNLSEGDTFSCNEGGVLGIQTSLAGNYQASLVLQYLLNPHQFELNTVYFIEWNPISFYQSKVEQDLQ
CPSCSEQRYLKKSEGNCLEIDQVGYLELKSKTSVILLDVREEEEVIHSPIPDAVWFPLSELEKGKSPPGISDQTIVCVCE
TGVRSLKATSYLTNFQNKFSLIGGRRVLSRFKNE
>Mature_354_residues
MKSEKEIFFQRQCLVPEIGQEGQKKWNDASVLIIGLGGLGCPSALQLALAGVSRIGLVDFDVVEVSNLHRQTLFTWKDIG
RKKTEVVSEVLKEHIPWIQIETFSEFLNSNSNTQIFETWDIVLDCTDTIISKYAINDFCLEKKIPLVTASVFRTSAQFAI
FSGDGKPCYRCLFPNLSEGDTFSCNEGGVLGIQTSLAGNYQASLVLQYLLNPHQFELNTVYFIEWNPISFYQSKVEQDLQ
CPSCSEQRYLKKSEGNCLEIDQVGYLELKSKTSVILLDVREEEEVIHSPIPDAVWFPLSELEKGKSPPGISDQTIVCVCE
TGVRSLKATSYLTNFQNKFSLIGGRRVLSRFKNE

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=330, Percent_Identity=33.030303030303, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4885649, Length=142, Percent_Identity=31.6901408450704, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38045942, Length=107, Percent_Identity=40.1869158878505, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI38045944, Length=107, Percent_Identity=40.1869158878505, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=32.1138211382114, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082356, Length=179, Percent_Identity=40.2234636871508, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789177, Length=131, Percent_Identity=30.5343511450382, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=315, Percent_Identity=30.4761904761905, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI193203301, Length=155, Percent_Identity=27.741935483871, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71984476, Length=161, Percent_Identity=26.7080745341615, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=383, Percent_Identity=30.5483028720627, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322639, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582879, Length=367, Percent_Identity=31.3351498637602, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24660640, Length=157, Percent_Identity=29.2993630573248, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20129973, Length=110, Percent_Identity=32.7272727272727, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 39856; Mature: 39856

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSEKEIFFQRQCLVPEIGQEGQKKWNDASVLIIGLGGLGCPSALQLALAGVSRIGLVDF
CCCCHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEE
DVVEVSNLHRQTLFTWKDIGRKKTEVVSEVLKEHIPWIQIETFSEFLNSNSNTQIFETWD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCEEEEEEE
IVLDCTDTIISKYAINDFCLEKKIPLVTASVFRTSAQFAIFSGDGKPCYRCLFPNLSEGD
EEEECHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCEEEEECCCCCEEEEECCCCCCCC
TFSCNEGGVLGIQTSLAGNYQASLVLQYLLNPHQFELNTVYFIEWNPISFYQSKVEQDLQ
EEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHHHHCC
CPSCSEQRYLKKSEGNCLEIDQVGYLELKSKTSVILLDVREEEEVIHSPIPDAVWFPLSE
CCCCCHHHHHHHCCCCEEEECCCCEEEECCCCEEEEEEECCHHHHHHCCCCCHHHCCHHH
LEKGKSPPGISDQTIVCVCETGVRSLKATSYLTNFQNKFSLIGGRRVLSRFKNE
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSEKEIFFQRQCLVPEIGQEGQKKWNDASVLIIGLGGLGCPSALQLALAGVSRIGLVDF
CCCCHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEE
DVVEVSNLHRQTLFTWKDIGRKKTEVVSEVLKEHIPWIQIETFSEFLNSNSNTQIFETWD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCEEEEEEE
IVLDCTDTIISKYAINDFCLEKKIPLVTASVFRTSAQFAIFSGDGKPCYRCLFPNLSEGD
EEEECHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCEEEEECCCCCEEEEECCCCCCCC
TFSCNEGGVLGIQTSLAGNYQASLVLQYLLNPHQFELNTVYFIEWNPISFYQSKVEQDLQ
EEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHHHHCC
CPSCSEQRYLKKSEGNCLEIDQVGYLELKSKTSVILLDVREEEEVIHSPIPDAVWFPLSE
CCCCCHHHHHHHCCCCEEEECCCCEEEECCCCEEEEEEECCHHHHHHCCCCCHHHCCHHH
LEKGKSPPGISDQTIVCVCETGVRSLKATSYLTNFQNKFSLIGGRRVLSRFKNE
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]