Click here to switch to the map view.

The map label for this gene is serA2 [H]

Identifier: 183221282

GI number: 183221282

Start: 1991775

End: 1992998

Strand: Direct

Name: serA2 [H]

Synonym: LEPBI_I1899

Alternate gene names: 183221282

Gene position: 1991775-1992998 (Clockwise)

Preceding gene: 183221280

Following gene: 183221283

Centisome position: 55.33

GC content: 40.28

Gene sequence:

>1224_bases
ATGGTATCTTATCCCAAAGGAAAAATAAAAGTCCTACTCCTGGAAAACATCCACAAGGATGCATATGAACTTTTCCACCG
AGATGGTTTTGATGTGACTCTCGTCAAAGATGCGATGGAAGAAGCGGAACTCATCGAAAAAATCGCAGATGTTCATGTCC
TCGGCATCCGCAGCAAAACAAATGTCACAAAGAAAGCGTTAGACAATGCAAAAAAATTAATGACGATCGGCTGTTTTTGT
ATTGGAACGAACCAAGTCGAATTGGAAGAAGCAGAAAAAAAAGCAGTTCCCGTTTTTAATGCTCCCTATAGCAACACTCG
GTCAGTCGCAGAACTTGTGATAGCTGAGATCATCATGCTCGCAAGGAAAGCATCTGACCAATCAAAAGATGTCCACCTTG
GTAAATGGAATAAAATAGCCAAGGGATGTTTTGAAGTACGAGGAAAAACGCTTGGGATCATTGGGTATGGGCATATTGGA
ACACAAGTATCCGTACTTGCCGAATCCATGGGGATGCGTGTTGTGTTTTATGATATCATTTCCAAACTCCCACTTGGGAA
TGCAACCGCTGCGCATAATTATGAAGAAGTTCTAAGACAAGCTGATTTTATCTCCTTTCATGTACCGGAAACAGAAGAGA
CCAAAAATTTATTCCGAAAAGAACATTTACCACTTCTAAAAGATGGCTCCTATGTTTTGAATTTGTCTCGCGGAAAGGTT
TTGGAAATTGATGCCCTTGTCGAAGGAATCAAATCTGGAAAAATTGCGGGAGCAGGTGTGGATGTTTTCCCAGAAGAACC
TAAGTCCAATGATGATCCCTTTGTGAGCGCACTCCAAGGTTTACCAAATGTAATCCTCACACCTCATATTGGAGGATCCA
CTGAGGAAGCGCAAAAAAATATTGGAACAGAAGTTGCGGAAAAATTATTAAAATTCATCAACAACGGCTCTACCACTTTT
TCTGTGAATTTTCCCAATATTGAACTTGGAAGTTTGAAATCCGGTTATCATCGTATTTTAAACATCCACCAAAACCAACC
AGGGTTTTTACGGGACATCAACTCGATCATCTCGGATATGGGCGGAAATATCCTAACTCAAAACCTCAGCACATCAACAA
ACATAGGTTATTTGAGTATGGAAATCGACAAAAACCTGGGTGATGAATTGAAAGATAAAATCAAAGCCCACAAACATTCG
ATTCGCACTCGAATTCTCTACTAA

Upstream 100 bases:

>100_bases
GGGAAATGGAGGAAATTCGGGTCAATGAGAAGATTCTTTCCATGATAAGCCCAACCTTTTTCGAGATGCAAGGTTTGGCA
AAGGAAAAAATCCTGTTCCT

Downstream 100 bases:

>100_bases
CCAACCGGGAAGGATCAGATCATCATGATGGAAGTCCTTCCCATTTTTACGAACTCACCCTTACGCAATTACACCTATCT
CATTTACTCAAATCGAACAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MVSYPKGKIKVLLLENIHKDAYELFHRDGFDVTLVKDAMEEAELIEKIADVHVLGIRSKTNVTKKALDNAKKLMTIGCFC
IGTNQVELEEAEKKAVPVFNAPYSNTRSVAELVIAEIIMLARKASDQSKDVHLGKWNKIAKGCFEVRGKTLGIIGYGHIG
TQVSVLAESMGMRVVFYDIISKLPLGNATAAHNYEEVLRQADFISFHVPETEETKNLFRKEHLPLLKDGSYVLNLSRGKV
LEIDALVEGIKSGKIAGAGVDVFPEEPKSNDDPFVSALQGLPNVILTPHIGGSTEEAQKNIGTEVAEKLLKFINNGSTTF
SVNFPNIELGSLKSGYHRILNIHQNQPGFLRDINSIISDMGGNILTQNLSTSTNIGYLSMEIDKNLGDELKDKIKAHKHS
IRTRILY

Sequences:

>Translated_407_residues
MVSYPKGKIKVLLLENIHKDAYELFHRDGFDVTLVKDAMEEAELIEKIADVHVLGIRSKTNVTKKALDNAKKLMTIGCFC
IGTNQVELEEAEKKAVPVFNAPYSNTRSVAELVIAEIIMLARKASDQSKDVHLGKWNKIAKGCFEVRGKTLGIIGYGHIG
TQVSVLAESMGMRVVFYDIISKLPLGNATAAHNYEEVLRQADFISFHVPETEETKNLFRKEHLPLLKDGSYVLNLSRGKV
LEIDALVEGIKSGKIAGAGVDVFPEEPKSNDDPFVSALQGLPNVILTPHIGGSTEEAQKNIGTEVAEKLLKFINNGSTTF
SVNFPNIELGSLKSGYHRILNIHQNQPGFLRDINSIISDMGGNILTQNLSTSTNIGYLSMEIDKNLGDELKDKIKAHKHS
IRTRILY
>Mature_407_residues
MVSYPKGKIKVLLLENIHKDAYELFHRDGFDVTLVKDAMEEAELIEKIADVHVLGIRSKTNVTKKALDNAKKLMTIGCFC
IGTNQVELEEAEKKAVPVFNAPYSNTRSVAELVIAEIIMLARKASDQSKDVHLGKWNKIAKGCFEVRGKTLGIIGYGHIG
TQVSVLAESMGMRVVFYDIISKLPLGNATAAHNYEEVLRQADFISFHVPETEETKNLFRKEHLPLLKDGSYVLNLSRGKV
LEIDALVEGIKSGKIAGAGVDVFPEEPKSNDDPFVSALQGLPNVILTPHIGGSTEEAQKNIGTEVAEKLLKFINNGSTTF
SVNFPNIELGSLKSGYHRILNIHQNQPGFLRDINSIISDMGGNILTQNLSTSTNIGYLSMEIDKNLGDELKDKIKAHKHS
IRTRILY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=325, Percent_Identity=34.7692307692308, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI145580578, Length=289, Percent_Identity=26.643598615917, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4557499, Length=289, Percent_Identity=26.643598615917, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4557497, Length=292, Percent_Identity=26.3698630136986, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI61743967, Length=292, Percent_Identity=26.3698630136986, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI145580575, Length=290, Percent_Identity=26.8965517241379, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=49.8777506112469, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=27.1375464684015, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=302, Percent_Identity=26.4900662251656, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081824, Length=190, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788660, Length=329, Percent_Identity=26.1398176291793, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=312, Percent_Identity=32.6923076923077, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=289, Percent_Identity=26.643598615917, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=418, Percent_Identity=48.5645933014354, Blast_Score=408, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322116, Length=418, Percent_Identity=48.5645933014354, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=29.2490118577075, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=27.5675675675676, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=27.741935483871, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=32.0872274143302, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646446, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646448, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646452, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646450, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI62472511, Length=291, Percent_Identity=28.5223367697594, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574286, Length=278, Percent_Identity=26.978417266187, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=25.886524822695, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=25.886524822695, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=25.886524822695, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=25.886524822695, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=25.886524822695, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571528, Length=281, Percent_Identity=28.8256227758007, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=23.5294117647059, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44951; Mature: 44951

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYPKGKIKVLLLENIHKDAYELFHRDGFDVTLVKDAMEEAELIEKIADVHVLGIRSKT
CCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCEEEEEECCCC
NVTKKALDNAKKLMTIGCFCIGTNQVELEEAEKKAVPVFNAPYSNTRSVAELVIAEIIML
HHHHHHHHHHHHHHHEEEEEEECCCEEHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
ARKASDQSKDVHLGKWNKIAKGCFEVRGKTLGIIGYGHIGTQVSVLAESMGMRVVFYDII
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEHHHHHH
SKLPLGNATAAHNYEEVLRQADFISFHVPETEETKNLFRKEHLPLLKDGSYVLNLSRGKV
HHCCCCCCHHHCCHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEECCCEEEEECCCCE
LEIDALVEGIKSGKIAGAGVDVFPEEPKSNDDPFVSALQGLPNVILTPHIGGSTEEAQKN
EEHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCHHHHHHH
IGTEVAEKLLKFINNGSTTFSVNFPNIELGSLKSGYHRILNIHQNQPGFLRDINSIISDM
HHHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHEECCCCCHHHHHHHHHHHHC
GGNILTQNLSTSTNIGYLSMEIDKNLGDELKDKIKAHKHSIRTRILY
CCCEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSYPKGKIKVLLLENIHKDAYELFHRDGFDVTLVKDAMEEAELIEKIADVHVLGIRSKT
CCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCEEEEEECCCC
NVTKKALDNAKKLMTIGCFCIGTNQVELEEAEKKAVPVFNAPYSNTRSVAELVIAEIIML
HHHHHHHHHHHHHHHEEEEEEECCCEEHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
ARKASDQSKDVHLGKWNKIAKGCFEVRGKTLGIIGYGHIGTQVSVLAESMGMRVVFYDII
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEHHHHHH
SKLPLGNATAAHNYEEVLRQADFISFHVPETEETKNLFRKEHLPLLKDGSYVLNLSRGKV
HHCCCCCCHHHCCHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEECCCEEEEECCCCE
LEIDALVEGIKSGKIAGAGVDVFPEEPKSNDDPFVSALQGLPNVILTPHIGGSTEEAQKN
EEHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCHHHHHHH
IGTEVAEKLLKFINNGSTTFSVNFPNIELGSLKSGYHRILNIHQNQPGFLRDINSIISDM
HHHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHEECCCCCHHHHHHHHHHHHC
GGNILTQNLSTSTNIGYLSMEIDKNLGDELKDKIKAHKHSIRTRILY
CCCEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]