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The map label for this gene is lysA [H]

Identifier: 183220822

GI number: 183220822

Start: 1499050

End: 1500318

Strand: Direct

Name: lysA [H]

Synonym: LEPBI_I1434

Alternate gene names: 183220822

Gene position: 1499050-1500318 (Clockwise)

Preceding gene: 183220816

Following gene: 183220823

Centisome position: 41.64

GC content: 43.26

Gene sequence:

>1269_bases
ATGACATCAATCGAAAAACTAAAGTTTTTGAAAGAAGACCAAGTGCGAACTTTGGCAAAAGAATTCGGAACCCCTCTCTT
TGTCTATTCTGAGAAAGAAATTGAACAAAAATGTGACGATACATTGGCATTTCCCAATGCATTTGGTTTACAAGTCCGTT
ATGCCATGAAGGCAAATCCCAATTCCAATATCTTACAAATCATGAAAAAAAAGGGTATCCTCATCGATGCATCCTCGGAA
CACGAAGTGGTAAGGGCTTTACATTTTGGATTTTCTCCTGAATCCATCATGCTCACGTCACAAGAATTCCCAAAAGCCTT
TGTGGAACTCATTGGAAAGGGTGTGAAGTTCAATGCTTGTTCCCTCCGCCAATTGGAACTCTTCGGACAACATTTCCCAG
GAAAATCAGTGTCGATTCGGTTTAACCCAGGCCTTGGATCAGGCCATACCAAAAAAACTGATGTGGGTGGGGTGACATCC
TCCTTTGGGATATGGCATGAGAAGTTAGAAGAAGTGAAAGCCATCGTAAACAAATACAACCTCGTTGTCGAAAAAGTCCA
CACCCATATTGGATCGGGCAGTGACCCTGAAGTGTGGAAGGCTGTCGCCAAATACACACTCGAATATGCAGAGAGTTTTC
CATCGGTGACGGTGGTGAGCCTTGGTGGTGGTTACAAAGTGGGTCGGATGGAAGATGAAAAATCGACCAACTTACAAACA
ATCGGTGCTCCTGTTAAAATCCAATTTGAAGAATTTGCCAAAAAACATGGAAGAAAACTCATCTTAGAGATTGAACCAGG
AACTTACCTCATCGCATTGTGCGGGGCTCTTCTCACTACTGTGGATGACAAAGTGGACACTGGAAAACATGGATTCCAGT
TTTTAAAATTGGATACGGGAATGGATTCTAATACAAGGCCTTCCCTCTACGGTGCACGCCACCCCCTCATCACGGTCAAA
AAAGATGGTGGGATTCCTTCGTCTCACAAAGAGTATGTGGTTGTCGGCCATTGTTGTGAGTCAGGAGATGTGTTCACCCA
AAAAGAAGGGGGAGAACCCATCACAAGGCTAATGGGTGAGGCAGAAATTGGAGACTATGTGGTGATGGAAGCGATTGGGG
CATATTGTTCCAGTATGTCCACAAAGAACTACAATAGTTTTCCCGAGACAGCTGAAGTTTTACTTCGAAAAAACGGAGAG
ACAAAACTCATTCGTAAAAAAGAACCAGTGATGGAAATCTTTCGCAATGAAATCTTAGTGGTGGAATGA

Upstream 100 bases:

>100_bases
TCACTTGGGAGAGTGCTTCAATATGTGTGATCTTTCCTGCCATTTTCTACTTTTTTGACTTTATGGATTGGAACCTATTG
AAAGGTTTATCTTAAATCCT

Downstream 100 bases:

>100_bases
ACCAACTCTTTGCCATCCTTCTCGCTGGTGGAACGGGTAGCCGAATGGGAGAATCTCTCCCAAAACAATTCTTACGCTTA
AGGGGGGAATCCCTCCTTAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTSIEKLKFLKEDQVRTLAKEFGTPLFVYSEKEIEQKCDDTLAFPNAFGLQVRYAMKANPNSNILQIMKKKGILIDASSE
HEVVRALHFGFSPESIMLTSQEFPKAFVELIGKGVKFNACSLRQLELFGQHFPGKSVSIRFNPGLGSGHTKKTDVGGVTS
SFGIWHEKLEEVKAIVNKYNLVVEKVHTHIGSGSDPEVWKAVAKYTLEYAESFPSVTVVSLGGGYKVGRMEDEKSTNLQT
IGAPVKIQFEEFAKKHGRKLILEIEPGTYLIALCGALLTTVDDKVDTGKHGFQFLKLDTGMDSNTRPSLYGARHPLITVK
KDGGIPSSHKEYVVVGHCCESGDVFTQKEGGEPITRLMGEAEIGDYVVMEAIGAYCSSMSTKNYNSFPETAEVLLRKNGE
TKLIRKKEPVMEIFRNEILVVE

Sequences:

>Translated_422_residues
MTSIEKLKFLKEDQVRTLAKEFGTPLFVYSEKEIEQKCDDTLAFPNAFGLQVRYAMKANPNSNILQIMKKKGILIDASSE
HEVVRALHFGFSPESIMLTSQEFPKAFVELIGKGVKFNACSLRQLELFGQHFPGKSVSIRFNPGLGSGHTKKTDVGGVTS
SFGIWHEKLEEVKAIVNKYNLVVEKVHTHIGSGSDPEVWKAVAKYTLEYAESFPSVTVVSLGGGYKVGRMEDEKSTNLQT
IGAPVKIQFEEFAKKHGRKLILEIEPGTYLIALCGALLTTVDDKVDTGKHGFQFLKLDTGMDSNTRPSLYGARHPLITVK
KDGGIPSSHKEYVVVGHCCESGDVFTQKEGGEPITRLMGEAEIGDYVVMEAIGAYCSSMSTKNYNSFPETAEVLLRKNGE
TKLIRKKEPVMEIFRNEILVVE
>Mature_421_residues
TSIEKLKFLKEDQVRTLAKEFGTPLFVYSEKEIEQKCDDTLAFPNAFGLQVRYAMKANPNSNILQIMKKKGILIDASSEH
EVVRALHFGFSPESIMLTSQEFPKAFVELIGKGVKFNACSLRQLELFGQHFPGKSVSIRFNPGLGSGHTKKTDVGGVTSS
FGIWHEKLEEVKAIVNKYNLVVEKVHTHIGSGSDPEVWKAVAKYTLEYAESFPSVTVVSLGGGYKVGRMEDEKSTNLQTI
GAPVKIQFEEFAKKHGRKLILEIEPGTYLIALCGALLTTVDDKVDTGKHGFQFLKLDTGMDSNTRPSLYGARHPLITVKK
DGGIPSSHKEYVVVGHCCESGDVFTQKEGGEPITRLMGEAEIGDYVVMEAIGAYCSSMSTKNYNSFPETAEVLLRKNGET
KLIRKKEPVMEIFRNEILVVE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=414, Percent_Identity=34.7826086956522, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46784; Mature: 46653

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIEKLKFLKEDQVRTLAKEFGTPLFVYSEKEIEQKCDDTLAFPNAFGLQVRYAMKANP
CCCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
NSNILQIMKKKGILIDASSEHEVVRALHFGFSPESIMLTSQEFPKAFVELIGKGVKFNAC
CHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCEECCC
SLRQLELFGQHFPGKSVSIRFNPGLGSGHTKKTDVGGVTSSFGIWHEKLEEVKAIVNKYN
CHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVVEKVHTHIGSGSDPEVWKAVAKYTLEYAESFPSVTVVSLGGGYKVGRMEDEKSTNLQT
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCEEE
IGAPVKIQFEEFAKKHGRKLILEIEPGTYLIALCGALLTTVDDKVDTGKHGFQFLKLDTG
CCCCEEEEHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
MDSNTRPSLYGARHPLITVKKDGGIPSSHKEYVVVGHCCESGDVFTQKEGGEPITRLMGE
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEECCCCCCHHHHHHCC
AEIGDYVVMEAIGAYCSSMSTKNYNSFPETAEVLLRKNGETKLIRKKEPVMEIFRNEILV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHCCEEE
VE
EC
>Mature Secondary Structure 
TSIEKLKFLKEDQVRTLAKEFGTPLFVYSEKEIEQKCDDTLAFPNAFGLQVRYAMKANP
CCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
NSNILQIMKKKGILIDASSEHEVVRALHFGFSPESIMLTSQEFPKAFVELIGKGVKFNAC
CHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCEECCC
SLRQLELFGQHFPGKSVSIRFNPGLGSGHTKKTDVGGVTSSFGIWHEKLEEVKAIVNKYN
CHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVVEKVHTHIGSGSDPEVWKAVAKYTLEYAESFPSVTVVSLGGGYKVGRMEDEKSTNLQT
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCEEE
IGAPVKIQFEEFAKKHGRKLILEIEPGTYLIALCGALLTTVDDKVDTGKHGFQFLKLDTG
CCCCEEEEHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
MDSNTRPSLYGARHPLITVKKDGGIPSSHKEYVVVGHCCESGDVFTQKEGGEPITRLMGE
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEECCCCCCHHHHHHCC
AEIGDYVVMEAIGAYCSSMSTKNYNSFPETAEVLLRKNGETKLIRKKEPVMEIFRNEILV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHCCEEE
VE
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]