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The map label for this gene is acoB [H]

Identifier: 183220945

GI number: 183220945

Start: 1625550

End: 1626524

Strand: Reverse

Name: acoB [H]

Synonym: LEPBI_I1558

Alternate gene names: 183220945

Gene position: 1626524-1625550 (Counterclockwise)

Preceding gene: 183220946

Following gene: 183220944

Centisome position: 45.19

GC content: 45.54

Gene sequence:

>975_bases
ATGGCCATTTTAACCTACAGAGAGGCACTGAACAGAGCCATGATCGAAGAGATGAAGCAAGACCCTCTTATCTATTTAAT
GGGAGAAGAAGTGGGTCATTACCAAGGAGCGTATAAAGTTTCGCAAGGTATGCTCGATTTATTTGGGGAAGGACGAGTGA
TTGATACACCGATATCTGAGAATGGATTTGCAGGGATTGGTGTTGGATCGGCGATGGTGGGACTTAGACCCATCATTGAA
TTTATGACTTGGAATTTTTCCCTTGTGGCAATCGACCAGATCATCAATTCCGCAGCGAAGATGAATTATATGAGTGGTGG
ACAATTTCCGATGCCGATTGTGTTTCGCGGAGCGGGAGGTGCGGGCGGAAGGCTTGCGGCACAACATTCACAAGCATTTG
AATCTTGGTATGCCCATTGCCCTGGCCTCAAGGTGGTCTGCCCTGCGACTCCGAAAGATGCTTATGGACTTCTCAAATCT
TCGATCCGAGACAATAACCCGACTATTTTTATCGAATCAGAAGTGTTATACGGGATGAAAGGAGAAGTACCGGAAGGTGA
ATTTACGATCCCACTGGGCCTCGGTGAAATCAAACGAAAAGGTACGGACATCACCCTTGTGACTTGGTCAAGAGCCCTTA
GTTTTGCTGAAGAAGCAGCTTTGATTTTAGAAAAGGAAGGGATATCTGTGGAAATCGTTGACCTTCGCAGTTTACGCCCG
TTAGATGAAAATCTGATCTATGAATCTGTAAAAAAAACCAATCGGGCCGTGGTTGTGGAAGAAGGATGGCCTGTCGCTGG
ATTTGGTGCTCAAATCTCGCACCTCATCCAAAAAAATGTTTTTTCCTATCTAGACCATCCTGTGGAACGAGTCACACAAA
TGGATGTTCCTATGTCTTACGCTGCCAACTTAGAAAAAATGAGTTTGCCGAGTGCCAATCGAGTGGCTGATACCATCCGC
GAGATGTTACGTTAA

Upstream 100 bases:

>100_bases
TATCCAAACACAAATTGATGAGGCCTACCAGTTTGCGGAAACCTCACCAGAGCCCCCTCTCTCCCAACTGCACAAGTATG
TGTATGCGGAGGATAAATAA

Downstream 100 bases:

>100_bases
GGAGACCATGATGGCAAAAATCCAAGAAATGACCCAATTATCTCCTACCATGGAAGAAGGAACCATTGTTAAGTGGTTGA
AAAATGAAGGGGACGCAATC

Product: pyruvate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAILTYREALNRAMIEEMKQDPLIYLMGEEVGHYQGAYKVSQGMLDLFGEGRVIDTPISENGFAGIGVGSAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSGGQFPMPIVFRGAGGAGGRLAAQHSQAFESWYAHCPGLKVVCPATPKDAYGLLKS
SIRDNNPTIFIESEVLYGMKGEVPEGEFTIPLGLGEIKRKGTDITLVTWSRALSFAEEAALILEKEGISVEIVDLRSLRP
LDENLIYESVKKTNRAVVVEEGWPVAGFGAQISHLIQKNVFSYLDHPVERVTQMDVPMSYAANLEKMSLPSANRVADTIR
EMLR

Sequences:

>Translated_324_residues
MAILTYREALNRAMIEEMKQDPLIYLMGEEVGHYQGAYKVSQGMLDLFGEGRVIDTPISENGFAGIGVGSAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSGGQFPMPIVFRGAGGAGGRLAAQHSQAFESWYAHCPGLKVVCPATPKDAYGLLKS
SIRDNNPTIFIESEVLYGMKGEVPEGEFTIPLGLGEIKRKGTDITLVTWSRALSFAEEAALILEKEGISVEIVDLRSLRP
LDENLIYESVKKTNRAVVVEEGWPVAGFGAQISHLIQKNVFSYLDHPVERVTQMDVPMSYAANLEKMSLPSANRVADTIR
EMLR
>Mature_323_residues
AILTYREALNRAMIEEMKQDPLIYLMGEEVGHYQGAYKVSQGMLDLFGEGRVIDTPISENGFAGIGVGSAMVGLRPIIEF
MTWNFSLVAIDQIINSAAKMNYMSGGQFPMPIVFRGAGGAGGRLAAQHSQAFESWYAHCPGLKVVCPATPKDAYGLLKSS
IRDNNPTIFIESEVLYGMKGEVPEGEFTIPLGLGEIKRKGTDITLVTWSRALSFAEEAALILEKEGISVEIVDLRSLRPL
DENLIYESVKKTNRAVVVEEGWPVAGFGAQISHLIQKNVFSYLDHPVERVTQMDVPMSYAANLEKMSLPSANRVADTIRE
MLR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=52.6153846153846, Blast_Score=350, Evalue=9e-97,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=49.5384615384615, Blast_Score=321, Evalue=5e-88,
Organism=Homo sapiens, GI4557353, Length=319, Percent_Identity=36.3636363636364, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI34101272, Length=319, Percent_Identity=36.3636363636364, Blast_Score=214, Evalue=7e-56,
Organism=Escherichia coli, GI1786622, Length=234, Percent_Identity=25.6410256410256, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=53.822629969419, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17506935, Length=317, Percent_Identity=41.3249211356467, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=50.6134969325153, Blast_Score=340, Evalue=2e-94,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=51.5337423312883, Blast_Score=343, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=51.5337423312883, Blast_Score=343, Evalue=9e-95,
Organism=Drosophila melanogaster, GI160714828, Length=319, Percent_Identity=36.3636363636364, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI160714832, Length=319, Percent_Identity=36.3636363636364, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24650943, Length=112, Percent_Identity=52.6785714285714, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24650945, Length=112, Percent_Identity=52.6785714285714, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35670; Mature: 35538

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILTYREALNRAMIEEMKQDPLIYLMGEEVGHYQGAYKVSQGMLDLFGEGRVIDTPISE
CEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHCCCEEEECCCCC
NGFAGIGVGSAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSGGQFPMPIVFRGAGG
CCCEECCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
AGGRLAAQHSQAFESWYAHCPGLKVVCPATPKDAYGLLKSSIRDNNPTIFIESEVLYGMK
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCEEECCC
GEVPEGEFTIPLGLGEIKRKGTDITLVTWSRALSFAEEAALILEKEGISVEIVDLRSLRP
CCCCCCCEEEEECHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEECCCCEEEEEECCCCCC
LDENLIYESVKKTNRAVVVEEGWPVAGFGAQISHLIQKNVFSYLDHPVERVTQMDVPMSY
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AANLEKMSLPSANRVADTIREMLR
HCCCHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AILTYREALNRAMIEEMKQDPLIYLMGEEVGHYQGAYKVSQGMLDLFGEGRVIDTPISE
EEEHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHCCCEEEECCCCC
NGFAGIGVGSAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSGGQFPMPIVFRGAGG
CCCEECCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
AGGRLAAQHSQAFESWYAHCPGLKVVCPATPKDAYGLLKSSIRDNNPTIFIESEVLYGMK
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCEEECCC
GEVPEGEFTIPLGLGEIKRKGTDITLVTWSRALSFAEEAALILEKEGISVEIVDLRSLRP
CCCCCCCEEEEECHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEECCCCEEEEEECCCCCC
LDENLIYESVKKTNRAVVVEEGWPVAGFGAQISHLIQKNVFSYLDHPVERVTQMDVPMSY
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AANLEKMSLPSANRVADTIREMLR
HCCCHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]