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The map label for this gene is ugd [H]

Identifier: 183220341

GI number: 183220341

Start: 969586

End: 970890

Strand: Direct

Name: ugd [H]

Synonym: LEPBI_I0937

Alternate gene names: 183220341

Gene position: 969586-970890 (Clockwise)

Preceding gene: 183220340

Following gene: 183220343

Centisome position: 26.94

GC content: 41.23

Gene sequence:

>1305_bases
ATGAAAGTTTGTGTGGTCGGAACCGGATATGTGGGCCTTGTTGCAGGTACTTGTTTTGCTGAGTATGGCAATGATGTGAT
TTGTATTGATAAAGATGAAAAAAAGATCAGTGACCTTAAAAAAGGGATCATCCCAATTTATGAGCCGGGTTTAACCGAAC
TCGTAGAACGCAATTATAAAGAAGGACGACTCAAATTTTCCACATCGTTAAAAGATGGTGTTGAATCATCGGAGTTTGTT
TTTATCGCTGTTGGGACACCCACATCTGACAACGGTTCGGCGGACTTACGTTTTGTTTTTGCCGTTGCGGAAGAAGTTGG
AAAAACAATGAATGGTTACAAAATCATCGTCGATAAGTCCACGGTTCCCGTAGGCACGGCAGATAAAGTAAAAGAAATTC
TATCCAAAAACACAAAACACCCATTTGACGTAGTCTCCAATCCAGAATTTTTAAAAGAAGGGGCGGCGATCGATGACTTT
ATGCGACCTGAACGAGTTGTGATCGGAGCAGAATCGGAATTGGCTGCCAAAAAAATGAGCGAACTTTATTCCCCTTTTGT
CCTCAACGGAAATCCGATCATCACTATGAGCATTCGTTCCGCAGAACTCACAAAGTATGCCTGTAACGCCTTCCTTGCCA
CAAAAATCTCCTTTGTGAATGAAATAGCCAACTTATGTGATGCCTTAGGTGCCAATTATGATGACGTTCGCAAAGGGATG
GGAACCGATTCAAGGATTGGTAGACAATTTTTATATGCAGGGATTGGATACGGTGGATCCTGTTTTCCTAAAGATGTGAG
AGCACTTTTAAGAACCGCAGAAGAAGTGAACGCTCCCATGCACATCATCCAGTCTGTTGAAGACGTGAATGAAAAACAAA
AAACTCGTCTAACAGATAAAATTTTCGAACACTTTAAATCAACCGATATGAAAGGGAAAACCTTTGGAATTTGGGGACTT
TCCTTCAAACCTGGAACAGATGATATGCGAGAAGCCCCGTCCATCCCTCTGATCTATGAACTCCATAAAAATGGTGCGAA
AATTCAAGTATTTGATCCTGCCGCGATGGAAACGTCTAAGTATTATTTTGATGGGAAAGTCGAATACAAAAAAGACGCAT
ATGCAACGTTAGAAGGTGCAGATGCCATGTTGTTGTTAACCGAATGGCGTGAATTCCGCGAGCCCGATTTTCAAAAAATC
AAGTCGTTACTGAAGTCTCCTCTGATTTTTGATGGAAGGAACCAATACAAACCAAATTTGATGCAAGAAATTGGGTTTAC
TTACTATTCGATCGGGAATCGGTAA

Upstream 100 bases:

>100_bases
GATTTGTCATATTCCCACAAGCTTTCAGATCAAGCAAGATCGAGGCACACGTTAGAAAAACAGTTTCCTTTTCGGTTAAA
ATTGAAAATCTGGAAATCCT

Downstream 100 bases:

>100_bases
AGTTTCCCGGCAAACATTCGTTTGCCGGAACTTACATTTTGCTTTAAAATCCTTTTTCGATTTGTTCTAAGGTTTCTTTA
CAAATCAATTGGTCTGATTC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKVCVVGTGYVGLVAGTCFAEYGNDVICIDKDEKKISDLKKGIIPIYEPGLTELVERNYKEGRLKFSTSLKDGVESSEFV
FIAVGTPTSDNGSADLRFVFAVAEEVGKTMNGYKIIVDKSTVPVGTADKVKEILSKNTKHPFDVVSNPEFLKEGAAIDDF
MRPERVVIGAESELAAKKMSELYSPFVLNGNPIITMSIRSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEKQKTRLTDKIFEHFKSTDMKGKTFGIWGL
SFKPGTDDMREAPSIPLIYELHKNGAKIQVFDPAAMETSKYYFDGKVEYKKDAYATLEGADAMLLLTEWREFREPDFQKI
KSLLKSPLIFDGRNQYKPNLMQEIGFTYYSIGNR

Sequences:

>Translated_434_residues
MKVCVVGTGYVGLVAGTCFAEYGNDVICIDKDEKKISDLKKGIIPIYEPGLTELVERNYKEGRLKFSTSLKDGVESSEFV
FIAVGTPTSDNGSADLRFVFAVAEEVGKTMNGYKIIVDKSTVPVGTADKVKEILSKNTKHPFDVVSNPEFLKEGAAIDDF
MRPERVVIGAESELAAKKMSELYSPFVLNGNPIITMSIRSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEKQKTRLTDKIFEHFKSTDMKGKTFGIWGL
SFKPGTDDMREAPSIPLIYELHKNGAKIQVFDPAAMETSKYYFDGKVEYKKDAYATLEGADAMLLLTEWREFREPDFQKI
KSLLKSPLIFDGRNQYKPNLMQEIGFTYYSIGNR
>Mature_434_residues
MKVCVVGTGYVGLVAGTCFAEYGNDVICIDKDEKKISDLKKGIIPIYEPGLTELVERNYKEGRLKFSTSLKDGVESSEFV
FIAVGTPTSDNGSADLRFVFAVAEEVGKTMNGYKIIVDKSTVPVGTADKVKEILSKNTKHPFDVVSNPEFLKEGAAIDDF
MRPERVVIGAESELAAKKMSELYSPFVLNGNPIITMSIRSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEKQKTRLTDKIFEHFKSTDMKGKTFGIWGL
SFKPGTDDMREAPSIPLIYELHKNGAKIQVFDPAAMETSKYYFDGKVEYKKDAYATLEGADAMLLLTEWREFREPDFQKI
KSLLKSPLIFDGRNQYKPNLMQEIGFTYYSIGNR

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=37.5809935205184, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI296040438, Length=365, Percent_Identity=38.0821917808219, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI296040443, Length=456, Percent_Identity=32.6754385964912, Blast_Score=211, Evalue=9e-55,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=28.0927835051546, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI48994968, Length=423, Percent_Identity=27.4231678486998, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=463, Percent_Identity=37.3650107991361, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=36.5010799136069, Blast_Score=291, Evalue=8e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48334; Mature: 48334

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCVVGTGYVGLVAGTCFAEYGNDVICIDKDEKKISDLKKGIIPIYEPGLTELVERNYK
CEEEEEECCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EGRLKFSTSLKDGVESSEFVFIAVGTPTSDNGSADLRFVFAVAEEVGKTMNGYKIIVDKS
CCCEEEECCHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADKVKEILSKNTKHPFDVVSNPEFLKEGAAIDDFMRPERVVIGAESELAAKKMS
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHCCCCEEEEECCHHHHHHHHH
ELYSPFVLNGNPIITMSIRSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGM
HHCCCEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEKQKTRLTDK
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IFEHFKSTDMKGKTFGIWGLSFKPGTDDMREAPSIPLIYELHKNGAKIQVFDPAAMETSK
HHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCCCCCEEEEECCCCCEEEEECCHHHCCCC
YYFDGKVEYKKDAYATLEGADAMLLLTEWREFREPDFQKIKSLLKSPLIFDGRNQYKPNL
EEECCEEEECCCCCEEECCCCEEEEHHHHHHHCCCCHHHHHHHHHCCCEECCCCCCCCHH
MQEIGFTYYSIGNR
HHHHCCEEEECCCC
>Mature Secondary Structure
MKVCVVGTGYVGLVAGTCFAEYGNDVICIDKDEKKISDLKKGIIPIYEPGLTELVERNYK
CEEEEEECCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EGRLKFSTSLKDGVESSEFVFIAVGTPTSDNGSADLRFVFAVAEEVGKTMNGYKIIVDKS
CCCEEEECCHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADKVKEILSKNTKHPFDVVSNPEFLKEGAAIDDFMRPERVVIGAESELAAKKMS
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHCCCCEEEEECCHHHHHHHHH
ELYSPFVLNGNPIITMSIRSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGM
HHCCCEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEKQKTRLTDK
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IFEHFKSTDMKGKTFGIWGLSFKPGTDDMREAPSIPLIYELHKNGAKIQVFDPAAMETSK
HHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCCCCCEEEEECCCCCEEEEECCHHHCCCC
YYFDGKVEYKKDAYATLEGADAMLLLTEWREFREPDFQKIKSLLKSPLIFDGRNQYKPNL
EEECCEEEECCCCCEEECCCCEEEEHHHHHHHCCCCHHHHHHHHHCCCEECCCCCCCCHH
MQEIGFTYYSIGNR
HHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]