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The map label for this gene is pheA [H]

Identifier: 183221757

GI number: 183221757

Start: 2458987

End: 2460078

Strand: Reverse

Name: pheA [H]

Synonym: LEPBI_I2387

Alternate gene names: 183221757

Gene position: 2460078-2458987 (Counterclockwise)

Preceding gene: 183221758

Following gene: 183221756

Centisome position: 68.34

GC content: 38.28

Gene sequence:

>1092_bases
ATGAGTAATGCGGAAGAAGAATTAAATAAACTCCGATCTGATATCGATTCCCTCGATACTCAAATCATAGATTTGATTCA
AAAACGAGCTGGTTTTGCACAGGAAATTGGTAGGGTGAAAAAAGAATCGGGTGGACCAATTTACCGACCTGATCGTGAAA
AAGATGTGTATGAAAAGGTAACAAAACTTTCCGGAGGACCACTTCCTTCTTCTGTGATCCGAGCTATTTATCGTGAAATG
ATGTCTGGCACCATCGCCTTAGAACACCCGTTAAGGATAGGTTTTTTGGGGCCAGAAGGTAGTTTTTCTCATTCGGCGCT
AAGATCCAAATTTGGAACTTCCATAGAAGCTGTTCCTCAAACTTCCATACCGGATGTATTTCGTATGGTAGAAGAAGAAA
AATTAGATTATGGTGTTGTCCCAGTTGAAAATTCGACGGAAGGGCAGGTGAGTTCCACTCTGGATATGTTTTTGGAAACA
GATCTCTTCGTCTATTCAGAGTTATACCAAAGGATCTCTTTTTCTTTACTTGGATTTGAAACAAATTTAGCTTCCGTGAA
AAAGATTTATGGAATACGGATTGGAAATGAACAATGCCGTAACTGGATCTCAGCGAACTTACCAAATGCAGAGGTTGTGG
ATACATCTTCCACTGCGATGGCTGCGAAATTAGTATCAGAACGAAAAGATGGTCTCGCAATTGCATCAAAAATTGCTGGA
GAAATTTATAACTTAGGGGTGATTGCGGAAGGCATTGAAGATTATTCAGGGAATACCACTCGGTTTTTGGTGATTGGTAA
AACCGAATCGCCTCAAACCAAAGAGGATAAAACATCTATCGTTTTTTCTATTCCCAACCAAACTGGATCATTATTTCAAA
TATTAAAAACTTTTAATGATGCTTCTGTGAACTTAACCAAAATTGAATCTAGACCACTCAAACGTAATTTATGGGAATAC
CATTTTTTCATTGATTTCATTGGTCATAAATCAGATCCAAAAATCAAATTCCTTCTTGAGTCCATCAAATCACAATGTAA
GGCATTAAAAGTCCTCGGTTCTTATCCAACTGCAGGATCCTTTCCGACATGA

Upstream 100 bases:

>100_bases
GATTTTTCACCTGATTCCATTATTGTCACTGATGAGACAGAAATGAATCCTGACTTTGATTTAGATTCTTTACCAGAAGA
ATTAAAAGAAGAGAAAATCA

Downstream 100 bases:

>100_bases
ATCTTCAGAAGGTCCTCATTTACGGAATGGGGCTTATGGGTGGATCACTTTCTCTTGCCATCCGAGACAAGTACCCCAAA
ACAAAAATTCATGCAGTGGT

Product: P-protein

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSNAEEELNKLRSDIDSLDTQIIDLIQKRAGFAQEIGRVKKESGGPIYRPDREKDVYEKVTKLSGGPLPSSVIRAIYREM
MSGTIALEHPLRIGFLGPEGSFSHSALRSKFGTSIEAVPQTSIPDVFRMVEEEKLDYGVVPVENSTEGQVSSTLDMFLET
DLFVYSELYQRISFSLLGFETNLASVKKIYGIRIGNEQCRNWISANLPNAEVVDTSSTAMAAKLVSERKDGLAIASKIAG
EIYNLGVIAEGIEDYSGNTTRFLVIGKTESPQTKEDKTSIVFSIPNQTGSLFQILKTFNDASVNLTKIESRPLKRNLWEY
HFFIDFIGHKSDPKIKFLLESIKSQCKALKVLGSYPTAGSFPT

Sequences:

>Translated_363_residues
MSNAEEELNKLRSDIDSLDTQIIDLIQKRAGFAQEIGRVKKESGGPIYRPDREKDVYEKVTKLSGGPLPSSVIRAIYREM
MSGTIALEHPLRIGFLGPEGSFSHSALRSKFGTSIEAVPQTSIPDVFRMVEEEKLDYGVVPVENSTEGQVSSTLDMFLET
DLFVYSELYQRISFSLLGFETNLASVKKIYGIRIGNEQCRNWISANLPNAEVVDTSSTAMAAKLVSERKDGLAIASKIAG
EIYNLGVIAEGIEDYSGNTTRFLVIGKTESPQTKEDKTSIVFSIPNQTGSLFQILKTFNDASVNLTKIESRPLKRNLWEY
HFFIDFIGHKSDPKIKFLLESIKSQCKALKVLGSYPTAGSFPT
>Mature_362_residues
SNAEEELNKLRSDIDSLDTQIIDLIQKRAGFAQEIGRVKKESGGPIYRPDREKDVYEKVTKLSGGPLPSSVIRAIYREMM
SGTIALEHPLRIGFLGPEGSFSHSALRSKFGTSIEAVPQTSIPDVFRMVEEEKLDYGVVPVENSTEGQVSSTLDMFLETD
LFVYSELYQRISFSLLGFETNLASVKKIYGIRIGNEQCRNWISANLPNAEVVDTSSTAMAAKLVSERKDGLAIASKIAGE
IYNLGVIAEGIEDYSGNTTRFLVIGKTESPQTKEDKTSIVFSIPNQTGSLFQILKTFNDASVNLTKIESRPLKRNLWEYH
FFIDFIGHKSDPKIKFLLESIKSQCKALKVLGSYPTAGSFPT

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=381, Percent_Identity=27.0341207349081, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324013, Length=322, Percent_Identity=29.1925465838509, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 40303; Mature: 40172

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAEEELNKLRSDIDSLDTQIIDLIQKRAGFAQEIGRVKKESGGPIYRPDREKDVYEKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TKLSGGPLPSSVIRAIYREMMSGTIALEHPLRIGFLGPEGSFSHSALRSKFGTSIEAVPQ
HHCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCCHHHHHHHHHCCCEECCCC
TSIPDVFRMVEEEKLDYGVVPVENSTEGQVSSTLDMFLETDLFVYSELYQRISFSLLGFE
CCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TNLASVKKIYGIRIGNEQCRNWISANLPNAEVVDTSSTAMAAKLVSERKDGLAIASKIAG
CCHHHHHHHHHEEECCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
EIYNLGVIAEGIEDYSGNTTRFLVIGKTESPQTKEDKTSIVFSIPNQTGSLFQILKTFND
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
ASVNLTKIESRPLKRNLWEYHFFIDFIGHKSDPKIKFLLESIKSQCKALKVLGSYPTAGS
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
FPT
CCC
>Mature Secondary Structure 
SNAEEELNKLRSDIDSLDTQIIDLIQKRAGFAQEIGRVKKESGGPIYRPDREKDVYEKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TKLSGGPLPSSVIRAIYREMMSGTIALEHPLRIGFLGPEGSFSHSALRSKFGTSIEAVPQ
HHCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCCHHHHHHHHHCCCEECCCC
TSIPDVFRMVEEEKLDYGVVPVENSTEGQVSSTLDMFLETDLFVYSELYQRISFSLLGFE
CCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TNLASVKKIYGIRIGNEQCRNWISANLPNAEVVDTSSTAMAAKLVSERKDGLAIASKIAG
CCHHHHHHHHHEEECCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
EIYNLGVIAEGIEDYSGNTTRFLVIGKTESPQTKEDKTSIVFSIPNQTGSLFQILKTFND
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
ASVNLTKIESRPLKRNLWEYHFFIDFIGHKSDPKIKFLLESIKSQCKALKVLGSYPTAGS
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
FPT
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1919506; 10368439 [H]