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The map label for this gene is panF [H]

Identifier: 183221246

GI number: 183221246

Start: 1952205

End: 1953515

Strand: Direct

Name: panF [H]

Synonym: LEPBI_I1862

Alternate gene names: 183221246

Gene position: 1952205-1953515 (Clockwise)

Preceding gene: 183221245

Following gene: 183221248

Centisome position: 54.23

GC content: 40.96

Gene sequence:

>1311_bases
ATGAATTTGCAAGCCATCTTCATTCTTGCCTACCTCGCCATTACCATAGGCATTGGCGTGTATGCGGCCCAAAAAGTCAA
AAATTCAAAAGACTTCATCCTTGCTGGTAGAAGTTTACCACTCCCCATTTCCACTGCTGCCTTATTTGCCACTTGGTTCG
GGAGCGAAACCATCCTTGGCTCGTCTGTCGAATTTGCAAAGGGTGGATTTTTAGCTGTCATCCAAGACCCGTTTGGTGGT
GCACTTTGTTTGTTTTTACTAGGATTAGTCTTTGCCAAATACCTCTACCGAATGCAAATCTTAACGTTCGGAGATTTTTA
TAAAAATCGGTATGGCAAAAAGATGGAATTCATTGCTGGGATCTGTCTTATTTTTTCCTATTTTGGATGGGTGGCGGCAC
AATTTGTGGCCCTTGGGATCATGGTGCAAATTTTATTTGGCATCAACCAATTCACAGCCATCGTCATCGGGCTTGTCGTT
GTCATCATCCAACTGAACGATGTTAAACCAATCTGGTCTTCCATTAGCGAAAAACCGGATGGATTCTTTTCCTTCTTTCC
AAAATCAAATTACCACGATTGGACCTTGTACCTCTCGGCTTGGATGGTTGTGGGATTTGGATCATTACCCCAACAAGATA
TCTTTCAGAGAGTGATGTCAGCCAAATCAGAAAAAGTAGCCATACGTGCCTCATATTATTCATCCGTCTTATACTTGTTA
TTTGCCTTAATCCCACTTTTTCTTGGACTTCATGCCAAAAGTTTACTTCCGGATTTTGATTTATATGCTGAATCGGGTCA
ACTCCTCATACCAACAATGGTTTCTAAATTTGTAAGCCCTTGGGTTCAGGTTTTATTTTTTTCGGCACTCATCTCAGCCA
TTTTATCAACAGCATCCGGAGCCATCCTTGCTCCTTCTTCCATTTTATCTGAGAATATTCTAAAATACGCATTTAAAGAA
ATGAATGATAAAAAATTACTCCTATTATCAAGGATTTCAGTTCTTATCATAGCAGGGATTTCTTTTTTACTCGCGGTGGG
TAAACCTTCCATCTATGCACTCGTAGAAGATTCCGGTGGAATCTCCCTTGTCACACTCTTTATCCCCATGGTATTTGGAC
TTTTGAGTCAGCGAGCCGACGAAAGGTCTACACTATTCTCTCTTTTTGTAGGAATTGGTACTTGGCTCTTACTTGAGATT
TATGGCGATGATATGACCAGTCATTTTTACGGAACCATCGCAAGCCTTGTGGCCATTCTCATTGGAATGTATCTCTTCCC
TAAGAAAGAGAAATCTCAAGTAACCACGTAA

Upstream 100 bases:

>100_bases
CTTAACAAAAGCACCTAACGGTGAAGTGGTGAAATCCACTGTGAAAAAAAAGAAGGATGAATCACCTTCAAAACAAGCGG
AAGAAGATTTATTTTAAAGA

Downstream 100 bases:

>100_bases
ATACATCTTTCATATTGATCCCCAAGGCTTTCGCTTGTTGAGGGATGAGACTTGTTCCCGTCATTCCAGGTAAGGTATTG
GTTTCTAGTACATAGGGAAC

Product: sodium:solute symporter family protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNLQAIFILAYLAITIGIGVYAAQKVKNSKDFILAGRSLPLPISTAALFATWFGSETILGSSVEFAKGGFLAVIQDPFGG
ALCLFLLGLVFAKYLYRMQILTFGDFYKNRYGKKMEFIAGICLIFSYFGWVAAQFVALGIMVQILFGINQFTAIVIGLVV
VIIQLNDVKPIWSSISEKPDGFFSFFPKSNYHDWTLYLSAWMVVGFGSLPQQDIFQRVMSAKSEKVAIRASYYSSVLYLL
FALIPLFLGLHAKSLLPDFDLYAESGQLLIPTMVSKFVSPWVQVLFFSALISAILSTASGAILAPSSILSENILKYAFKE
MNDKKLLLLSRISVLIIAGISFLLAVGKPSIYALVEDSGGISLVTLFIPMVFGLLSQRADERSTLFSLFVGIGTWLLLEI
YGDDMTSHFYGTIASLVAILIGMYLFPKKEKSQVTT

Sequences:

>Translated_436_residues
MNLQAIFILAYLAITIGIGVYAAQKVKNSKDFILAGRSLPLPISTAALFATWFGSETILGSSVEFAKGGFLAVIQDPFGG
ALCLFLLGLVFAKYLYRMQILTFGDFYKNRYGKKMEFIAGICLIFSYFGWVAAQFVALGIMVQILFGINQFTAIVIGLVV
VIIQLNDVKPIWSSISEKPDGFFSFFPKSNYHDWTLYLSAWMVVGFGSLPQQDIFQRVMSAKSEKVAIRASYYSSVLYLL
FALIPLFLGLHAKSLLPDFDLYAESGQLLIPTMVSKFVSPWVQVLFFSALISAILSTASGAILAPSSILSENILKYAFKE
MNDKKLLLLSRISVLIIAGISFLLAVGKPSIYALVEDSGGISLVTLFIPMVFGLLSQRADERSTLFSLFVGIGTWLLLEI
YGDDMTSHFYGTIASLVAILIGMYLFPKKEKSQVTT
>Mature_436_residues
MNLQAIFILAYLAITIGIGVYAAQKVKNSKDFILAGRSLPLPISTAALFATWFGSETILGSSVEFAKGGFLAVIQDPFGG
ALCLFLLGLVFAKYLYRMQILTFGDFYKNRYGKKMEFIAGICLIFSYFGWVAAQFVALGIMVQILFGINQFTAIVIGLVV
VIIQLNDVKPIWSSISEKPDGFFSFFPKSNYHDWTLYLSAWMVVGFGSLPQQDIFQRVMSAKSEKVAIRASYYSSVLYLL
FALIPLFLGLHAKSLLPDFDLYAESGQLLIPTMVSKFVSPWVQVLFFSALISAILSTASGAILAPSSILSENILKYAFKE
MNDKKLLLLSRISVLIIAGISFLLAVGKPSIYALVEDSGGISLVTLFIPMVFGLLSQRADERSTLFSLFVGIGTWLLLEI
YGDDMTSHFYGTIASLVAILIGMYLFPKKEKSQVTT

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=389, Percent_Identity=24.4215938303342, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI87082237, Length=451, Percent_Identity=24.6119733924612, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539284, Length=433, Percent_Identity=23.3256351039261, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24648033, Length=407, Percent_Identity=24.8157248157248, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356865, Length=407, Percent_Identity=24.8157248157248, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 48059; Mature: 48059

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQAIFILAYLAITIGIGVYAAQKVKNSKDFILAGRSLPLPISTAALFATWFGSETILG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHCC
SSVEFAKGGFLAVIQDPFGGALCLFLLGLVFAKYLYRMQILTFGDFYKNRYGKKMEFIAG
CCCHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ICLIFSYFGWVAAQFVALGIMVQILFGINQFTAIVIGLVVVIIQLNDVKPIWSSISEKPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
GFFSFFPKSNYHDWTLYLSAWMVVGFGSLPQQDIFQRVMSAKSEKVAIRASYYSSVLYLL
CCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
FALIPLFLGLHAKSLLPDFDLYAESGQLLIPTMVSKFVSPWVQVLFFSALISAILSTASG
HHHHHHHHHHHHHHHCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AILAPSSILSENILKYAFKEMNDKKLLLLSRISVLIIAGISFLLAVGKPSIYALVEDSGG
CEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
ISLVTLFIPMVFGLLSQRADERSTLFSLFVGIGTWLLLEIYGDDMTSHFYGTIASLVAIL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IGMYLFPKKEKSQVTT
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNLQAIFILAYLAITIGIGVYAAQKVKNSKDFILAGRSLPLPISTAALFATWFGSETILG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHCC
SSVEFAKGGFLAVIQDPFGGALCLFLLGLVFAKYLYRMQILTFGDFYKNRYGKKMEFIAG
CCCHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ICLIFSYFGWVAAQFVALGIMVQILFGINQFTAIVIGLVVVIIQLNDVKPIWSSISEKPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
GFFSFFPKSNYHDWTLYLSAWMVVGFGSLPQQDIFQRVMSAKSEKVAIRASYYSSVLYLL
CCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
FALIPLFLGLHAKSLLPDFDLYAESGQLLIPTMVSKFVSPWVQVLFFSALISAILSTASG
HHHHHHHHHHHHHHHCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AILAPSSILSENILKYAFKEMNDKKLLLLSRISVLIIAGISFLLAVGKPSIYALVEDSGG
CEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
ISLVTLFIPMVFGLLSQRADERSTLFSLFVGIGTWLLLEIYGDDMTSHFYGTIASLVAIL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IGMYLFPKKEKSQVTT
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]