Click here to switch to the map view.

The map label for this gene is hemL2 [H]

Identifier: 183220154

GI number: 183220154

Start: 757654

End: 759120

Strand: Reverse

Name: hemL2 [H]

Synonym: LEPBI_I0742

Alternate gene names: 183220154

Gene position: 759120-757654 (Counterclockwise)

Preceding gene: 183220156

Following gene: 183220151

Centisome position: 21.09

GC content: 43.9

Gene sequence:

>1467_bases
ATGGCCACAGGCTTTTCCATCAATGAATACCCGAATGTAGACCAAATCTACAAAGACTTACGGAAATTAGTTTCCCTACC
GATCCGTTCCATTCGCAAAAACGAAATGGAAAACATCATCCAAAACTATTTCGAAACAAAATGCGCCAAGTCCAAAACGA
TGATCACCAAGGCTTCGGAATTCATTCCTGGTGGTGTCCAACACAACTTGTCTTTTAATTTTCCATTCCCTCTCGTGTTC
ACCAAAGCGGCCGGCGCTTATTTGTATGATTTAGATGGAAACAAATACATCGACTTTTTACAAGCTGGTGGACCCACAGT
GCTTGGAAGTAACCCAACCAGTGTTCGTAAAAAAGTCATCGAACTTTTGGATTCCACAGGGCCTGTGACAGGTCTCTTTC
ATGAATACGAATACAAACTCGCTGAGAAAATTGTCGAACTCGTTCCTTCAGTGGAGATGTTTCGCATGTTAGGTTCAGGA
ACGGAAGCTTGTATGGCATCCATACGCGTGGCAAGGCTTGCAACAAAGAAAAAAAACATCGTGAAGATGGGGGGAGCTTA
TCATGGATGGAGTGACCAACTTGCTTACGGACTACGAATCCCAGGAACAAGACATTTCGAAGCCAATGGTGTTCCTAGAT
CCATTTTCAAATACACACAAGAATTTTATCCCAATGATTTAAACTCACTCGAATCTGTCCTCAAACGAAATCGTTTTTTT
GGAGGGACAGCAGCAGTCCTCATTGAACCTGTCGGACCCGAAAGTGGCACTAGGCCTCTTGACTTTGACTTCAATAAAGG
TGTGAGAGAACTTTGTAACAAGTATGGCGCCCTTCTCATTTTTGATGAAGTGGTCACGGCATTTCGTATTGGGCTCAGCG
GGGCACAAGGGTATTTTGGTGTGGATCCTGATCTCACTGTATTTGGAAAGGTAGTCGCAGGTGGTTACCCTTCTGCCGGT
GGACTTGGTGGTAAAAAAGAATACATGAAGTATGTATCCGCTGGATTACAAACTGGCACCAAAAAGGCGTTAATCGGTGG
GACAATGGCCGCAAACCCACTCAGTTCCCTTGCCGGATATTTCACGTTATGCGAAATGGAAAAAACCAAGGCTTGCGAAA
CATCAGGAAGGGCTGGAGATAGACTGACCAAAGGCCTACAAAAACTCATTAAAAAATACGATCTTCCTTTTGTTGCTTTC
AACCAAGGTTCCATTTGCCACTTGGAAACAGTTGGTACCATGTTACTCGACATCGATATCAAAAAGTTTTGGACCATCAA
AAAGACCATCGCGGAAGCTCATAAACGAAAACATGCAATGGAAGAAATGGGAGCCGCTTACATGTCGGAAGGTCTTGTGA
CACTTGCGGGAAGTCGTTTGTATACAAGTGCTTCTGATACGGACGCAGTGATTGATGATGCCTTAAAACGATTTGACCGA
GTGTTCCAAAAAGTGGAAGGAGTTTAG

Upstream 100 bases:

>100_bases
AGAATCCAAGAAACTTTCTAAATTTTCAAATTTCCTTCTTGACAATGAGTGATGACTCACTCATTGTCAAGTGAAAAGAA
ACCGGACGAGGACAAATCGT

Downstream 100 bases:

>100_bases
GTGGTCTAAGAGATTAAGGAAGTATGATTGTTAGGATTTCCATTGATATCGATATCCTTTCAATCAACTAACATTTCTTT
GATCACATTCTTAATTTTTT

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MATGFSINEYPNVDQIYKDLRKLVSLPIRSIRKNEMENIIQNYFETKCAKSKTMITKASEFIPGGVQHNLSFNFPFPLVF
TKAAGAYLYDLDGNKYIDFLQAGGPTVLGSNPTSVRKKVIELLDSTGPVTGLFHEYEYKLAEKIVELVPSVEMFRMLGSG
TEACMASIRVARLATKKKNIVKMGGAYHGWSDQLAYGLRIPGTRHFEANGVPRSIFKYTQEFYPNDLNSLESVLKRNRFF
GGTAAVLIEPVGPESGTRPLDFDFNKGVRELCNKYGALLIFDEVVTAFRIGLSGAQGYFGVDPDLTVFGKVVAGGYPSAG
GLGGKKEYMKYVSAGLQTGTKKALIGGTMAANPLSSLAGYFTLCEMEKTKACETSGRAGDRLTKGLQKLIKKYDLPFVAF
NQGSICHLETVGTMLLDIDIKKFWTIKKTIAEAHKRKHAMEEMGAAYMSEGLVTLAGSRLYTSASDTDAVIDDALKRFDR
VFQKVEGV

Sequences:

>Translated_488_residues
MATGFSINEYPNVDQIYKDLRKLVSLPIRSIRKNEMENIIQNYFETKCAKSKTMITKASEFIPGGVQHNLSFNFPFPLVF
TKAAGAYLYDLDGNKYIDFLQAGGPTVLGSNPTSVRKKVIELLDSTGPVTGLFHEYEYKLAEKIVELVPSVEMFRMLGSG
TEACMASIRVARLATKKKNIVKMGGAYHGWSDQLAYGLRIPGTRHFEANGVPRSIFKYTQEFYPNDLNSLESVLKRNRFF
GGTAAVLIEPVGPESGTRPLDFDFNKGVRELCNKYGALLIFDEVVTAFRIGLSGAQGYFGVDPDLTVFGKVVAGGYPSAG
GLGGKKEYMKYVSAGLQTGTKKALIGGTMAANPLSSLAGYFTLCEMEKTKACETSGRAGDRLTKGLQKLIKKYDLPFVAF
NQGSICHLETVGTMLLDIDIKKFWTIKKTIAEAHKRKHAMEEMGAAYMSEGLVTLAGSRLYTSASDTDAVIDDALKRFDR
VFQKVEGV
>Mature_487_residues
ATGFSINEYPNVDQIYKDLRKLVSLPIRSIRKNEMENIIQNYFETKCAKSKTMITKASEFIPGGVQHNLSFNFPFPLVFT
KAAGAYLYDLDGNKYIDFLQAGGPTVLGSNPTSVRKKVIELLDSTGPVTGLFHEYEYKLAEKIVELVPSVEMFRMLGSGT
EACMASIRVARLATKKKNIVKMGGAYHGWSDQLAYGLRIPGTRHFEANGVPRSIFKYTQEFYPNDLNSLESVLKRNRFFG
GTAAVLIEPVGPESGTRPLDFDFNKGVRELCNKYGALLIFDEVVTAFRIGLSGAQGYFGVDPDLTVFGKVVAGGYPSAGG
LGGKKEYMKYVSAGLQTGTKKALIGGTMAANPLSSLAGYFTLCEMEKTKACETSGRAGDRLTKGLQKLIKKYDLPFVAFN
QGSICHLETVGTMLLDIDIKKFWTIKKTIAEAHKRKHAMEEMGAAYMSEGLVTLAGSRLYTSASDTDAVIDDALKRFDRV
FQKVEGV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=331, Percent_Identity=26.2839879154079, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786349, Length=450, Percent_Identity=34, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789016, Length=361, Percent_Identity=29.0858725761773, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788044, Length=304, Percent_Identity=32.2368421052632, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789759, Length=449, Percent_Identity=24.2761692650334, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1787560, Length=339, Percent_Identity=28.3185840707965, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI145693181, Length=345, Percent_Identity=25.5072463768116, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=330, Percent_Identity=27.5757575757576, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=168, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=341, Percent_Identity=25.5131964809384, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=355, Percent_Identity=23.943661971831, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357415, Length=359, Percent_Identity=25.9052924791086, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 53674; Mature: 53542

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGFSINEYPNVDQIYKDLRKLVSLPIRSIRKNEMENIIQNYFETKCAKSKTMITKASE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FIPGGVQHNLSFNFPFPLVFTKAAGAYLYDLDGNKYIDFLQAGGPTVLGSNPTSVRKKVI
HCCCCCCCCCEECCCCCHHHHCCCCCEEEECCCCCEEHHHHCCCCEEECCCHHHHHHHHH
ELLDSTGPVTGLFHEYEYKLAEKIVELVPSVEMFRMLGSGTEACMASIRVARLATKKKNI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VKMGGAYHGWSDQLAYGLRIPGTRHFEANGVPRSIFKYTQEFYPNDLNSLESVLKRNRFF
HHCCCCCCCCCHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GGTAAVLIEPVGPESGTRPLDFDFNKGVRELCNKYGALLIFDEVVTAFRIGLSGAQGYFG
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCC
VDPDLTVFGKVVAGGYPSAGGLGGKKEYMKYVSAGLQTGTKKALIGGTMAANPLSSLAGY
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHH
FTLCEMEKTKACETSGRAGDRLTKGLQKLIKKYDLPFVAFNQGSICHLETVGTMLLDIDI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEEHHHHHHHHEEEHH
KKFWTIKKTIAEAHKRKHAMEEMGAAYMSEGLVTLAGSRLYTSASDTDAVIDDALKRFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCEEECCCCCHHHHHHHHHHHHHH
VFQKVEGV
HHHHHCCC
>Mature Secondary Structure 
ATGFSINEYPNVDQIYKDLRKLVSLPIRSIRKNEMENIIQNYFETKCAKSKTMITKASE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FIPGGVQHNLSFNFPFPLVFTKAAGAYLYDLDGNKYIDFLQAGGPTVLGSNPTSVRKKVI
HCCCCCCCCCEECCCCCHHHHCCCCCEEEECCCCCEEHHHHCCCCEEECCCHHHHHHHHH
ELLDSTGPVTGLFHEYEYKLAEKIVELVPSVEMFRMLGSGTEACMASIRVARLATKKKNI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VKMGGAYHGWSDQLAYGLRIPGTRHFEANGVPRSIFKYTQEFYPNDLNSLESVLKRNRFF
HHCCCCCCCCCHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GGTAAVLIEPVGPESGTRPLDFDFNKGVRELCNKYGALLIFDEVVTAFRIGLSGAQGYFG
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCC
VDPDLTVFGKVVAGGYPSAGGLGGKKEYMKYVSAGLQTGTKKALIGGTMAANPLSSLAGY
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHH
FTLCEMEKTKACETSGRAGDRLTKGLQKLIKKYDLPFVAFNQGSICHLETVGTMLLDIDI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEEHHHHHHHHEEEHH
KKFWTIKKTIAEAHKRKHAMEEMGAAYMSEGLVTLAGSRLYTSASDTDAVIDDALKRFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCEEECCCCCHHHHHHHHHHHHHH
VFQKVEGV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA