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The map label for this gene is acoA [H]

Identifier: 183220946

GI number: 183220946

Start: 1626525

End: 1627493

Strand: Reverse

Name: acoA [H]

Synonym: LEPBI_I1559

Alternate gene names: 183220946

Gene position: 1627493-1626525 (Counterclockwise)

Preceding gene: 183220948

Following gene: 183220945

Centisome position: 45.21

GC content: 47.06

Gene sequence:

>969_bases
TTGGTTTCTTCTATTCCCAAAGACTCACACTCTGTGAGCGAGTTAAAAGAGTTCTACAGACAGATGGTACTGATACGTAA
GTTTGAAGAAGCTGCCGCAAAAGCCTATAGTGTTGGAAAAATCGGTGGATTCCTCCATTTATACATCGGGCAAGAGGCTG
TGGGTGTTGGATCGATCGCTGCCCTCACCCCTCACGACTATATCGTATCTACCTACCGTGACCACGGACATGCATTGGCA
CGTGGTTTACATCCAAATCCTCTGATGGCAGAACTTTTTGGAAAGGCAACGGGAATCTCCAAAGGGAACGGTGGGTCCAT
GCATTTTTTTGATAAAAATGCCCATTTTATGGGAGGGCACATCTCACTTGCGGCAGGCATCGCCTTTGCTTCCAAATACA
AAAAGGAAGATTCCGTTACCATTTGTTTTTTTGGAGAAGGTGCGGCCAATATCGGATCCTTTCACGAAGGACTAAACCTC
GCCGCCATTTGGAAACTCCCCGTCGTTTTTATCTGCGAAAACAACCATTATGCGATGGGAACCCCGGAATACCGTGCCCT
TGCTGTCAAGGATGTCTCCATCAGAGCCCACGCTTATGATATGGCAAGAGACCATATTGAAGGGGATGAAGTCCGAAAAG
TGCGAGACCATGTGAAAGTGGCAGTGGAACGTGCACGGCGCGGCGAAGGACCTACTCTCATCGAAGTCTCAACTTACCGC
TTTCGTGGGCATTCGATGTCAGACCCTGCCAAGTATCGAACCAAAGAAGAATTAGAAGCTTATAAAAAAAAGGATCCACT
GATGCGGGCAAGACACGAACTTGAGTTAGGTGGGATAAAACCAAATGAGTTAGACAAACTCGAAACTGATATCCAAACAC
AAATTGATGAGGCCTACCAGTTTGCGGAAACCTCACCAGAGCCCCCTCTCTCCCAACTGCACAAGTATGTGTATGCGGAG
GATAAATAA

Upstream 100 bases:

>100_bases
GTCCTAGGGAAACTGTCTTTTATGTTCTTTTAAGAGCAAGATTTTTGCTTTCTTTCTTTGTCTAAATAGTGTAGTTTTTT
AGTCGTTTTGGAGGTTCTAT

Downstream 100 bases:

>100_bases
ATGGCCATTTTAACCTACAGAGAGGCACTGAACAGAGCCATGATCGAAGAGATGAAGCAAGACCCTCTTATCTATTTAAT
GGGAGAAGAAGTGGGTCATT

Product: pyruvate dehydrogenase E1 subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVSSIPKDSHSVSELKEFYRQMVLIRKFEEAAAKAYSVGKIGGFLHLYIGQEAVGVGSIAALTPHDYIVSTYRDHGHALA
RGLHPNPLMAELFGKATGISKGNGGSMHFFDKNAHFMGGHISLAAGIAFASKYKKEDSVTICFFGEGAANIGSFHEGLNL
AAIWKLPVVFICENNHYAMGTPEYRALAVKDVSIRAHAYDMARDHIEGDEVRKVRDHVKVAVERARRGEGPTLIEVSTYR
FRGHSMSDPAKYRTKEELEAYKKKDPLMRARHELELGGIKPNELDKLETDIQTQIDEAYQFAETSPEPPLSQLHKYVYAE
DK

Sequences:

>Translated_322_residues
MVSSIPKDSHSVSELKEFYRQMVLIRKFEEAAAKAYSVGKIGGFLHLYIGQEAVGVGSIAALTPHDYIVSTYRDHGHALA
RGLHPNPLMAELFGKATGISKGNGGSMHFFDKNAHFMGGHISLAAGIAFASKYKKEDSVTICFFGEGAANIGSFHEGLNL
AAIWKLPVVFICENNHYAMGTPEYRALAVKDVSIRAHAYDMARDHIEGDEVRKVRDHVKVAVERARRGEGPTLIEVSTYR
FRGHSMSDPAKYRTKEELEAYKKKDPLMRARHELELGGIKPNELDKLETDIQTQIDEAYQFAETSPEPPLSQLHKYVYAE
DK
>Mature_322_residues
MVSSIPKDSHSVSELKEFYRQMVLIRKFEEAAAKAYSVGKIGGFLHLYIGQEAVGVGSIAALTPHDYIVSTYRDHGHALA
RGLHPNPLMAELFGKATGISKGNGGSMHFFDKNAHFMGGHISLAAGIAFASKYKKEDSVTICFFGEGAANIGSFHEGLNL
AAIWKLPVVFICENNHYAMGTPEYRALAVKDVSIRAHAYDMARDHIEGDEVRKVRDHVKVAVERARRGEGPTLIEVSTYR
FRGHSMSDPAKYRTKEELEAYKKKDPLMRARHELELGGIKPNELDKLETDIQTQIDEAYQFAETSPEPPLSQLHKYVYAE
DK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=314, Percent_Identity=41.7197452229299, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=41.025641025641, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=41.025641025641, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=40.1253918495298, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI291084757, Length=308, Percent_Identity=38.3116883116883, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI11386135, Length=324, Percent_Identity=32.0987654320988, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI258645172, Length=316, Percent_Identity=32.9113924050633, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32564172, Length=309, Percent_Identity=37.2168284789644, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17536047, Length=309, Percent_Identity=37.2168284789644, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI86563355, Length=262, Percent_Identity=31.6793893129771, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI86563357, Length=262, Percent_Identity=31.6793893129771, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=37.3040752351097, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24639744, Length=312, Percent_Identity=39.1025641025641, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28571106, Length=312, Percent_Identity=39.1025641025641, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24639740, Length=312, Percent_Identity=39.1025641025641, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24639748, Length=311, Percent_Identity=38.9067524115756, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=39.0879478827362, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355903, Length=317, Percent_Identity=26.1829652996845, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35881; Mature: 35881

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSIPKDSHSVSELKEFYRQMVLIRKFEEAAAKAYSVGKIGGFLHLYIGQEAVGVGSIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEE
ALTPHDYIVSTYRDHGHALARGLHPNPLMAELFGKATGISKGNGGSMHFFDKNAHFMGGH
EECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCH
ISLAAGIAFASKYKKEDSVTICFFGEGAANIGSFHEGLNLAAIWKLPVVFICENNHYAMG
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCEEEEEECCEEEEECCCEEECC
TPEYRALAVKDVSIRAHAYDMARDHIEGDEVRKVRDHVKVAVERARRGEGPTLIEVSTYR
CCCCEEEEEEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
FRGHSMSDPAKYRTKEELEAYKKKDPLMRARHELELGGIKPNELDKLETDIQTQIDEAYQ
ECCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FAETSPEPPLSQLHKYVYAEDK
HHCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MVSSIPKDSHSVSELKEFYRQMVLIRKFEEAAAKAYSVGKIGGFLHLYIGQEAVGVGSIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEE
ALTPHDYIVSTYRDHGHALARGLHPNPLMAELFGKATGISKGNGGSMHFFDKNAHFMGGH
EECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCH
ISLAAGIAFASKYKKEDSVTICFFGEGAANIGSFHEGLNLAAIWKLPVVFICENNHYAMG
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCEEEEEECCEEEEECCCEEECC
TPEYRALAVKDVSIRAHAYDMARDHIEGDEVRKVRDHVKVAVERARRGEGPTLIEVSTYR
CCCCEEEEEEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
FRGHSMSDPAKYRTKEELEAYKKKDPLMRARHELELGGIKPNELDKLETDIQTQIDEAYQ
ECCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FAETSPEPPLSQLHKYVYAEDK
HHCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]