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The map label for this gene is clpX

Identifier: 183220374

GI number: 183220374

Start: 1005900

End: 1007180

Strand: Direct

Name: clpX

Synonym: LEPBI_I0970

Alternate gene names: 183220374

Gene position: 1005900-1007180 (Clockwise)

Preceding gene: 183220373

Following gene: 183220375

Centisome position: 27.94

GC content: 43.79

Gene sequence:

>1281_bases
ATGACCAAACGTGCAAGCCAAACAGGGAATTCCAGAGAAAAATTACATTGTTCTTTCTGCGGAAAGGCCCAAGACGAAGT
CAGAAGGCTTGTGGCAGGTCCTGGTGTTTATATCTGCGATGAATGTATCTCTTTATGTAACGAAATCATCGCCGAAGAAC
CACAATCAGGTGAAAAAACTGCGATTGTGGGTGACATTCCAAAACCAACCGAAATCAAAAAGATCTTAGACCAGTATGTA
ATTGGGCAAGAACAAGCCAAAAAGGCTTTGGCTGTTGCCGTCTACAATCACTACAAACGTATTTTTCATAACGAACGTAA
GGCGGGAGATGTGGAATTGGAAAAATCCAATATCATGCTCATCGGTCCCACTGGATCGGGGAAAACCTTACTCGCACAAA
CCCTTGCCCGTATCTTAAAAGTTCCTTTTGCCATTGTGGATGCCACAGCTCTCACTGAGGCTGGGTATGTGGGGGAAGAT
GTGGAAAACATCATCCTCAAACTCATCCAAAACGCGGACAATGATGTGAAACGAGCAGAGATGGGAATCATCTACATCGA
CGAAATTGATAAGATCTCTCGTAAATCAGACTCGGCTTCCATCACACGTGATGTGAGTGGGGAAGGGGTCCAACAAGCCC
TCTTAAAAATCATTGAAGGCACTGTTGCCAATGTCCCACCGCAAGGTGGACGCAAACACCCACACCAGGAATACATCCCG
GTGGAAACCAAAAACATCCTCTTCATTTGTGGAGGAGCTTTTGTAGGTCTCACTGATATCATCAAACAACGAGTTGGTGT
GAAATCCATTGGATTCCATTCCAATGAAGTGGTCAACGATCGCGGAAGAAAGATCGAAGAAGGGGAATCACTTGTGCATC
ATGTGATCCCTGACGATTTGATGAAATTTGGCCTCATCCCAGAATTCATCGGTCGCCTTCCCATCATCGCCACACTTGAT
GAACTCACGATCGAAAGTTTAAAATCGATTTTTACAGAACCAAAAAATTCCCTTCTCAAACAATACCAAAAGATGTTTGA
TATCGAGAATGTAAAACTGAAGTTCACAGAATCTGCCATTGAAGCCATTGCCCAAACCGCCATCAAACGGGAAAGTGGAG
CGAGGGGACTTCGTGCCATTGTGGAAGAAATCATGATGGAACTCATGTTCCAAATTCCTTCAAGAAAGGATGTTTTGGAA
GTGGTGGTGACAGACGATACTGTTCTGAAAAAAGAAGCACCCATTACAATTTTAAAGGGTGATATCGAAAAGATCGCTTA
A

Upstream 100 bases:

>100_bases
TTTCTTCATGAGTGCCGAGGAAGCGAAAGAATACGGTATCATTGATAACGTGATCCTAGAACGCAAACAAATGATACAAG
CCTAAAGGGGGCAACTCTCC

Downstream 100 bases:

>100_bases
AAAAAAGAAATGTTACTTTGGTAATGTGGTTCGTTAAAACGAAAGCAATCCAAATTTCCTTCCTGGGAATTTACTTTTTA
TTGGGGGTATTTGTTTCCGG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKTAIVGDIPKPTEIKKILDQYV
IGQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIMLIGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGED
VENIILKLIQNADNDVKRAEMGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIP
VETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDLMKFGLIPEFIGRLPIIATLD
ELTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAIEAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLE
VVVTDDTVLKKEAPITILKGDIEKIA

Sequences:

>Translated_426_residues
MTKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKTAIVGDIPKPTEIKKILDQYV
IGQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIMLIGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGED
VENIILKLIQNADNDVKRAEMGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIP
VETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDLMKFGLIPEFIGRLPIIATLD
ELTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAIEAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLE
VVVTDDTVLKKEAPITILKGDIEKIA
>Mature_425_residues
TKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKTAIVGDIPKPTEIKKILDQYVI
GQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIMLIGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGEDV
ENIILKLIQNADNDVKRAEMGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIPV
ETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDLMKFGLIPEFIGRLPIIATLDE
LTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAIEAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLEV
VVTDDTVLKKEAPITILKGDIEKIA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=401, Percent_Identity=41.645885286783, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1786642, Length=404, Percent_Identity=61.6336633663366, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=44.2307692307692, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=312, Percent_Identity=42.6282051282051, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71982905, Length=312, Percent_Identity=42.6282051282051, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71988663, Length=489, Percent_Identity=35.7873210633947, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71988660, Length=331, Percent_Identity=36.2537764350453, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=428, Percent_Identity=40.6542056074766, Blast_Score=270, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24648291, Length=322, Percent_Identity=44.7204968944099, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24648289, Length=322, Percent_Identity=44.7204968944099, Blast_Score=282, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_LEPBA (B0SEC2)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962043.1
- ProteinModelPortal:   B0SEC2
- GeneID:   6388231
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0938
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   LBIF355278:LBF_0938-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47066; Mature: 46935

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKT
CCCCCCCCCCCCCEEEEHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCE
AIVGDIPKPTEIKKILDQYVIGQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIML
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEE
IGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGEDVENIILKLIQNADNDVKRAE
EECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHH
MGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIP
CCEEEECCHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCC
VETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDL
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCHHHH
MKFGLIPEFIGRLPIIATLDELTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAI
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEHHHHH
EAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLEVVVTDDTVLKKEAPITILKG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCEEEEEC
DIEKIA
CHHHCC
>Mature Secondary Structure 
TKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKT
CCCCCCCCCCCCEEEEHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCE
AIVGDIPKPTEIKKILDQYVIGQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIML
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEE
IGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGEDVENIILKLIQNADNDVKRAE
EECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHH
MGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIP
CCEEEECCHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCC
VETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDL
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCHHHH
MKFGLIPEFIGRLPIIATLDELTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAI
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEHHHHH
EAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLEVVVTDDTVLKKEAPITILKG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCEEEEEC
DIEKIA
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA