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The map label for this gene is perR [H]

Identifier: 183221534

GI number: 183221534

Start: 2241479

End: 2241853

Strand: Reverse

Name: perR [H]

Synonym: LEPBI_I2152

Alternate gene names: 183221534

Gene position: 2241853-2241479 (Counterclockwise)

Preceding gene: 183221538

Following gene: 183221533

Centisome position: 62.28

GC content: 43.2

Gene sequence:

>375_bases
ATGAAAGCATTGACCAAACACAGAGAATTGATTTTACAAGATCTAAAAGACAGGCACGACCATCCAACCGCAAAAATGGT
ATTTGAGTCAGTTCGGGACAAAGCAGACAAAATCAGTTTTGCCACAGTCTACAATTCCTTGGAATACTTGGTAGACCACA
ATCTAGTGAACAAACTCAATATTGAATCGGATTCGGTTCGTTACGATGCCTTCCTGGATGACCATTCGCATTTGATTTGT
AAGTCTTGTGGTACCGTTCTTGATGTCCCAGCCTTACAACTCAGTGCCAATACGGATTGGAAAGCCATGGGATTTGTGGC
AGACCACATAGACATTGTGGTGAGTGGCACCTGTTCGTCTTGCCAATCCCTCTAA

Upstream 100 bases:

>100_bases
TCCGTATTGACAAATATCAATTTCTGGAAGGATTCTAAAATCGAAATTCCATTTGACCCTTTGATAATTTTACGAGTCTC
ATAAGGGAAAGGGCATCTCC

Downstream 100 bases:

>100_bases
AATGTAATGGATAGGGAGGTTTCCCCTCCCAAGCTTGCCCTATATGGGCATCATCCATTCCCTCTCTCCCGACCTCATCA
ACCAAATTGCCGCGGGAGAA

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MKALTKHRELILQDLKDRHDHPTAKMVFESVRDKADKISFATVYNSLEYLVDHNLVNKLNIESDSVRYDAFLDDHSHLIC
KSCGTVLDVPALQLSANTDWKAMGFVADHIDIVVSGTCSSCQSL

Sequences:

>Translated_124_residues
MKALTKHRELILQDLKDRHDHPTAKMVFESVRDKADKISFATVYNSLEYLVDHNLVNKLNIESDSVRYDAFLDDHSHLIC
KSCGTVLDVPALQLSANTDWKAMGFVADHIDIVVSGTCSSCQSL
>Mature_124_residues
MKALTKHRELILQDLKDRHDHPTAKMVFESVRDKADKISFATVYNSLEYLVDHNLVNKLNIESDSVRYDAFLDDHSHLIC
KSCGTVLDVPALQLSANTDWKAMGFVADHIDIVVSGTCSSCQSL

Specific function: Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 13920; Mature: 13920

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTKHRELILQDLKDRHDHPTAKMVFESVRDKADKISFATVYNSLEYLVDHNLVNKLN
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IESDSVRYDAFLDDHSHLICKSCGTVLDVPALQLSANTDWKAMGFVADHIDIVVSGTCSS
CCCCCEEEEEEECCCCHHHHHHCCCEECCCCEEEECCCCCHHHHHHHCCEEEEEECCCHH
CQSL
CCCC
>Mature Secondary Structure
MKALTKHRELILQDLKDRHDHPTAKMVFESVRDKADKISFATVYNSLEYLVDHNLVNKLN
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IESDSVRYDAFLDDHSHLICKSCGTVLDVPALQLSANTDWKAMGFVADHIDIVVSGTCSS
CCCCCEEEEEEECCCCHHHHHHCCCEECCCCEEEECCCCCHHHHHHHCCEEEEEECCCHH
CQSL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202460; 9384377; 9701813; 12100544 [H]