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The map label for this gene is uvrB

Identifier: 183220252

GI number: 183220252

Start: 857245

End: 859239

Strand: Direct

Name: uvrB

Synonym: LEPBI_I0845

Alternate gene names: 183220252

Gene position: 857245-859239 (Clockwise)

Preceding gene: 183220251

Following gene: 183220253

Centisome position: 23.81

GC content: 39.05

Gene sequence:

>1995_bases
ATGGCAAATTTCAAAATGGTTTCTCCCTTTAAAGCTGCCGGAGACCAAGTGAAAGCAATTGAAAATATTGCGAAGTCATT
CGGTGAAGGTAAAAATAAAATCACTCTAGTCGGTGTGACTGGGTCAGGTAAGACGTTTACTATGGCCGAGGTGATCACTC
GGGTCAAAAAACCCACCTTGATTTTATCGCATAATAAAACATTAGCGGCGCAGTTATTCCGTGAGTTTAAAGAATTTTTT
CCTGAAAATGCCGTAGAGTATTTTGTTTCTTATTACGATTATTACCAACCAGAAGCCTATGTCCCTTCTTCTGATACCTT
TATCGAAAAAGATATGTCGATGAATGAAGAAATCGACAAACTGAGGTTACGTGCCACTTCCAGTCTTTTGGAACGAGATG
ATGTGATTATCGTAAGTTCAGTTTCTTGCATTTATGGTTTGGGTTCACCTGAAGATTATATGAACTCTGTGGTGATGTTA
CAAGTTGGTGATAAAATTGACCGCGACCAAATCATTCGTAAATTCTTACACATCCAATATGCGAGAAACGATATTGATTT
TAGTCGTGGTAATTTTCGTGTTCGCGGAGATACAATTGAAATCATGCCTTCTTACCAAGAAGAGGGAATCCGAATTGAAC
TTTTTGGAGATGAAATCGATGGACTTTCCAAAATTGATCCTCTCACGGGAAAGGTAAAAATCAAACTTGATCGTGTCGTC
GTTTATCCCGCCAAACACTTCATCACTTCAGGGCCTAAAATCAAAGATGCCATGGAAAAAATCAAAGAAGAGATGGCGGC
CCAAAAGGAATATTTTTTAAAACAAGGCAAACACCTCGAAGCAGAACGAATTGAGTCTCGAACGAATTACGATATGGAAA
TGTTACTCGAACTTGGGTATTGTAGTGGGATCGAAAACTACTCTCGTCATCTGACTGGAAGAGCGGAAGGGGAACGGCCT
GCCTGTTTACTCGATTATTTTCCTGGAAAAGATTTTTTACTCATCATTGATGAATCACATGTCACTCTCCCACAAATTGG
TGGAATGTATGCAGGTGATAGATCCAGAAAACAAACGTTAGTTGAATTTGGGTTTCGGTTACCGAGTGCACTCGATAACA
GACCATTGAATTTTACAGAATTTGAAGCGATGACTCCAAGGACTTTGTATGTGTCAGCAACTCCAGACCAAAATGAATTG
AATAAAAGTGAAGCGGTATTTGAACAAATCATTCGGCCTACTGGACTTCTGGATCCAGTCGTGGAAGTAAGGCCAACGAC
AAATCAAATCGAAGATTTATTAAATGAAATCAGGCTTCGTATCAACCAAAAAGAAAGGGTCCTCATTACCACTCTCACTA
AAAAAATGTCAGAAGATTTGACTGACTATTATAAAGAAGTGGGTCTAAAGATCGCTTATTTACATTCGGAAATTGATACT
ATCGAAAGAACTGAAATCATTCGGGACTTACGAAAGGGAGTTTACGATTGTATTGTCGGGATCAATTTGTTACGTGAAGG
TTTGGATATTCCTGAAGTTTCGCTTGTTGCCATCTTAGATGCTGACAAAGAGGGTTTCCTTCGAAATTATAAATCACTCG
TCCAAACCATTGGTCGTGCCGCAAGGAACGTAAACGGAAAAGCCATCCTCTATGCAGATCGTATGACTGATTCCATCAAA
AAAGCGATGAGTGAAACAGAACGTCGTCGGTTGATCCAAGAAGCACATAATGAGAAAATGGGGATCACACCACAGACAAT
TCAAAAAGAAATTCATGATATCCTTCCAAGAGAGATGGCAGAAGAGGATAGCAAAGAAGAAGCATTAAAAGATTTAGAAA
AAGAATTTACCTTGAAGAAATACAAAACCAAAGACAAGTTACGTGAAGCTTTGAAACGTGAGATGTTACGTTACGCAAAT
GACATGGATTTTGAGAAGGCGGCCATGTTTCGTGATAAAATGTTAGCACTTGGCCCAGACAAAATTGAAACATAA

Upstream 100 bases:

>100_bases
GATGGTCATGCAAAAACTTTTTGATTCAGTGGACTTAGAGATCACTGATAACAGAAAACAAGCTATCCTTAAAGCAACTC
GTAAACTAACATAGGTTCCT

Downstream 100 bases:

>100_bases
GGAAGGATACGGATTGGAATCAAATGAATTTTGGGAAAACCCAAACAAATTGGCAAGACTAGAAGATACTTTACCGAAAC
AGATCTTTTTACTTCCGATC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTLILSHNKTLAAQLFREFKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDKLRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVML
QVGDKIDRDQIIRKFLHIQYARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVV
VYPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGYCSGIENYSRHLTGRAEGERP
ACLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTLVEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNEL
NKSEAVFEQIIRPTGLLDPVVEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDT
IERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRAARNVNGKAILYADRMTDSIK
KAMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMAEEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYAN
DMDFEKAAMFRDKMLALGPDKIET

Sequences:

>Translated_664_residues
MANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTLILSHNKTLAAQLFREFKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDKLRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVML
QVGDKIDRDQIIRKFLHIQYARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVV
VYPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGYCSGIENYSRHLTGRAEGERP
ACLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTLVEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNEL
NKSEAVFEQIIRPTGLLDPVVEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDT
IERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRAARNVNGKAILYADRMTDSIK
KAMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMAEEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYAN
DMDFEKAAMFRDKMLALGPDKIET
>Mature_663_residues
ANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTLILSHNKTLAAQLFREFKEFFP
ENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDKLRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVMLQ
VGDKIDRDQIIRKFLHIQYARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVVV
YPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGYCSGIENYSRHLTGRAEGERPA
CLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTLVEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNELN
KSEAVFEQIIRPTGLLDPVVEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDTI
ERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRAARNVNGKAILYADRMTDSIKK
AMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMAEEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYAND
MDFEKAAMFRDKMLALGPDKIET

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=56.9924812030075, Blast_Score=745, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_LEPBA (B0SDE2)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961925.1
- ProteinModelPortal:   B0SDE2
- SMR:   B0SDE2
- GeneID:   6387285
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0814
- HOGENOM:   HBG703949
- OMA:   EKDLAIN
- ProtClustDB:   PRK05298
- BioCyc:   LBIF355278:LBF_0814-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76207; Mature: 76075

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTL
CCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHHHHHCCCEE
ILSHNKTLAAQLFREFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDK
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHH
LRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVMLQVGDKIDRDQIIRKFLHIQY
HHHHHHHHHHCCCCEEEEECCHHHHCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHH
ARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVV
HCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEECCCCCCCHHCCCCCCEEEEEEEEEE
VYPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGY
EECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHH
CSGIENYSRHLTGRAEGERPACLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTL
HCCHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHCCCCCCCCCHHHHHH
VEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNELNKSEAVFEQIIRPTGLLDPV
HHHHHHCCHHHCCCCCCCHHHHCCCCCEEEEECCCCHHHCCHHHHHHHHHHCCCCCCCCH
VEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDT
HCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHH
IERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGKAILYADRMTDSIKKAMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMA
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHH
EEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYANDMDFEKAAMFRDKMLALGPD
HCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
KIET
HCCC
>Mature Secondary Structure 
ANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTL
CCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHHHHHCCCEE
ILSHNKTLAAQLFREFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDK
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHH
LRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVMLQVGDKIDRDQIIRKFLHIQY
HHHHHHHHHHCCCCEEEEECCHHHHCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHH
ARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVV
HCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEECCCCCCCHHCCCCCCEEEEEEEEEE
VYPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGY
EECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHH
CSGIENYSRHLTGRAEGERPACLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTL
HCCHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHCCCCCCCCCHHHHHH
VEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNELNKSEAVFEQIIRPTGLLDPV
HHHHHHCCHHHCCCCCCCHHHHCCCCCEEEEECCCCHHHCCHHHHHHHHHHCCCCCCCCH
VEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDT
HCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHH
IERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGKAILYADRMTDSIKKAMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMA
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHH
EEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYANDMDFEKAAMFRDKMLALGPD
HCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
KIET
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA