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The map label for this gene is fabG [C]

Identifier: 183219957

GI number: 183219957

Start: 536179

End: 536931

Strand: Reverse

Name: fabG [C]

Synonym: LEPBI_I0539

Alternate gene names: 183219957

Gene position: 536931-536179 (Counterclockwise)

Preceding gene: 183219961

Following gene: 183219956

Centisome position: 14.92

GC content: 40.37

Gene sequence:

>753_bases
ATGGGGAAAAAAATAATCGTCGTCGGTGCCTCGAGTGGGATCGGAAAAGCCATTGCTGAACAAGAATTGAACGCTGGGTC
CTCTGTGGTCCTTTTAGCAAGAAGGGAAAAATCCCTCGAATCCATCGCAAAAAAAGGAAATACTTCCAAAGAAAAACGAG
CCTTCCCGCTTGTCTTTGATGTGACCAAATTTGCGACAGCAGAGAAAACATTTCAAAAAGCGGTTTCAATACTCGGTGGA
GTGGACGAAGTGTATTTTGCCTCTGGAGTGATGCCTGAGATTTCCAAAGAAGAATACAACACAGGCAAAGATTTAGAAAT
GTTAAACGTTAATCTTTTAGGAGCTGTTGCCTTCCTCAATCCTGTTGCTAGTTTTTTTACCAAACAAAAATCGGGTAAGA
TTATTGGAATTTCTTCCATTGCAGGAGAAAGAGGGAGAAAAGGGAATCCTGTATATAACACTTCGAAAGCAGGACTCAAT
ACCTATTTAGAGGCTCTACGGAATCGTTTATCAGAATCGAATGTACAAGTAACAACGATTAAACCTGGTTTCGTAAAAAC
TGATATGACCAAAGGACTCACATTACCAGAGAAAGGATTGTTAAAAGCAATCACGGCAGAAGAAGCCGCAGAAAAAATTC
GCGTCATTGTGGCGAATGGTAAGGATGAGGCTTTTGTTCCAGGAATTTGGGCATTAGTAGCACTCATCATCCGCAACATT
CCCAATTTTATCTTCAAAAAACTGAGTATATAA

Upstream 100 bases:

>100_bases
TATACATCAAATTCATCCCGTCGATCAGGATTCTTTCATTTACGGGCACAACTCTAATGAAACCACTTGCCAGATTCGAT
TAAACCAAAAAAACGTAAAC

Downstream 100 bases:

>100_bases
TATGGTAACAAAAAAAACAAAATCCATTCCTAGTATCAAAGTTCCTCATAAAGAAAAGGTAGAAGCATGGGGAATGAGTT
CTTTTTCCATGTCACCAGTG

Product: SDR family dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MGKKIIVVGASSGIGKAIAEQELNAGSSVVLLARREKSLESIAKKGNTSKEKRAFPLVFDVTKFATAEKTFQKAVSILGG
VDEVYFASGVMPEISKEEYNTGKDLEMLNVNLLGAVAFLNPVASFFTKQKSGKIIGISSIAGERGRKGNPVYNTSKAGLN
TYLEALRNRLSESNVQVTTIKPGFVKTDMTKGLTLPEKGLLKAITAEEAAEKIRVIVANGKDEAFVPGIWALVALIIRNI
PNFIFKKLSI

Sequences:

>Translated_250_residues
MGKKIIVVGASSGIGKAIAEQELNAGSSVVLLARREKSLESIAKKGNTSKEKRAFPLVFDVTKFATAEKTFQKAVSILGG
VDEVYFASGVMPEISKEEYNTGKDLEMLNVNLLGAVAFLNPVASFFTKQKSGKIIGISSIAGERGRKGNPVYNTSKAGLN
TYLEALRNRLSESNVQVTTIKPGFVKTDMTKGLTLPEKGLLKAITAEEAAEKIRVIVANGKDEAFVPGIWALVALIIRNI
PNFIFKKLSI
>Mature_249_residues
GKKIIVVGASSGIGKAIAEQELNAGSSVVLLARREKSLESIAKKGNTSKEKRAFPLVFDVTKFATAEKTFQKAVSILGGV
DEVYFASGVMPEISKEEYNTGKDLEMLNVNLLGAVAFLNPVASFFTKQKSGKIIGISSIAGERGRKGNPVYNTSKAGLNT
YLEALRNRLSESNVQVTTIKPGFVKTDMTKGLTLPEKGLLKAITAEEAAEKIRVIVANGKDEAFVPGIWALVALIIRNIP
NFIFKKLSI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=215, Percent_Identity=31.1627906976744, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI20149619, Length=259, Percent_Identity=22.007722007722, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4503817, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7706318, Length=194, Percent_Identity=30.4123711340206, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI32455239, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031765, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031737, Length=188, Percent_Identity=28.7234042553192, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=212, Percent_Identity=29.7169811320755, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI87082160, Length=195, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790717, Length=205, Percent_Identity=25.3658536585366, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789208, Length=199, Percent_Identity=26.1306532663317, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786812, Length=205, Percent_Identity=24.8780487804878, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=202, Percent_Identity=33.1683168316832, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=205, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193210355, Length=200, Percent_Identity=28, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=205, Percent_Identity=27.3170731707317, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=195, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=195, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=192, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21358495, Length=256, Percent_Identity=24.609375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=208, Percent_Identity=29.8076923076923, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI116007236, Length=223, Percent_Identity=27.8026905829596, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571387, Length=193, Percent_Identity=30.0518134715026, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007234, Length=224, Percent_Identity=28.125, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640492, Length=246, Percent_Identity=27.2357723577236, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643142, Length=225, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=188, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649181, Length=257, Percent_Identity=26.4591439688716, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641232, Length=194, Percent_Identity=26.8041237113402, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571526, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26893; Mature: 26761

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKIIVVGASSGIGKAIAEQELNAGSSVVLLARREKSLESIAKKGNTSKEKRAFPLVFD
CCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHCCCCEEEH
VTKFATAEKTFQKAVSILGGVDEVYFASGVMPEISKEEYNTGKDLEMLNVNLLGAVAFLN
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCCCCEEEEHHHHHHHHHHHH
PVASFFTKQKSGKIIGISSIAGERGRKGNPVYNTSKAGLNTYLEALRNRLSESNVQVTTI
HHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
KPGFVKTDMTKGLTLPEKGLLKAITAEEAAEKIRVIVANGKDEAFVPGIWALVALIIRNI
CCCCEECHHHCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHH
PNFIFKKLSI
HHHHHHHHCC
>Mature Secondary Structure 
GKKIIVVGASSGIGKAIAEQELNAGSSVVLLARREKSLESIAKKGNTSKEKRAFPLVFD
CCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHCCCCEEEH
VTKFATAEKTFQKAVSILGGVDEVYFASGVMPEISKEEYNTGKDLEMLNVNLLGAVAFLN
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCCCCEEEEHHHHHHHHHHHH
PVASFFTKQKSGKIIGISSIAGERGRKGNPVYNTSKAGLNTYLEALRNRLSESNVQVTTI
HHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
KPGFVKTDMTKGLTLPEKGLLKAITAEEAAEKIRVIVANGKDEAFVPGIWALVALIIRNI
CCCCEECHHHCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHH
PNFIFKKLSI
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]