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The map label for this gene is mutL

Identifier: 183221533

GI number: 183221533

Start: 2239591

End: 2241435

Strand: Reverse

Name: mutL

Synonym: LEPBI_I2151

Alternate gene names: 183221533

Gene position: 2241435-2239591 (Counterclockwise)

Preceding gene: 183221534

Following gene: 183221532

Centisome position: 62.27

GC content: 46.34

Gene sequence:

>1845_bases
ATGGGCATCATCCATTCCCTCTCTCCCGACCTCATCAACCAAATTGCCGCGGGAGAAGTCATTGAATCCACTCATTCCAT
CCTAAAAGAACTCATTGAAAATTCCATCGATGCGGGTGCTTCGAAGATTGAAATTGCAACCGAAAGCGCAGGCCTTGGCC
GGATCCTTGTTTCCGACGACGGGCACGGGATTACGAAAGAGGATTTGCCTCTTGCCATCAAACGGTATGCCACAAGTAAA
ATCCAAACCTTCCACGACTTAGAACACCTCTTCACCTTTGGGTTTCGGGGGGAGGCACTTGCGTCCATTGCCTCGGTTTC
AAGGCTTGTGATTGAGTCAGGGACAGAAGGAAACCGCATGGCTCAACGTGTGGTAGTAGAGGAAGGAAAGGTGGTATCGG
AAGAAGAGATTCCATTTTTCCAAGGGACAAAGATTGAAATCAAAGATTTATTCTACAATACGCCTGTTAGGCGAAAGTTC
TTAAAAACGGAATCGGGGGAAGAGAAAAAAAACAGAACCCGAGTCCAAACCATGGCACTCGGCGAACCTTCCATCGGGTT
TCGGTATGTACAAAATGGAAAGGAAGTGTTCCATGTCCAAAAAGAAGAACCTTTGGAACGGGTGCTTTCGATTTACGGTG
AAAACCTTCGGGACCATCTTTTGCCTGTCCACTCGAGCCGCAATGGAATGACCTTACGTGGGTTTATCTCTCATCCAGAT
TTTTACAAATCTTCTCGGATGGGCCAGTTTTTTTTCGTGAACAACCGTTCGGTGGAACTCAAATTTTCAGCCCAAATTTT
GAAACGTTGTTACGGGGAATTATTACCAAGTGGTGCCTTTCCGTATGCCTTTTTGTTTTTTGATCTGCCTCGTGAGTTTG
TGGATGTGAATGTCCACCCCCAAAAAAAAGAAGTTCGGTTTTTATCAGAAGAAACCATCACGGGGATCTTATTCCAAGGG
ATCACAGAAGTTTTACGTACCTCAACCCCTGTTGAATTTTTAGAAATGAGACGTAGGCTTTCCATGCCCATACCATACCA
TTCATCGGCCGACAAATCACAGTTTGGTGGTGAAGGTATGTCAATGGGAGGTCCTGGGTTTGGCTTTGGGATGGCGGGCA
GAGGACAAGCCGTGTGGGGGAGTCAAAATGAAGAAGGAAACCCACTTCTCGGACCAAGTTCCATTGAGGGAAGGGCCGGT
TTTTCTTTGGATGGGATTGGTGCCGGAACAAACTTACATTTACTCGGTGACAATCTGACCAAACACAATTTGTTTGTTCC
GAAAAAACACTATGGAGTGATTTTTGAAACCTTTATTTTGGCGGAAGCAGAAGACGGGCTCTACATCATCGACCAACACA
CAGCCCACGAACGGATTCGTTACGAAGAGGTTCTACGTGATTTAAAATCGAAAGCCTACAAATCCCAAAGTTTACTCACA
CCCATCCGACTCGAGCTCACAAAAGAGGAAGCAGAGGAGATGATCGCAGAAAAACATCGGTTTTCTGAACTTGGGATCAC
ACTCGAACCATTCTCTGGTGGCACCATCCTCATCCGCGAGGTTCCGTCTTATATCGATCCAGGGAAAGAAACAGAAACCA
TCCTCGACCTTTGGGAACGATTCAAATCCAAGGACCCAGAAGAGAAAGAGTTGTATGATGAGATGGCAAAATGTGTCGCC
TGTCGGTCGGCCATCAAAAAAGGGGACCAGGTCTCTGATCCCATCATTGGCGAACTCTTACAAAGGCTTTCCTATTGTGA
AAACCCTTCCCTTTGCCCGCATGGTCGGCCCACCCTCATCAAACTCACAAGAAAAGACTTAGAGACCATGTTCCATAGAA
TCTAA

Upstream 100 bases:

>100_bases
GCAGACCACATAGACATTGTGGTGAGTGGCACCTGTTCGTCTTGCCAATCCCTCTAAAATGTAATGGATAGGGAGGTTTC
CCCTCCCAAGCTTGCCCTAT

Downstream 100 bases:

>100_bases
ACTGCCAGCAGATACCGAAAAACATTGATTGATTTATCGGTTTCGAAATTCTAGGTTCTGATGTCAAGACCCTTAGAAGG
CAAAAACATGACCCTGCGTG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MGIIHSLSPDLINQIAAGEVIESTHSILKELIENSIDAGASKIEIATESAGLGRILVSDDGHGITKEDLPLAIKRYATSK
IQTFHDLEHLFTFGFRGEALASIASVSRLVIESGTEGNRMAQRVVVEEGKVVSEEEIPFFQGTKIEIKDLFYNTPVRRKF
LKTESGEEKKNRTRVQTMALGEPSIGFRYVQNGKEVFHVQKEEPLERVLSIYGENLRDHLLPVHSSRNGMTLRGFISHPD
FYKSSRMGQFFFVNNRSVELKFSAQILKRCYGELLPSGAFPYAFLFFDLPREFVDVNVHPQKKEVRFLSEETITGILFQG
ITEVLRTSTPVEFLEMRRRLSMPIPYHSSADKSQFGGEGMSMGGPGFGFGMAGRGQAVWGSQNEEGNPLLGPSSIEGRAG
FSLDGIGAGTNLHLLGDNLTKHNLFVPKKHYGVIFETFILAEAEDGLYIIDQHTAHERIRYEEVLRDLKSKAYKSQSLLT
PIRLELTKEEAEEMIAEKHRFSELGITLEPFSGGTILIREVPSYIDPGKETETILDLWERFKSKDPEEKELYDEMAKCVA
CRSAIKKGDQVSDPIIGELLQRLSYCENPSLCPHGRPTLIKLTRKDLETMFHRI

Sequences:

>Translated_614_residues
MGIIHSLSPDLINQIAAGEVIESTHSILKELIENSIDAGASKIEIATESAGLGRILVSDDGHGITKEDLPLAIKRYATSK
IQTFHDLEHLFTFGFRGEALASIASVSRLVIESGTEGNRMAQRVVVEEGKVVSEEEIPFFQGTKIEIKDLFYNTPVRRKF
LKTESGEEKKNRTRVQTMALGEPSIGFRYVQNGKEVFHVQKEEPLERVLSIYGENLRDHLLPVHSSRNGMTLRGFISHPD
FYKSSRMGQFFFVNNRSVELKFSAQILKRCYGELLPSGAFPYAFLFFDLPREFVDVNVHPQKKEVRFLSEETITGILFQG
ITEVLRTSTPVEFLEMRRRLSMPIPYHSSADKSQFGGEGMSMGGPGFGFGMAGRGQAVWGSQNEEGNPLLGPSSIEGRAG
FSLDGIGAGTNLHLLGDNLTKHNLFVPKKHYGVIFETFILAEAEDGLYIIDQHTAHERIRYEEVLRDLKSKAYKSQSLLT
PIRLELTKEEAEEMIAEKHRFSELGITLEPFSGGTILIREVPSYIDPGKETETILDLWERFKSKDPEEKELYDEMAKCVA
CRSAIKKGDQVSDPIIGELLQRLSYCENPSLCPHGRPTLIKLTRKDLETMFHRI
>Mature_613_residues
GIIHSLSPDLINQIAAGEVIESTHSILKELIENSIDAGASKIEIATESAGLGRILVSDDGHGITKEDLPLAIKRYATSKI
QTFHDLEHLFTFGFRGEALASIASVSRLVIESGTEGNRMAQRVVVEEGKVVSEEEIPFFQGTKIEIKDLFYNTPVRRKFL
KTESGEEKKNRTRVQTMALGEPSIGFRYVQNGKEVFHVQKEEPLERVLSIYGENLRDHLLPVHSSRNGMTLRGFISHPDF
YKSSRMGQFFFVNNRSVELKFSAQILKRCYGELLPSGAFPYAFLFFDLPREFVDVNVHPQKKEVRFLSEETITGILFQGI
TEVLRTSTPVEFLEMRRRLSMPIPYHSSADKSQFGGEGMSMGGPGFGFGMAGRGQAVWGSQNEEGNPLLGPSSIEGRAGF
SLDGIGAGTNLHLLGDNLTKHNLFVPKKHYGVIFETFILAEAEDGLYIIDQHTAHERIRYEEVLRDLKSKAYKSQSLLTP
IRLELTKEEAEEMIAEKHRFSELGITLEPFSGGTILIREVPSYIDPGKETETILDLWERFKSKDPEEKELYDEMAKCVAC
RSAIKKGDQVSDPIIGELLQRLSYCENPSLCPHGRPTLIKLTRKDLETMFHRI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=318, Percent_Identity=35.2201257861635, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4505911, Length=316, Percent_Identity=30.379746835443, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI189458898, Length=316, Percent_Identity=30.379746835443, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI189458896, Length=305, Percent_Identity=29.8360655737705, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI4505913, Length=337, Percent_Identity=27.893175074184, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI310128478, Length=337, Percent_Identity=27.893175074184, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=31.0810810810811, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=26.1744966442953, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1790612, Length=543, Percent_Identity=30.3867403314917, Blast_Score=212, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=35.9133126934984, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562796, Length=356, Percent_Identity=26.685393258427, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=323, Percent_Identity=35.9133126934984, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=30.028328611898, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=723, Percent_Identity=23.789764868603, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323063, Length=354, Percent_Identity=23.1638418079096, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=33.7386018237082, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI17136970, Length=352, Percent_Identity=28.6931818181818, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_LEPBA (B0SB85)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963169.1
- ProteinModelPortal:   B0SB85
- SMR:   B0SB85
- GeneID:   6387719
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2096
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   CLSK573800
- BioCyc:   LBIF355278:LBF_2096-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69050; Mature: 68919

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIHSLSPDLINQIAAGEVIESTHSILKELIENSIDAGASKIEIATESAGLGRILVSDD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCC
GHGITKEDLPLAIKRYATSKIQTFHDLEHLFTFGFRGEALASIASVSRLVIESGTEGNRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
AQRVVVEEGKVVSEEEIPFFQGTKIEIKDLFYNTPVRRKFLKTESGEEKKNRTRVQTMAL
HHHHHHHCCCEECCCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCHHHHHHHHHEEEC
GEPSIGFRYVQNGKEVFHVQKEEPLERVLSIYGENLRDHLLPVHSSRNGMTLRGFISHPD
CCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHCEECCCCCCCCEEEEECCCCC
FYKSSRMGQFFFVNNRSVELKFSAQILKRCYGELLPSGAFPYAFLFFDLPREFVDVNVHP
HHHHCCCCEEEEEECCEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHEECCCCC
QKKEVRFLSEETITGILFQGITEVLRTSTPVEFLEMRRRLSMPIPYHSSADKSQFGGEGM
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCCC
SMGGPGFGFGMAGRGQAVWGSQNEEGNPLLGPSSIEGRAGFSLDGIGAGTNLHLLGDNLT
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
KHNLFVPKKHYGVIFETFILAEAEDGLYIIDQHTAHERIRYEEVLRDLKSKAYKSQSLLT
CCCEECCCHHCCHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PIRLELTKEEAEEMIAEKHRFSELGITLEPFSGGTILIREVPSYIDPGKETETILDLWER
HHHEEECHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECHHHCCCCCHHHHHHHHHHH
FKSKDPEEKELYDEMAKCVACRSAIKKGDQVSDPIIGELLQRLSYCENPSLCPHGRPTLI
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEE
KLTRKDLETMFHRI
EHHHHHHHHHHHCC
>Mature Secondary Structure 
GIIHSLSPDLINQIAAGEVIESTHSILKELIENSIDAGASKIEIATESAGLGRILVSDD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCC
GHGITKEDLPLAIKRYATSKIQTFHDLEHLFTFGFRGEALASIASVSRLVIESGTEGNRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
AQRVVVEEGKVVSEEEIPFFQGTKIEIKDLFYNTPVRRKFLKTESGEEKKNRTRVQTMAL
HHHHHHHCCCEECCCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCHHHHHHHHHEEEC
GEPSIGFRYVQNGKEVFHVQKEEPLERVLSIYGENLRDHLLPVHSSRNGMTLRGFISHPD
CCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHCEECCCCCCCCEEEEECCCCC
FYKSSRMGQFFFVNNRSVELKFSAQILKRCYGELLPSGAFPYAFLFFDLPREFVDVNVHP
HHHHCCCCEEEEEECCEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHEECCCCC
QKKEVRFLSEETITGILFQGITEVLRTSTPVEFLEMRRRLSMPIPYHSSADKSQFGGEGM
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCCC
SMGGPGFGFGMAGRGQAVWGSQNEEGNPLLGPSSIEGRAGFSLDGIGAGTNLHLLGDNLT
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
KHNLFVPKKHYGVIFETFILAEAEDGLYIIDQHTAHERIRYEEVLRDLKSKAYKSQSLLT
CCCEECCCHHCCHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PIRLELTKEEAEEMIAEKHRFSELGITLEPFSGGTILIREVPSYIDPGKETETILDLWER
HHHEEECHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECHHHCCCCCHHHHHHHHHHH
FKSKDPEEKELYDEMAKCVACRSAIKKGDQVSDPIIGELLQRLSYCENPSLCPHGRPTLI
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEE
KLTRKDLETMFHRI
EHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA