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The map label for this gene is clpP [H]

Identifier: 183220373

GI number: 183220373

Start: 1005282

End: 1005884

Strand: Direct

Name: clpP [H]

Synonym: LEPBI_I0969

Alternate gene names: 183220373

Gene position: 1005282-1005884 (Clockwise)

Preceding gene: 183220372

Following gene: 183220374

Centisome position: 27.93

GC content: 44.11

Gene sequence:

>603_bases
ATGTCCACATTATTACCATATGTTTCAGAACAAACAAGCCGGGGCATCGATCGCATGGATGTCTATTCCAGACTTCTACG
GGATCGGATTATTTTTTTGGGTGCGGGCATTGACGACACCTATGCCAACGCTGTTTGTGCACAACTTTTGTTTTTAGAAG
CAGAAAACCCAGACCGTGATATCTATCTCTACATCAATAGCCCAGGTGGGTATGTGAGTTCAGGACTTGCCATTTACGAT
ACCATGCAACTCATCAAACCAGAGGTGAGAACCCTTTGTATTGGTCAGGCATCTTCCATGGCGGCACTTTTACTTGCGGG
CGGTGCCAAAGGAAAACGTTCTGCTCTTCCTAATGGTAGGATTATGATGCACCAACCTTATGGTGGAGCCGGTGGACAAG
CTTCGGATATTGAAATCTCCGCAAAAGAAATCATCAAGACGAAGAACACTTTGATCGATTTATATTGTAAACATATCGGA
AAACCTGCGGCGCAGATCCAAAAAGACACCGAAAGGAATTTCTTCATGAGTGCCGAGGAAGCGAAAGAATACGGTATCAT
TGATAACGTGATCCTAGAACGCAAACAAATGATACAAGCCTAA

Upstream 100 bases:

>100_bases
AATTGACGAGTTTGTATACGCTGAAGTAGAGAAAAAATCGCCGAAAGCAATTTCAACGGAAGAAGCTGAGAAAATTCTTA
GCGGGAAAGAAGAGTAAACT

Downstream 100 bases:

>100_bases
AGGGGGCAACTCTCCATGACCAAACGTGCAAGCCAAACAGGGAATTCCAGAGAAAAATTACATTGTTCTTTCTGCGGAAA
GGCCCAAGACGAAGTCAGAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSTLLPYVSEQTSRGIDRMDVYSRLLRDRIIFLGAGIDDTYANAVCAQLLFLEAENPDRDIYLYINSPGGYVSSGLAIYD
TMQLIKPEVRTLCIGQASSMAALLLAGGAKGKRSALPNGRIMMHQPYGGAGGQASDIEISAKEIIKTKNTLIDLYCKHIG
KPAAQIQKDTERNFFMSAEEAKEYGIIDNVILERKQMIQA

Sequences:

>Translated_200_residues
MSTLLPYVSEQTSRGIDRMDVYSRLLRDRIIFLGAGIDDTYANAVCAQLLFLEAENPDRDIYLYINSPGGYVSSGLAIYD
TMQLIKPEVRTLCIGQASSMAALLLAGGAKGKRSALPNGRIMMHQPYGGAGGQASDIEISAKEIIKTKNTLIDLYCKHIG
KPAAQIQKDTERNFFMSAEEAKEYGIIDNVILERKQMIQA
>Mature_199_residues
STLLPYVSEQTSRGIDRMDVYSRLLRDRIIFLGAGIDDTYANAVCAQLLFLEAENPDRDIYLYINSPGGYVSSGLAIYDT
MQLIKPEVRTLCIGQASSMAALLLAGGAKGKRSALPNGRIMMHQPYGGAGGQASDIEISAKEIIKTKNTLIDLYCKHIGK
PAAQIQKDTERNFFMSAEEAKEYGIIDNVILERKQMIQA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=193, Percent_Identity=52.8497409326425, Blast_Score=207, Evalue=5e-54,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=57.8125, Blast_Score=246, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.1505376344086, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=55.8510638297872, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22015; Mature: 21884

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLLPYVSEQTSRGIDRMDVYSRLLRDRIIFLGAGIDDTYANAVCAQLLFLEAENPDRD
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
IYLYINSPGGYVSSGLAIYDTMQLIKPEVRTLCIGQASSMAALLLAGGAKGKRSALPNGR
EEEEEECCCCCHHCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCCCE
IMMHQPYGGAGGQASDIEISAKEIIKTKNTLIDLYCKHIGKPAAQIQKDTERNFFMSAEE
EEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEECHHH
AKEYGIIDNVILERKQMIQA
HHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLLPYVSEQTSRGIDRMDVYSRLLRDRIIFLGAGIDDTYANAVCAQLLFLEAENPDRD
CCCCCHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
IYLYINSPGGYVSSGLAIYDTMQLIKPEVRTLCIGQASSMAALLLAGGAKGKRSALPNGR
EEEEEECCCCCHHCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCCCE
IMMHQPYGGAGGQASDIEISAKEIIKTKNTLIDLYCKHIGKPAAQIQKDTERNFFMSAEE
EEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEECHHH
AKEYGIIDNVILERKQMIQA
HHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA