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The map label for this gene is abcA [H]

Identifier: 183220340

GI number: 183220340

Start: 968341

End: 969540

Strand: Direct

Name: abcA [H]

Synonym: LEPBI_I0936

Alternate gene names: 183220340

Gene position: 968341-969540 (Clockwise)

Preceding gene: 183220339

Following gene: 183220341

Centisome position: 26.9

GC content: 38.25

Gene sequence:

>1200_bases
ATGCTTTCTGTATTCATCGAAAACCTTTCCAAGGACTATCATGGATTCACAAAACCTTGGAAACGAATTCTTGCTGGACT
TAGTTTTGGTTACTTCGGCATTGATTCAAAGTTTACAGCAATCCAATCCTTAAATTTGCAAGTAAATCCTGGTGAAATTC
TTGGGATCATCGGAAGGAATGGAGCTGGGAAATCCACATTATTAAAACTCATCACTGGTGTGATCCAAAAGGACCAAGGT
AACTTAAAAGTATATGGATCCGTCCGTGCACTGTTAGAACTCAGTGTGGGATTCAATCCCGAACTTTCTGGAGAAGAGAA
TGTTTATTTTAATGGGCTTGTTTGGGGTTACAAACCGTCTGAAATCAAGATGCTTGCAGATTCTATTTTTGAATTTGCAG
AATTAAAAGAATTTCGATCCTCTCCTTTAAAAAATTATAGTTCGGGAATGGCGATGCGACTTGGGTTTAGTTTGGCGACA
GCAAAACGGCCTGATATCCTCATTGTGGATGAAGCATTGGCAGTCGGTGATGCTAGTTTCCAACAAAAATGCCTGAAACG
AATCCAAGAATTTTCAAAACTAGGTACTTCGATTTTAGTTGTCAGTCATGATTTAGGACTTGTTTCTTATTTTTGTACAA
GGGTTGTTTTGTTGGAAAAAGGAAAACTCCTTTTTGATGGGAACCCAAAAGAGACGATTGAAAAATACATGCATGTGTTA
GCTGGTGAACTCCCTGTATCAGAATCGTATTCATCGAATGCCATACAAGATCTACGTGTGGTTTTAGAAAATGAAAAGGG
AATCCAATCCAATGTCTTTTTTATCGGCAGTCAAGTATGTCTGAGACTTTCATTCAAAACACTAACTTCAATCGAATCAG
CCACCATTGGCTTTCATATCGATAATGATAAAGGGATTCGTATTTTTGGTACCAATACCTTCCATTTAGGTGATACGAAT
CGAATCTTCCAAAACGACAAGGAATATGAAGTGAGATTTGAATTCCCCATTCAATTTACTGCGGGAAAGTATAGTCTCGG
AATCGCCATCCACAAGGGTGAATCCCATATCGAAGGGAGTTATTTTTGGAAGGAATCGATTTTAGATTTTGAAGTAGAGA
CTGGCAAAATTCAAAAATTTGTAGGGATTTGTCATATTCCCACAAGCTTTCAGATCAAGCAAGATCGAGGCACACGTTAG

Upstream 100 bases:

>100_bases
CTGGTTCCATATTGCCCCGTTTCTTTTTTTCTTTGTCCTTGTGTATTTACTGGCAAAACGAAAATTCCAATCAGTGATAT
TGGATCACCTTTAAATCCTA

Downstream 100 bases:

>100_bases
AAAAACAGTTTCCTTTTCGGTTAAAATTGAAAATCTGGAAATCCTATGAAAGTTTGTGTGGTCGGAACCGGATATGTGGG
CCTTGTTGCAGGTACTTGTT

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLSVFIENLSKDYHGFTKPWKRILAGLSFGYFGIDSKFTAIQSLNLQVNPGEILGIIGRNGAGKSTLLKLITGVIQKDQG
NLKVYGSVRALLELSVGFNPELSGEENVYFNGLVWGYKPSEIKMLADSIFEFAELKEFRSSPLKNYSSGMAMRLGFSLAT
AKRPDILIVDEALAVGDASFQQKCLKRIQEFSKLGTSILVVSHDLGLVSYFCTRVVLLEKGKLLFDGNPKETIEKYMHVL
AGELPVSESYSSNAIQDLRVVLENEKGIQSNVFFIGSQVCLRLSFKTLTSIESATIGFHIDNDKGIRIFGTNTFHLGDTN
RIFQNDKEYEVRFEFPIQFTAGKYSLGIAIHKGESHIEGSYFWKESILDFEVETGKIQKFVGICHIPTSFQIKQDRGTR

Sequences:

>Translated_399_residues
MLSVFIENLSKDYHGFTKPWKRILAGLSFGYFGIDSKFTAIQSLNLQVNPGEILGIIGRNGAGKSTLLKLITGVIQKDQG
NLKVYGSVRALLELSVGFNPELSGEENVYFNGLVWGYKPSEIKMLADSIFEFAELKEFRSSPLKNYSSGMAMRLGFSLAT
AKRPDILIVDEALAVGDASFQQKCLKRIQEFSKLGTSILVVSHDLGLVSYFCTRVVLLEKGKLLFDGNPKETIEKYMHVL
AGELPVSESYSSNAIQDLRVVLENEKGIQSNVFFIGSQVCLRLSFKTLTSIESATIGFHIDNDKGIRIFGTNTFHLGDTN
RIFQNDKEYEVRFEFPIQFTAGKYSLGIAIHKGESHIEGSYFWKESILDFEVETGKIQKFVGICHIPTSFQIKQDRGTR
>Mature_399_residues
MLSVFIENLSKDYHGFTKPWKRILAGLSFGYFGIDSKFTAIQSLNLQVNPGEILGIIGRNGAGKSTLLKLITGVIQKDQG
NLKVYGSVRALLELSVGFNPELSGEENVYFNGLVWGYKPSEIKMLADSIFEFAELKEFRSSPLKNYSSGMAMRLGFSLAT
AKRPDILIVDEALAVGDASFQQKCLKRIQEFSKLGTSILVVSHDLGLVSYFCTRVVLLEKGKLLFDGNPKETIEKYMHVL
AGELPVSESYSSNAIQDLRVVLENEKGIQSNVFFIGSQVCLRLSFKTLTSIESATIGFHIDNDKGIRIFGTNTFHLGDTN
RIFQNDKEYEVRFEFPIQFTAGKYSLGIAIHKGESHIEGSYFWKESILDFEVETGKIQKFVGICHIPTSFQIKQDRGTR

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27881501, Length=211, Percent_Identity=27.4881516587678, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI30795238, Length=211, Percent_Identity=27.4881516587678, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI31657092, Length=229, Percent_Identity=24.8908296943231, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI150417984, Length=245, Percent_Identity=24.0816326530612, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI153792144, Length=241, Percent_Identity=26.5560165975104, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI27436953, Length=207, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI47078218, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI45446740, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI6005701, Length=207, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI105990541, Length=193, Percent_Identity=25.3886010362694, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI27477115, Length=220, Percent_Identity=24.5454545454545, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI27262624, Length=204, Percent_Identity=25.9803921568627, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI27262626, Length=204, Percent_Identity=25.9803921568627, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI116734710, Length=208, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI21536376, Length=195, Percent_Identity=23.5897435897436, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787029, Length=209, Percent_Identity=27.7511961722488, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081791, Length=207, Percent_Identity=25.6038647342995, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787370, Length=267, Percent_Identity=25.8426966292135, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994943, Length=209, Percent_Identity=25.3588516746411, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789873, Length=200, Percent_Identity=27, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788450, Length=209, Percent_Identity=29.1866028708134, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081709, Length=204, Percent_Identity=24.0196078431373, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789593, Length=208, Percent_Identity=24.5192307692308, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081782, Length=218, Percent_Identity=25.2293577981651, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788225, Length=251, Percent_Identity=22.7091633466135, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787758, Length=221, Percent_Identity=25.7918552036199, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786319, Length=207, Percent_Identity=25.1207729468599, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786563, Length=193, Percent_Identity=27.4611398963731, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786398, Length=206, Percent_Identity=26.2135922330097, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789032, Length=212, Percent_Identity=26.4150943396226, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790467, Length=202, Percent_Identity=26.2376237623762, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082267, Length=218, Percent_Identity=26.605504587156, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787712, Length=205, Percent_Identity=23.9024390243902, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87081834, Length=200, Percent_Identity=27, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787089, Length=224, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786703, Length=206, Percent_Identity=27.1844660194175, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788897, Length=207, Percent_Identity=24.1545893719807, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790190, Length=217, Percent_Identity=23.963133640553, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115533608, Length=241, Percent_Identity=24.896265560166, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17565586, Length=210, Percent_Identity=25.7142857142857, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17510237, Length=208, Percent_Identity=24.5192307692308, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=206, Percent_Identity=26.2135922330097, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=206, Percent_Identity=26.2135922330097, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=206, Percent_Identity=26.2135922330097, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565938, Length=212, Percent_Identity=25.9433962264151, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573571, Length=217, Percent_Identity=29.4930875576037, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573573, Length=217, Percent_Identity=29.4930875576037, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI116007184, Length=192, Percent_Identity=24.4791666666667, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221500365, Length=192, Percent_Identity=24.4791666666667, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648314, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666092, Length=217, Percent_Identity=23.5023041474654, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574150, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007328, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643674, Length=218, Percent_Identity=22.9357798165138, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 44613; Mature: 44613

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVFIENLSKDYHGFTKPWKRILAGLSFGYFGIDSKFTAIQSLNLQVNPGEILGIIGRN
CCEEEEHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCEEEEEEEEEEECCCCEEEEEECC
GAGKSTLLKLITGVIQKDQGNLKVYGSVRALLELSVGFNPELSGEENVYFNGLVWGYKPS
CCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCH
EIKMLADSIFEFAELKEFRSSPLKNYSSGMAMRLGFSLATAKRPDILIVDEALAVGDASF
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECEEEECCCCCCEEEEECHHHCCCHHH
QQKCLKRIQEFSKLGTSILVVSHDLGLVSYFCTRVVLLEKGKLLFDGNPKETIEKYMHVL
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHEECCCEEECCCCHHHHHHHHHHH
AGELPVSESYSSNAIQDLRVVLENEKGIQSNVFFIGSQVCLRLSFKTLTSIESATIGFHI
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEHHHHHHCCCCEEEEEEE
DNDKGIRIFGTNTFHLGDTNRIFQNDKEYEVRFEFPIQFTAGKYSLGIAIHKGESHIEGS
ECCCCEEEEECCEEECCCCHHHHCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCCCCC
YFWKESILDFEVETGKIQKFVGICHIPTSFQIKQDRGTR
EEEECCCEEEEECCCHHHHHEEEEECCCCEEEECCCCCC
>Mature Secondary Structure
MLSVFIENLSKDYHGFTKPWKRILAGLSFGYFGIDSKFTAIQSLNLQVNPGEILGIIGRN
CCEEEEHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCEEEEEEEEEEECCCCEEEEEECC
GAGKSTLLKLITGVIQKDQGNLKVYGSVRALLELSVGFNPELSGEENVYFNGLVWGYKPS
CCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCH
EIKMLADSIFEFAELKEFRSSPLKNYSSGMAMRLGFSLATAKRPDILIVDEALAVGDASF
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECEEEECCCCCCEEEEECHHHCCCHHH
QQKCLKRIQEFSKLGTSILVVSHDLGLVSYFCTRVVLLEKGKLLFDGNPKETIEKYMHVL
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHEECCCEEECCCCHHHHHHHHHHH
AGELPVSESYSSNAIQDLRVVLENEKGIQSNVFFIGSQVCLRLSFKTLTSIESATIGFHI
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEHHHHHHCCCCEEEEEEE
DNDKGIRIFGTNTFHLGDTNRIFQNDKEYEVRFEFPIQFTAGKYSLGIAIHKGESHIEGS
ECCCCEEEEECCEEECCCCHHHHCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCCCCC
YFWKESILDFEVETGKIQKFVGICHIPTSFQIKQDRGTR
EEEECCCEEEEECCCHHHHHEEEEECCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]