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The map label for this gene is bioA [H]

Identifier: 183220234

GI number: 183220234

Start: 839741

End: 841072

Strand: Direct

Name: bioA [H]

Synonym: LEPBI_I0827

Alternate gene names: 183220234

Gene position: 839741-841072 (Clockwise)

Preceding gene: 183220233

Following gene: 183220235

Centisome position: 23.33

GC content: 38.06

Gene sequence:

>1332_bases
ATGAGGAATGAAAATCCCGTAAACACATACACTTGGGTGCCTCTCACAATCCAAGATGAATCGGAAACATTATTAAATAT
CGTTTCTGCAGAAAAAGAATTTGTAACTGATAGTGATGGGAATGTATGGATTGATGCCATCTCTAGTTGGTGGACGATGA
TTTTTGGGCATAGACACCCAAGGCTTCTTTTGGCATTACAAAACCAATTACAATCTTTAGATCATGTGATGCTTGCTGGG
AACATCCATGAACCAGCAGAAAACTTATCGAAGGCCATTTTAGATCTTACAGAATCAAATTTTGCGAAAGTGTTTTATTC
GGATAACGGATCCAATGCGATTGAGATCTCTCTGAAACTTGCGATCCAATACTATCAAAATCTTCCCAATTCTAAACCAA
GATCTGAGTTTTTGGTTTTTTCCAATTCTTATCATGGTGATAGTATTGGCGCGATGAATGTCTCGGGACAAAACTACTTC
AATCGAATTTTTTCAGAGTTACGTTTCCCAACAAAAGAATTCCCTGCACCAAATTGTATGAATTGTCCCTGGGGCAAAAA
ACCGGATCATTGTTCTACGGAATGTTTGTCAGATTTAGAACTCGCTATCAAACAAAAAGATTTTGCAGGCATTGTGATTG
AACCTTTGGTCTTTGGAGCCAACGGAATGCTTTTTTATGATAAAAAGGTTTTGGTCAAACTAAGAGAACTTGCCACTTAC
ACAGGCACCTTACTCATCTTTGACGAAGTATTTACGGGGATGGGAAAATTGGGAGAACCGTTTGCTTTTCAAAAGGCTGG
CGTTGTCCCAGATTTACTAGTATTTGCGAAAGGATTAACAGGTGGAATATTACCTCTCGCTTGTACTCTCGTTCCAAAGT
TTATTTATGAAACCTTTAGATCCAAAGATCCGTATAAAGCTTTTTTCCATGCACATACCATGACAGGAAATGCACTCGCA
TGTAGTCTTGGTTATGAAGCCATAACGATGTTAAATGAATTTGGTCTCACTCAAGTTAAAGAGTTAGAGAAAAAATTAAA
ACAATATGCAGAATCGTTTCAAAAGAAAATGGGAAATTCGATTGAGAATGTCAGAGTGATGGGTGGGATTTTTGCCTTTG
AGTGGAAGGAACCTGTCGCCAATGATGAGTATCTCAATCCCATCGGAAAACAAATTCGAAACTCACTACGAAAATTTTTG
ATCTTACTTAGGCCTCTAGGGAGAACCATTTACATCACACCTCCCTATACCATTTCCGATGCATCCTTGGAAAAGATATT
TTTTGCCTTGGAAACGACACTGCTTGGATTTTTAGAACCAGAAAAATACTAA

Upstream 100 bases:

>100_bases
AATTTCCCTGAACAAAAATTGACATCTGATGAGTTTATCAGATTTGCCTCAGAACATTTTGATCCAAACCGAAATGTGAT
CGATGTTGTATTGAATGCAG

Downstream 100 bases:

>100_bases
AACTCCCATTCCATTTTCTTCGTTTACAGAGTCACCCACGCAAAAGATTTTGTTCTCATGATTGCAGAAGTCCAAGAAAA
AACTATCTCTTCCTCTCCCT

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRNENPVNTYTWVPLTIQDESETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHPRLLLALQNQLQSLDHVMLAG
NIHEPAENLSKAILDLTESNFAKVFYSDNGSNAIEISLKLAIQYYQNLPNSKPRSEFLVFSNSYHGDSIGAMNVSGQNYF
NRIFSELRFPTKEFPAPNCMNCPWGKKPDHCSTECLSDLELAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATY
TGTLLIFDEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFRSKDPYKAFFHAHTMTGNALA
CSLGYEAITMLNEFGLTQVKELEKKLKQYAESFQKKMGNSIENVRVMGGIFAFEWKEPVANDEYLNPIGKQIRNSLRKFL
ILLRPLGRTIYITPPYTISDASLEKIFFALETTLLGFLEPEKY

Sequences:

>Translated_443_residues
MRNENPVNTYTWVPLTIQDESETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHPRLLLALQNQLQSLDHVMLAG
NIHEPAENLSKAILDLTESNFAKVFYSDNGSNAIEISLKLAIQYYQNLPNSKPRSEFLVFSNSYHGDSIGAMNVSGQNYF
NRIFSELRFPTKEFPAPNCMNCPWGKKPDHCSTECLSDLELAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATY
TGTLLIFDEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFRSKDPYKAFFHAHTMTGNALA
CSLGYEAITMLNEFGLTQVKELEKKLKQYAESFQKKMGNSIENVRVMGGIFAFEWKEPVANDEYLNPIGKQIRNSLRKFL
ILLRPLGRTIYITPPYTISDASLEKIFFALETTLLGFLEPEKY
>Mature_443_residues
MRNENPVNTYTWVPLTIQDESETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHPRLLLALQNQLQSLDHVMLAG
NIHEPAENLSKAILDLTESNFAKVFYSDNGSNAIEISLKLAIQYYQNLPNSKPRSEFLVFSNSYHGDSIGAMNVSGQNYF
NRIFSELRFPTKEFPAPNCMNCPWGKKPDHCSTECLSDLELAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATY
TGTLLIFDEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFRSKDPYKAFFHAHTMTGNALA
CSLGYEAITMLNEFGLTQVKELEKKLKQYAESFQKKMGNSIENVRVMGGIFAFEWKEPVANDEYLNPIGKQIRNSLRKFL
ILLRPLGRTIYITPPYTISDASLEKIFFALETTLLGFLEPEKY

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=333, Percent_Identity=27.9279279279279, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4557809, Length=409, Percent_Identity=24.9388753056235, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI284507298, Length=243, Percent_Identity=27.1604938271605, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI188536080, Length=392, Percent_Identity=24.234693877551, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679950, Length=392, Percent_Identity=24.234693877551, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679946, Length=392, Percent_Identity=24.234693877551, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI24119277, Length=322, Percent_Identity=22.0496894409938, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=26.161369193154, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789759, Length=356, Percent_Identity=28.6516853932584, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=26.5, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=28.641975308642, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=25.7831325301205, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786349, Length=415, Percent_Identity=22.6506024096386, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=317, Percent_Identity=27.4447949526814, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=337, Percent_Identity=28.486646884273, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=143, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=29.8245614035088, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324432, Length=409, Percent_Identity=25.1833740831296, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=26.0545905707196, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=362, Percent_Identity=24.3093922651934, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357415, Length=342, Percent_Identity=23.6842105263158, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=25.8278145695364, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161085790, Length=450, Percent_Identity=25.7777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366494, Length=393, Percent_Identity=24.1730279898219, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=393, Percent_Identity=24.1730279898219, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=393, Percent_Identity=24.1730279898219, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50036; Mature: 50036

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNENPVNTYTWVPLTIQDESETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHP
CCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHCCCCC
RLLLALQNQLQSLDHVMLAGNIHEPAENLSKAILDLTESNFAKVFYSDNGSNAIEISLKL
HHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHH
AIQYYQNLPNSKPRSEFLVFSNSYHGDSIGAMNVSGQNYFNRIFSELRFPTKEFPAPNCM
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHCCCCCCC
NCPWGKKPDHCSTECLSDLELAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATY
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHEECCCCEEEECHHHHHHHHHHHHH
TGTLLIFDEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFR
HHHHEEHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
SKDPYKAFFHAHTMTGNALACSLGYEAITMLNEFGLTQVKELEKKLKQYAESFQKKMGNS
CCCCHHHHHEEEECCCCEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
IENVRVMGGIFAFEWKEPVANDEYLNPIGKQIRNSLRKFLILLRPLGRTIYITPPYTISD
HHHEEHECCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECC
ASLEKIFFALETTLLGFLEPEKY
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRNENPVNTYTWVPLTIQDESETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHP
CCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHCCCCC
RLLLALQNQLQSLDHVMLAGNIHEPAENLSKAILDLTESNFAKVFYSDNGSNAIEISLKL
HHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHH
AIQYYQNLPNSKPRSEFLVFSNSYHGDSIGAMNVSGQNYFNRIFSELRFPTKEFPAPNCM
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHCCCCCCC
NCPWGKKPDHCSTECLSDLELAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATY
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHEECCCCEEEECHHHHHHHHHHHHH
TGTLLIFDEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFR
HHHHEEHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
SKDPYKAFFHAHTMTGNALACSLGYEAITMLNEFGLTQVKELEKKLKQYAESFQKKMGNS
CCCCHHHHHEEEECCCCEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
IENVRVMGGIFAFEWKEPVANDEYLNPIGKQIRNSLRKFLILLRPLGRTIYITPPYTISD
HHHEEHECCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECC
ASLEKIFFALETTLLGFLEPEKY
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]