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The map label for this gene is mmgC [H]

Identifier: 183220511

GI number: 183220511

Start: 1159717

End: 1161291

Strand: Direct

Name: mmgC [H]

Synonym: LEPBI_I1112

Alternate gene names: 183220511

Gene position: 1159717-1161291 (Clockwise)

Preceding gene: 183220510

Following gene: 183220512

Centisome position: 32.22

GC content: 39.49

Gene sequence:

>1575_bases
ATGATCAATCCAAAACTAAATCCTTATCTAAATGATGAGGAACGAAGTTTTTACAATACAGTGTTTCAATTTTCAGAAGA
AAAAGTGTATCCTACTTCTGAAGAAAGAGATGAAAAAGAAATTTGGTCAGACGAACTTTGGAAAGAGTTCTCGAAGGCTG
GACTCACAGGTCTCACGATCCCTACCGAGTATGGTGGTGAGGGTGCCAGTTGTTTACTTTGTTCCATTGCAACCGATGCT
TTTGCATCAGGATCTTTGGACGGTGGCATTGGTTTGTCTTGGGTGGCCCATCTTGTCATCGGAACAATGCCCATTGTTTT
CCAAGGAACCGAATCTCAAAAAACAAAATACCTCACAAAACTAGCGACAGGTGAATGGATGGCAGGTTTTGCACTCACAG
AACCTGCCTCTGGTTCCGATGCTGCATCCCTTCTCACGAAAGCCGAAGAAGTGGAAGGTGGATGGAAATTAAATGGGTCC
AAAACTTTTATCACGAATGGTCCTGTTGGGCAAGTTTTTATTGTGATGGCGAGAACTTCTGAAAAAGGAAGGGGACCAAT
GGGAATTTCTGCCTTTATCGTGGAAAGTGATACACCTGGGTTTAAGGTAAGTAAGGTTTTAAAAAAATTAGGCCATCATA
CTTCCATGACGGCTGAATTAGTTTTTGAAGATATGATCATTCCAAAAGAAAACCTACTTGGACCTTTAAACACTGGTTTT
ATGAGAATTGGAAAGGAAACATTGGAATGGGAAAGGACAGTATTTGTCGCAGGACTTGCCGGTGCGATGGAGTTCTGTCT
CCGAAAGGGATTACGTTATGCGAATGAACGAGTCCAATTTGGAAAACCAATTTCTAGTTTTTATGGAATGAGAGATATAT
TAGTTCGTAATTGGGTGTACATCCAAGCAGCTAGACGATTGATTTATTGGGTAGCGGAAAGAAAAGACAAAGGAATCCCA
TCTCCACTTGAAAGTAGTTTGGGGAAATTAATTTCCTCTGAACTTGCGGAAGATGTCGCTAAAGACACTGTACAATTGTT
TGGTGGATACGGTTATATGAAAGAGTATGCGGTGGAACGATTTTACCGCGACGTCAAATTAGGTACAATCGGTGGGGGAA
CAAGTGAAATCCAAAGATCCATTATTTCGTCATTGTATCCAGGAAAGGAGAAATTCCAAAAGGAATTCAAACGAATTGAA
TCTCCAAGCAACACTTCTGACAAAATTCAAAATATATTATTTGAAATCGTTCTCAAAATGGACACTGAACCCAATCATAA
AAAGCAGCAATCAATTGAATTTGCCTTTGCTGATGTTTTATCTGTATTTGTGATCCTGTATTTATCAGAAATTGACTCAC
ACAAAACGATAGATTCTTATCCAACCGAAGAAAAAATGATAGATCGGAAGTTACTTTCGTATTATCTTGTGGGTAAGTAT
TTGATGTCTATGAGTCGATTAAACCAATTTGTGCCAAAAGAGTTAGCGGATTTGTGGAATCATTATACACAACTGAGTAC
CTCCATCGAAGAGATGGTTCATACTCGCTATAGTTCACTCCAGGAGTTCGCCTAA

Upstream 100 bases:

>100_bases
CACGGCCATTTGACCCAGATGTCGAAATGACTCGCACTCTTAAAATGAAGAGAAACATCATCTCTGATGTATTTTCAAAA
CAAATCGAAGGAATTTACCA

Downstream 100 bases:

>100_bases
ATTGTGAAAGCAGCCGCCCGAATTGCAATTTTTTATCTGTTTTTCGGGTATCTGTGGATTTACTTTTCAGACTACACTAT
CTCTATTTTCTTTTTGTCTG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MINPKLNPYLNDEERSFYNTVFQFSEEKVYPTSEERDEKEIWSDELWKEFSKAGLTGLTIPTEYGGEGASCLLCSIATDA
FASGSLDGGIGLSWVAHLVIGTMPIVFQGTESQKTKYLTKLATGEWMAGFALTEPASGSDAASLLTKAEEVEGGWKLNGS
KTFITNGPVGQVFIVMARTSEKGRGPMGISAFIVESDTPGFKVSKVLKKLGHHTSMTAELVFEDMIIPKENLLGPLNTGF
MRIGKETLEWERTVFVAGLAGAMEFCLRKGLRYANERVQFGKPISSFYGMRDILVRNWVYIQAARRLIYWVAERKDKGIP
SPLESSLGKLISSELAEDVAKDTVQLFGGYGYMKEYAVERFYRDVKLGTIGGGTSEIQRSIISSLYPGKEKFQKEFKRIE
SPSNTSDKIQNILFEIVLKMDTEPNHKKQQSIEFAFADVLSVFVILYLSEIDSHKTIDSYPTEEKMIDRKLLSYYLVGKY
LMSMSRLNQFVPKELADLWNHYTQLSTSIEEMVHTRYSSLQEFA

Sequences:

>Translated_524_residues
MINPKLNPYLNDEERSFYNTVFQFSEEKVYPTSEERDEKEIWSDELWKEFSKAGLTGLTIPTEYGGEGASCLLCSIATDA
FASGSLDGGIGLSWVAHLVIGTMPIVFQGTESQKTKYLTKLATGEWMAGFALTEPASGSDAASLLTKAEEVEGGWKLNGS
KTFITNGPVGQVFIVMARTSEKGRGPMGISAFIVESDTPGFKVSKVLKKLGHHTSMTAELVFEDMIIPKENLLGPLNTGF
MRIGKETLEWERTVFVAGLAGAMEFCLRKGLRYANERVQFGKPISSFYGMRDILVRNWVYIQAARRLIYWVAERKDKGIP
SPLESSLGKLISSELAEDVAKDTVQLFGGYGYMKEYAVERFYRDVKLGTIGGGTSEIQRSIISSLYPGKEKFQKEFKRIE
SPSNTSDKIQNILFEIVLKMDTEPNHKKQQSIEFAFADVLSVFVILYLSEIDSHKTIDSYPTEEKMIDRKLLSYYLVGKY
LMSMSRLNQFVPKELADLWNHYTQLSTSIEEMVHTRYSSLQEFA
>Mature_524_residues
MINPKLNPYLNDEERSFYNTVFQFSEEKVYPTSEERDEKEIWSDELWKEFSKAGLTGLTIPTEYGGEGASCLLCSIATDA
FASGSLDGGIGLSWVAHLVIGTMPIVFQGTESQKTKYLTKLATGEWMAGFALTEPASGSDAASLLTKAEEVEGGWKLNGS
KTFITNGPVGQVFIVMARTSEKGRGPMGISAFIVESDTPGFKVSKVLKKLGHHTSMTAELVFEDMIIPKENLLGPLNTGF
MRIGKETLEWERTVFVAGLAGAMEFCLRKGLRYANERVQFGKPISSFYGMRDILVRNWVYIQAARRLIYWVAERKDKGIP
SPLESSLGKLISSELAEDVAKDTVQLFGGYGYMKEYAVERFYRDVKLGTIGGGTSEIQRSIISSLYPGKEKFQKEFKRIE
SPSNTSDKIQNILFEIVLKMDTEPNHKKQQSIEFAFADVLSVFVILYLSEIDSHKTIDSYPTEEKMIDRKLLSYYLVGKY
LMSMSRLNQFVPKELADLWNHYTQLSTSIEEMVHTRYSSLQEFA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=37.6315789473684, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=39.067055393586, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=33.1550802139037, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=35.4591836734694, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=35.4591836734694, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=33.5897435897436, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=33.0666666666667, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI21361497, Length=381, Percent_Identity=37.007874015748, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=30.7291666666667, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=30.7291666666667, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=33.0645161290323, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4503943, Length=398, Percent_Identity=28.1407035175879, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=28.9617486338798, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI48976061, Length=397, Percent_Identity=27.2040302267003, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI211971008, Length=397, Percent_Identity=27.2040302267003, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI38505218, Length=321, Percent_Identity=23.0529595015576, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786223, Length=370, Percent_Identity=28.6486486486486, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081958, Length=341, Percent_Identity=29.9120234604106, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI87082384, Length=298, Percent_Identity=24.1610738255034, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081702, Length=414, Percent_Identity=23.9130434782609, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=36.968085106383, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=33.0708661417323, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=393, Percent_Identity=34.3511450381679, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=32.2997416020672, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=34.2175066312997, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=32.5699745547074, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=31.1170212765957, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=340, Percent_Identity=34.1176470588235, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=28.0748663101604, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=33.9285714285714, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=405, Percent_Identity=30.1234567901235, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=386, Percent_Identity=26.9430051813472, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17505929, Length=358, Percent_Identity=27.0949720670391, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=288, Percent_Identity=30.2083333333333, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=31.7596566523605, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=229, Percent_Identity=28.82096069869, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17531913, Length=116, Percent_Identity=34.4827586206897, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355753, Length=376, Percent_Identity=36.436170212766, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI21356377, Length=384, Percent_Identity=34.6354166666667, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=32.9787234042553, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=31.9261213720317, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363737, Length=371, Percent_Identity=34.5013477088949, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=30.5851063829787, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=26.530612244898, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 58913; Mature: 58913

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINPKLNPYLNDEERSFYNTVFQFSEEKVYPTSEERDEKEIWSDELWKEFSKAGLTGLTI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEC
PTEYGGEGASCLLCSIATDAFASGSLDGGIGLSWVAHLVIGTMPIVFQGTESQKTKYLTK
CCCCCCCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
LATGEWMAGFALTEPASGSDAASLLTKAEEVEGGWKLNGSKTFITNGPVGQVFIVMARTS
HHCCCHHCCEEECCCCCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECC
EKGRGPMGISAFIVESDTPGFKVSKVLKKLGHHTSMTAELVFEDMIIPKENLLGPLNTGF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCHHH
MRIGKETLEWERTVFVAGLAGAMEFCLRKGLRYANERVQFGKPISSFYGMRDILVRNWVY
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IQAARRLIYWVAERKDKGIPSPLESSLGKLISSELAEDVAKDTVQLFGGYGYMKEYAVER
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FYRDVKLGTIGGGTSEIQRSIISSLYPGKEKFQKEFKRIESPSNTSDKIQNILFEIVLKM
HHHHHCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DTEPNHKKQQSIEFAFADVLSVFVILYLSEIDSHKTIDSYPTEEKMIDRKLLSYYLVGKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LMSMSRLNQFVPKELADLWNHYTQLSTSIEEMVHTRYSSLQEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINPKLNPYLNDEERSFYNTVFQFSEEKVYPTSEERDEKEIWSDELWKEFSKAGLTGLTI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEC
PTEYGGEGASCLLCSIATDAFASGSLDGGIGLSWVAHLVIGTMPIVFQGTESQKTKYLTK
CCCCCCCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
LATGEWMAGFALTEPASGSDAASLLTKAEEVEGGWKLNGSKTFITNGPVGQVFIVMARTS
HHCCCHHCCEEECCCCCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECC
EKGRGPMGISAFIVESDTPGFKVSKVLKKLGHHTSMTAELVFEDMIIPKENLLGPLNTGF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCHHH
MRIGKETLEWERTVFVAGLAGAMEFCLRKGLRYANERVQFGKPISSFYGMRDILVRNWVY
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IQAARRLIYWVAERKDKGIPSPLESSLGKLISSELAEDVAKDTVQLFGGYGYMKEYAVER
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FYRDVKLGTIGGGTSEIQRSIISSLYPGKEKFQKEFKRIESPSNTSDKIQNILFEIVLKM
HHHHHCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DTEPNHKKQQSIEFAFADVLSVFVILYLSEIDSHKTIDSYPTEEKMIDRKLLSYYLVGKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LMSMSRLNQFVPKELADLWNHYTQLSTSIEEMVHTRYSSLQEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]