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The map label for this gene is dut [H]

Identifier: 183220918

GI number: 183220918

Start: 1597669

End: 1598118

Strand: Direct

Name: dut [H]

Synonym: LEPBI_I1531

Alternate gene names: 183220918

Gene position: 1597669-1598118 (Clockwise)

Preceding gene: 183220917

Following gene: 183220919

Centisome position: 44.38

GC content: 52.44

Gene sequence:

>450_bases
ATGTTAGAACCCGAGAACTACCTCCAAATCCAAATCTTAAAAGAGGGAGCCGTCCTCCCAGAATACAAAACACCAGGGGC
TGCTGGGATGGATCTCTCTGCTTGCCTCAGTGAAAACCTCCTCCTACCCAAGGGAGAAGTGGTACTCGTTCCCACAGGTT
TAGCCATGGCAATCCCCGAAGGGTACGAAGGGCAAATTCGGCCACGAAGTGGGTTTTCCACAAAACACAGAATCATCATG
CCCAATAGCCCCGGGACCATCGACTCTGACTACCGGGGTGAGATCCTCATCCCACTCCTCAATCTGAGTGGCGAGGATTT
CGTGTTAAAACCAGGGACTCGTGTGGCCCAATTGGTGATCCAAGCCGTATCACAACTTCCCATCCAAGTGGTCACAGGCC
TTGACGCAACGCAGCGCGGAACAGGTGGATTTGGGAGCACTGGAAAATAA

Upstream 100 bases:

>100_bases
TGACAGAAAGCCAATTTGCCAAAATCCCGGTCCAATTTGGCGGTTGAGAAGGAAATATCGATTCGGCTTTAGCTCGTATG
AATCGCATGTTAAGGAATTT

Downstream 100 bases:

>100_bases
GACATAACGAAGAAAAAAGACACTTAGCTTTTTTGGGAGATGACCGATAGAAGCTGTAGAGGTGCCTTTTTATGATGCGA
TCCCTTTGGACCGGTGCTAC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLVPTGLAMAIPEGYEGQIRPRSGFSTKHRIIM
PNSPGTIDSDYRGEILIPLLNLSGEDFVLKPGTRVAQLVIQAVSQLPIQVVTGLDATQRGTGGFGSTGK

Sequences:

>Translated_149_residues
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLVPTGLAMAIPEGYEGQIRPRSGFSTKHRIIM
PNSPGTIDSDYRGEILIPLLNLSGEDFVLKPGTRVAQLVIQAVSQLPIQVVTGLDATQRGTGGFGSTGK
>Mature_149_residues
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLVPTGLAMAIPEGYEGQIRPRSGFSTKHRIIM
PNSPGTIDSDYRGEILIPLLNLSGEDFVLKPGTRVAQLVIQAVSQLPIQVVTGLDATQRGTGGFGSTGK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=142, Percent_Identity=40.1408450704225, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4503423, Length=142, Percent_Identity=40.1408450704225, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI70906441, Length=142, Percent_Identity=40.1408450704225, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1790071, Length=132, Percent_Identity=43.9393939393939, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=142, Percent_Identity=42.2535211267606, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319729, Length=147, Percent_Identity=38.0952380952381, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921126, Length=141, Percent_Identity=36.1702127659575, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583610, Length=141, Percent_Identity=36.1702127659575, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15844; Mature: 15844

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLVPTGLAMAIPE
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCEEEECCC
GYEGQIRPRSGFSTKHRIIMPNSPGTIDSDYRGEILIPLLNLSGEDFVLKPGTRVAQLVI
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHH
QAVSQLPIQVVTGLDATQRGTGGFGSTGK
HHHHHCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLVPTGLAMAIPE
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCEEEECCC
GYEGQIRPRSGFSTKHRIIMPNSPGTIDSDYRGEILIPLLNLSGEDFVLKPGTRVAQLVI
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHH
QAVSQLPIQVVTGLDATQRGTGGFGSTGK
HHHHHCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA