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The map label for this gene is hisB

Identifier: 183220279

GI number: 183220279

Start: 893149

End: 893742

Strand: Direct

Name: hisB

Synonym: LEPBI_I0874

Alternate gene names: 183220279

Gene position: 893149-893742 (Clockwise)

Preceding gene: 183220278

Following gene: 183220280

Centisome position: 24.81

GC content: 44.28

Gene sequence:

>594_bases
ATGCTTAGGAATATGGTGGAATCCAGAAAAACATCCGAAACGGACATCCGCTTGGACCTAAACCTCCGAGGCAGTGGTGT
TTATGCATTTGATACAGAAATCCCTTTTTTTGAGCATATGCTCTCTCATATCGCCAAACATGGCCTAATTGACATGGATC
TAAAACTACGGGGAGACATTGGCATTGATTGCCACCACTCCGTAGAAGATACGGCCATTCTACTTGGTCAAATGATCCAC
ACCCAACTGGGGGACAAAAAAGGAATCTTTCGGTATGGAAATTTCACCCTTCCCATGGATGAAGTTTTGACCACAGTTGC
CGTTGATCTTGGTGGAAGATTTTATTTTAAGTACACTGGACCTGCACTCGACGGCAAGTTTGGTATTTATGACGCAGAAC
TCACATTAGAGTTTTTACAAAAGCTTGCCCTCAATGCTAAAATGAACCTTCACGTTGTGGTTCATTACGGAGAAAACAGA
CACCATATCCACGAGTCGATTTTTAAGGCTTTGGGAAAGGCACTCCGGCAAGCCATTGCAATCGACACGAGCGCCAAAGA
CCAAATTCCATCCACAAAGGGAATGCTCGAGTGA

Upstream 100 bases:

>100_bases
GTTTTTGGGTTTTTATTGGATATAATTTGGTAGGTGTTTTGAGCTTCGCTTCCTAATTCTCACTCACATTCTCTCTTGAC
AGCTGGGTTTTCTACCAAAC

Downstream 100 bases:

>100_bases
TCGCTGTTTTGGATTTTGGAATGGGAAATATCCATTCCTTGTTAAAGGCAGTCTCGCTATATACAAACGATTTTGTTTTT
ACGAGTGATCCCGAAAAGGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MLRNMVESRKTSETDIRLDLNLRGSGVYAFDTEIPFFEHMLSHIAKHGLIDMDLKLRGDIGIDCHHSVEDTAILLGQMIH
TQLGDKKGIFRYGNFTLPMDEVLTTVAVDLGGRFYFKYTGPALDGKFGIYDAELTLEFLQKLALNAKMNLHVVVHYGENR
HHIHESIFKALGKALRQAIAIDTSAKDQIPSTKGMLE

Sequences:

>Translated_197_residues
MLRNMVESRKTSETDIRLDLNLRGSGVYAFDTEIPFFEHMLSHIAKHGLIDMDLKLRGDIGIDCHHSVEDTAILLGQMIH
TQLGDKKGIFRYGNFTLPMDEVLTTVAVDLGGRFYFKYTGPALDGKFGIYDAELTLEFLQKLALNAKMNLHVVVHYGENR
HHIHESIFKALGKALRQAIAIDTSAKDQIPSTKGMLE
>Mature_197_residues
MLRNMVESRKTSETDIRLDLNLRGSGVYAFDTEIPFFEHMLSHIAKHGLIDMDLKLRGDIGIDCHHSVEDTAILLGQMIH
TQLGDKKGIFRYGNFTLPMDEVLTTVAVDLGGRFYFKYTGPALDGKFGIYDAELTLEFLQKLALNAKMNLHVVVHYGENR
HHIHESIFKALGKALRQAIAIDTSAKDQIPSTKGMLE

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=188, Percent_Identity=40.9574468085106, Blast_Score=139, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324776, Length=212, Percent_Identity=33.4905660377358, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_LEPBA (B0SDS4)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961952.1
- ProteinModelPortal:   B0SDS4
- SMR:   B0SDS4
- GeneID:   6389337
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0841
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   CLSK573360
- BioCyc:   LBIF355278:LBF_0841-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22172; Mature: 22172

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRNMVESRKTSETDIRLDLNLRGSGVYAFDTEIPFFEHMLSHIAKHGLIDMDLKLRGDI
CCCHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GIDCHHSVEDTAILLGQMIHTQLGDKKGIFRYGNFTLPMDEVLTTVAVDLGGRFYFKYTG
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEC
PALDGKFGIYDAELTLEFLQKLALNAKMNLHVVVHYGENRHHIHESIFKALGKALRQAIA
CCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IDTSAKDQIPSTKGMLE
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRNMVESRKTSETDIRLDLNLRGSGVYAFDTEIPFFEHMLSHIAKHGLIDMDLKLRGDI
CCCHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GIDCHHSVEDTAILLGQMIHTQLGDKKGIFRYGNFTLPMDEVLTTVAVDLGGRFYFKYTG
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEC
PALDGKFGIYDAELTLEFLQKLALNAKMNLHVVVHYGENRHHIHESIFKALGKALRQAIA
CCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IDTSAKDQIPSTKGMLE
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA