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The map label for this gene is yqjQ [H]

Identifier: 183220099

GI number: 183220099

Start: 695730

End: 696503

Strand: Reverse

Name: yqjQ [H]

Synonym: LEPBI_I0687

Alternate gene names: 183220099

Gene position: 696503-695730 (Counterclockwise)

Preceding gene: 183220100

Following gene: 183220098

Centisome position: 19.35

GC content: 39.92

Gene sequence:

>774_bases
ATGAAAAATGCATATGTTACTGGCGCATCGCAAGGTATCGGAAAAGAATTTGTTAGGGCTCTTGGCAAAGATTATAACGT
ATTTTTAATTTCACGTACAGAAGCAGACCTAAAAAAAGTGATAGTCGAACTTGAACCAAAGTCGAGAGGGATGTTAAAGT
ATTATGCTTTGGATCTCACTAAAAAAAAGGATGTGGAAGAACTAGCAAATCTCATTGAAAAAGACAAAGATGCGGAAGTT
CTAGTGAACAATGCAGGATTTGGAACCGTTGGTGAATTTGCCGCCCTCCCCTTAGACAAAGAATTGGATGAAGTCAATCT
GAATGTAAAAACATTGGTTCACCTCAGTCACACAGCCCTCAATCGTTTCAAAAAAAATAAAAAAGGTTTTTTGATCAATG
TTGCGTCTATCGCAGGTTATCTGCCAGCACCAGGCAGTGCGATTTATGCGGCAACCAAAGCCTTTGTAAAATCATTCACT
GAATCCATTCATGAAGAAGCAAAAAACTACGGAATCCATGTGCAGGCTCTTTGCCCAGGCCTCACTCATTCCGATTTCCA
TCAAAGAGCAGGGATCAACAAATCCAAATACCCATCCTTTATGTGGCAAACTGCAGATGAAGTCGTCGAAGAGTCGTTAA
GTGCGCTCAAATACAACCAAGCTGTTTGTATCACAGGAAGTTTTAACCAAGGTGCCATTACTGTATCAGAATTGATCCCA
AGAGGTTTTTTACGAAAACTGAGTGGCCGATATTTGAAACTAGAAGAGGAATAA

Upstream 100 bases:

>100_bases
TCAAACTTTATTTGTCTGCTGGTTTTTTTGAACTCGAGAGACGTAAAAAATATTATCCGGACGGATCAACTGCCGTTCTA
ATGAAGAGGAATCCCATCGA

Downstream 100 bases:

>100_bases
GATGGATGTCGCTAAACTAGATACTTGGTATCGCAGACTTCTTGTACTATCTTCTGTTATATGTGGAGGATTCCAGGTAT
ACTACGAAGGGAATGTTTGG

Product: oxidoreductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKNAYVTGASQGIGKEFVRALGKDYNVFLISRTEADLKKVIVELEPKSRGMLKYYALDLTKKKDVEELANLIEKDKDAEV
LVNNAGFGTVGEFAALPLDKELDEVNLNVKTLVHLSHTALNRFKKNKKGFLINVASIAGYLPAPGSAIYAATKAFVKSFT
ESIHEEAKNYGIHVQALCPGLTHSDFHQRAGINKSKYPSFMWQTADEVVEESLSALKYNQAVCITGSFNQGAITVSELIP
RGFLRKLSGRYLKLEEE

Sequences:

>Translated_257_residues
MKNAYVTGASQGIGKEFVRALGKDYNVFLISRTEADLKKVIVELEPKSRGMLKYYALDLTKKKDVEELANLIEKDKDAEV
LVNNAGFGTVGEFAALPLDKELDEVNLNVKTLVHLSHTALNRFKKNKKGFLINVASIAGYLPAPGSAIYAATKAFVKSFT
ESIHEEAKNYGIHVQALCPGLTHSDFHQRAGINKSKYPSFMWQTADEVVEESLSALKYNQAVCITGSFNQGAITVSELIP
RGFLRKLSGRYLKLEEE
>Mature_257_residues
MKNAYVTGASQGIGKEFVRALGKDYNVFLISRTEADLKKVIVELEPKSRGMLKYYALDLTKKKDVEELANLIEKDKDAEV
LVNNAGFGTVGEFAALPLDKELDEVNLNVKTLVHLSHTALNRFKKNKKGFLINVASIAGYLPAPGSAIYAATKAFVKSFT
ESIHEEAKNYGIHVQALCPGLTHSDFHQRAGINKSKYPSFMWQTADEVVEESLSALKYNQAVCITGSFNQGAITVSELIP
RGFLRKLSGRYLKLEEE

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4557649, Length=226, Percent_Identity=30.0884955752212, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7705855, Length=183, Percent_Identity=32.2404371584699, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI226371731, Length=181, Percent_Identity=29.8342541436464, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI109715829, Length=192, Percent_Identity=28.6458333333333, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI40548397, Length=232, Percent_Identity=26.2931034482759, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010158, Length=232, Percent_Identity=26.2931034482759, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010156, Length=232, Percent_Identity=26.2931034482759, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22758144, Length=232, Percent_Identity=26.2931034482759, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI32483357, Length=205, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20149619, Length=269, Percent_Identity=25.2788104089219, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=233, Percent_Identity=27.0386266094421, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082100, Length=192, Percent_Identity=27.6041666666667, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=29.608938547486, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=28.6458333333333, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=181, Percent_Identity=29.2817679558011, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=27.4590163934426, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=209, Percent_Identity=28.7081339712919, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=210, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560176, Length=190, Percent_Identity=27.8947368421053, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559552, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557668, Length=193, Percent_Identity=29.5336787564767, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212646214, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=240, Percent_Identity=27.9166666666667, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=218, Percent_Identity=29.8165137614679, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25152911, Length=197, Percent_Identity=29.9492385786802, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=229, Percent_Identity=31.0043668122271, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319635, Length=234, Percent_Identity=26.4957264957265, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322067, Length=178, Percent_Identity=28.0898876404494, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584752, Length=181, Percent_Identity=37.5690607734807, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=32.3232323232323, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24584744, Length=184, Percent_Identity=32.0652173913043, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574402, Length=184, Percent_Identity=32.0652173913043, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24584748, Length=192, Percent_Identity=32.2916666666667, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=32.2916666666667, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644339, Length=203, Percent_Identity=29.5566502463054, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640442, Length=221, Percent_Identity=28.0542986425339, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=28.2828282828283, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=205, Percent_Identity=29.7560975609756, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI116007236, Length=195, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364494, Length=197, Percent_Identity=30.4568527918782, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24639444, Length=185, Percent_Identity=31.3513513513514, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24580925, Length=197, Percent_Identity=27.9187817258883, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28449; Mature: 28449

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAYVTGASQGIGKEFVRALGKDYNVFLISRTEADLKKVIVELEPKSRGMLKYYALDLT
CCCCEECCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHEEECCCCCCEEEEEEECCC
KKKDVEELANLIEKDKDAEVLVNNAGFGTVGEFAALPLDKELDEVNLNVKTLVHLSHTAL
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCHHHCCCCHHHHHHHHHHHH
NRFKKNKKGFLINVASIAGYLPAPGSAIYAATKAFVKSFTESIHEEAKNYGIHVQALCPG
HHHHCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
LTHSDFHQRAGINKSKYPSFMWQTADEVVEESLSALKYNQAVCITGSFNQGAITVSELIP
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHH
RGFLRKLSGRYLKLEEE
HHHHHHHCCCEEEEECC
>Mature Secondary Structure
MKNAYVTGASQGIGKEFVRALGKDYNVFLISRTEADLKKVIVELEPKSRGMLKYYALDLT
CCCCEECCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHEEECCCCCCEEEEEEECCC
KKKDVEELANLIEKDKDAEVLVNNAGFGTVGEFAALPLDKELDEVNLNVKTLVHLSHTAL
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCHHHCCCCHHHHHHHHHHHH
NRFKKNKKGFLINVASIAGYLPAPGSAIYAATKAFVKSFTESIHEEAKNYGIHVQALCPG
HHHHCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
LTHSDFHQRAGINKSKYPSFMWQTADEVVEESLSALKYNQAVCITGSFNQGAITVSELIP
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHH
RGFLRKLSGRYLKLEEE
HHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]